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27541
Disruption of erythroid nuclear opening and histone release in myelodysplastic syndromes
Published 2019-03-01“…Here, we use an in vitro human CD34‐positive hematopoietic stem and progenitor cell culture system and reveal that nuclear openings and histone release are also identified during human terminal erythropoiesis. …”
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27542
Transition of Thyroid Autoantibodies by Rituximab Treatment in Women with Rheumatoid Arthritis
Published 2024-10-01“…Rituximab was first used as a treatment for B-cell malign lymphoma, and it is currently used in the treatment of rheumatoid arthritis. …”
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27543
Range-Dependent Variance Correction Method for High-Resolution and Wide-Swath Spaceborne Synthetic Aperture Radar Imaging Based on Block Processing in Range Dimension
Published 2024-12-01“…Previous research has primarily focused on the impact of range-dependent variance on range cell migration and the quadratic phase of range frequency, while often neglecting the effects of the cubic phase of range frequency. …”
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27544
Light‐Processed 3D Bioprinting of Symblepharon Rings Fortified with l‐Ascorbic Acid for Ocular Tissue Engineering
Published 2025-01-01“…In biocompatibility tests, Gelas and Gelas‐low rings achieve over 75% viability. Following the cell test, scanning electron microscope images reveal fibroblasts adhering to Gelas and Gelas‐low rings, spreading across their surfaces. …”
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27545
Mechanisms of nucleus accumbens deep brain stimulation in treating mental disorders
Published 2025-01-01“…Moreover, by outlining the various NAc cell types, transmitter systems (i.e., predominantly GABAergic and dopaminergic systems) and anatomical pathways that have been shown to be relevant for NAc DBS stimulation effects, we aim to further elucidate the neurobiological determinants of NAc DBS efficacy. …”
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27546
Neuroprotective Effects of Salidroside in the MPTP Mouse Model of Parkinson’s Disease: Involvement of the PI3K/Akt/GSK3β Pathway
Published 2016-01-01“…Our in vitro experiments suggested that salidroside (Sal) could protect against 1-methyl-4-phenylpyridine-induced cell apoptosis in part by regulating the PI3K/Akt/GSK3β pathway. …”
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27547
Maternal Serum Cytokine Concentrations in Healthy Pregnancy and Preeclampsia
Published 2021-01-01“…This theory is simplistic as it is based on limited information and does not consider the role of other T cell subsets, Th17 and Tregs. A range of maternal peripheral cytokines have been measured in pregnancy cohorts, albeit the changes in individual cytokine concentrations across gestation is not well summarised. …”
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27548
High Level Aminoglycoside Resistance and Distribution of Aminoglycoside Resistant Genes among Clinical Isolates of Enterococcus Species in Chennai, India
Published 2014-01-01“…Aminoglycosides along with cell wall inhibitors are given clinically for treating enterococcal infections. 178 enterococcal isolates were analyzed in this study. …”
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27549
The Therapeutic Potential of Low-Intensity Pulsed Ultrasound in Enhancing Gallbladder Function and Reducing Inflammation in Cholesterol Gallstone Disease
Published 2025-01-01“…It also reduced inflammatory cell infiltration and tissue edema, and promoted new capillary formation in the gallbladder, mitigating the progression of CGS. …”
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27550
Silicon Effects Depend upon Insect Herbivore Guild and Has Limited Influence on Gall-Inducing Insects of <i>Bauhinia brevipes</i>
Published 2025-01-01“…Silicon (Si) is a widely recognized element in plant defense, often enhancing resistance to herbivory by strengthening cell walls and deterring feeding by external herbivores. …”
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27551
Assessment of access and outcomes of kidney transplantation through the reforms of the Swiss organ allocation system
Published 2025-01-01“…Initially based on waiting time, HLA compatibility, and crossmatch performed by cell complement-dependent cytotoxicity techniques, the system moved in 2012 to a score including HLA compatibility, waiting time, anti-HLA antibodies detected by the Luminex® technology, and a virtual crossmatch. …”
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27552
Bio- synthesis zinc oxide nanoparticle: Azadirachta indica and Phyllanthus acidus mediated green approach for enhanced biological efficacy
Published 2025-06-01“…The synthesized ZnO NPs demonstrated cytotoxic effects on the cell lines at higher concentration. However, there was a significant increase in the inhibition of alpha amylase and alpha- glucosidase activity. …”
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27553
MCL Plays an Anti-Inflammatory Role in Mycobacterium tuberculosis-Induced Immune Response by Inhibiting NF-κB and NLRP3 Inflammasome Activation
Published 2017-01-01“…In this experiment, we examined the inhibitory effect of MCL on Mtb-induced inflammatory response in mouse macrophage-like cell line Raw264.7 by downregulating the activation of nuclear factor kappa B (NF-κB) and NLRP3 inflammasome. …”
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27554
Ferroptosis in thyroid cancer: mechanisms, current status, and treatment
Published 2025-01-01“…Comprehensive investigations into the pathogenesis of TC have identified a significant association with ferroptosis, a newly characterized form of cell death mediated by iron ions. Distinct from apoptosis, necrosis, and autophagy, ferroptosis is characterized by the accumulation of lipid peroxides and reactive oxygen species, culminating in cellular damage and death.Recent research has elucidated a connection between ferroptosis and the initiation, progression, and treatment of thyroid cancer. …”
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27555
Tumor microenvironment–responsive and modulatory manganese-based nanoenzyme for enhanced tumor immunotherapy
Published 2025-01-01“…Besides the photothermal effect and the enhancement of ROS burst-induced immunogenic cell death, combination of Mn2+ released from Mn-based nanoenzyme in acidic TME and programmed death-ligand 1 blockade triggered a significant anti-tumor immune response. …”
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27556
Major royal-jelly proteins intake modulates immune functions and gut microbiota in mice
Published 2024-01-01“…The splenocytes and mesenteric lymphocytes activated by T-cell mitogens (ConA and anti-CD3/CD28 antibodies) released high levels of IL-2 but low levels of IFN-γ and IL-17A. …”
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27557
Vitamin C exerts anti-cadmium induced fracture functions/targets: bioinformatic and biostructural findings
Published 2022-09-01“…Furthermore, biological processes, cell components, molecular functions, and pharmacological pathways involved in the action of VC against cadmium-induced fracture were identified and visualized. …”
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27558
Transcriptome Concordance Between Borderline Tumors and Endometrioid Carcinoma: An Integrative Genomic Analysis
Published 2025-01-01“…This study aims to address this gap by integrating whole‐exome sequencing (WES) and RNA sequencing (RNA‐seq) to compare BOTs with high‐grade serous carcinoma (HGSC), endometrioid carcinoma (EC), and clear‐cell carcinoma (CCC). Objective To elucidate the molecular features of BOTs and evaluate their similarities and differences in comparison to HGSC, EC, and CCC. …”
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27559
Silymarin: a promising modulator of apoptosis and survival signaling in cancer
Published 2025-01-01“…By upregulating pro-apoptotic and downregulating anti-apoptotic proteins, silymarin controls a series of events that result in tumor suppression and cell death in a variety of cancer types. The low bioavailability and limited therapeutic efficacy of silymarin are improved by the application of various nano-delivery systems. …”
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27560
Oncological outcomes in non-seminomatous testicular tumors and residual mass after cisplatin-based chemotherapy
Published 2024-04-01“…A residual mass (RM) in non-seminomatous germ cell tumors (NSGCT) after chemotherapy (CT) is defined as a mass >1 cm in greatest diameter. …”
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