A practical guide to FAIR data management in the age of multi-OMICS and AI by Douaa Mugahid, Jared Lyon, Charlie Demurjian, Nathan Eolin, Charlie Whittaker, Mark Godek, Douglas Lauffenburger, Sarah Fortune, Stuart Levine

“…The advent of automation, OMICs and single-cell technologies now allows high dimensional multi-modal data acquisition from the same biological samples multiplexed at scale (multi-OMICs). …”
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Th17/Treg balance is regulated during the suppression of experimental autoimmune encephalomyelitis treated by Astragalus polysaccharides via the microbiota-gut-brain axis by Jinyun Ma, Xiaojun Liu, Yan Zhao, Qijin Lu, Guiqing Ding, Yuanhua Wang, Xiaodong Cheng

“…The Th17/Treg imbalance is an important cause of immune cell infiltration into the central nervous system (CNS) in multiple sclerosis (MS). …”
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A scoping review examining the relationship between green tea and skin cancers by Ram Lakhan, Louisa Summers, Olugbemiga Ekundayo, Jedidiah Radosevich, Sierra Turner, Sangyal Dorjee, Vinayak K. Nahar, Manoj Sharma

“…Particularly, EGCG has been found as a contributing factor to inhibit cell invasion, angiogenesis, and metastasis in skin cancer. …”

Natural history of radiotherapy-induced dysgeusia among oral and oropharyngeal cancer patients undergoing different treatment modalities by Natália Rangel Palmier, Bruno Augusto Linhares Almeida Mariz, Letícia Rodrigues-Oliveira, Karina Morais-Faria, César Augusto Migliorati, Luiz Paulo Kowalski, Karina Moutinho, Thaís Bianca Brandão, Alan Roger Santos-Silva, Ana Carolina Prado-Ribeiro

“…Aims: To assess the patterns of radiotherapy-induced dysgeusia among oral and oropharyngeal squamous cell carcinoma (OOSCC) patients subjected to different oncological treatment modalities. …”
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Rational engineering of Escherichia coli strain for stable and enhanced biosynthesis of pinene by Muhammad Hammad Hussain, Lu Han, Yanlong Wei, Muhammad Javid, Kamran Ashraf, Maria Martuscelli, Waleed Aldahmash, Meijin Guo, Ali Mohsin, Zhanxia Li

“…Considering this, the microbial cell factory is the only viable option for achieving sustainable pinene production. …”
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Enhanced Expression of NR2B Subunits of NMDA Receptors in the Inherited Glaucomatous DBA/2J Mouse Retina by Ling-Dan Dong, Jie Chen, Fang Li, Feng Gao, Jihong Wu, Yanying Miao, Zhongfeng Wang

“…Meanwhile, the protein levels of Brn-3a, a retinal ganglion cell (RGC) maker, remarkably decreased at 9–12 months in DBA/2J mice, which was in parallel with the changes of NR2B expression. …”
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Multimodal low-opioid anesthesia as a factor in reducing the activation of the proinflammatory response in cardiac surgery by S.R. Maruniak, O.A. Loskutov, O.M. Druzhyna, I.R. Malysh, V.G. Kolesnikov, N.O. Korotchuk

“…Intraoperative use of red blood cell was characterized by a significant increase in interleukin-6 levels at the end of surgery. …”
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Quantitative Proteomics Analysis Reveals XDH Related with Ovarian Oxidative Stress Involved in Broodiness of Geese by Ning Zhou, Yaoyao Zhang, Youluan Jiang, Wang Gu, Shuai Zhao, Wanwipa Vongsangnak, Yang Zhang, Qi Xu, Yu Zhang

“…The results of this study showed that during the broody period, geese exhibited degraded ovarian tissues, disrupted follicular development, a thinner granulosa cell layer, and lower levels of ovarian hormones E2, P4, and AMH. …”
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Integration of ATAC-seq and RNA-seq reveals signal regulation during post-molt and inter-molt stages in muscle of Eriocheir sinensis by Bin Wang, Bin Wang, Jingjing Li, Mingzhi Zhang, Mingzhi Zhang, Anqi Li, Zhentao Song, Zhentao Song, Zhen He, Zhen He, Ruiqi Zhang, Ruiqi Zhang, Tong Hao, Tong Hao, Jinsheng Sun, Jinsheng Sun

“…GO enrichment analysis revealed that the up-regulated genes are largely associated with protein phosphorylation and phosphorus metabolism, while the down-regulated genes are mainly involved in DNA metabolism, transcription, cell adhesion, and G protein-coupled receptor (GPCR) signaling pathway. …”
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Anti-Idiotypic Antibody as a Booster Vaccine Against Respiratory Syncytial Virus by Shreya Mukhopadhyay, Ioannis Manolaridis, Christopher Warren, Aimin Tang, Gregory O’Donnell, Bin Luo, Ryan P. Staupe, Kalpit A. Vora, Zhifeng Chen

“…With nearly everyone infected by the age of five, there is an opportunity to develop booster vaccines that enhance B-cell immunity, promoting potent and broadly neutralizing antibodies. …”
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SpecPCM: A Low-Power PCM-Based In-Memory Computing Accelerator for Full-Stack Mass Spectrometry Analysis by Keming Fan, Ashkan Moradifirouzabadi, Xiangjin Wu, Zheyu Li, Flavio Ponzina, Anton Persson, Eric Pop, Tajana Rosing, Mingu Kang

