Cannabidiol Rescues Acute Hepatic Toxicity and Seizure Induced by Cocaine by Luciano Rezende Vilela, Lindisley Ferreira Gomides, Bruna Araújo David, Maísa Mota Antunes, Ariane Barros Diniz, Fabrício de Araújo Moreira, Gustavo Batista Menezes

“…Considering the protective role of the endocannabinoid system against cell toxicity, we hypothesized that treatment with an anandamide hydrolysis inhibitor, URB597, or with a phytocannabinoid, cannabidiol (CBD), protects against cocaine toxicity. …”
Get full text

SIAE Rare Variants in Juvenile Idiopathic Arthritis and Primary Antibody Deficiencies by Eirini Sevdali, Elena Tsitsami, Maria Tsinti, Evangelia Farmaki, Efimia Papadopoulou-Alataki, Anastasios E. Germenis, Matthaios Speletas

“…Sialic acid acetylesterase (SIAE) deficiency was suggested to lower the levels of ligands for sialic acid-binding immunoglobulin-like receptors, decreasing the threshold for B-cell activation. In humans, studies of rare heterozygous loss-of-function mutations in SIAE gene in common autoimmune diseases, including juvenile idiopathic arthritis (JIA), yielded inconsistent results. …”
Get full text

Impaired Healing of a Cutaneous Wound in an Inducible Nitric Oxide Synthase-Knockout Mouse by Takashi Kitano, Hiroshi Yamada, Maki Kida, Yuka Okada, Shizuya Saika, Munehito Yoshida

“…Population of granulation tissue-related cell types, that is, myofibroblasts and macrophages, growth factor expression, and reepithelialization were evaluated. …”
Get full text

Mechanisms and Consequences of Dopamine Depletion-Induced Attenuation of the Spinophilin/Neurofilament Medium Interaction by Andrew C. Hiday, Michael C. Edler, Asma B. Salek, Cameron W. Morris, Morrent Thang, Tyler J. Rentz, Kristie L. Rose, Lisa M. Jones, Anthony J. Baucum

“…Specifically, there was a decrease in the association of spinophilin with neurofilament medium (NF-M) in dopamine-depleted striatum. Using a heterologous cell line, we determined that spinophilin binding to NF-M required overexpression of the catalytic subunit of protein kinase A and was decreased by cyclin-dependent protein kinase 5. …”
Get full text

An Injectable IPN Nanocomposite Hydrogel Embedding Nano Silica for Tissue Engineering Application by Ali Kakapour, Saied Nouri Khorasani, Shahla Khalili, Mahshid Hafezi, Mehdi Sattari‐Najafabadi, Mahsa Najarzadegan, Samin Saleki, Shadab Bagheri‐Khoulenjani

“…The performance of the hydrogels is evaluated in terms of physico‐mechanical properties (viscoelasticity, compressive modulus, degradation, and swelling), rheological properties, and biological properties (fibroblast cell growth and adhesion, and MTT assay). The results demonstrated that the GM/SA/SNP hydrogel with 1% SNPs provided desirable physical (645% swelling and 59.3% degradation), mechanical strength (270 kPa), rheological (tan δ of almost 0.14), and biological performances (≈98% viability after 3 days) while maintaining appropriate printability. …”
Get full text

Predicting the Onset of Cavitation in Automotive Torque Converters—Part I: Designs with Geometric Similitude by D. L. Robinette, J. M. Schweitzer, D. G. Maddock, C. L. Anderson, J. R. Blough, M. A. Johnson

“…Torque converter operating thresholds for cavitation were determined experimentally with a dynamometer test cell at the stall operating condition using nearfield acoustical measurements. …”
Get full text

Multiomics-based assessment of the impact of airflow on diverse plant callus cultures by June-Sik Kim, Muneo Sato, Mikiko Kojima, Muchamad Imam Asrori, Yukiko Uehara-Yamaguchi, Yumiko Takebayashi, Thi Nhung Do, Thi Yen Do, Kieu Oanh Nguyen Thi, Hitoshi Sakakibara, Keiichi Mochida, Shinjiro Ogita, Masami Yokota Hirai

“…Abstract Plant cell culture has multiple applications in biotechnology and horticulture, from plant propagation to the production of high-value biomolecules. …”
Get full text

Pulmonary Talcosis in an Immunocompromised Patient by Thanh-Phuong Nguyen, Sowmya Nanjappa, Manjunath Muddaraju, John N. Greene

“…We report an 82-year-old man who is diagnosed with Philadelphia chromosome positive pre-B cell acute lymphoblastic leukemia (ALL) treated with palliative imatinib who presented with chronic hemoptysis and dyspnea shortly after his diagnosis. …”
Get full text

Thermo-mechanical and micro-structural properties of xylanase containing whole wheat bread by G. Ghoshal, U.S. Shivhare, U.C. Banerjee

“…Hemicelluloses are main components of cell walls of cereal grains. Moreover, hemicelluloses are considered as potential sources of mono- and oligosaccharides. …”
Get full text

A Lifelong Smoker with Hypopituitarism: Rethinking the Hypothesis of a Tumor in the Hypophysis by Nestoras Mathioudakis, Alfredo Quinones-Hinojosa, Roberto Salvatori, Shehzad Basaria

