regionalpcs improve discovery of DNA methylation associations with complex traits by Tiffany Eulalio, Min Woo Sun, Olivier Gevaert, Michael D. Greicius, Thomas J. Montine, Daniel Nachun, Stephen B. Montgomery

“…Applying regionalpcs to Alzheimer’s disease brain methylation data, combined with cell type deconvolution, we uncover 838 differentially methylated genes associated with neuritic plaque burden—significantly outperforming conventional methods. …”
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Very Late Relapse of Testicular Tumour in Combination with Renal Cancer and Their Retroperitoneoscopic Removal by Mihály Murányi, Morshed Ali Salah, Béla Tállai, Mátyás Benyó, Tibor Flaskó

“…The histology revealed embryonal carcinoma for the retroperitoneal lymph node and renal cell carcinoma for the left renal mass. We can conclude that late followup of patients with testicular tumour is important. …”
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Comparison of Wide Conjunctival Flap and Conjunctival Autografting Techniques in Pterygium Surgery by Lokman Aslan, Murat Aslankurt, Adnan Aksoy, Murat Özdemir, Erdem Yüksel

“…A stromal overgrowth of fibroblast and blood vessels is accompanied by an inflammatory cell infiltrate and abnormal extracellular matrix accumulation. …”
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An experimental study on photocatalytic degradation to free river water from toxic dye pollutant using Zn doped TiO2 nanoparticles by Sarathi R, Sheeba N. L., Selva Esakki E, Renuga Devi L, Meenakshi Sundar S

“…From the XRD Spectra average crystallite size, lattice parameters, volume of unit cell are studied. The bandgap of the material was found by using UV-Vis absorbance Spectroscopy. …”
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DIA-based quantitative proteomic analysis on porcine meat quality at different chilling rates by Yuqiang Bai, Tongjing Yan, Fei Fang, Xin Li, Su Wang, Juan Li, Chengli Hou, Dequan Zhang

“…These pathways indicated that VFC delayed cell metabolism and glycolysis by down-regulating the expression of metabolic enzymes. …”
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Mechanism for microbial population collapse in a fluctuating resource environment by Serdar Turkarslan, Arjun V Raman, Anne W Thompson, Christina E Arens, Mark A Gillespie, Frederick von Netzer, Kristina L Hillesland, Sergey Stolyar, Adrian López García de Lomana, David J Reiss, Drew Gorman‐Lewis, Grant M Zane, Jeffrey A Ranish, Judy D Wall, David A Stahl, Nitin S Baliga

“…We have characterized the mechanism for collapse by conducting RNA‐seq analysis, proteomics, microcalorimetry, and single‐cell transcriptome analysis. We demonstrate that the collapse was caused by conditional gene regulation, which drove precipitous decline in intracellular abundance of essential transcripts and proteins, imposing greater energetic burden of regulation to restore function in a fluctuating environment.…”
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Proteostasis and Mitochondrial Role on Psychiatric and Neurodegenerative Disorders: Current Perspectives by Pablo Olivero, Carlo Lozano, Ramón Sotomayor-Zárate, Nicolás Meza-Concha, Marcelo Arancibia, Claudio Córdova, Wilfredo González-Arriagada, Ricardo Ramírez-Barrantes, Ivanny Marchant

“…Altered mitochondrial dynamics, especially in proteostasis processes, could impede the normal compensatory mechanisms against cell damage. Thereby, altered mitochondrial functions on regulatory modulation of dendritic development, neuroinflammation, and respiratory function may underlie the development of some psychiatric conditions, such as schizophrenia, being influenced by a genetic background. …”
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Evolution of Magnetic Reconnection in an Electron-scale Current Sheet by Yundan Guan, Quanming Lu, San Lu, Rongsheng Wang

“…In this paper, by performing a 2.5-dimensional particle-in-cell simulation, we investigate the evolution of electron-only magnetic reconnection to standard magnetic reconnection in a current sheet, whose initial width is of the electron inertial length. …”
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Designing a Ring-VCO for RFID Transponders in 0.18 μm CMOS Process by Jubayer Jalil, Mamun Bin Ibne Reaz, Mohammad Arif Sobhan Bhuiyan, Labonnah Farzana Rahman, Tae Gyu Chang

“…For ease of integration and implementation of the module in tiny die area, a novel pseudodifferential delay cell based 3-stage ring oscillator has been introduced to fabricate the ring-VCO. …”
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Improvement in the Gain of UWB Antenna for GPR Applications by Using Frequency-Selective Surface by Iftikhar Ud Din, Sadiq Ullah, Syeda Iffat Naqvi, Raza Ullah, Shakir Ullah, Esraa Mousa Ali, Mohammad Alibakhshikenari

“…In addition, the reported unit cell having dimension of 0.11λ×0.11λ gives wide bandwidth (7.2 GHz) from 3.3 GHz to 10.5 GHz. …”
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An oligodendrocyte silencer element underlies the pathogenic impact of lamin B1 structural variants by Bruce Nmezi, Guillermo Rodriguez Bey, Talia DeFrancesco Oranburg, Kseniia Dudnyk, Santana M. Lardo, Nathan Herdman, Anastasia Jacko, Sandy Rubio, Emanuel Loeza-Alcocer, Julia Kofler, Dongkyeong Kim, Julia Rankin, Emma Kivuva, Nicholas Gutowski, Katherine Schon, Jelle van den Ameele, Patrick F. Chinnery, Sérgio B. Sousa, Filipe Palavra, Camilo Toro, Filippo Pinto e Vairo, Jonas Saute, Lisa Pan, Murad Alturkustani, Robert Hammond, Francois Gros-Louis, Michael S. Gold, Yungki Park, Geneviève Bernard, Raili Raininko, Jian Zhou, Sarah J. Hainer, Quasar S. Padiath

