Hyaluronan Does Not Affect Bupivacaine’s Inhibitory Action on Voltage-Gated Potassium Channel Activities in Bovine Articular Chondrocytes by William Hester, Jinnan Yang, Guo-Yong Wang, Sen Liu, Michael J. O'Brien, Felix H. Savoie, Zongbing You

“…The objective of this paper is to determine if hyaluronan affects bupivacaine’s anesthetic function. Methods. Whole cell patch clamp recordings were performed on bovine articular chondrocytes cultured in 60 mm dishes. …”
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Glycyrrhizic Acid Promotes M1 Macrophage Polarization in Murine Bone Marrow-Derived Macrophages Associated with the Activation of JNK and NF-κB by Yulong Mao, Baikui Wang, Xin Xu, Wei Du, Weifen Li, Youming Wang

“…Our results showed that GA obviously increased the cell surface expression of CD80, CD86, and MHCII molecules. …”
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24-epibrassinolide regulates oxytetracycline-induced phytotoxicity and its detoxification mechanism by Suya Chen, Shanshan Zhou, Xuan Xuan, Lili Niu, Lu Zhao, Jingjie Guo, Dongmei Xu

“…Exogenous EBL significantly decreased reactive oxygen species (ROS) accumulation, alleviating OTC-induced cell membrane lipid peroxidation. This was achieved by increasing the antioxidant capacity and secondary metabolism levels. …”
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A multilayered regulatory network mediated by protein phosphatase 4 controls carbon catabolite repression and de-repression in Magnaporthe oryzae by Zhicheng Huang, Qing Wang, Yan Li, Pengyun Huang, Jian Liao, Jing Wang, Hui Li, Yingying Cai, Jiaoyu Wang, Xiaohong Liu, Fu-Cheng Lin, Jianping Lu

“…Phosphorylation-mediated activation or inactivation of CreA and Crf1 drives CCR and CCDR, thereby governing the metabolism of carbon sources derived from plant cell walls and contributing to fungal pathogenicity. …”
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Combined Supplementation of Choline and Docosahexaenoic Acid during Pregnancy Enhances Neurodevelopment of Fetal Hippocampus by Huban Thomas Rajarethnem, Kumar Megur Ramakrishna Bhat, Malsawmzuali Jc, Siva Kumar Gopalkrishnan, Ramesh Babu Mugundhu Gopalram, Kiranmai Sesappa Rai

“…Docosahexaenoic acid (DHA) is a polyunsaturated fatty acid, highly enriched in cell membranes of the brain. Dietary intake of choline or DHA alone by pregnant mothers directly affects fetal brain development and function. …”
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Synthesis, characterization, In silico, and In vitro studies of CuS–ZnO nanocomposite using mushroom extract by S. Anbazhagi, A. Murugesan, M. Paramanantham, K. Chinnaiah, Karthik Kannan, Nadezhda Palko, K. Gurushankar

“…The cytotoxicity analysis shows a CuS–ZnO Nanoparticles have more cytotoxic effect in U87 cell lines. Clavilactone D could be more effective against fungal infections. …”
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Spectroscopic Characterization and Biological Activity of Mixed Ligand Complexes of Ni(II) with 1,10-Phenanthroline and Heterocyclic Schiff Bases by Y. Prashanthi, K. Kiranmai, Ira, Sathish kumar K, Vijay kumar Chityala, Shivaraj

“…MTT is used to test the anticancer effect of the complexes with HL60 tumor cell. The inhibition ratio was accelerated by increasing the dosage, and it had significant positive correlation with the medication dosage.…”
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Development and validation of an in vitro release test and use of Strat-M synthetic membrane as a predictor for the in vitro permeation test of topical gel formulations by Marija Grozdanoska Kostadinovska, Sacha Manuel, Nena Velevska, Packa Antovska, Jelena Lazova, Jasmina Tonic Ribarska, Rumenka Petkovska, Suzana Trajkovic Jolevska

“…The purpose of this research was to use the vertical diffusion cell method to produce an appropriate in vitro release test for topical gel formulations. …”
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Differential Immunogenicity and Protective Efficacy Elicited by MTO- and DMT-Adjuvanted CMFO Subunit Vaccines against Mycobacterium tuberculosis Infection by Nadeem Ullah, Ling Hao, Yaqi Wu, Yandi Zhang, Qing Lei, Jo-Lewis Banga Ndzouboukou, Xiaosong Lin, Xionglin Fan

“…In particular, the adjuvant DMT showed a stronger ability than the O/W emulsion to adjuvant CMFO subunit vaccine and enhanced protection, attributed to elicit Th1-biased responses, strong Th1/Th17 cytokine responses, and IFN-γ+ or IL-2+ T cell responses. Therefore, our findings demonstrate that the liposome delivery system shows more effectiveness to adjuvant TB subunit vaccine than O/W emulsion and highlight the importance of adjuvant formulation for the better efficacy of a protein vaccine.…”
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Network pharmacology-based screening of the active ingredients and mechanisms of Cymbaria daurica against diabetes mellitus by Ruyu Shi, Dongxue Chen, Mingyue Ji, Baochang Zhou, Ziyan Zhang, Chunhong Zhang, Minhui Li

“…Molecular docking was performed to validate the predicted results. Then, a HepG2 cell insulin resistance model and a high-fat, high-glucose diet combined with a streptozotocin-induced T2DM rat model was established to assess the fasting glucose changes and lipid profile after C. daurica treatment, respectively. …”
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ZFP36 Regulates Vascular Smooth Muscle Contraction and Maintains Blood Pressure by Xiuru Cui, Yawei Wang, Hanlin Lu, Lei Wang, Xianwei Xie, Shenghao Zhang, Pavel Kovarik, Shuijie Li, Shanshan Liu, Qunye Zhang, Jianmin Yang, Cheng Zhang, Jinwei Tian, Yan Liu, Wencheng Zhang

