Exosomes Derived from Schistosoma japonicum Cystatin-Treated Macrophages Attenuated CLP-Induced Sepsis in Mice by Feifei Huang, Yayun Qian, Huihui Li, Liang Chu, Chen Wan, Qili Shen, Qianqian Li, Xiuxiu Li, Xinyue Wu, Bin Zhan, Rui Zhou, Xiaodi Yang

“…To determine whether the therapeutic effect of Sj-Cys on sepsis can be conveyed by the exosomes released by Sj-Cys-stimulated macrophages, RAW264.7 macrophages were stimulated with rSj-Cys in vitro, the exosomes were obtained from the cell culture supernatant by ultracentrifugation. …”
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Transcriptomic and proteomic analysis of the jejunum revealed the effects and mechanism of protocatechuic acid on alleviating Salmonella typhimurium infection in chickens by Sheng Zhang, Qin Wang, Xiangtian Yao, Jingjing Dong, Guanhuo Li, Yingan Zang, Shouqun Jiang, Yibing Wang

“…Results of proteomic showed that protocatechuic acid inhibited the positive regulation of dendritic cell cytokine production and I-κB kinase/NF-κB signaling, as well as cytokine-cytokine receptor interaction and MAPK signaling pathways, and activated the mTOR signaling pathways. …”
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Positive Expression of IGFBP2 as a Novel Prognostic Biomarker for Patients with Lower-Grade Gliomas by Yanguo Li, Jiawei Fan, Zhuo Shen, Jun Zhang, Xuemei Yin, Fang Han, Wenfei Li

“…Gene set enrichment analysis (GSEA) was conducted to investigate signaling pathways influencing glioma cell proliferation at the transcriptional level of IGFBP2. …”
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Transcriptomic reprogramming and epigenetic regulation underlying pollination-dependent and auxin-induced fruit set in tomato by Xiaohan Li, Xiaohan Li, Xiaohan Li, Bing He, Anis Djari, Pierre Frasse, Elie Maza, Farid Regad, Julien Pirrello, Guojian Hu, Guojian Hu, Guojian Hu, Guojian Hu, Mondher Bouzayen

“…In contrast, Teosinte branched1/Cincinnata/proliferating cell factor (TCP), SQUAMOSA -promoter binding proteins (SBP), Sucrose nonfermenting 2 (SNF2), Growth-regulating factor (GRF), and Su (var)3-9, Enhancer-of-zeste and Trithorax (SET) family genes were significantly upregulated in both pollinated and auxin-treated young developing fruits, suggesting their active roles in promoting fruit sets. …”
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In-silico study of E169G and F242K double mutations in leucine-rich repeats (LRR) polygalacturonase inhibiting protein (PGIP) of Gossypium barbadense and associated defense mechani... by Sneha Murmu, Mayank Rashmi, Dipak T. Nagrale, Tejasman Kour, Mahender Kumar Singh, Anurag Chaurasia, Santosh Kumar Behera, Raja Shankar, Rajiv Ranjan, Girish Kumar Jha, Shailesh P. Gawande, Neelakanth S. Hiremani, Y. G. Prasad, Sunil Kumar

“…Abstract Background Polygalacturonase inhibiting proteins (PGIPs) play a pivotal role in plant defense against plant pathogens by inhibiting polygalacturonase (PG), an enzyme produced by pathogens to degrade plant cell wall pectin. PGIPs, also known as leucine-rich repeat pathogenesis-related (PR) proteins, activate the host’s defense response upon interaction with PG, thereby reinforcing the host defense against plant pathogens attacks. …”
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Bellini Duct Carcinoma Misdiagnosed with Urothelial Papillary Carcinoma by Joey El Khoury, Maher Abdessater, Rami Halabi, Fadi Nasr, Johnny Boustany, Anthony Kanbar, Charbel El Hachem, Raghid El Khoury

“…In this patient, CDC was masquerading as a transitional cell carcinoma that should always be kept in mind as a possible presentation. …”
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Incidence of HTLV-1-associated myelopathy in the UK from 1991 to 2024: a longitudinal observational cohort study by Carolina Rosadas, Jerico Baylon, Claire Greiller, Adine Adonis, Divya Dhasmana, Nicholas W. S. Davies, Graham P. Taylor, Graham P. Taylor

