The Emerging Roles of the Calcineurin-Nuclear Factor of Activated T-Lymphocytes Pathway in Nervous System Functions and Diseases by Maulilio John Kipanyula, Wahabu Hamisi Kimaro, Paul F. Seke Etet

“…Evidence from murine and cell line models has implicated calcineurin-nuclear factor of activated T-lymphocytes (NFAT) signaling pathway, a Ca2+/calmodulin-dependent major proinflammatory pathway, in the pathogenesis of these diseases. …”
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Biological and Social Predictors of HIV-1 RNA Viral Suppression in ART Treated PWLH in Sub-Saharan Africa by Sindhuri Gandla, Raja Nakka, Ruhul Ali Khan, Eliezer Bose, Musie Ghebremichael

“…Our findings indicated that besides ART treatment status, older age, higher CD4 T-cell count, and longer duration of ART were identified as significant predictors of viral suppression. …”
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The efficacy of virtual reality in adults during puncture biopsy: A protocol of a systematic review and meta-analysis. by Xueling Qiu, Lukun Sun, Lu Tang, Xiaochen Jiang, Weifeng Wang, Fan Sun, Chenxi Sun, Tianyi Song

“…<h4>Background</h4>Puncture biopsy is a primary method for obtaining tissue or cell samples from tumors for histopathological diagnosis. …”
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Detection of host-derived sphingosine by Pseudomonas aeruginosa is important for survival in the murine lung. by Annette E LaBauve, Matthew J Wargo

“…These sphingolipids not only play a structural role in lipid membranes, but some are also intracellular and intercellular signaling molecules important in normal eukaryotic cell functions as well as orchestrating immune responses. …”
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Physical and Biological Characterizations of Injectable Thermosensitive Poly(N-Isopropylacrylamide)-Collagen I Hydrogels Intended for Meniscus Repair by Chunhai Ke, Xuanyuan Lu, Jiahua Ni, Ruicong Li, Qi Chen, Zhaoxiang Peng

“…Rheological characterizations showed that, under room temperature, the complex viscosity, the storage modulus, and the loss modulus, respectively, increased from 0.71±0.35 Pa•s to 110.95±23.22 Pa•s, from 3.28±2.02 Pa to 658.06±128.07 Pa, and from 3.30±1.01 Pa to 308.78±56.67 Pa, as the collagen I content in the hydrogel increased from 0% to 1%. Cell proliferation tests and high-density culture also revealed that collagen I promoted bioactivity of the hydrogels and induced fibrochondrocyte phenotype of the chondrocytes. …”
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Etoricoxib–NLC Mitigates Radiation-Induced Ovarian Damage in Rats: Insights into Pro-Inflammatory Cytokines, Antioxidant Activity, and Hormonal Responses by Sahar Khateeb

“…These therapeutic effects were achieved through the modulation of oxidative stress, inflammation, augmentation of antioxidant defenses (including <i>Nrf2</i> activation), support for cell survival pathways (via PI3K/Akt signaling), regulation of MAPK, mitigation of fibrosis (<i>TGF-β</i>), and preservation of ovarian reserve (as evidenced by AMH, FSH/LH, and estrogen levels). …”
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Olfactory transport efficiency of the manganese oxide nanoparticles (II) after their single or multiple intranasal administrations by A. V. Romashchenko, M. B. Sharapova, D. V. Petrovskii, M. P. Moshkin

“…In this case, the concentration of particles in the olfactory bulb was proportional to the volume of the structure, which in particular depends on the number of synaptic contacts between the mitral cell of the olfactory bulb (OB) and olfactory epithelium (OE). …”
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Correction: Saber et al. BD-AcAc2 Mitigates Chronic Colitis in Rats: A Promising Multi-Pronged Approach Modulating Inflammasome Activity, Autophagy, and Pyroptosis. <i>Pharmaceutic... by Sameh Saber, Mohannad Mohammad S. Alamri, Jaber Alfaifi, Lobna A. Saleh, Sameh Abdel-Ghany, Adel Mohamed Aboregela, Alshaimaa A. Farrag, Abdulrahman H. Almaeen, Masoud I. E. Adam, AbdulElah Al Jarallah AlQahtani, Ali M. S. Eleragi, Mustafa Ahmed Abdel-Reheim, Heba A. Ramadan, Osama A. Mohammed

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Role of Mitogen-Activated Protein Kinases in Myocardial Ischemia-Reperfusion Injury during Heart Transplantation by Giuseppe Vassalli, Giuseppina Milano, Tiziano Moccetti

“…Intracellular mitogen-activated protein kinase (MAPK) signaling pathways regulate inflammation and cell survival during IR injury. The four best-characterized MAPK subfamilies are the c-Jun NH2-terminal kinase (JNK), extracellular signal- regulated kinase-1/2 (ERK1/2), p38 MAPK, and big MAPK-1 (BMK1/ERK5). …”
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TLR7 Polymorphism (rs179008 and rs179009) in HIV-Infected Individual Naïve to ART by HariOm Singh, Dharmesh Samani, Sumit Aggarwal

