Dietary supplementation with Jasminum sambac leaf powder: Effects on growth, hematology, and immune parameters in broiler chickens by Iram Maqsood, Samreen Sareer, Shafique Ur Rehman, Ayesha Hidayat, Madeeha Shah, Saira Awaz, Rong Ke

“…Further, haemoglobin concentration and red blood cell counts (RBC) on days 14, 28, and 42, were significantly increased(P<0.01). …”
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A network-based systems genetics framework identifies pathobiology and drug repurposing in Parkinson’s disease by Lijun Dou, Zhenxing Xu, Jielin Xu, Chengxi Zang, Chang Su, Andrew A. Pieper, James B. Leverenz, Fei Wang, Xiongwei Zhu, Jeffrey Cummings, Feixiong Cheng

“…We then prioritized 175 PD likely risk genes (pdRGs), such as SNCA, CTSB, LRRK2, DGKQ, and CD44, which are enriched in druggable targets and differentially expressed genes across multiple human brain-specific cell types. Integrating network proximity-based drug repurposing and patient electronic health record (EHR) data observations, we identified Simvastatin as being significantly associated with reduced incidence of PD (hazard ratio (HR) = 0.91 for fall outcome, 95% confidence interval (CI): 0.87–0.94; HR = 0.88 for dementia outcome, 95% CI: 0.86–0.89) after adjusting for 267 covariates. …”
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Expression Profiling of Proliferation and Apoptotic Markers along the Adenoma-Carcinoma Sequence in Familial Adenomatous Polyposis Patients by Jayson Wang, Nabil El-Masry, Ian Talbot, Ian Tomlinson, Malcolm R. Alison, Mona El-Bahrawy

“…This results in alterations in cell proliferation and apoptosis. We investigated the expression of beta-catenin and related proliferation and apoptotic factors in FAP patients, exploring the expression along the adenoma-carcinoma sequence. …”
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Polysaccharide-based biomaterials for regenerative therapy in intervertebral disc degeneration by Xin Wang, Yixue Huang, Yilin Yang, Xin Tian, Yesheng Jin, Weimin Jiang, Hanliang He, Yong Xu, Yijie Liu

“…These materials have demonstrated the capacity to support cell viability, facilitate matrix production, and alleviate inflammation in vitro and in vivo, thus supporting tissue regeneration and restoring disc function in comparison to conventional treatment. …”
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Leveraging computational approaches in identifying novel HER-2 + breast cancer potential therapeutics: integrating virtual screening and molecular dynamics simulation by Olawale Quadri Bolaji, Temitope Isaac Adelusi, Taiwo Ooreoluwa Ojo, Ibrahim Damilare Boyenle, Abdul-Quddus Kehinde Oyedele, Taiwo Temitope Ogunjobi, Adegboye Oyewole Oyaronbi, Sukurat Oluwatoyin Ayoola, Abdeen Tunde Ogunlana

“…This study delves into the molecular intricacies of HER-2 positive breast cancer, with an emphasis on the role of the HER-2 oncoprotein and its associated signaling pathways in cell growth, differentiation, and survival. In our pursuit of overcoming the limitations of one of the leading therapeutic options, Lapatinib, such as its inhibition of hERG, we embarked on a comprehensive research journey. …”
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Generation of transgenic chicken through ovarian injection by Jinghua Jiang, Caiying Wang, Xuguang Du, Fei Gao, Sen Wu

“…This study seeks to establish an efficient method for generating transgenic chickens through ovarian injection, potentially bypassing the challenges associated with primordial germ cell (PGC) manipulation and fertilized egg microinjection. …”
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Minimally Invasive Bilateral Lung Resections and CABG through 5 Ports by N. Asemota, M. J. Rouhani, L. Harling, H. Raubenheimer, A. C. De Souza, E. Lim

