Purification, Characterization and Antibacterial Mechanism of Plantaricin 2-1 by Mengyang LI, Xiaoxue CHE, Qingshen SUN

“…Additionally, plantaricin P2-1 could cause the death of indicator strains by destroying cell integrity, breaking down cytoderm and cytomembrane, as indicated by leakage of AKP, ATP and LDH. …”
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Levying evidence of the impact of Triphala in the mildly constipated human colon microbiota by Elizabeth Goya-Jorge, Pauline Bondue, Irma Gonza, Samiha Boutaleb, Caroline Douny, Marie-Louise Scippo, Joël Pincemail, Patrice Chiap, Jeoffrey Christyn de Ribaucourt, Fabienne Crahay, Véronique Delcenserie

“…Potential herb-human host interactions were assessed using in vitro cell-based methods. Triphala extract increased Akkermansia muciniphila but decreased Bifidobacterium spp. in the simulated colon microbiota. …”
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A Novel Algorithm for Aspect Ratio Estimation in SRAM Design to Achieve High SNM, High Speed, and Low Leakage Power by Sanket M. Mantrashetti, Arunkumar P Chavan, Prakash Pawar, H. V. Ravish Aradhya, Omkar S. Powar

“…The inclusion of precharge and write driver circuits allows for a compact SRAM layout, occupying <inline-formula> <tex-math notation="LaTeX">$9.79~\mu $ </tex-math></inline-formula> m², with the SRAM cell itself occupying <inline-formula> <tex-math notation="LaTeX">$4.1~\mu $ </tex-math></inline-formula> m². …”
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Instance maps as an organising concept for complex experimental workflows as demonstrated for (nano)material safety research by Benjamin Punz, Maja Brajnik, Joh Dokler, Jaleesia D. Amos, Litty Johnson, Katie Reilly, Anastasios G. Papadiamantis, Amaia Green Etxabe, Lee Walker, Diego S. T. Martinez, Steffi Friedrichs, Klaus M. Weltring, Nazende Günday-Türeli, Claus Svendsen, Christine Ogilvie Hendren, Mark R. Wiesner, Martin Himly, Iseult Lynch, Thomas E. Exner

“…Application of the InstanceMaps tool (described herein) to research workflows of increasing complexity is presented to demonstrate its utility, starting from (i) documentation of a nanomaterial’s synthesis, functionalisation, and characterisation, over (ii) assessment of a nanomaterial’s transformations in complex media, (iii) description of the culturing of ecotoxicity model organisms Daphnia magna and their use in standardised tests for nanomaterials ecotoxicity assessment, and (iv) visualisation of complex workflows in human immunotoxicity assessment using cell lines and primary cellular models, to (v) the use of the instance map approach for the coordination of materials and data flows in complex multipartner collaborative projects and for the demonstration of case studies. …”
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Betulinic acid protects against ovarian impairment by decreasing F-2 toxin-induced oxidative stress and inflammation associated with the downregulation of p38 expression in mice by Li Kong, Xinyu Gao, Lijuan Zhu, Xing Lin, You Huang, Chunlin Huang, Wenjiang Yang, Yazhi Chen, Haoqiang Zhao, Jing Wu, Zhihang Yuan, Jin’e Yi

“…We found that BA alleviated the F-2 toxin-induced ovarian impairment by stimulating follicle growth, reducing inflammatory cell infiltration, repairing damaged mitochondria and endoplasmic reticulum. …”
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In Situ Modulation of NiFeOOH Coordination Environment for Enhanced Electrocatalytic‐Conversion of Glucose and Energy‐Efficient Hydrogen Production by Ning Wei, Sufeng Zhang, Xue Yao, Qinglu Li, Nan Li, Jinrui Li, Dingjie Pan, Qiming Liu, Shaowei Chen, Scott Renneckar

“…Thus, the two‐electrode electrolyzer of the W‐NiFeP/NF||W,P‐NiFeOOH/NF for HER||GCR needs only a low cell voltage of 1.56 V to deliver 100 mA cm−2 at a remarkable hydrogen production efficiency of 1.86 mmol h−1, with a high glucose conversion (98.0%) and formic acid yields (85.2%). …”
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Intratumoral <i>Fusobacterium nucleatum</i> in Pancreatic Cancer: Current and Future Perspectives by Domenica Lucia D’Antonio, Anna Zenoniani, Samia Umme, Adriano Piattelli, Maria Cristina Curia

