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28581
Synthesis, Characterization, and Cytotoxicity Research of Sulfur-Containing Metal Complexes
Published 2025-01-01“…In terms of application, the biological activity of complexes (I)–(III) in human cancer cell lines (lung cancer A549, liver cancer SMMC-7721, breast cancer MDA-MB-231, and colon cancer SW480) was tested using the MTS method. …”
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28582
Current views on etiology, diagnosis, epidemiology and gene therapy of maturity onset diabetes in the young
Published 2025-01-01“…Mutations in the HNF1A and HNF4A genes result in pancreatic β-cell dysfunction, which in turn causes hyperglycemia. …”
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28583
Compact modified rectangular split ring resonator for tri-band satellite applications
Published 2024-11-01“…Two symmetrical rectangular split ring resonators (SRR) were carefully engineered and then connected by their edges along the axis (Ox) with a substantial C-shaped structure, experiencing the peak surface current value near the magnetic resonances, causing the proposed unit cell to resonate at 5.73 GHz, 8.67 GHz, and 13.78 GHz, where it exhibited negative effective permittivity (ENG), permittivity and permeability (DNG), and permeability (MNG), respectively. …”
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28584
IP3 receptor depletion in a spontaneous canine model of Charcot-Marie-Tooth disease 1J with amelogenesis imperfecta.
Published 2025-01-01“…The involvement of the three IP3R genes (ITPR1, ITPR2 and ITPR3) in inherited human diseases has started to shed light on the essential roles of each receptor in different human tissues and cell types. Variants in the ITPR3 gene, which encodes IP3R3, have recently been found to cause demyelinating sensorimotor Charcot-Marie-Tooth neuropathy type 1J (CMT1J). …”
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28585
Neurodegeneration in Patients with Type 2 Diabetes Mellitus without Diabetic Retinopathy
Published 2019-01-01“…Sixty eyes of 60 patients with DM2 and without any signs of diabetic retinopathy and 60 eyes of 60 healthy controls underwent retinal evaluation using Spectralis optical coherence tomography. Macular ganglion cell layer (GCL) and retinal nerve fiber layer (RNFL) were evaluated. …”
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28586
Nicorandil Ameliorates Depression‐Like Behaviors After Traumatic Brain Injury by Suppressing Ferroptosis Through the SLC7A11/GPX4 Axis in the Hippocampus
Published 2025-01-01“…Ferroptosis, an iron‐dependent form of regulated cell death, exacerbates the neurological damage associated with TBI. …”
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28587
Polymerase chain reaction for detection of some highly dangerous viral fish disease agents
Published 2020-03-01“…The research data correlated with the results obtained from virus neutralization in cell culture and ELISA performed using commercial kits. …”
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28588
Efficacy and Safety of Primary Glaucoma Device Implantation Surgery in Exfoliative Glaucoma: A Retrospective Consecutive Case Series
Published 2020-01-01“…Intraocular pressure (IOP), the mean deviation (MD) from the visual field exam, corneal endothelial cell density (ECD), and the number of topical antiglaucoma agents used during the preoperative and postoperative periods were retrospectively analyzed. …”
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28589
Evolution of the RNA alternative decay cis element into a high-affinity target for the immunomodulatory protein Roquin
Published 2025-12-01“…While the interaction of Roquin with several CDEs is described, our knowledge about ADE complex formation is limited to the mRNA of Ox40, a gene encoding a T-cell costimulatory receptor. The Ox40 3’UTR comprises both a CDE and ADE, each sufficient for Roquin-mediated control. …”
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28590
Bacteriophages RCF and 1-6bf can control the growth of avian pathogenic Escherichia coli
Published 2025-02-01“…Rcf and 1-6bf produce clear plaques with a latent period of 10 min and 5 min with a burst size of 85 and 220 PFU/cell respectively.…”
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28591
T4 Phage Displaying Dual Antigen Clusters Against H3N2 Influenza Virus Infection
Published 2025-01-01“…Additionally, animal experiments demonstrated that this nanoparticle vaccine displaying dual antigen clusters induced a stronger specific immune response, higher antibody titers, a more balanced Th1/Th2 immune response, and enhanced CD4<sup>+</sup> and CD8<sup>+</sup> T cell effects compared to immunization with HA1 and M2e antigen molecules alone. …”
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28592
Resistance mechanisms involved in complex immunity of wheat against rust diseases
Published 2019-08-01“…The presence of these genes in the genotype ensures the interruption of early pathogenesis through the following mechanisms: disorientation and branching of the germ tube; formation of aberrant fungal penetration structures (appressorium, substomatal vesicle); accumulation of callose in mesophyll cell walls. Breeding for immunity is accelerated by implementation of data on various mechanisms of wheat resistance to rust diseases, which are summarized in this review.…”
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28593
Hepatitis B virus genotypes A1 and A2 have distinct replication phenotypes due to polymorphisms in the HBx gene.