“…An 81-year-old woman was diagnosed with T1aN0M0 left upper lobe small-cell lung cancer and underwent single-port left video-assisted thoracoscopic surgery (VATS) upper lobectomy in 2016. …”
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Ammonia electrosynthesis from nitrate using a stable amorphous/crystalline dual-phase Cu catalyst by Yi Wang, Shuo Wang, Yunfan Fu, Jiaqi Sang, Pengfei Wei, Rongtan Li, Dunfeng Gao, Guoxiong Wang, Xinhe Bao

“…The ammonia partial current density and formation rate reach 3.33 ± 0.005 A cm−2 and 15.5 ± 0.02 mmol h−1 cm−2 at a low cell voltage of 2.6 ± 0.01 V, respectively. Remarkably, the dual-phase Cu catalyst can maintain stable ammonia production with a Faradaic efficiency of around 90% at a high current density of 1.5 A cm−2 for up to 300 h. …”
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Association between allergic rhinitis and development of autoimmune thyroid diseases in Egyptian patients by Magdy Mohamed Allam, Soha Magdy Ahmed, Dalia Khamis El-Deeb, Ahmed Yassin Bahgat, Ramy Mohamed Ghazy, Hanaa Tarek El-Zawawy

“…Multivariate-adjusted hazardous ratios showed that patients with AR, female sex, higher white blood cell count, and diagnosis in November had a higher risk of developing AITD. …”
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Microbial succinate promotes the response to metformin by upregulating secretory immunoglobulin a in intestinal immunity by Ying Zhang, Aiting Wang, Wei Zhao, Jia’an Qin, Yu Zhang, Bing Liu, Chengcheng Yao, Jianglan Long, Mingxia Yuan, Dan Yan

“…In conclusion, we demonstrated that upregulated SIgA, which could be regulated by succinate, was functionally involved in metformin response through its influence on immune cell-mediated inflammation and insulin resistance. …”
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Topological transformation of microbial proteins into iron single-atom sites for selective hydrogen peroxide electrosynthesis by Xiaofeng Xiao, Zechao Zhuang, Shuhu Yin, Jiexin Zhu, Tao Gan, Ruohan Yu, Jinsong Wu, Xiaochun Tian, Yanxia Jiang, Dingsheng Wang, Feng Zhao

“…Remarkably, the optimal catalyst featuring FeN3O2 sites demonstrates a selectivity of up to 93.7% and generates hydrogen peroxide in a flow cell at an impressive rate of 29.6 mol g−1 h−1 at 200 mA cm−2. …”
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Isolation of PCSK9-specific nanobodies from synthetic libraries using a combined protein selection strategy by Apisitt Thaiprayoon, Yodpong Chantarasorn, Worrapoj Oonanant, Anongnard Kasorn, Phoomintara Longsompurana, Satita Tapaneeyakorn, Pinpunya Riangrungroj, Fabien Loison, Andrew C. Kruse, Matthew P. DeLisa, Dujduan Waraho-Zhmayev

“…We have developed a reliable protein selection strategy that combines magnetic activated cell sorting (MACS)-based screening of yeast surface display (YSD) libraries and functional ligand-binding identification by Tat-based recognition of associating proteins (FLI-TRAP) to isolate antigen-specific Nbs from synthetic libraries. …”
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Exploratory analysis of a Novel RACK1 mutation and its potential role in epileptic seizures via Microglia activation by Sai Zhang, Zhaofei Dong, Jing Guo, Ze Li, Hong Wu, Linming Zhang, Fuli Min, Tao Zeng

“…In this study, we identified the key gene RACK1 and its novel mutation RACK1-p.L206P as being associated with seizures through single-cell transcriptome sequencing (scRNA-seq) and whole exome sequencing (WES) techniques. …”
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Nanoemulsified Butenafine for Enhanced Performance against Experimental Cutaneous Leishmaniasis by Adriana Bezerra-Souza, Jéssica A. Jesus, Márcia D. Laurenti, Aikaterini Lalatsa, Dolores R. Serrano, Luiz Felipe D. Passero

