Barcoded screening identifies nanocarriers for protein delivery to kidney by Luyao Wang, Wen Zhou, Hang Chen, Xiangqian Jia, Peiyuan Zheng, Haolin Jiang, Mengling Wu, Yaning Zhang, Yanchao Ding, Yexi Peng, Rui Zhu, Tiantian Li, Boxue Tian, Bujie Du, Juanjuan Du

“…In vitro and in vivo screening, using female mice, identify nanocapsules with high cell association and different biodistribution. Our investigation into kidney-enriched nanocapsules highlights the crucial role of polymer composition in biodistribution, demonstrating the potential of surface engineering for precise control over nanoparticle distribution. …”
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Predicting the Onset of Cavitation in Automotive Torque Converters—Part II: A Generalized Model by D. L. Robinette, J. M. Schweitzer, D. G. Maddock, C. L. Anderson, J. R. Blough, M. A. Johnson

“…Stator torque thresholds at the onset of cavitation for the stall operating condition were experimentally determined with a dynamometer test cell using nearfield acoustical measurements. Cavitation torques, design parameters, and operating conditions were resolved into a set of dimensionless quantities for use in the development of dimensionless empirical models. …”
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Structural insights into GrpEL1-mediated nucleotide and substrate release of human mitochondrial Hsp70 by Marc A. Morizono, Kelly L. McGuire, Natalie I. Birouty, Mark A. Herzik

“…Abstract Maintenance of protein homeostasis is necessary for cell viability and depends on a complex network of chaperones and co-chaperones, including the heat-shock protein 70 (Hsp70) system. …”
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Annotation-free deep learning for predicting gene mutations from whole slide images of acute myeloid leukemia by Bo-Han Wei, Xavier Cheng-Hong Tsai, Kuo-Jui Sun, Min-Yen Lo, Sheng-Yu Hung, Wen-Chien Chou, Hwei-Fang Tien, Hsin-An Hou, Chien-Yu Chen

“…Our model predicts NPM1 mutations and FLT3-ITD without requiring patch-level or cell-level annotations. Using a dataset of 572 WSIs, the largest database with both WSI and genetic mutation information, our model achieved an AUC of 0.90 ± 0.08 for NPM1 and 0.80 ± 0.10 for FLT3-ITD in the testing cohort. …”
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Hidden route of protein damage through oxygen-confined photooxidation by Seoyoon Kim, Eojin Kim, Mingyu Park, Seong Ho Kim, Byung-Gyu Kim, Seungjin Na, Victor W. Sadongo, W. C. Bhashini Wijesinghe, Yu-Gon Eom, Gwangsu Yoon, Hannah Jeong, Eunhye Hwang, Chaiheon Lee, Kyungjae Myung, Chae Un Kim, Jeong-Mo Choi, Seung Kyu Min, Tae-Hyuk Kwon, Duyoung Min

“…The effects of this photooxidative reaction appear to be extensive, impacting a wide range of cellular proteins, as supported by whole-cell proteomic analysis. This photooxidative mechanism may represent a latent oxidation pathway in human tissues directly exposed to visible light, such as skin and eyes.…”
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General (hetero)polyaryl amine synthesis via multicomponent cycloaromatization of amines by Lebin Su, Jianyu Dong, Yang Shen, Shimin Xie, Shaofeng Wu, Neng Pan, Feng Liu, Qian Shang, Fangfang Cai, Tian-Bing Ren, Lin Yuan, Shuang-Feng Yin, Li-Biao Han, Yongbo Zhou

“…Due to the easy introduction of various functional units into heteropolyarylamines, multiple functionalized fluorescent dyes can be arbitrarily synthesized, which can serve as effective fluorescent probes for monitoring the pathological processes (e.g. chemotherapy-induced cell apoptosis) and studying the related disease mechanisms.…”
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Coordinated optimization and management of oxygen content and cathode pressure for PEMFC based on hybrid nonlinear robust control by Fang Shiyi, Feng Jianan, Zhu Yuxin, Chen Zehang, Fang Xiening, Chen Daifen, Fan Xinyu

“…Cathode inlet and exhaust management remains a significant challenge in Proton Exchange Fuel Cell (PEMFC). Achieving optimal oxygen content in real-time through precise control of the inlet gas is crucial for maintaining optimal output. …”
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HSCT-GAVE as a Manifestation of Chronic Graft versus Host Disease: A Case Report and Review of the Existing Literature by Michael J. Grant, Mitchell E. Horwitz

“…Over 30 cases of hematopoietic stem cell transplant-related GAVE (HSCT-GAVE) have been reported in the literature to date and there are likely many more that go undiagnosed or are attributed to another cause of upper gastrointestinal bleeding. …”
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Boosting bulk photovoltaic effect in transition metal dichalcogenide by edge semimetal contact by Shuang Qiao, Jihong Liu, Chengdong Yao, Ni Yang, Fangyuan Zheng, Wanqing Meng, Yi Wan, Philip C. Y. Chow, Dong-Keun Ki, Lijie Zhang, Yumeng Shi, Lain-Jong Li

