Multilevel Precision-Based Rational Design of Chemical Inhibitors Targeting the Hydrophobic Cleft of Apical Membrane Antigen 1 (AMA1) by Umashankar Vetrivel, Shalini Muralikumar, B Mahalakshmi, K Lily Therese, HN Madhavan, Mohamed Alameen, Indhuja Thirumudi

“…T. gondii invades the host cell by forming a moving junction (MJ) complex. This complex formation is initiated by intermolecular interactions between the two secretory parasitic proteins—namely, apical membrane antigen 1 (AMA1) and rhoptry neck protein 2 (RON2) and is critically essential for the host invasion process. …”
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Optimizing Non-Thermal Magnetic Field to Minimize Weight Loss and Tissue Degradation: Identifying Possible Enzyme Inhibition Mechanisms by Chao-Kai Chang, Prakoso Adi, Rizka Mulyani, Chun-Fu Lin, Ratna Sari Listyaningrum, Shella Permatasari Santoso, Mohsen Gavahian, Chang-Wei Hsieh

“…This research investigates potential mechanisms of novel magnetic field (MF) treatments in inhibiting cell-wall-degrading enzymes, aiming to reduce weight loss and preserve the post-harvest quality of tomatoes (<i>Solanum lycopersicum</i> L.) as a climacteric fruit. …”
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Optimizing longifolene production in Yarrowia lipolytica via metabolic and protein engineering by Yi-Tong Yao, Xiao Zhang, Chen-Yu Wang, Yu-He Zhang, Da-Wei Li, Wei-Dong Yang, Hong-Ye Li, Li-Gong Zou

“…This study aimed to develop a microbial cell factory for enhanced longifolene production. …”
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Biosynthesis and in-vitro characterizations of copper oxide nanoparticle using Mangifera indica seed kernel extract and assessment of pharmacological properties by Pranay Pramanik, Krishnendu Dakua, Trisha Kar, Ranabir Sahu, Tarun Kumar Dua, Gouranga Nandi, Sangita Dey, Anoop Kumar, Ritu Khanra, Paramita Paul

“…Moreover, MTT assay exhibited strong anticancer potential of CONPs against SH-SY5Y neuroblastoma cell-lines with IC50 of 24.14 μg/mL.…”
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Investigating the ROS Formation and Particle Behavior of Food-Grade Titanium Dioxide (E171) in the TIM-1 Dynamic Gastrointestinal Digestion Model by Nicolaj S. Bischoff, Anna K. Undas, Greet van Bemmel, Jacco J. Briedé, Simone G. van Breda, Jessica Verhoeven, Sanne Verbruggen, Koen Venema, Dick T. H. M. Sijm, Theo M. de Kok

“…ROS formation was inhibited post-digestion in this cell-free environment, likely due to increased particle aggregation and protein corona formation. …”
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Dietary Flaxseed Oil Protects against Bleomycin-Induced Pulmonary Fibrosis in Rats by Joshua Lawrenz, Betty Herndon, Afrin Kamal, Aaron Mehrer, Daniel C. Dim, Cletus Baidoo, David Gasper, Jonathan Nitz, Agostino Molteni, Richard C. Baybutt

“…Animals receiving flaxseed oil showed a delay in edema formation (𝑃=0.025) and a decrease in inflammatory cell infiltrate and vasculitis (𝑃=0.04 and 0.007, resp.). …”
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Comparison of the Minimental State Examination Scale and the International HIV Dementia Scale in Assessing Cognitive Function in Nigerian HIV Patients on Antiretroviral Therapy by O. Olajumoke Oshinaike, A. Akinsegun Akinbami, O. Oluwadamilola Ojo, I. Frank Ojini, U. Njideka Okubadejo, A. Mustapha Danesi

“…Baseline demographic data were documented and cognitive function assessed using the two instruments. CD4 cell counts were recorded. Results. Cases comprised 137 females and 71 males. …”
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The antidepressant drug sertraline is a novel inhibitor of yeast Pah1 and human lipin 1 phosphatidic acid phosphatases by Geordan J. Stukey, Matthew R. Breuer, Natalie Burchat, Ruta Jog, Kollin Schultz, Gil-Soo Han, Matthew S. Sachs, Harini Sampath, Ronen Marmorstein, George M. Carman

“…That Pah1 is a physiological target of sertraline in S. cerevisiae is supported by the observations that the overexpression of PAH1 rescued the sertraline-mediated inhibition of pah1Δ mutant cell growth, the lethal effect of overexpressing Pah1-CC was rescued by sertraline supplementation, and that a sublethal dose of the drug resulted in a 2-fold decrease in TAG content.…”
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ATP Citrate Lyase <i>ClACLB-1</i> Facilitates Citrate Cleavage in Lemon by Chuang Lu, Wenhui Yang, Huaxi Zhang, Yanrong Wu, Huina Meng, Lifeng Lv, Wanping Lu, Dongmei Zhao, Guixiang Huang

“…The putative protein coded by the gene <i>ClACLB</i>-1 is localized in the nuclear and cell membranes. The <i>ClACLB</i>-1 gene was expressed in all tissues, with the highest expression in male flowers and the lowest expression in mature fruits; the expression decreased during lemon fruit development. …”
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Methyl Canthin-6-one-2-carboxylate Inhibits the Activation of the NLRP3 Inflammasome in Synovial Macrophages by Upregulating Nrf2 Expression by Yuanyuan Chen, Zongying Zhang, Yuan Yao, Xiaorong Zhou, Yong Ling, Liming Mao, Zhifeng Gu

