CircRNAs in colorectal cancer: potential roles, clinical applications, and natural product-based regulation by Jingjing Yang, Jingjing Yang, Qiqi Fan, Yiyun Wang, Yuanyue Liu, Xiaoning Xu, Yeqi Liang, Jiakang Xie, Jiajie Li, Fengting Ai, Yong Cao, Shangzhen Yu, Jinman Liu

“…This review summarizes the role of circRNAs in CRC, particularly their mechanisms in cell proliferation, migration, apoptosis, tumor microenvironment (TME) remodeling, and immune evasion. …”
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Cellular Harmony Search for Optimization Problems by Mohammed Azmi Al-Betar, Ahamad Tajudin Khader, Mohammed A. Awadallah, Mahmmoud Hafsaldin Alawan, Belal Zaqaibeh

“…In cHS, the population is arranged as a two-dimensional toroidal grid, where each individual in the grid is a cell and only interacts with its neighbors. The memory consideration and population update are modified according to cellular EA theory. …”
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CORRELATION BETWEEN SGOT AND SGPT LEVELS WITH POSITIVE HBsAg LEVELS by Nisa'ur Rosyidah, Erlinda Widyastuti, Annisa Auliya Rahman, Nur Septia Handayani, Belgis

“…The increase in both enzymes can indicate the level of liver cell damage. Hepatitis B surface antigen (HBsAg) is an antigen that can indicate an acute infection or a chronic carrier. …”
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Advanced In Vitro Models for Preclinical Drug Safety: Recent Progress and Prospects by Dileep G. Nair, Ralf Weiskirchen

“…Differences in physiology between humans and animals or cell lines contribute to the failure of many drug programs during clinical trials. …”
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Antimicrobial potential and mechanism of infant feces-derived Enterococcus faecalis in inhibiting Enterotoxigenic Escherichia coli by Xi Lu, Wei Sang, Lei Pan

“…E. faecalis LX25 and LX39 showed significant inhibition of ETEC growth, virulence gene (eltA and stA) expression (P < 0.05) and disrupted biofilm formation. Notably, LX39's cell-free supernatant (CFS) increased reactive oxygen species in ETEC, leading to cellular damage. …”
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Renal Tubular Acidosis an Adverse Effect of PD-1 Inhibitor Immunotherapy by Sandy El Bitar, Chanudi Weerasinghe, Elie El-Charabaty, Marcel Odaimi

“…We report the case of a 79-year-old female with metastatic non-small cell lung cancer on anti-PD-1 therapy nivolumab. …”
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Bing and Neel Syndrome by S. Jennane, K. Doghmi, E. M. Mahtat, N. Messaoudi, B. Varet, M. Mikdame

“…The treatment was followed by intensification and autologous stem cell transplantation. At D58, the patient died due to a septic shock. …”
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Oral plasmablastic lymphoma: at the origin of the discovery of an HIV infection by Rahman Nurhayu Ab, Hussain Faezatul Arbaeyah, Eng Kam Chuan

“…Introduction: Plasmablastic lymphoma is a rare and aggressive malignancy derived from a B cell lineage. It has a predilection for extranodal sites, particularly arises de novo in the oral cavity. …”
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msiFlow: automated workflows for reproducible and scalable multimodal mass spectrometry imaging and microscopy data analysis by Philippa Spangenberg, Sebastian Bessler, Lars Widera, Jenny Bottek, Mathis Richter, Stephanie Thiebes, Devon Siemes, Sascha D. Krauß, Lukasz G. Migas, Siva Swapna Kasarla, Prasad Phapale, Jens Kleesiek, Dagmar Führer, Lars C. Moeller, Heike Heuer, Raf Van de Plas, Matthias Gunzer, Oliver Soehnlein, Jens Soltwisch, Olga Shevchuk, Klaus Dreisewerd, Daniel R. Engel

“…Abstract Multimodal imaging by matrix-assisted laser desorption ionisation mass spectrometry imaging (MALDI MSI) and microscopy holds potential for understanding pathological mechanisms by mapping molecular signatures from the tissue microenvironment to specific cell populations. However, existing software solutions for MALDI MSI data analysis are incomplete, require programming skills and contain laborious manual steps, hindering broadly applicable, reproducible, and high-throughput analysis to generate impactful biological discoveries. …”
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Investigation of the Heterovalent Substitution Cadmium for Lanthanum in Molybdate La2MoO6 by K. A. Chebyshev, A. V. Ignatov, L. V. Pasechnik, N. I. Selikova, E. I. Get`man

“…The content of the cubic phase reaches 94% in the Lа1.4Cd0.6MoO5.7 sample. The unit cell parameter of fluorite-like-phase decreases with cadmium content rising. …”
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Biomolecules of the Horseshoe Crab’s Hemolymph: Components of an Ancient Defensive Mechanism and Its Impact on the Pharmaceutical and Biomedical Industry by Md. Ashrafuzzaman, Mamudul Hasan Razu, Nazmir-Nur Showva, Tohmina Afroze Bondhon, Md. Moniruzzaman, Sad Al Rezwan Rahman, Md. Raisul Islam Rabby, Fatema Akter, Mala Khan