“…Abstract Oxide materials with a non-centrosymmetric structure exhibit bulk photovoltaic effect (BPVE) but with a low cell efficiency. Over the past few years, relatively larger BPVE coefficients have been reported for two-dimensional (2D) layers and stacks with asymmety-induced spontaneous polarization. …”
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Rare skin adverse reactions induced by osimertinib: a case report and literature review by Ye Zhang, Mingzhu Ling, Min Wang, Ye Chen, Liting Zhang

“…Osimertinib is a third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) used in the treatment of EGFR mutation-positive advanced non-small cell lung cancer. Osimertinib-induced cutaneous vasculitis is a rare skin adverse reaction. …”
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Novel thiophene derivatives with sulfonamide, isoxazole, benzothiazole, quinoline and anthracene moieties as potential anticancer agents by Ghorab Mostafa M., Bashandy Mahmoud S., Alsaid Mansour S.

“…All newly synthesized compounds were evaluated for their in vitro anticancer activity against human breast cancer cell line (MCF7). Most of the screened compounds showed cytotoxic activities compared to doxorubicin as a positive control. …”
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Correction of Iron Deficiency in the Cardiorenal Syndrome by Donald S. Silverberg, Dov Wexler, Adrian Iaina, Doron Schwartz

“…Iron deficiency has been shown to reduce energy production in the cell in animals and humans. Iron deficiency is common in both Chronic Kidney Disease (CKD) and in CHF. …”
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Bioengineering strategies targeting angiogenesis: Innovative solutions for osteonecrosis of the femoral head by Weihong Zhu, Zhenmu Xu, Ding Zhou, Jiankun Xu, Yuchen He, Zhong Alan Li

“…This vascular deficit results in cell apoptosis, trabecular bone loss, and structural collapse of the femoral head at late stage, significantly impairing joint function. …”
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The transcriptomic footprint of Mytella strigata: de novo transcriptome assembly of a major invasive species by V. G. Vysakh, Sandhya Sukumaran, Wilson Sebastian, A. Gopalakrishnan

“…Gene Ontology and pathway analyses identified transcripts associated with key biological processes, including those associated with cell signalling, metabolism, stress responses, cancer pathways, and immune regulation. …”
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Density Functional Theory Investigation into the B and Ga Doped Clean and Water Covered γ-Alumina Surfaces by Lihong Cheng, Tianliang Xu, Wenkui Li, Zhiqin Chen, Jianping Ai, Zehua Zhou, Jianwen Liu

“…The studies show the coverage of water at 7.5 H2O/nm2 (five H2O molecules per unit cell) can fully cover the active sites and the further water molecule could only be physically adsorbed on the surface.…”
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An atomically controlled insulator-to-metal transition in iridate/manganite heterostructures by Enyang Men, Deyang Li, Haiyang Zhang, Jingxin Chen, Zhihan Qiao, Long Wei, Zhaosheng Wang, Chuanying Xi, Dongsheng Song, Yuhan Li, Hyoungjeen Jeen, Kai Chen, Hong Zhu, Lin Hao

“…We further showcased the central role of effective correlation in modulating the insulator-to-metal transition, by demonstrating that the critical thickness of iridate for triggering the metallic state can be systematically reduced down to a single unit-cell layer.…”
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Propagation Mechanism Modeling in the Near-Region of Arbitrary Cross-Sectional Tunnels by Ke Guan, Zhangdui Zhong, Bo Ai, Ruisi He, Yuanxuan Li, César Briso Rodríguez

“…Along with the increase of the use of working frequencies in advanced radio communication systems, the near-region inside tunnels lengthens considerably and even occupies the whole propagation cell or the entire length of some short tunnels. …”
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BIOMARKERS, NEOANGIOGENESIS AND GROWTH FACTORS IN PANCREATIC CANCER by E. M. Frantsiyants, O. I. Kit, V. I. Aleynov, I. A. Goroshinskaya

“…IGF-I and its receptor are highly expressed on the surface of pancreatic cancer cell lines that initiate the transduction of intracellular signals associated with the proliferation, invasion and expression of angiogenesis mediators. …”
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Gene Expression Profiling Identifies Downregulation of the Neurotrophin-MAPK Signaling Pathway in Female Diabetic Peripheral Neuropathy Patients by Lin Luo, Wen-Hua Zhou, Jiang-Jia Cai, Mei Feng, Mi Zhou, Su-Pei Hu, Jin Xu, Lin-Dan Ji

“…A further KEGG pathway analysis indicated that DPN and DM share four pathways, including apoptosis, B cell receptor signaling pathway, endocytosis, and Toll-like receptor signaling pathway. …”
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Effect of lipid peroxidation on the allergenicity and functional properties of soybean β-conglycinin (7S) and glycinin (11S) by Liying Ye, Liangtao Lü, Xiao Lin, Kan He, Xiaoquan Yang, Zhili Wan, Lizhong Liu, Haiqian Wu, Shaojun Xing, Xuli Wu

“…The IgE-binding capacity of 7S and 11S reduced after oxidation. KU812 cell assays showed that both histamine and IL-4 release decreased after oxidation treatment. …”
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