“…SpecPCM, with up to three bits per cell, achieves speedups of up to <inline-formula> <tex-math notation="LaTeX">$82\times $ </tex-math></inline-formula> and <inline-formula> <tex-math notation="LaTeX">$143\times $ </tex-math></inline-formula> for MS clustering and DB search tasks, respectively, along with a four-orders-of-magnitude improvement in energy efficiency compared with state-of-the-art (SoA) CPU/GPU tools.…”
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Evidence of Divergent Amino Acid Usage in Comparative Analyses of R5- and X4-Associated HIV-1 Vpr Sequences by Gregory C. Antell, Will Dampier, Benjamas Aiamkitsumrit, Michael R. Nonnemacher, Vanessa Pirrone, Wen Zhong, Katherine Kercher, Shendra Passic, Jean Williams, Yucheng Liu, Tony James, Jeffrey M. Jacobson, Zsofia Szep, Brian Wigdahl, Fred C. Krebs

“…Vpr is an HIV-1 accessory protein that plays numerous roles during viral replication, and some of which are cell type dependent. To test the hypothesis that HIV-1 tropism extends beyond the envelope into the vpr gene, studies were performed to identify the associations between coreceptor usage and Vpr variation in HIV-1-infected patients. …”
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A Threshold Technique Study to Understand Patient Preference for Smooth Versus Textured Breast Implants by Dallas Wood, PhD, Peyton N. Williams, MPH, Jessica E. Thompson, PhD, Susana Peinado, PhD, Avery A. Tilley, MS, David Gebben, PhD, Jacqueline M. Major, PhD, Jessica P. Weinberg, MPP, Sung W. Yoon, MD, Michelle E. Tarver, MD, PhD

“…Compared with smooth implants, textured surface implants have a higher risk of breast implant–associated anaplastic large cell lymphoma (BIA-ALCL) but may have a lower risk of capsular contracture (CC). …”
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Chronic GIPR agonism results in pancreatic islet GIPR functional desensitisation by Iona Davies, Alice E. Adriaenssens, William R. Scott, David Carling, Kevin G. Murphy, James S. Minnion, Stephen R. Bloom, Ben Jones, Tricia M-M. Tan

“…Methods: A long-acting GIPR agonist, GIP108, was used to probe the effect of sustained agonist exposure on cAMP responses in dispersed pancreatic islets using live cell imaging, with rechallenge cAMP responses after prior agonist treatment used to quantify functional desensitisation. …”
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Sorafenib-Loaded Silica-Containing Redox Nanoparticle Decreases Tumorigenic Potential of Lewis Lung Carcinoma by Babita Shashni, Hao Thi Tran, Long Binh Vong, Ren-Jei Chung, Yukio Nagasaki

“…<b>Background:</b> Orally administered sorafenib has shown limited improvement in overall survival for non-small-cell lung cancer patients, likely due to poor pharmacokinetics and adverse effects, including gastrointestinal toxicity. …”
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Novel Antibacterial 4-Piperazinylquinoline Hybrid Derivatives Against <i>Staphylococcus aureus</i>: Design, Synthesis, and In Vitro and In Silico Insights by Gabriele La Monica, Annamaria Gallo, Alessia Bono, Federica Alamia, Antonino Lauria, Rosa Alduina, Annamaria Martorana

“…Notably, <b>5k</b> exhibited potent and selective activity against <i>S. aureus</i> (MIC 10 μM), with a dose- and time-dependent response and capability to affect cell membrane integrity. On the other hand, no significant activity was observed against <i>P. aeruginosa</i>. …”
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Effects of different vaccination regimes on the immunodiagnosis of tuberculosis in goats and evaluation of defined antigens by Patricia Cuenca-Lara, Patricia Cuenca-Lara, Miriam Blay-Benach, Miriam Blay-Benach, Zoraida Cervera, Zoraida Cervera, Cristian Melgarejo, Cristian Melgarejo, Julia Moraleda, Julia Moraleda, Iker A. Sevilla, Joseba M. Garrido, Mahavir Singh, Gareth J. Jones, Bernat Pérez de Val, Bernat Pérez de Val

“…The two prime-boosted and the single-dose intranasal BCG groups displayed greater cell-mediated immune responses to PPDs than the two single-dose intranasal HIMB vaccines. …”
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A novel TGFBR2 mutation causes Loeys-Dietz syndrome in a Chinese infant: A case report by Xin Liu, Kaiqing Liu, Lifu Hu, Zixiao Liu, Xinhua Liu, Jiantao Wang

“…Molecular dynamics simulations and in vitro cell experiments further analyzed the structural changes and functional abnormalities of the variation. …”
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Development of therapeutic supplement using roasted-cashew-nut to protect cerebral vasoconstriction injury triggered by mixture of petroleum hydrocarbons in the hypothalamus and hi... by J.K. Akintunde, V.O. Akomolafe, R.N. Ugbaja, A.M. Olude, A.D. Folayan

“…The regimen period was 28 days. Cell pathological evaluation was done using hematoxylin and eosin staining and visualized under the microscope. …”
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Real‐world efficacy of transfusion with liberal or restrictive strategy in traumatic brain injury by Liang‐Wen Cui, Nian Liu, Chao Yu, Ming Fang, Rui Huang, Cheng Zhang, Min Shao

“…Abstract Objective The short‐term efficacy of red blood cell (RBC) transfusion among general traumatic brain injury (TBI) patients is unclear. …”
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