“…Increased steady-state flux was reported for nanoenabled butenafine formulations with reduced lag time in Franz cell diffusion assays across Strat-M membranes. No toxic or inflammatory reactions were detected in animals treated with BUT-SNEDDS, BUT-SNEDDS gel, or butenafine. …”
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Flat-band based high-temperature ferromagnetic semiconducting state in the graphitic C4N3 monolayer by Chaoyu He, Yujie Liao, Tao Ouyang, Huimin Zhang, Hongjun Xiang, Jianxin Zhong

“…Herein, the 2 × 2 super-cell of the honeycomb lattice with a single-hole defect is proposed as a new lattice model (HL-D-1/8) to realize nontrivial isolated flat-bands. …”
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Unveiling the Electrocatalytic Activity of Bifunctional Iron‐Niobium Double Perovskites for Overall Water Splitting: A‐Site Cation Influence by Celal Avcıoğlu, Maged F. Bekheet, Suna Avcıoğlu, Figen Kaya, Byung Chul Kim, Cengiz Kaya, Aleksander Gurlo

“…An electrolyzer employing Sr2FeNbO6 electrodes for both the anode and cathode delivers a current density of 10 mA cm⁻2 at an efficient cell voltage of 1.76 V for complete alkaline water splitting, while also demonstrating exceptional stability. …”
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Necrostatin-1 Alleviates Diffuse Pulmonary Haemorrhage by Preventing the Release of NETs via Inhibiting NE/GSDMD Activation in Murine Lupus by Xinai Han, Xiaoming Zhang, Rui Song, Shiqi Li, Shujing Zou, Quanguang Tan, Tianyang Liu, Shugeng Luo, Zhe Wu, Hongyu Jie, Jinhong Wang

“…In vitro experiments revealed that Nec-1 inhibited alveolar epithelial cell damage by preventing the release of NETs. Furthermore, vivo studies showed that Nec-1 alleviated lupus pulmonary haemorrhage in mice by reducing lung pathology severity, body weight, and serum inflammatory cytokine levels. …”
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A Comparative Study of the In Vitro Intestinal Permeability of Pinnatoxins and Portimine by Rachelle Lanceleur, Vincent Hort, Marion Peyrat, Denis Habauzit, Andrew I. Selwood, Valérie Fessard

“…Therefore, we investigated the impact of PnTX analogs (PnTX-A, -E, -F, -G, and -H) and portimine (8, 16, and 32 ng/mL) on intestinal barrier integrity and their oral bioavailability using human Caco-2 cell monolayers treated for 2, 6, and 24 h. Our results demonstrated that all of the toxins could impair barrier integrity after 24 h, with differences observed for PnTX-A, -E, and -F, as well as portimine, the most potent of all. …”
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Exploring northeast India’s culturable soil Actinomycetia for potent antibacterial agents against gram-positive bacterial pathogens of clinical importance by Aditya Narayan Konwar, Surajit Basak, Shalini Gurumayum, Jagat Chandra Borah, Debajit Thakur

“…Toxicity studies against animal liver cell lines indicated that the ethyl acetate extract was non-toxic at concentrations below 125 µg/mL, compared to Vancomycin, which was found to be hepatotoxic at similar concentrations. …”
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Follistatin-Like 1: A Potential Mediator of Inflammation in Obesity by Nengguang Fan, Haiyan Sun, Yufan Wang, Yifei Wang, Lijuan Zhang, Zhenhua Xia, Liang Peng, Yanqiang Hou, Weiqin Shen, Rui Liu, Jiajing Yin, Yongde Peng

“…The expression of proinflammatory mediators including IL-6, TNF-α, and MCP-1 was upregulated by recombinant FSTL1 in a dose-dependent manner, paralleled with activation of the IKKβ-NFκB and JNK signaling pathways in the two cell lines. Moreover, FSTL1 impaired insulin signaling in 3T3-L1 adipocytes, as revealed by attenuated phosphorylation of both Akt and IRS-1 in response to insulin stimulation. …”
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