“…IntroductionHuman T-cell lymphotropic virus type 1 (HTLV-1) may cause spinal cord inflammation, leading to HTLV-1-associated myelopathy (HAM). …”
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Adaptive radiotherapy in locally advanced head and neck cancer: The importance of reduced margins by Hedda Enocson, André Haraldsson, Per Engström, Sofie Ceberg, Maria Gebre-Medhin, Gabriel Adrian, Per Munck af Rosenschöld

“…This study retrospectively assessed the technical feasibility and potential benefits of daily ART in combination with reduced planning target volume (PTV) margins for head and neck squamous cell carcinoma (HNSCC). Materials and Methods: Thirty-one patients, encompassing 902 treatment fractions, treated with radiotherapy to 60.0–68.0 Gy in 2 Gy/fraction were studied. …”
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Unraveling the genetic mysteries of spinal muscular atrophy in Chinese families by Shanshan Gao, Duo Chen, Qianqian Li, Xuechao Zhao, Chen Chen, Lina Liu, Miao Jiang, Zhenhua Zhao, Yanhua Wang, Xiangdong Kong

“…Abstract Objective Spinal muscular atrophy (SMA) is a motor neuron disorder encompassing 5q and non-5q forms, causing muscle weakness and atrophy due to spinal cord cell degeneration. Understanding its genetic basis is crucial for genetic counseling and personalized treatment options. …”
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Genome-wide characterization and expression analysis of the ADF gene family in response to salt and drought stress in alfalfa (Medicago sativa) by Mengmeng Shi, Yike Wang, Peng Lv, Yujie Gong, Qi Sha, Xinyan Zhao, Wen Zhou, Lingtao Meng, Zegang Han, Lingxiao Zhang, Lingxiao Zhang, Yongwang Sun, Yongwang Sun

“…The microfilament cytoskeleton, formed by the process of actin polymerization, serves not only to support the morphology of the cell, but also to regulate a number of cellular activities. …”
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Novel green synthesis of silver nanoparticles from empty fruit bunch waste: Biomedical applications and mechanistic insights by Bashirat Olamide Yusuf-Salihu, Shakirat Afodun Abdulmumini, Toheeb Taiye Bajepade, Halimah Adekunbi Durosinmi, Muinat Olanike Kazeem, Victoria Atinuke Ajayi, Agbaje Lateef

“…Reactive oxygen species (ROS) may cause cell membrane rupture and oxidative stress. Antioxidant testing demonstrated concentration-dependent activity across multiple assays: DPPH scavenging reached 81.49 % at 160 µg/ml, ferric-reducing activity was 90.05 % at 150 µg/ml, H₂O₂ scavenging achieved 91.00 % at 80 µg/ml, and NO scavenging reached 83.43 % at 150 µg/ml. …”
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Deciphering the multifaceted mechanism of Shuang Huang Lian in treating upper respiratory tract infections: A metabolomics-based network pharmacology approach by Gang Xu, Akshay Suresh Patil, Ruhan Wei, Dan Liu, Aimin Zhou, Yan Xu

“…Finally, pivotal protein targets and key active SHL components were validated through molecular docking simulations and in vitro cell culture experiments. Results: Our analysis identified TNF, CASP1, and MAPK14 as pivotal protein targets in SHL's action against URTIs, with brusatol, an active SHL component, confirmed as a critical ligand that modulates these targets. …”
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Deep learning-based histopathological assessment of tubulo-interstitial injury in chronic kidney diseases by Nonoka Suzuki, Kaname Kojima, Silvia Malvica, Kenshi Yamasaki, Yoichiro Chikamatsu, Yuji Oe, Tasuku Nagasawa, Ekyu Kondo, Satoru Sanada, Setsuya Aiba, Hiroshi Sato, Mariko Miyazaki, Sadayoshi Ito, Mitsuhiro Sato, Tetsuhiro Tanaka, Kengo Kinoshita, Yoshihide Asano, Avi Z. Rosenberg, Koji Okamoto, Kosuke Shido

“…Methods We develop a deep learning-based method named DLRS to quantify interstitial fibrosis and inflammatory cell infiltration as tubulo-interstitial injury scores, from WSIs of renal biopsy specimens. …”
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Evaluation of Inflammatory, Cardiac and Hematological Parameters in Hospitalized Children with COVID-19 by Damla Geçkalan, Rahmi Özdemir, Zülal Yılmaz, Onur Sivas, Yasin Yılmaz, Cemile Hilal Çelik