“…<i>Fn</i> engages in pancreatic tumorigenesis and metastasis through multifaceted mechanisms, including immune response modulation, virulence factors, control of cell proliferation, intestinal metabolite interactions, DNA damage, and epithelial–mesenchymal transition. …”
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Preparation and in vitro biological evaluation of strontium doped β-tricalcium phosphate scaffolds for alveolar bone tissue regeneration by Congrui Liu, Guiyong Xiao, Zichen Wang, Mengchen Xu, Yinchuan Wang, Nan Wang, Zhenlong Sun, Xiaoyan Li, Yixin Yin

“…Confocal laser scanning microscopy analysis revealed that Srx-TCP offered favorable circumstances for cell adhesion. The alkaline phosphatase assay and mineralization staining confirmed the osteogenic differentiation potential of Srx-TCP in vitro, particularly evident in the Sr8-TCP scaffold. …”
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Untargeted Metabolomics Reveals Key Differences Between Yak, Buffalo, and Cow Colostrum Based on UHPLC-ESI-MS/MS by Yuzhuo Wang, Changhui Li, Jiaxiang Huang, Qingkun Zeng, Ling Li, Pan Yang, Pengjie Wang, Min Chu, Jie Luo, Fazheng Ren, Hao Zhang

“…Conclusions: YC has greater advantages in energy supply, antioxidant activity, immune regulation, and cell homeostasis, and BC holds unique significance in physical development and energy balance regulation. …”
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Complexed hyaluronic acid-based nanoparticles in cancer therapy and diagnosis: Research trends by natural language processing by Abd Kakhar Umar, Patanachai K. Limpikirati, Bachtiar Rivai, Ilham Ardiansah, Sriwidodo Sriwidodo, Jittima Amie Luckanagul

“…However, HA alone faces limitations in lipid solubility, biocompatibility, and cell internalization, making it less effective as a standalone delivery system. …”
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Lipidomics-based association study reveals genomic signatures of anti-cancer qualities of pigmented rice sprouts by Rhowell Navarro Tiozon, Rhowell Navarro Tiozon, Erstelle Pasion-Uy, Saleh Alseekh, Saleh Alseekh, Kristel June D. Sartagoda, Shem Gempesaw, Joel H. G. Tolentino, Alisdair R. Fernie, Alisdair R. Fernie, Nese Sreenivasulu

“…This superior MTA combination exhibited potent inhibitory activity against HCT116 and A549 cell lines, with average 1/IC50 values of 0.03 and 0.02 (mL/μg), respectively, compared to the inferior MTAs.DiscussionCollectively, our findings demonstrate that MTAs linked to selected GDSL esterase/lipase (GELP) genes, OsACP1, and lecithin-cholesterol acyltransferase significantly enhance antioxidant and anti-cancer properties, potentially through the mobilization of unsaturated lipids and carotenoids during germination. …”
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Akkermansia muciniphila Enhances the Antitumor Effect of Cisplatin in Lewis Lung Cancer Mice by Zhuo Chen, Xiang Qian, Shasha Chen, Xiaoxuan Fu, Guanjun Ma, Aiqin Zhang

“…In addition, transcriptome analysis indicated that Akk combining with CDDP increased obviously the levels of IFI27l2 and IGFBP7 and was related to those pathways including the cytokine-cytokine receptor interaction, Th17 cell differentiation, FOXO, JAK-STAT, and PI3K-Akt signaling pathways. …”
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Low-energy Injection and Nonthermal Particle Acceleration in Relativistic Magnetic Turbulence by Divjyot Singh, Omar French, Fan Guo, Xiaocan Li

“…In this study, we carry out two-dimensional fully kinetic particle-in-cell simulations of magnetically dominated decaying turbulence in a relativistic pair plasma. …”
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Leverage of lysozyme dietary supplementation on gut health, hematological, antioxidant, and immune parameters in different plumage-colors Japanese quails by Ibrahim A. Elkhaiat, Seham El-Kassas, Safaa E Abdo, Karima El-Naggar, Haitham K. Shalaby, Reyad Y. Nofal, Mayada R. Farag, Mahmoud M. Azzam, Antonia Lestingi