Published 2025-01-01“…Using HBV generated from molecule clones of subtypes A1 and A2 in cell culture (HBVcc), we demonstrate that HBVcc of subtypes A1 and A2 can be passaged in vitro and in vivo and respond equally well to human IFN-α treatment. …”
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28594
Serological Detection of Rh-Del Phenotype among Rh-Negative Blood Donors at National Blood Center, Yangon, Myanmar
Published 2020-01-01“…Background. Red cell Rhesus (Rh) antigen expression is influenced by the genetic polymorphism of RHD and RHCE genes and reveals serologically different reactions of RhD variants such as partial D, weak D, and Rh-Del. …”
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28595
Systemic and Lung Inflammation and Oxidative Stress Associated With Behavioral Changes Induced by Inhaled Paraquat Are Ameliorated by Carvacrol
Published 2024-01-01“…Inhaled PQ markedly enhanced total and differential white blood cell (WBC) counts, nitric oxide (NO), and malondialdehyde (MDA) levels but decreased catalase (CAT) and superoxide dismutase (SOD) activities and thiol levels both in the bronchoalveolar lavage fluid (BALF) and blood and increased interferon-gamma (INF-γ) and interleukin-10 (IL-10) levels in the BALF (p<0.001 for all cases) except lymphocyte count in blood which was not significantly changed. …”
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28596
Investigating the mechanistic role of oxidative stress in brain–gut axis disruption in rat model
Published 2024-11-01“… This study investigated the impact of endotoxin exposure on intestinal oxidative stress and white blood cell (WBC) subtypes in a rat model to understand its role in disrupting brain–gut communication. …”
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28597
The Role of Pharmaceutical Innovation in Clinical Practice Guidelines for Chronic Diseases
Published 2024-01-01“…Clinical practice guidelines published from 2000 to 2021 were identified for five chronic diseases: ischemic heart disease (IHD), non-small cell lung cancer (NSCLC), chronic obstructive pulmonary disease (COPD), Alzheimer’s disease (AD), and type 2 diabetes (T2D). …”
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28598
Relations hommes-primates et politiques environnementales à l'épreuve du virus Ebola en Afrique de l'Ouest
Published 2015-03-01“…Nous interrogerons la pertinence de ce modèle, également endossé par une majorité de décideurs politiques, au moyen de connaissances ethnographiques, historiques et écologiques récentes concernant les dynamiques sociales et spatiales des relations humains-chimpanzés dans plusieurs localités ouest-africaines. Celles-ci peuvent non seulement contribuer à prévenir les anthropozoonoses mais aussi à repenser le rôle des pratiques locales dans l'élaboration des politiques environnementales.…”
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28599
Impact of daily diet on military training injuries among high-altitude officers and soldiers
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28600
Detection of CRISPR cassettes and cas genes in the Arabidopsis thaliana genome
Published 2019-11-01“…According to the endosymbiotic theory, mitochondria descended from alphaproteobacteria that had been absorbed but not degraded by the host cell. The discovery of CRISPR-Cas systems (clustered regularly interspaced short palindromic repeats (CRISPR)-associated proteins), which implement the adaptive immunity function in prokaryotes, raises the question whether such a mechanism of antiviral protection could be caught up by evolution and used by representatives of eukaryotes (in particular, plants). …”
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