“…Recent data in biochemistry and immunology on the granular constituents of granule-specific proteins are stored in large and small granules which are involved in the cell-mediated immune response. L-granules contain most clotting proteins, which are necessary for hemolymph coagulation. …”
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Social Support Network among People Living with HIV/AIDS in Iran by Ameneh Setareh Forouzan, Zahra Jorjoran Shushtari, Homeira Sajjadi, Yahya Salimi, Masoumeh Dejman

“…Social support of participants has been found to be associated with CD4 cell count (P=0.000), sex (P=0.049), and network size (P=0.000) after adjusted for other variables in the final model. …”
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Discovery of novel and highly potent small molecule inhibitors targeting FLT3-ITD for the treatment of acute myeloid leukemia using structure-based virtual screening and biological... by Kun Shi, Kun Shi, Ye Hong, Ye Hong, Ye Hong, Huajing Liu, Xiaotian Yang, Fengzhen Wang, Fengzhen Wang, Yanming Zhang

“…Furthermore, cytotoxicity assays revealed that FLIN-4 has significant anti-proliferative activity against the AML cell line MV4-11 (IC50 = 1.31 ± 0.06 nM). Overall, these data suggest that FLIN-4, as a potential therapeutic candidate for AML, is valuable for further research and development.…”
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A multifunctional quasi-solid-state polymer electrolyte with highly selective ion highways for practical zinc ion batteries by Chengwu Yang, Pattaraporn Woottapanit, Sining Geng, Rungroj Chanajaree, Yue Shen, Kittima Lolupiman, Wanwisa Limphirat, Teerachote Pakornchote, Thiti Bovornratanaraks, Xinyu Zhang, Jiaqian Qin, Yunhui Huang

“…The resultant Zn | |V2O5 offers a stable long-term cycling performance and its pouch cell achieves a cycling capacity of 1.13 Ah at industrial-level loading mass of 31.3 mg.…”
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Kidney damage associated with COVID-19: from the acute to the chronic phase by Yannick Mayamba Nlandu, Elliot Koranteng Tannor, Titilope Adetoun Bamikefa, Jean-Robert Rissassi Makulo

“…The entry point into the renal cell remains the angiotensin-converting enzyme 2 (ACE-2) receptor and the spectrum of renal lesions is broad, with a clear predominance of structural and functional tubular lesions. …”
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Identification and Screening of Natural Neuraminidase Inhibitors from Reduning Injection via One-Step High-Performance Liquid Chromatography-Fraction Collector and UHPLC/Q-TOF-MS by Lijun An, Xie-An Yu, Wei Liu, Jin Li, Yan-Xu Chang

“…Neuraminidase plays an essential role in the spread of influenza viruses via cleaving sialic acids from the host cell receptors and virions. Neuraminidase has been regarded as an essential target for prevention and treatment of influenza infection. …”
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Morphological, physiological, element absorption, and transcriptomic analysis reveals the mechanism of 2-(3,4-Dichlorophenoxy) trimethylamine alleviating copper stress in cucumber... by Yang Li, Xiaoning Wang, Mengwei Huang, Yijing Xing, Xueting Wang, Hu Wang, Meng Li, Qingjie Du, Huaijuan Xiao, Jiqing Wang, Juanqi Li

“…Transcriptome analysis showed that copper absorption, transport, detoxification genes, cell wall component related genes and nitrogen metabolism related genes played a crucial role. …”
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Endogenous electric field-driven neuro-immuno-regulatory scaffold for effective diabetic wound healing by Zhiqing Liu, Tianlong Wang, Jinhui Zhao, Lei Zhang, Yiping Luo, Yixing Chen, Xinhui Wu, Yaqi Liu, Aihemaitijiang Aierken, Dilixiati Duolikun, Hui Jiang, Xinyu Zhao, Chang Li, Yingchuan Li, Wentao Cao, Jianzhong Du, Longpo Zheng

“…The BNIR system comprises microporous structure scaffolds and nanosheets, enabling swift biofluid collection and electrical signal transmission, with the ability to promote cell proliferation and migration and exhibit antioxidant properties. …”
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Design of novel graded bone scaffolds based on triply periodic minimal surfaces with multi-functional pores by Rongwu Lai, Rongwu Lai, Jian Jiang, Jian Jiang, Yi Huo, Hao Wang, Sergei Bosiakov, Yongtao Lyu, Yongtao Lyu, Lei Li

“…BackgroundVarious mechanical and biological requirements on bone scaffolds were proposed due to the clinical demands of human bone implants, which remains a challenge when designing appropriate bone scaffolds.MethodsIn this study, novel bone scaffolds were developed by introducing graded multi-functional pores onto Triply Periodic Minimal Surface (TPMS) structures through topology optimization of unit cell. The performance of these scaffolds was evaluated using finite element (FE) analysis and computational fluid dynamics (CFD) method.ResultsThe results from FE analysis indicated that the novel scaffold exhibited a lower elastic modulus, potentially mitigating the issue of stress shielding. …”
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Effects of Surface Modification of Nanodiamond Particles for Nucleation Enhancement during Its Film Growth by Microwave Plasma Jet Chemical Vapour Deposition Technique by Chii-Ruey Lin, Da-Hua Wei, Minh-Khoa BenDao, Hong-Ming Chang, Wei-En Chen, Jen-Ai Lee

“…These results indeed open up a prospect of nanocrystalline diamond films in solar cell applications.…”
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