Phosphorylation of a nuclear condensate regulates cohesion and mRNA retention by Alexa B. R. McIntyre, Adrian Beat Tschan, Katrina Meyer, Severin Walser, Arpan Kumar Rai, Keisuke Fujita, Lucas Pelkmans

“…Abstract Nuclear speckles are membraneless organelles that associate with active transcription sites and participate in post-transcriptional mRNA processing. During the cell cycle, nuclear speckles dissolve following phosphorylation of their protein components. …”
Get full text

Short Telomere Length in Plasma of Sudanese Patients with Hepatocellular Carcinoma and Chronic Liver Diseases by Fayza A. Rahamtalla, Iman M. Shammat, Salma B. M. Mudawi, Maram Abbas, Mohammed A. H. Kheir Elsid, Mohammed S. M. Abdalla

“… Background: Telomeres, a protective sequence of DNA at the end of chromosomes, are essential for the maintenance of chromosomal integrity and stability. With each cell division, telomeres are shortened until a critical length is reached. …”
Get full text

Bias Calibration of Optically Pumped Magnetometers Based on Variable Sensitivity by Jieya Chen, Chaofeng Ye, Xingshen Hou, Yaqiong Niu, Limin Sun

“…The sensitivity of the OPM was altered by adjusting the cell temperature. The output of the OPM was then documented with varying sensitivity. …”
Get full text

The tyrosine kinase inhibitor lenvatinib is oxidized by rat cytochromes P450 and affects their expression in rat liver by Indra Radek, Jelínková Sandra, Kollárová Katarína, Zahumenská Petra, Dvořák Josef, Dušková Šárka, Dračínská Helena

“…Lenvatinib is an orally effective tyrosine kinase inhibitor used to treat several types of tumors, including progressive, radioiodine-refractory differentiated thyroid cancer and advanced renal cell carcinoma. Although this drug is increasingly used in therapy, its metabolism and effects on the organism are still not described in detail. …”
Get full text

Unravelling anti-cancer properties of solanaceous extracts using GC–MS and HPLC by Iqra Riaz, Yamin Bibi, Muhammad Arshad, Muhammad Sheeraz Ahmad, Manzer H. Siddiqui, Yawen Zeng, Abdul Qayyum

“…The plant material was dried, pulverized, and small-scale extraction was done. Brine shrimps, cell lines (A549, Hela, HEPG), and Caenorhabditis elegans were used initially to examine three solanaceous plant extracts (Solanum villosum (SV), Cestrum aurantiacum (CA), and Brugmansia suaveolens (BS)). …”
Get full text

Tumor Necrosis Factor Alpha Mediates GABAA Receptor Trafficking to the Plasma Membrane of Spinal Cord Neurons In Vivo by Ellen D. Stück, Randolph N. Christensen, J. Russell Huie, C. Amy Tovar, Brandon A. Miller, Yvette S. Nout, Jacqueline C. Bresnahan, Michael S. Beattie, Adam R. Ferguson

“…The proinflammatory cytokine TNFα contributes to cell death in central nervous system (CNS) disorders by altering synaptic neurotransmission. …”
Get full text

Effective in vivo binding energy landscape illustrates kinetic stability of RBPJ-DNA binding by Duyen Huynh, Philipp Hoffmeister, Tobias Friedrich, Kefan Zhang, Marek Bartkuhn, Francesca Ferrante, Benedetto Daniele Giaimo, Rhett A. Kovall, Tilman Borggrefe, Franz Oswald, J. Christof M. Gebhardt

“…We determine the binding kinetics, transcriptional activity, and genome-wide chromatin occupation of RBPJ and mutant variants by live-cell single-molecule tracking, reporter assays, and ChIP-Seq. …”
Get full text

Evaluation of immunomodulatory effects of lamotrigine in BALB/c mice by Abu-Rish Eman Y., Elhayek Shada Y., Mohamed Yehia S., Hamad Islam, Bustanji Yasser

“…These included the in vivo effects of lamotrigine on delayed-type hypersensitivity (DTH) response to sheep red blood cell (SRBC) antigens, hemagglutination titer assays and hematological changes. …”
Get full text

A review on the chemical ecology of the Fucaceae holobionts: from fundamental knowledge to applications by Rousseau, Coralie, Demoulinger, Gautier, Rousvoal, Sylvie, Champeval, Delphine, Dolly, Maurane, Michel, Gurvan, Thomas, François, Markov, Gabriel V., Potin, Philippe, Dittami, Simon M., Prado, Soizic, Leblanc, Catherine, Le Guillard, Cécile

“…For some compounds, an alternative to wild harvesting could be the production of molecules of interest by organic synthesis or by biotechnological production, e.g., in microbial cell factories incorporating selected members of the algal microbiota. …”
Get full text

Embedded-Based Quadratic Boost Converter With Sliding-Mode Controller for the Integration of Solar Photo-Voltaic Source With Microgrid by S. Chitra Selvi, Ramya Govindaraj, Subrata Chowdhury, Saumya Singh, Baseem Khan

“…Microgrids use renewable energy sources like the wind and solar photo-voltaic energy source, and the fuel cell-based energy conversion systems. DC to DC converters is inevitable in a microgrid. …”
Get full text

