Holotranscobalamin Is a Useful Marker of Vitamin B12 Deficiency in Alcoholics by Alberto Fragasso, Clara Mannarella, Angela Ciancio, Oronzo Scarciolla, Nicoletta Nuzzolese, Rocco Clemente, Eustachio Vitullo, Andrea Sacco

“…For assessing vitamin B12 status, we evaluated 22 adult alcoholic male patients by measuring in parallel serum Cbl, serum folate and red blood cell folate levels, HoloTC levels by the AxSYM assay. …”
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Uncovering somatic mosaic variants of PIK3CA-related overgrowth disorders – three cases with different clinical presentations by M. Tooming, M. Tooming, P. Mertsina, T. Kahre, T. Kahre, R. Teek, I. Vainumäe, I. Vainumäe, S. Lilles, S. Lilles, M. H. Wojcik, M. H. Wojcik, M. H. Wojcik, P. Ilves, P. Ilves, K. Õunap, K. Õunap

“…IntroductionPIK3CA related disorders (PRD, OMIM: *171834) are genetic disorders resulting from pathogenic somatic mosaic variants in the PIK3CA gene, which encodes a protein crucial for regulating cell growth and division. PRD typically manifest during the post-zygotic phase, leading to a broad spectrum of overgrowth and vascular malformations affecting various body regions.MethodsConventional diagnostic methods struggle to detect and confirm pathogenic PIK3CA gene variants due to the mosaic nature of these disorders and the limited accessibility of affected tissues. …”
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PRMT5 promotes ovarian cancer growth through enhancing Warburg effect by methylating ENO1 by Fei Xie, Han Zhang, Kongkai Zhu, Cheng‐Shi Jiang, Xiaoya Zhang, Hongkai Chang, Yaya Qiao, Mingming Sun, Jiyan Wang, Mukuo Wang, Junzhen Tan, Tao Wang, Lianmei Zhao, Yuan Zhang, Jianping Lin, Chunze Zhang, Shuangping Liu, Jianguo Zhao, Cheng Luo, Shuai Zhang, Changliang Shan

“…However, the exactly roles and underlying mechanisms of PRMT5 contributing to the progression of ovarian cancer mediated by reprogramming cell metabolism remain largely elusive. Here, we report that PRMT5 is highly expressed and correlates with poor survival in ovarian cancer. …”
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Anti-Inflammatory and Organ-Protective Effects of Resveratrol in Trauma-Hemorrhagic Injury by Fu-Chao Liu, Yung-Fong Tsai, Hsin-I Tsai, Huang-Ping Yu

“…Resveratrol also possesses antioxidant, anti-coagulation and anti-aging properties, and it may control of cell cycle and apoptosis. Resveratrol has been shown to reduce organ damage following traumatic and shock-like states. …”
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The Correlation between Chronic Periodontitis and Oral Cancer by Maximilian Krüger, Torsten Hansen, Adrian Kasaj, Maximilian Moergel

“…The discussion about human papilloma virus (HPV) in oral squamous cell carcinoma (OSCC) points at a general role of infection for the development of oral carcinomas. …”
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In vitro inhibition mechanisms of Trichoderma yunnanense TM10 against Pyricularia oryzae and Rhizoctonia solani causing blast and sheath blight diseases in rice (Oryza sativa L.) by Dedat Prismantoro, Thomas Argyarich Jefferson, Sulistya Ika Akbari, Mia Miranti, Muhamad Shakirin Mispan, Febri Doni

“…Additionally, T. yunnanense TM10 was capable of producing cell wall-degrading enzymes (CWDEs) such as chitinase and cellulase, as well as volatile organic compounds (VOCs) such as hydrogen cyanide (HCN). …”
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Unveiling promising sepsis biomarkers: a clinical perspective by Hong Zhang, Junpeng Zhao, Zhiping Wang, Mengxiang Huang, Zhonghua Tan, Feng Jiang, Yuhong Zhou, Linhua Wang, Mingbing Xiao

“…In recent years, new biomarkers, such as neutrophil extracellular traps, interleukin-6, histones, cell-free DNA and composite indicators, such as the systemic immune inflammation index,have been identified. …”
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Preliminary study on screening and selection of Lactic Acid Bacteria (LAB) from gastrointestinal tract of naleh fish (Barbonymus sp.) by Yulvizar Cut, Yunita Dewi, A Muchlizin Zainal, Suhartono Suhartono

“…The edges were noted to be smooth (100%) and the elevation was observed to be flat (100%). The cell morphology is coccus - shaped (100%) and the bacteria are classified as Gram staining positive (100%). …”
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Management of Maillard reaction-derived reactive carbonyl species and advanced glycation end products by tea and tea polyphenols by Yue Luo, Jianan Zhang, Chi-Tang Ho, Shiming Li

“…By analyzing recent publications, we have covered across chemistry models, cell lines and animal studies. Tea polyphenols, particularly catechins, showed outstanding antiglycation effect by trapping α-dicarbonyl compounds and impeding AGEs formation. …”
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The Microbiota–Gut–Brain Axis: Key Mechanisms Driving Glymphopathy and Cerebral Small Vessel Disease by Che Mohd Nasril Che Mohd Nassir, Muhammad Danial Che Ramli, Mazira Mohamad Ghazali, Usman Jaffer, Hafizah Abdul Hamid, Muhammad Zulfadli Mehat, Zaw Myo Hein