“…Notably, pretreatment with Cant significantly reduced LPS/ATP-induced activation of the NLRP3 inflammasome, as evidenced by the decline in the cleaved forms of IL-1β and caspase-1 in cell culture supernatants of BMDMs. Regarding the mechanisms, our data show that Cant could enhance the expression of Nrf2 in macrophages, which play an inhibitory role in ROS production. …”
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Synthesis, Spectral Characterization, and Thermal and Cytotoxicity Studies of Cr(III), Ru(III), Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) Complexes of Schiff Base Derived from 5-H... by Amani S. Alturiqi, Abdel-Nasser M. A. Alaghaz, Reda A. Ammar, Mohamed E. Zayed

“…The cytotoxic activities of all inspected compounds were evaluated towards human breast (MCF-7) and lung cancer (A549) cell lines.…”
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Neoadjuvant or concurrent atezolizumab with chemoradiation for locally advanced cervical cancer: a randomized phase I trial by Jyoti Mayadev, Dmitriy Zamarin, Wei Deng, Heather A. Lankes, Giulio Pesci, Hayeon Kim, Junzo P. Chino, Barbara Banbury, Ned Sherry, Elad Sharon, Sharad A. Ghamande, Catherine Ferguson, Loren Mell, Laura Holman, Cara Mathews, David O’Malley, Alexander Olawaiye, Elizabeth Hopp, Charles Leath, Larry Copeland, Robert Mannel, Roisin O’Cearbhaill, Carol Aghajanian, Russell J. Schilder

“…The primary endpoint was the fraction of expanded tumor-associated T-cell receptor (TCR) clones in blood at day 21 as a surrogate measure of anti-tumor immune response. …”
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Elucidating the metabolic mechanisms and active constituents of ZuoGui Wan in combatting postmenopausal osteoporosis: A metabolomics and network pharmacology approach by Yanchen Feng, KaiKai Shi, Dingming Li, Shunzhi Yang, Xue Dang, Jinyao Li, Yan Chen, Jianping Yao, Yunke Zhang, Lu Sun, Feixiang Liu

“…The metabolic mechanism of ZGW against PMOP was further confirmed by combining network pharmacology and metabolomics results and constructing an in vitro cell model for validation. Result: ZGW reversed OVX-induced bone loss by enhancing bone density and improving bone microstructural integrity. …”
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Proteomic analysis reveals the roles of silicon in mitigating glyphosate-induced toxicity in Brassica napus L. by Probir Kumar Mittra, Md Atikur Rahman, Swapan Kumar Roy, Soo-Jeong Kwon, Abhik Mojumdar, Sung Ho Yun, Kun Cho, Seong-Woo Cho, Meiliang Zhou, Tomoyuki Katsube-Tanaka, Sun-Hee Woo

“…These proteins are associated with diverse biological processes in B. napus, including energy metabolism, antioxidant activity, signal transduction, photosynthesis, sulfur assimilation, cell wall functions, herbicide tolerance, and plant development. …”
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Synthesis of N-Methylmorpholinium Derivatives Possessing a 1,3,4-Oxadiazole Core as Feasible Antibacterial Agents against Plant Bacterial Diseases by Xinxin Tuo, Jie Yang, Yedong Zhang, Peiyi Wang

“…Preliminary antibacterial mechanism studies suggested that target compounds had strong interactions with the cell membrane of bacteria via scanning electron microscopy imaging. …”
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Identification of blood plasma protein ratios for distinguishing Alzheimer's disease from healthy controls using machine learning by Ali Safi, Elisa Giunti, Omar Melikechi, Weiming Xia, Noureddine Melikechi

“…Notably, the protein ratios kynureninase to macrophage scavenger receptor type 1, Neurocan to protogenin, and interleukin-5 receptor alpha to glial cell line-derived neurotrophic factor receptor alpha 1 achieving accuracy up to 98 % in differentiating between the two groups. …”
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Chlormethine Gel for Treatment of Patients with Mycosis Fungoides: Best Practices and Guidance to Clinicians by Larisa Geskin, Christiane Querfeld, Emmilia Hodak, Neda Nikbakht, Evangelia Papadavid, Marco Ardigò, Ulrike Wehkamp, Martine Bagot

“…Abstract Background Mycosis fungoides (MF) is the most common form of cutaneous T cell lymphoma. While multiple guidelines provide treatment recommendations, there are currently no clear treatment algorithms for MF. …”
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Role of CXCL10 released from osteocytes in response to TNF-α stimulation on osteoclasts by Mariko Miura, Hideki Kitaura, Fumitoshi Ohori, Kohei Narita, Jiayi Ren, Takahiro Noguchi, Aseel Marahleh, Jinghan Ma, Angyi Lin, Ziqiu Fan, Itaru Mizoguchi

“…In this study, highly purified osteocytes were isolated from dentin matrix protein 1 (DMP1)-Topaz mice using cell sorter. RNA sequencing (RNA-seq) revealed that TNF-α stimulation increased C-X-C motif chemokine ligand 10 (CXCL10) gene expression in osteocytes. …”
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Legionella pneumophila response to shifts in biofilm structure mediated by hydrodynamics by Ana Rosa Silva, C. William Keevil, Ana Pereira

“…Finally, shear conditions favoured the transition of L. pneumophila to VBNC states (∼94 %), despite the high viable cell counts (∼8 log10 CFU/cm2) found throughout the experiments. …”
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Huge Intravascular Tumor Extending to the Heart: Leiomyomatosis by Suat Doganci, Erkan Kaya, Murat Kadan, Kubilay Karabacak, Gökhan Erol, Ufuk Demirkilic

“…Intravenous leiomyomatosis (IVL) is a rare neoplasm characterized by histologically benign-looking smooth muscle cell tumor mass, which is growing within the intrauterine and extrauterine venous system. …”
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