“…For gut status, both varieties exhibited increases in intestinal villi length and goblet cell count with significant reductions in the total lactobacillus, total coliform, and total bacterial counts. …”
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Molecular genetic and bacteriological methods of bovine mycoplasmosis diagnosis by E. V. Remizova, A. V. Gorbatov, L. K. Semina, Z. A. Skulyabina, N. V. Shmidt, G. A. Baldicheva, N. N. Avduevskaya

“…Mycoplasmas are bacteria that are extremely unstable in vitro as they lack a rigid cell wall. They are most often detected in association with other pathogens, including those that can become L-forms if treated with antibiotics. …”
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Bruton’s tyrosine kinase inhibition re-sensitizes multidrug-resistant DLBCL tumors driven by BCL10 gain-of-function mutants to venetoclax by Caroline A. Coughlin, Dhanvantri Chahar, Marianna Lekakis, Abdessamad A. Youssfi, Lingxiao Li, Evan Roberts, Natalia Campos Gallego, Claude-Henry Volmar, Ola Landgren, Shaun Brothers, Anthony J. Griswold, Catalina Amador, Daniel Bilbao, Francesco Maura, Jonathan H. Schatz

“…Abstract Disparate pathogenic mechanisms complicate precision-medicine efforts to treat diffuse large B-cell lymphoma (DLBCL), the most common lymphoma diagnosis. …”
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RUBY® – a tetravalent (2+2) bispecific antibody format with excellent functionality and IgG-like stability, pharmacology and developability properties by Barnabas Nyesiga, Mattias Levin, Anna Säll, Anna Rosén, Kim Jansson, Sara Fritzell, Karin Hägerbrand, Dietmar Weilguny, Laura von Schantz

“…Our data demonstrate that RUBY bsAbs are compatible with small-scale production systems for screening purposes and can be produced at high yields (>3 g/L) from stable cell lines. The bsAbs produced are shown to, in general, contain low amounts of aggregates and display favorable solubility and stress endurance profiles. …”
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Ameliorative effect of liprotide-encapsulated vitamin D3 on blood glucose, calcium homeostasis, and vitamin D level in a vitamin D and calcium deficient rat model by Gemala Anjani, Reza Achmad Maulana, Sylvia Rahmi Putri, Faizah Fulyani, Ahmad Syauqy, Diana Nur Afifah, Fitriyono Ayustaningwarno, Refani Alycia Kusuma, Zulfatul Masruroh

“…Vitamin D3, recognized for its higher bioavailability and direct cell utilization, plays a vital role in the human body. …”
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Long term effectiveness of intraoperative radiotherapy given as a boost in adjuvant treatment for oral cavity cancers by Grzegorz Woźniak, Tomasz Rutkowski, Wojciech Majewski, Aleksandra Napieralska, Jerzy Wydmański, Agnieszka Czarniecka, Cezary Szymczyk, Adam Bekman, Żaneta Kaniszewska Dorsz, Tomasz Latusek, Bogusław Maciejewski

“…The aim of this retrospective study is to evaluate the effectiveness of IORT combined with postoperative fractionated irradiation (EBRT) of patients with squamous cell carcinoma of the oral cavity. The study included 23 patients: IORT dose of 5–7.5 Gy was delivered using 50 kV X-rays generated by INTRABEAM™, combined with EBRT of 50–60 Gy in 25–30 fractions depending on presence of extracapsular invasion and narrow or positive surgical margins. …”
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Multiorgan proteomic analysis of infected animal models predict potential host factors for chikungunya virus by Dongdong Lin, Cong Tang, Junbin Wang, Yun Yang, Hao Yang, Yanan Zhou, Wenhai Yu, Bai Li, Qing Huang, Haixuan Wang, Ran An, Xiaoming Liang, Yuhuan Yan, Longhai Yuan, Xuena Du, Yuxia Yuan, Yanwen Li, Shuaiyao Lu

“…Additionally, we identified host factors such as S100 Calcium‐Binding Protein A8/A9 (S100A8/A9), Voltage‐Dependent Anion Channel 1/2 (VDAC1/2), Complement Component 3 (C3), Apoptosis‐Inducing Factor Mitochondria‐Associated 1 (AIFM1), Endothelial Cell‐Specific Chemotaxis Regulator (ECSCR), and Kininogen 1 (KNG1) that may contribute to CHIKV‐induced inflammation and hemorrhage. …”
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