“…This narrative review represents state-of-the-art knowledge of the intimate, complex interplay between microbiota and brain health through the gut–brain axis (GBA) and the emerging role of glymphatic system dysfunction (glymphopathy) and circulating cell-derived microparticles (MPs) as mediators of these interactions. …”
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Molecular mechanisms in liver repair and regeneration: from physiology to therapeutics by Xiao Ma, Tengda Huang, Xiangzheng Chen, Qian Li, Mingheng Liao, Li Fu, Jiwei Huang, Kefei Yuan, Zhen Wang, Yong Zeng

“…This review systematically delineates advancements in the field, emphasizing the essential roles played by diverse liver cell types. Their coordinated actions, supported by complex crosstalk within the liver microenvironment, are pivotal to enhancing regenerative outcomes. …”
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Effects of Polysaccharide Elicitors on Secondary Metabolite Production and Antioxidant Response in Hypericum perforatum L. Shoot Cultures by Sonja Gadzovska Simic, Oliver Tusevski, Stéphane Maury, Alain Delaunay, Claude Joseph, Daniel Hagège

“…The POD activity was in significantly positive correlation with flavonoid and hypericin contents, suggesting a strong perturbation of the cell redox system and activation of defense responses in polysaccharide-elicited H. perforatum shoot cultures.…”
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The investigation of marek disease, lenfoid leucosis and reticuloendotheliosis by elisa and histopathologic methods in chickens in konya province by Uçkun Sait Uçan, Mehmet Ateş, M. Metin Kıran, H. Hüseyin Hadimli, Mustafa Ortatatlı, E. Özlem Kuyucuoğlu

“…Lenfoid Leucosis (LL) and reticuloentdotheliosis (RE), Of these, MD is characterized by malign T cell transformation while LL comprises a variety of transmissible benign and malign neoplasms of different organs. …”
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The different faces of GATA2 deficiency: implications for therapy and surveillance by Luca Vinci, Brigitte Strahm, Carsten Speckmann, Carsten Speckmann, Miriam Erlacher, Miriam Erlacher

“…Due to the elevated risk of progression, nearly all individuals with GATA2-related MDS eventually undergo a hematopoietic stem cell transplantation (HSCT) at some point in their lives. …”
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FTO deficiency facilitates epithelia dysfunction in oral lichen planus by Yufeng Fan, Yukai Hao, Yan Ding, Xiangyu Wang, Xuejun Ge

“…At the molecular level, we explained that GSK-3β-induced phosphorylation promoted FTO protein degradation in diseased oral keratinocytes. Using a cell co-culture model, we further confirmed that FTO deficiency facilitated NF-κB activation and apoptosis in oral keratinocytes under inflammatory conditions. …”
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Remarkable Conversion of 2-Thioxo-2,3-dihydroquinazolin-4(1H)-ones into the Corresponding Quinazoline-2,4(1H,3H)-diones: Spectroscopic Analysis and X-Ray Crystallography by Adel S. El-Azab, Nasr Y. Khalil, Alaa A.-M. Abdel-Aziz

“…The crystal structure of 6-methyl-3-phenylquinazoline-2,4(1H,3H)-dione (11) [C15H12N2O2: MF = 252.27, triclinic, P-1, a = 7.8495 (13) Å, b = 12.456 (2) Å, c = 13.350 (2) Å, α = 103.322 (3)°, β = 90.002 (3)°, γ = 102.671 (4)°, V = 1237.5 (3) Å3, Z = 4, R = 0.0592, wR = 0.1699, S = 1.039] was determined. In the crystal cell, two identical conformers of compound 11 were found connected by intramolecular hydrogen bonds, responsible for the favourable occurrence of these two independent molecules.…”
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Role of Platelet Indices as a Potential Marker for Malaria Severity by Biruk Bayleyegn, Fikir Asrie, Aregawi Yalew, Berhanu Woldu

“…Platelet parameter alteration such as platelet count and platelet indices are more common than in other blood cell lines due to diverse causative pathophysiological mechanisms in severe malaria infection. …”
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Dipropyl phthalate induces craniofacial chondrogenic defects in zebrafish embryos by Qinyuan Shen, Weitao Hu, Fasheng Liu, Si Dong, Xinya Peng, Yihang Zhong, Chao Chen, Yuhua Zuo, Chenkai Ge, Weirong Li, Wenwen Zha, Zhijun Ye, Zigang Cao, Lan Liao

“…Transcriptome sequencing and molecular docking analyses revealed that DPRP down-regulated chondrocyte-related genes and induced activation of the FoxO signaling pathway, which in turn interfered with cell proliferation and apoptosis. In this process, DPRP induced elevated levels of oxidative stress in the craniofacial pharyngeal arch while promoting inflammatory responses. …”
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From the Role of Microbiota in Gut-Lung Axis to SARS-CoV-2 Pathogenesis by Sara Ahmadi Badi, Samira Tarashi, Abolfazl Fateh, Pejman Rohani, Andrea Masotti, Seyed Davar Siadat

“…The effects of microbiota on antiviral immune responses, including dendritic cell (DC) function and lymphocyte homing in the gut-lung axis, have been reported in the recent literature. …”
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Tailoring high-performance bipolar membrane for durable pure water electrolysis by Weisheng Yu, Zirui Zhang, Fen Luo, Xiaojiang Li, Fanglin Duan, Yan Xu, Zhiru Liu, Xian Liang, Yaoming Wang, Liang Wu, Tongwen Xu

“…Incorporating the bipolar membrane into a flow-cell electrolyzer enables an ampere-level pure water electrolysis with a total voltage of 2.68 V at 1000 mA cm–2, increasing the energy efficiency to twice that of the state-of-the-art commercial BPM. …”
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