“…Transsphenoidal resection of the tumor was performed and histopathology revealed small cell carcinoma. The patient received chemotherapy, but died 18 months later due to widespread brain metastases. …”
Get full text

The peculiar characteristics and advancement in diagnostic methodologies of influenza A virus by Muhammad Asif Raza, Muhammad Asif Raza, Muhammad Awais Ashraf, Muhammad Awais Ashraf, Muhammad Nabeel Amjad, Muhammad Nabeel Amjad, Ghayyas Ud Din, Ghayyas Ud Din, Bei Shen, Yihong Hu, Yihong Hu

“…Detection of IAV relies on methods like hemagglutination assay, PCR, cell culturing, and immunochromatography-based tests. …”
Get full text

Remission Achieved in Refractory Advanced Takayasu Arteritis Using Rituximab by D. Ernst, M. Greer, M. Stoll, D. Meyer-Olson, R. E. Schmidt, T. Witte

“…Given evidence of refractory disease activity on maximal standard therapy, we initiated rituximab, based on recently reported B-cell activity in TA.…”
Get full text

Gastric Glomus Tumor: A Rare Cause of Upper Gastrointestinal Bleeding by Yoshinori Handa, Mikihiro Kano, Mayumi Kaneko, Naoki Hirabayashi

“…Because analysis of the possible medical causes remained inconclusive and the risk of rebleeding, laparoscopy-assisted gastric wedge resection was performed after administration of 10 units of red cell concentrate. Histological and immunohistological analysis revealed the tumor to be a gastric glomus tumor. …”
Get full text

Oligodendrocyte Injury in Multiple Sclerosis. by Mateo Përgjegji, Klei Bame, Ketrina Ceka, Jera Cenalia , Sibora Bërdica , Teona Bushati

“…Emerging therapeutic strategies, such as targeting metabolic pathways, reducing oxidative stress, and enhancing autophagy, have demonstrated potential in preclinical studies. Furthermore, stem cell therapies are being explored for their ability to regenerate oligodendrocytes and restore myelin integrity. …”
Get full text

in vitro evaluation of the efficiency of Artemisia judaica leaf extract on sporulation of Eimeria papillate oocysts and its cytotoxicity by M.A. Esam, N.M. Saleh, A.G. Rewaida, A.Q.H. Waleed, A. Afaf, A.A. Sarah, Al-Q. Saleh

“…Our results revealed that A. judaica has cytotoxic activity against breast and lung cancer cell line with a promising IC50 of 480.3 and 359.2µg/mL, respectively compared to doxorubicin as a standard.…”
Get full text

Mitochondrial Fusion Proteins and Human Diseases by Michela Ranieri, Simona Brajkovic, Giulietta Riboldi, Dario Ronchi, Federica Rizzo, Nereo Bresolin, Stefania Corti, Giacomo P. Comi

“…Mitochondria are highly dynamic, complex organelles that continuously alter their shape, ranging between two opposite processes, fission and fusion, in response to several stimuli and the metabolic demands of the cell. Alterations in mitochondrial dynamics due to mutations in proteins involved in the fusion-fission machinery represent an important pathogenic mechanism of human diseases. …”
Get full text

The anti-oxidation related bioactive materials for intervertebral disc degeneration regeneration and repair by Yingjie Mai, Siying Wu, Penghui Zhang, Ningning Chen, Jun Wu, Fuxin Wei

“…Consequently, oxidative stress contributes to the degradation of the extracellular matrix (ECM), promotes cell apoptosis, and exacerbates disc tissue damage. …”
Get full text

Intranasally administrated fusion-inhibitory lipopeptides block SARS-CoV-2 infection in mice and enable long-term protective immunity by Said Mougari, Valérie Favède, Camilla Predella, Olivier Reynard, Stephanie Durand, Magalie Mazelier, Edoardo Pizzioli, Didier Decimo, Francesca T. Bovier, Lauren M. Lapsley, Candace Castagna, Nicole A. P. Lieberman, Guillaume Noel, Cyrille Mathieu, Bernard Malissen, Thomas Briese, Alexander L. Greninger, Christopher A. Alabi, N. Valerio Dorrello, Stéphane Marot, Anne-Geneviève Marcelin, Ana Zarubica, Anne Moscona, Matteo Porotto, Branka Horvat

“…The lipopeptides block SARS-CoV-2 infection in cell lines and lung-derived organotypic cultures. …”
Get full text

Exploring the prognosis of calponin h1 in carcinogenesis: A novel target in biomedical research by Roshna Sankar, Sharon John, Priya Devi, Sameer Gupta, Shalini Gupta

“…Calponin plays varied roles in different types of cancer, such as stomach adenocarcinoma, bladder, colorectal, oral malignancies, fibrosarcoma, lung squamous cell carcinoma, breast and leiomyosarcoma. Its functions may also vary in terms of tissue specificity and varying expression levels. …”
Get full text

Undifferentiated pleomorphic sarcoma in the maxillary sinus: a case report by Seyed Hosein Tabatabaei, Alireza Navabazam, Mohammad amin Yektaie, Farinaz Sabaghzadegan

“…In the initial incisional biopsy, peripheral giant cell granuloma was diagnosed in the hospital service. …”
Get full text