“…In cultured vascular smooth muscle cell (VSMC), angiotensin II (AngII) activates poly (ADP‐ribose) polymerases1 (PARP1) to stimulate Zfp36 expression at the transcriptional level. …”
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Mechanism of microplastics in the reduction of cadmium toxicity in tomato by Rongchao Yang, Long Cheng, Zhenqin Li, Yilan Cui, Jiawei Liu, Duo Xu, Sijia Liu, Zhong Lin, Jiugeng Chen, Yueqin Zhang

“…Transcriptome analysis further revealed that combined treatment reprogrammed key pathways, including cell wall synthesis, antioxidant systems, Cd transport, hormone signaling, nitrogen metabolism, and glutathione metabolism, to alleviate Cd toxicity. …”
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Development and functional validation of a disulfidoptosis-related gene prognostic model for lung adenocarcinoma based on bioinformatics and experimental validation by Tao Shen, Tao Shen, Zhuming Lu, Sisi Yang, Dongxi Zhang, Yongwen Ke, Zhuowen Chen, Jinqiang Wu, Jinqiang Wu, Weidong Wu

“…IHC showed elevated TNS4 levels in LUAD tissues, while in vitro TNS4 knockdown reduced both cell proliferation and migration.ConclusionThis study highlights the role of DRGs in LUAD, with a validated gene signature offering new avenues for targeted therapies, potentially improving LUAD treatment outcomes.…”
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Truncated SPAG9 as a novel candidate gene for a new syndrome: Coarse facial features, albinism, cataract and developmental delay (CACD syndrome) by Majid Alfadhel, Bashayr S. Alhubayshi, Muhammad Umair, Ahmed Alfaidi, Deemah Alwadaani, Essra Aloyouni, Safdar Abbas, Abdulkareem Al Abdulrahman, Mohammed Aldrees, Abeer Al Tuwaijri, Ruaa S. Alharithy, Abdulaziz Alajlan, Abdulrahman Alswaid, Saad Almohrij, Sultan Al-Khenaizan

“…Abstract Sperm-associated antigen 9 (SPAG9) is a member of cancer-testis antigen, having characteristics of a scaffold protein, which is involved in the c-Jun N-terminal kinase JNK signaling pathway, suggesting its key involvement in different physiological processes, such as survival, apoptosis, tumorigenesis, and cell proliferation. We identified two families (A and B) having multisystem features like coarse facial features, albinism, cataracts, skeletal abnormalities, and developmental delay. …”
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Molecular Mechanisms Linking Omega-3 Fatty Acids and the Gut–Brain Axis by Anna Zinkow, Wojciech Grodzicki, Malwina Czerwińska, Katarzyna Dziendzikowska

“…Derived mainly from marine sources, these long-chain polyunsaturated fatty acids are integral to cell membrane structure, enhancing fluidity and influencing neurotransmitter function and signal transduction. …”
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Chronic exposure to diesel engine exhaust and alteration of the airway bacteriome by Menghui Jiang, Yongwei Yan, Tao Wang, Bojia Wang, Yanting Li, Jinglong Tang, Yuxin Zheng

“…Furthermore, the Spearman analysis indicated notable correlations of specific species with carbon content in airway macrophages (CCAM), club cell protein (CC16), FVC and FEV1. Taken together, our study provided new information on the difference in the airway bacterial signature under exposure to DEE and supported a potential new link between specific species and lung function in occupational populations.…”
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A pan-cancer analysis of MARCH8: molecular characteristics, clinical relevance, and immuno-oncology features by Zihan Quan, Songqing Fan, Hongmei Zheng, Yue Ning, Yang Yang

“…The expression of MARCH8 protein was detected via immunohistochemistry in non-small cell lung cancer (NSCLC) and non-cancerous lung tissues. …”
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Lipid Isolated from a Leishmania donovani Strain Reduces Escherichia coli Induced Sepsis in Mice through Inhibition of Inflammatory Responses by Subhadip Das, Nabanita Chatterjee, Dipayan Bose, Somenath Banerjee, Prajnamoy Pal, Tarun Jha, Krishna Das Saha

“…LTL also improved the lung injury and suppressed the cell adhesion molecules in lung tissue. These findings indicate that LTL may prove to be a potential anti-inflammatory agent and provide protection against gram-negative bacterial sepsis with pulmonary impairment.…”
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MicroRNA Biomarker hsa-miR-195-5p for Detecting the Risk of Lung Cancer by Lei Li, Tienan Feng, Weituo Zhang, Sumeng Gao, Ruoyang Wang, Wenwen Lv, Tengteng Zhu, Herbert Yu, Biyun Qian

“…Lung cancer is one of the leading diagnosed cancers worldwide, and microRNAs could be used as biomarkers to diagnose lung cancer. hsa-miR-195 has been demonstrated to affect the prognosis of NSCLC (non-small-cell lung cancer) in a previous study. However, the diagnostic value of hsa-miR-195-5p in lung cancer has not been investigated. …”
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Adjuvant Radiotherapy for Synchronous Bilateral Testicular Seminoma: A Case Report and a Review of the Pertinent Literature by Daniel A. Jones, Elizabeth C. Ester, David Leavitt, Robert Sweet, Badrinath Konety, Gautam Jha, L. Chinsoo Cho

“…After 18 months of followup, he remains well, without evidence of recurrence. Bilateral germ cell tumors (BGCTs) are reported consistently at a low rate. …”
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