“…There was a statistically significant difference in the length of hospitalization, age, white blood cell and troponin values between the patients with COVID-19 pneumonia and those without pneumonia (p<0.001, p=0.008, p=0.048, and p=0.003, respectively). …”
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Characterization and Probiotic Potential of <i>Levilactobacillus brevis</i> DPL5: A Novel Strain Isolated from Human Breast Milk with Antimicrobial Properties Against Biofilm-Formi... by Ivan Iliev, Galina Yahubyan, Elena Apostolova-Kuzova, Mariyana Gozmanova, Daniela Mollova, Iliya Iliev, Lena Ilieva, Mariana Marhova, Velizar Gochev, Vesselin Baev

“…Employing in vitro approaches, we demonstrate <i>L. brevis</i> DPL5′s ability to endure at pH 3 with survival rates above 30%, and withstand the osmotic stress often found during industrial processes like fermentation and freeze drying, retaining over 90% viability. The lyophilized cell-free supernatant of <i>L. brevis</i> DPL5 had a significant antagonistic effect against biofilm-producing nasal strains of <i>Staphylococcus aureus</i>, and it completely eradicated biofilms at subinhibitory concentrations of 20 mg·mL⁻¹. …”
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Whole blood transcriptome profiles of trypanotolerant and trypanosusceptible cattle highlight a differential modulation of metabolism and immune response during infection by Trypan... by Peylhard, Moana, Berthier, David, Dayo, Guiguigbaza-Kossigan, Chantal, Isabelle, Sylla, Souleymane, Nidelet, Sabine, Dubois, Emeric, Martin, Guillaume, Sempéré, Guilhem, Flori, Laurence, Thévenon, Sophie

“…The functional analysis of differentially expressed genes over time in each breed confirmed an early activation of the innate immune response, followed by an activation of the humoral response and an inhibition of T cell functions at the chronic stage of infection. …”
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Egg freshness during storage: the effect of laying hen age and shelf life prediction using a novel hybrid modeling method by Yifeng Lu, Jing Li, Zihao He, Linyun Chen, Huixin Tian, Chen Xu, Xinglian Xu, Minyi Han

“…A novel hybrid model combining BP-ANN, cuckoo search and adaptive boosting (CS-BP-AdaBoost) was proposed for predicting the remaining egg shelf life, with the input being Haugh unit, yolk index, air cell depth, albumen pH, hen age, and breed. The tuning process of hyperparameters such as learning rate, training function, and transfer function was presented in detail. …”
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Immunohistochemical Study of NR2C2, BTG2, TBX19, and CDK2 Expression in 31 Paired Primary/Recurrent Nonfunctioning Pituitary Adenomas by Xiaohui Yao, Yazhuo Zhang, Lijuan Wu, Rui Cheng, Chuzhong Li, Chongxiao Qu, Hongming Ji

“…Expressions of nuclear receptor subfamily 2 group C member 2 (NR2C2), B cell translocation gene 2, T-box-19 (TBX19), and cyclin-dependent kinase 2 (CDK2) in surgically resected specimens were assessed by immunohistochemistry. …”
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Silicon-based all-solid-state batteries operating free from external pressure by Zhiyong Zhang, Xiuli Zhang, Yan Liu, Chaofei Lan, Xiang Han, Shanpeng Pei, Linshan Luo, Pengfei Su, Ziqi Zhang, Jingjing Liu, Zhengliang Gong, Cheng Li, Guangyang Lin, Cheng Li, Wei Huang, Ming-Sheng Wang, Songyan Chen

“…And the Li21Si5/Si–Li21Si5|Li6PS5Cl|Li3InCl6|LCO cell achieve an high initial Coulombic efficiency of (97 ± 0.7)% with areal capacity of 2.8 mAh cm−2 at 0.25 mA cm−2, as well as a low expansion rate of 14.5% after 1000 cycles at 2.5 mA cm−2.…”
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Puerariae Radix protects against ulcerative colitis in mice by inhibiting NLRP3 inflammasome activation by Yu Ga, Yuanyuan Wei, Qingyu Zhao, Yimeng Fan, Yannan Zhang, Zhifang Zhang, Sijia Hao, Lixia Wang, Zhifen Wang, Jinlong Han, Shuang Wu, Zhihui Hao

“…PR also alleviated intestinal mucosal shedding, infl ammatory cell infi ltration and mucin loss. PR treatment suppressed upregulation of NOD-like receptor protein 3 (NLRP3), cysteinyl aspartate-specific proteases-1 (caspase-1), apoptosis-associated speck-like (ASC) and gasdermin D (GSDMD) at both the protein and mRNA expression levels. …”
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