Nonlinearity of the post-spinel transition and its expression in slabs and plumes worldwide by Junjie Dong, Rebecca A. Fischer, Lars P. Stixrude, Matthew C. Brennan, Kierstin Daviau, Terry-Ann Suer, Katlyn M. Turner, Yue Meng, Vitali B. Prakapenka

“…Here we present laser-heated diamond anvil cell experiments with synchrotron X-ray diffraction to better constrain this boundary, especially at higher temperatures. …”
Get full text

P2X7 Receptor Function in Bone-Related Cancer by Elena Adinolfi, Francesca Amoroso, Anna Lisa Giuliani

“…Among these molecules extracellular ATP is emerging as a good candidate in promoting cell growth, neovascularization, tumor-host interactions, and metastatization. …”
Get full text

The Pivotal Role of TBK1 in Inflammatory Responses Mediated by Macrophages by Tao Yu, Young-Su Yi, Yanyan Yang, Jueun Oh, Deok Jeong, Jae Youl Cho

“…Inflammation is a complex biological response of tissues to harmful stimuli such as pathogens, cell damage, or irritants. Inflammation is considered to be a major cause of most chronic diseases, especially in more than 100 types of inflammatory diseases which include Alzheimer's disease, rheumatoid arthritis, asthma, atherosclerosis, Crohn's disease, colitis, dermatitis, hepatitis, and Parkinson's disease. …”
Get full text

Transport and inhibition of the sphingosine-1-phosphate exporter SPNS2 by Huanyu Z. Li, Ashley C. W. Pike, Yung-Ning Chang, Dheeraj Prakaash, Zuzana Gelova, Josefina Stanka, Christophe Moreau, Hannah C. Scott, Frank Wunder, Gernot Wolf, Andreea Scacioc, Gavin McKinley, Helena Batoulis, Shubhashish Mukhopadhyay, Andrea Garofoli, Adán Pinto-Fernández, Benedikt M. Kessler, Nicola A. Burgess-Brown, Saša Štefanić, Tabea Wiedmer, Katharina L. Dürr, Vera Puetter, Alexander Ehrmann, Syma Khalid, Alvaro Ingles-Prieto, Giulio Superti-Furga, David B. Sauer

“…Accordingly, mutations in the S1P transporter SPNS2 are associated with reduced white cell count and hearing defects. SPNS2 also exports the S1P-mimicking FTY720-P (Fingolimod) and thereby is central to the pharmacokinetics of this drug when treating multiple sclerosis. …”
Get full text

An Evaluation of Deep Learning Methods for Small Object Detection by Nhat-Duy Nguyen, Tien Do, Thanh Duc Ngo, Duy-Dinh Le

“…These innovations proposed comprise region proposals, divided grid cell, multiscale feature maps, and new loss function. …”
Get full text

Reconfigurable anomalous reflectors with stretchable elastic substrates at 140 GHz band by Kato Yuto, Yonemura Kazuma, Seki Kento, Kambara Retsuku, Sanada Atsushi

“…The proposed reflector dynamically controls the reflection direction by mechanically stretching the substrate to induce a physical change of the unit cell period. Owing to the simple and scalable tuning mechanism, the proposed approach is applicable in the millimeter-wave and terahertz bands for a wide reflection steering. …”
Get full text

Modulating gene expression as a strategy to investigate thyroid cancer biology by Diego Claro de Mello, Joice Moraes Menezes, Antonio Tarelo Freitas de Oliveira, Marcella Maringolo Cristovão, Edna Teruko Kimura, Cesar Seigi Fuziwara

“…Allied with that, the existence of various human cell line models for cancer covering different histotypes and biological behaviors, especially for thyroid cancer, has helped improve the understanding of cancer biology. …”
Get full text

Epigenetic regulation and post-translational modifications of ferroptosis-related factors in cardiovascular diseases by Chunlu Jing, Yupeng Wu, Yuzhu Zhang, Zaihan Zhu, Yong Zhang, Zhen Liu, Dandan Sun

“…In the past decade, ferroptosis (a form of iron-dependent regulated cell death) has been reported to contribute to the pathogenesis and progression of various diseases. …”
Get full text

NLRP3 Deficiency Attenuates Renal Fibrosis and Ameliorates Mitochondrial Dysfunction in a Mouse Unilateral Ureteral Obstruction Model of Chronic Kidney Disease by Honglei Guo, Xiao Bi, Ping Zhou, Shijian Zhu, Wei Ding

“…The severe glomerular injury and tubulointerstitial fibrosis induced in WT mice by UUO was markedly attenuated in NLRP3−/− mice as evidenced by blockade of extracellular matrix deposition, decreased cell apoptosis, and phenotypic alterations. Moreover, NLRP3 deletion reversed UUO-induced impairment of mitochondrial morphology and function. …”
Get full text

A Rare Case of Paraneoplastic Syndrome Presented with Severe Gastroparesis due to Ganglional Loss by Konstantinos N. Argyriou, Martin Peters, Javaid Ishtiaq, Santosh Enaganti

“…In our report, so as to increase the clinical awareness of this rare clinical entity, we present the case of a 70-year-old Caucasian female who presented in our hospital with severe gastroparesis that was later proven to be associated with an overt small cell lung cancer (SCLC) and we discuss the existing knowledge of the pathophysiology, diagnosis, and management of this disorder.…”
Get full text