“…Single nucleotide polymorphism (SNP) in TLR7 (Gln11Leu) gene has been associated with a rapid decline of CD4T cell count. Hence, we assessed the TLR7 (rs179008, Gln11Leu (A/T) and rs179009, IVS2-151 (A/G)) polymorphism in 150 HIV-infected individuals naïve to ART and 158 healthy controls. …”
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Development of a chemically defined medium for Yarrowia yeasts using a strategy of biological mimicry by Oliver Birrenbach, Peter Czermak

“…Thiamine hydrochloride was a growth-limiting component, and higher concentrations increased the cell density of Y. lipolytica PO1f cultures by a factor of 30. …”
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The Effect of Endotoxin-Induced Inflammation on the Activity of the Somatotropic Axis in Sheep by Maciej Wójcik, Dorota Anna Zieba, Joanna Bochenek, Agata Krawczyńska, Marcin Barszcz, Alina Gajewska, Hanna Antushevich, Andrzej Przemysław Herman

“…Our study suggests that disruption of the GH cell signaling pathway may be one of the important elements of the pathophysiology of inflammation. …”
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Bortezomib, thalidomide, and dexamethasone versus bortezomib, lenalidomide, and dexamethasone in transplant-eligible newly diagnosed multiple myeloma: a systemic review and meta-an... by Yin-Che Wang, Cheng-Hsien Lin, Yu-Chen Su, Chieh-Lin Jerry Teng

“…The primary endpoints were response rates after induction therapy and the incidence of a need for autologous hematopoietic stem cell transplantion (auto-HSCT) between the groups. …”
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Nanoparticles in gynecologic cancers: a bibliometric and visualization analysis by Yunzhe Zhou, Lizhang Chen, Tingting Wang

“…BackgroundGynecological cancers are characterized by uncontrolled cell proliferation within the female reproductive organs. …”
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Gastroprotective properties of flavonoid-rich extract of Pulicaria odora against ethanol-induced gastric ulcer in mice by Khadidja Boudebbaz, Manel Brouk, Roumaissa Laalem, Nada Zabaiou

“…In vitro anti-inflammatory activity was investigated through the human red blood cell membrane stabilization method and the bovine serum albumin denaturation method. …”
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Massive Orbital Myiasis Caused by Sarcophaga argyrostoma Complicating Eyelid Malignancy by Anfisa Ayalon, Veronika Yehezkeli, Yossi Paitan, Krzysztof Szpila, Kosta Y. Mumcuoglu, Elad Moisseiev

“…A 98-year-old man first presented to our clinic noted to have a fast-growing lesion on his right upper and lower eyelids. Squamous cell carcinoma of the eyelids was highly suspected, and surgical excision was advised, but the patient refused any surgical or nonsurgical intervention. …”
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A study of serum prolactin in dermatological diseases in a tertiary care hospital of Assam by Talukdar C, Boro B

“…Background: Prolactin functions as a neuroendocrine modulator of the skin immune system and epithelial cell proliferation. Prolactin and the immune system inter relationship have been studied extensively and opened new avenues in the field of immunoendocrinology. …”
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Comparison between Vascular Endothelial Growth Factor and Platelet-Derived Growth Factor Levels in Rhegmatogenous Retinal Detachment by Andi Muhammad Ichsan, Dyah Ayu Windy, Habibah Setyawati Muhiddin, null Budu, Muhammad Nasrum Massi, Itzar Chaidir Islam

“…Based on the tendency of VEGF-A and PDGF-AA levels, RRD surgery has to be performed as soon as possible prior to retinal cell death and membrane proliferative formation.…”
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Recognition of ZnT8, Proinsulin, and Homologous MAP Peptides in Sardinian Children at Risk of T1D Precedes Detection of Classical Islet Antibodies by Magdalena Niegowska, Daniela Paccagnini, Carla Mannu, Clara Targhetta, Marco Songini, Leonardo A. Sechi

“…Being MAP easily transmitted to humans with infected cow’s milk and detected in retail infant formulas, MAP epitopes could be present in extensively hydrolyzed formula and act as antigens stimulating β-cell autoimmunity.…”
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Identification of Differentially Expressed Genes in COVID-19 and Integrated Bioinformatics Analysis of Signaling Pathways by Linjie Fang, Tingyu Tang, Mengqi Hu

“…Then, based on GSEA, the enrichment of the gene set in the sample was analyzed in the GO terms, and the gene set was enriched in the positive regulation of myeloid leukocyte cytokine production involved in immune response, programmed necrotic cell death, translesion synthesis, necroptotic process, and condensed nuclear chromosome. …”
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