“…Utilizing data from recently identified families that carry LMNB1 gene duplications but do not exhibit demyelination, ADLD patient tissues, CRISPR edited cell lines and mouse models, we have identified a silencer element that is lost in ADLD patients and that specifically targets expression to oligodendrocytes. …”
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Effect of iron fortification and prebiotics on iron biomarkers in anemic rats by S. Iqbal, S. Zafar, W. Ahmed, S. H. B. U. Shah, J. Abid, U. Farooq, A. M. R. Ahmad

“…The duration of the trials was 3 months aimed at determining the effect of iron fortification and prebiotics on different iron biomarkers including Hemoglobin (Hb), Hematocrit, Red Blood Cell (RBC) count, Mean Corpuscular Volume (MCV), Mean Corpuscular Hemoglobin (MCH) and Mean Corpuscular Hemoglobin Concentration (MCHC). …”
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Expressions of CXCL12/CXCR4 in Oral Premalignant and Malignant Lesions by Juan Xia, Na Chen, Yun Hong, Xiaobing Chen, Xiaoan Tao, Bin Cheng, Yulei Huang

“…The goal of the present study was to investigate alterations of CXCL12/CXCR4 in oral premalignant lesions and oral squamous cell carcinoma (OSCC). Methods. In 13 normal oral epithelia, 24 dysplastic oral leukoplakia (OLK), and 40 OSCC specimens, expressions of CXCL12 and CXCR4 were evaluated by immunohistochemistry. …”
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Unexpected events trigger task-independent signaling in VIP and excitatory neurons of mouse visual cortex by Farzaneh Najafi, Simone Russo, Jérôme Lecoq

“…To test this hypothesis, we analyzed the Allen Institute Visual Behavior dataset, in which mice viewed repeated familiar images and unexpected omissions of these images, while two-photon calcium imaging was performed from distinct cell types across primary and higher-order visual areas. …”
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COFcap2, a recyclable tandem catalysis reactor for nitrogen fixation and conversion to chiral amines by Qianqian Zhu, Peijie Dong, Jiangyue Yu, Zhifang Wang, Ting Wang, Shan Qiao, Jinjin Liu, Shubo Geng, Yunlong Zheng, Peng Cheng, Michael J. Zaworotko, Zhenjie Zhang, Yao Chen

“…Herein we report that co-immobilization of metal nanoparticles and a biocatalytic system within a synthetic covalent organic framework capsule, COFcap-2, functions like an artificial cell in that, whereas the catalysts are trapped within 300-400 nm cavities, substrates/products can ingress/egress through ca. 2 nm windows. …”
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Respiratory Syncytial Virus Infections in Infants Affected by Primary Immunodeficiency by Marcello Lanari, Silvia Vandini, Maria Grazia Capretti, Tiziana Lazzarotto, Giacomo Faldella

“…Respiratory syncytial virus (RSV) is one of the most frequent pathogens during early infancy and the infection is more severe in immunocompromised infants than in healthy infants, as a result of impaired T- and B-cell immune response unable to efficaciously neutralize viral replication, with subsequent increased viral shedding and potentially lethal lower respiratory tract infection. …”
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Intracranial Blood Flow Velocity in Patients with β-Thalassemia Intermedia Using Transcranial Doppler Sonography: A Case-Control Study by Nahid Ashjazadeh, Sajad Emami, Peyman Petramfar, Ehsan Yaghoubi, Mehran Karimi

“…Previous studies have shown that patients with sickle cell disease, who are also prone to ischemic events, have higher intracranial arterial blood flow velocities measured by transcranial Doppler sonography (TCD). …”
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Orthogonal validation of PROTAC mediated degradation of the integral membrane proteins EGFR and c-MET by Camilla Ruffilli, Sascha Röth, Noam Zelcer, Kevin Moreau

“…Overall, we recommend the use of immunofluorescence and flow cytometry, for an increased accuracy with both a qualitative and quantitative insight into degradation efficacy and a critical distinction between cell membrane-localized and intracellular IMP protein pools.…”
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Human Herpesvirus 6 is Associated with Status Epilepticus and Hyponatremia after Umbilical Cord Blood Transplantation by Fernanda Leite de Souza Franceschi, Jaime Green, Zuzan Cayci, Evan Mariash, Mustapha Ezzeddine, Veronika Bachanova, Celalettin Ustun

“…Status epilepticus after allogeneic hematopoietic cell transplantation (alloHCT) is rare. The authors report a case involving a 65-year-old man with nonconvulsive status epilepticus 34 days after umbilical cord blood transplantion for chronic lymphocytic leukemia. …”
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Quantifying the regulatory potential of genetic variants via a hybrid sequence-oriented model with SVEN by Yu Wang, Nan Liang, Ge Gao

“…Here, we integrate regulatory-specific neural networks and tissue-specific gradient-boosting trees to build SVEN: a hybrid sequence-oriented architecture that can accurately predict tissue-specific gene expression level and quantify the tissue-specific transcriptomic impacts of structural variants across more than 350 tissues and cell lines. We further systematically screen a large-scale structural variants dataset derived from 3622 individuals and clinical structural variants from ClinVar, and provide an overview of transcriptomic impacts of structural variants in population. …”
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