Mobilization of subcutaneous fascia contributes to the vascularization and function of acellular adipose matrix via formation of vascular matrix complex by Han Yang, Yidan Xu, Sousan Cheong, Cuiying Xie, Yufan Zhu, Shujie Xu, Feng Lu, Yunfan He

“…In this study, we employed matrix-tracing, vessel-tracing, cell-tracing, and matrix analysis techniques, etc. to investigate the vascularization process of acellular adipose matrix (AAM) implants in a murine model. …”
Get full text

Unlocking precision medicine: clinical applications of integrating health records, genetics, and immunology through artificial intelligence by Yi-Ming Chen, Tzu-Hung Hsiao, Ching-Heng Lin, Yang C. Fann

“…AI-enabled immunology data analysis, including dimensionality reduction, cell population identification, and sample classification, provides unprecedented insights into complex immune responses. …”
Get full text

Ir-O-Mn embedded in porous nanosheets enhances charge transfer in low-iridium PEM electrolyzers by Dawei Wang, Fangxu Lin, Heng Luo, Jinhui Zhou, Wenshu Zhang, Lu Li, Yi Wei, Qinghua Zhang, Lin Gu, Yanfei Wang, Mingchuan Luo, Fan Lv, Shaojun Guo

“…Notably, Ir/MnOx-based PEMWE demonstrates comparable performance under 10-fold lower Ir loading (0.2 mgIr cm−2), taking a low cell voltage of 1.63 V to deliver 1 A cm−2 for over 300 h, which positions it among the elite of low Ir-based PEMWEs.…”
Get full text

The role of Mitofusin-1 and Mitofusin-2 in periodontal disease: a comprehensive review by Sudhir R. Varma, Sudhir R. Varma, Omar H. A. A. Ani, Jayaraj K. Narayanan, Jayaraj K. Narayanan, Asok Mathew, Asok Mathew

“…The current comprehensive review shows the important roles of MFN1 along with MFN2 in inflammation regulation, cell survival, and mitochondrial dynamics within periodontal disease. …”
Get full text

Fully CMOS Boost Converter Operating at 2.65 GHz for Photovoltaic Energy Harvesting by Pedro Mendonca Dos Santos, Ricardo Alexandre Marques Lameirinhas, Catarina P. Correia V. Bernardo, Joao Paulo Neto Torres, Antonio Serralheiro, Rafael Vieira, Nuno Lourenco

“…This research describes the design of a fully CMOS-integrated boost DC-DC converter to be supplied by an ultra-low power solar cell for energy harvesting applications. The monolithic system is based on the inductive boost converter, with both the energy storage spiral inductor and the output filter capacitor integrated together with an LC oscillator at 2.65 GHz, to drive both MOSFET switches, in a 110 nm CMOS process. …”
Get full text

Harnessing natural polymers and nanoparticles: Synergistic scaffold design for improved wound healing by Anitha S, Nandini Robin Nadar, Srividya Shivakumar, Sharma S C, Siddharth P, Surekha Varalakshmi V, Rajesh Lenka, Rajadurai S

“…The synergistic approach results in novel scaffold designs that promote cell functions and mimic the extracellular matrix (ECM) to further enhance wound healing. …”
Get full text

Label-free proteomic analysis of Duchenne and Becker muscular dystrophy showed decreased sarcomere proteins and increased ubiquitination-related proteins by Juliana Cristina Tobar da Silva, Mariângela Rangel Alves Nogueira, Yara Martins da Silva, Fábio César Sousa Nogueira, Nathalie Henriques Silva Canedo, Katia Carneiro, Denise de Abreu Pereira

“…Enrichment of functions associated with cell structure and RNA binding was also observed, including cytoskeletal protein binding and RNA binding. …”
Get full text

Effect of Creatine Monohydrate Supplementation on Various Hematological and Serum Biochemical Parameters of Male Albino Mice following Neonatal Hypoxia-Ischemia Encephalopathy by Shahid Iqbal, Nabia Nazir, Quratulane Gillani, Atif Akbar, Furhan Iqbal

“…Methods. 66 Blood samples (2% creatine monohydrate supplemented (N=34) and unsupplemented (N=32)) were analyzed for various hematological (blood glucose, packed cell volume, total WBC count, total RBC count) and serum biochemical parameters (cholesterol, AST, ALT, HDL, LDL, total protein, triglycerides). …”
Get full text

Therapeutic effect of selective interleukin-2-inducible tyrosine kinase inhibitor in orbital fibroblasts from patients with Graves’ orbitopathy by Yeonjung Yoon, Hyun Young Park, Min Kyung Chae, Sun Young Jang, Jin Sook Yoon

“…Interleukin-2-inducible tyrosine kinase (ITK) is a crucial cytoplasmic protein in the T-cell signaling pathway. Here, we aimed to demonstrate the anti-inflammatory effect of the selective IL-2-induced tyrosine kinase inhibitor BMS-509744 (BMS) on Graves’ orbitopathy (GO) in an in vitro model. …”
Get full text

Exploring the application of dietary antioxidant index for disease risk assessment: a comprehensive review by Hossein Pourmontaseri, Sina Bazmi, Matin Sepehrinia, Matin Sepehrinia, Ayda Mostafavi, Reza Arefnezhad, Reza Arefnezhad, Reza Homayounfar, Farhad Vahid

“…On the other hand, antioxidants play a crucial role in preventing oxidative stress or postponing cell damage via the direct scavenging of free radicals or indirectly via the Keap1/Nrf2/ARE pathway, among others. …”
Get full text

Immune and Inflammatory Responses of the Intestinal Mucosa following Extended Liver Radiofrequency Ablation by Petros Ypsilantis, Maria Lambropoulou, Antonios Evagellou, Nikolaos Papadopoulos, Constantinos Simopoulos

“…Forty-eight hours later, ileal tissue specimens were excised for immunohistochemical assessment of CD68+ macrophages, CD4+ T-lymphocytes, CD8+ T-lymphocytes, mucosal addressin cell adhesion molecule-1 (MAdCAM-1), tumor necrosis factor-α (TNFα), interleukin-6 (IL-6), and nuclear factor-κB (NFκB) expression. …”
Get full text

Long-Term High Salt Intake Involves Reduced SK Currents and Increased Excitability of PVN Neurons with Projections to the Rostral Ventrolateral Medulla in Rats by Andrew D. Chapp, Renjun Wang, Zixi (Jack) Cheng, Zhiying Shan, Qing-Hui Chen

“…The present study determined whether 5 weeks of HS (2% NaCl) intake alters the small conductance Ca2+-activated potassium channel (SK) current in presympathetic PVN neurons and whether this change affects the neuronal excitability. In whole-cell voltage-clamp recordings, HS-treated rats had significantly decreased SK currents compared to rats with normal salt (NS, 0.4% NaCl) intake in PVN neurons. …”
Get full text

Ability of Swept-Source Optical Coherence Tomography to Detect Retinal and Choroidal Changes in Patients with Multiple Sclerosis by Elena Garcia-Martin, Laura Jarauta, Elisa Vilades, Jose Ramon Ara, Jesus Martin, Vicente Polo, Jose Manuel Larrosa, Luis Emilio Pablo, Maria Satue

“…Macular thickness and peripapillary data (retinal, ganglion cell layer (GCL+, GCL++) and retinal nerve fiber layer (RNFL) thickness) were analyzed, including choroidal thickness evaluation. …”
Get full text

Ethylene Response Factor Sl-ERF.B.3 Is Responsive to Abiotic Stresses and Mediates Salt and Cold Stress Response Regulation in Tomato by Imen Klay, Julien Pirrello, Leila Riahi, Anne Bernadac, Ameur Cherif, Mondher Bouzayen, Sadok Bouzid

“…Furthermore, the cold stress essay clearly revealed that introducing antisense Sl-ERF.B.3 in transgenic tomato plants reduces their cell injury and enhances their tolerance against 14 d of cold stress. …”
Get full text

Targeted modulation of intestinal barrier and mucosal immune-related microbiota attenuates IgA nephropathy progression by Ran Zhang, Yuyan Tang, Xiangru Feng, Xiaoxuan Lu, Mengyao Zhao, Jiayang Jin, Xiaoguo Ji, Haidong He, Liming Zhao

“…There was also an imbalance in intestinal B-cell immunity and a decrease in the level of tight junction proteins (ZO-1 and Occludin). …”
Get full text

Combined Input Deep Learning Pipeline for Embryo Selection for In Vitro Fertilization Using Light Microscopic Images and Additional Features by Krittapat Onthuam, Norrawee Charnpinyo, Kornrapee Suthicharoenpanich, Supphaset Engphaiboon, Punnarai Siricharoen, Ronnapee Chaichaowarat, Chanakarn Suebthawinkul

“…In this study, a deep learning-based pipeline was developed to classify the viability of embryos using combined inputs, including microscopic images of embryos and additional features, such as patient age and developed pseudo-features, including a continuous interpretation of Istanbul grading scores by predicting the embryo stage, inner cell mass, and trophectoderm. For viability prediction, convolution-based transferred learning models were employed, multiple pretrained models were compared, and image preprocessing techniques and hyperparameter optimization via Optuna were utilized. …”
Get full text

Characterization of Cellulolytic Bacterial Cultures Grown in Different Substrates by Mohamed Idris Alshelmani, Teck Chwen Loh, Hooi Ling Foo, Wei Hong Lau, Awis Qurni Sazili

“…Nine aerobic cellulolytic bacterial cultures were obtained from the Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Culture (DSMZ) and the American Type Culture Collection (ATCC). …”
Get full text

Experimental investigation on the reverse mechano-electrical effect of porcine articular cartilage by Chunsheng Liu, Le Zhao, Hao Dong, Zekun Hua, Yanqin Wang, Yongxing Wang, Pengcui Li, Xiaochun Wei, Kai Zhang, Yanru Xue, Xiaogang Wu, Weiyi Chen

“…This may provide valuable insights for further investigation into the microscopic mechanisms of cell proliferation, differentiation, and cartilage regeneration induced by electrical stimulation.…”
Get full text

A Rabbit Model Study to Determine the Efficacy of a Prototype Corneal Endothelium Protector during Cataract Surgery by Annabel C. Y. Chew, Anita Chan, Monisha E. Nongpiur, Gary Peh, Veluchamy A. Barathi, Nyein C. Lwin, Charles Ong, Shamira Perera

“…There was a trend towards lesser endothelial cell loss for the P-chute group at POD1 (4.9% versus 12.5%, p=0.53), POD5 (10.4% versus 12.2%, p=0.77), and POD7 (10.5% versus 17.2%, p=0.52). …”
Get full text

Identification of Aberrantly Expressed miRNAs in Gastric Cancer by Dan Liu, Xiaowei Hu, Hongfeng Zhou, Guangyue Shi, Jin Wu

“…Gene ontology analysis revealed that those dysregulated miRNAs mainly take part in regulating cell proliferation. The levels of has-miR-105, -213*, -514b, and -548n were tested by real-time PCR and have high levels in cancerous tissues. …”
Get full text