Expert insights on Hodgkin’s lymphoma development in an activated PI3K delta syndrome patient undergoing leniolisib treatment by Francesca Conti, Francesca Conti, Mattia Moratti, Mattia Moratti, Elena Sabattini, Pier Luigi Zinzani, Pier Luigi Zinzani

“…Management of APDS is complex and variable due to the heterogeneous nature of the disease and ranges from antimicrobial and immunosuppressant agents to haematopoetic stem cell transplantation. More recently, an increasing level of interest has been shown in the use of more targeted agents such as PI3Kδ-specific inhibitors. …”
Get full text

A novel dual fixation method for improving the reliable assessment of pulmonary vascular morphology in pulmonary hypertension rats by Yan Xu, Pu Liao, Xinyu Song, Wenchuan Guo, Bingxun Liu, Tong Ye, Ting Zhang, Rui Xiao, Liping Zhu, Yujun Shen, Yanjiang Xing, Jing Wang, Qinghua Hu

“…Utilizing a monocrotaline-induced PH rat model, this study compared the dual fixation with the traditional immersion fixation, focusing on the quantitative assessment of alveolar expansion degree, capillary patency, endothelial cell quantity and wall thickness of pulmonary vein and artery. …”
Get full text

Pulmonary Sarcomatoid Carcinoma Associated with Arterial Thromboembolism in a Cat by Aria L. Guarino, Albert B. Jeon, Jeffrey R. Abbott, Richard C. Hill

“…Using the World Health Organization classification scheme for mixed pulmonary tumors, this tumor would be characterized as a pleomorphic squamous cell carcinoma under the umbrella term of pulmonary sarcomatoid carcinoma. …”
Get full text

Chronic Corynebacterium striatum Septic Arthritis in a Patient Referred for Total Knee Arthroplasty by Katharine Hollnagel, Jacob Willen, Michael Ellis, Yalda Soleimanifard, Robert Booth, Sumon Nandi

“…Joint aspiration white blood cell count was 30,548/mm3, but multiple cultures were positive for C. striatum. …”
Get full text

Structure and Function of the LRBA Protein by Ege Ezen, Mehmet Cihangir Çatak, Feyza Bayram Çatak, Sofia Piepoli, Pegah Zahedimaram, Ecem Ultanır, Safa Barış, Batu Erman

“…LRBA was shown to be responsible for the re-shuttling of the T-cell co-inhibitory receptor CTLA4 back to the plasma membrane after internalization and lack or mutation of LRBA results in surface deficiency of CTLA4 in regulatory and activated T lymphocytes. …”
Get full text

Multicentric Castleman’s Disease in a Child Revealed by Chronic Diarrhea by Sarra Benmiloud, Sana Chaouki, Samir Atmani, Moustapha Hida

“…The diagnosis of celiac or inflammatory bowel diseases was suspected, but two and a half years later, the diagnosis of multicentric Castleman’s disease was brought following the appearance of abdominal mass whose biopsy revealed Castleman’s disease in the plasma cell form. The outcome was favorable after treatment by corticosteroid, chemotherapy, and surgery. …”
Get full text

The Nrf2/Keap1/ARE Pathway and Oxidative Stress as a Therapeutic Target in Type II Diabetes Mellitus by Joshua A. David, William J. Rifkin, Piul S. Rabbani, Daniel J. Ceradini

“…There is accumulating evidence that this pathway is implicated in diabetic damage to the pancreas, heart, and skin, among other cell types and tissues. Animal studies and clinical trials have shown promising results suggesting that activation of this pathway can delay or reverse some of these impairments in TIIDM. …”
Get full text

Superficial Dorsal Vein Thrombosis of the Penis and Pulmonary Embolism in a 15-year-old Boy: A Case Report by Tomas Leng, Jason H. Homme, Jana Anderson

“…Case Report: A 15-year-old male with a high-risk, B-cell acute lymphocytic leukemia and recent pegaspargase administration presented to the ED with new-onset penile pain. …”
Get full text

Swords and shields: the war between Candidatus Liberibacter asiaticus and citrus by Yanan Hu, Nannan Lu, Kaiqiang Bao, Shuting Liu, Ruimin Li, Ruimin Li, Ruimin Li, Guiyan Huang, Guiyan Huang, Guiyan Huang

“…We further investigate the impact of SDEs on various physiological processes, including systemic acquired resistance (SAR), reactive oxygen species (ROS) accumulation, vesicle trafficking, callose deposition, cell death, autophagy, chlorosis and flowering. Additionally, we focus on the functional research on specific disease-resistant genes in citrus and the molecular mechanisms underlying disease resistance. …”
Get full text

A three-dimensional mouse liver organoid platform for assessing EDCs metabolites simulating liver metabolism by Ji Hyun Moon, Hyun-Soo Roh, Young Jae Park, Hyun Ho Song, Jieun Choi, Da Woon Jung, Soo Jin Park, Ho Jin Park, So-Hyeon Park, Da-Eun Kim, Gahee Kim, Joong-Hyuck Auh, Dong Ha Bhang, Hong Jin Lee, Do Yup Lee

“…We evaluated the effects the activity of EDC metabolites generated through mLOs based on human cell-based reporter gene assays in addition to existing models. …”
Get full text

Identifiability investigation of within-host models of acute virus infection by Yuganthi R. Liyanage, Nora Heitzman-Breen, Necibe Tuncer, Stanca M. Ciupe

“…We then refined the results by predicting practical identifiability of parameters under daily influenza A virus titers alone or together with daily adaptive immune cell data. Using these approaches, we presented insight into the sources of uncertainty in parameter estimation and provided guidelines for the types of model assumptions, optimal experimental design, and biological information needed for improved predictions.…”
Get full text

Effect of Nitrogen Source and Inorganic Phosphate Concentration on Methanol Utilization and PEX Genes Expression in Pichia pastoris by A. M. Rumjantsev, O. V. Bondareva, M. V. Padkina, E. V. Sambuk

“…In biotechnology it is very important to maintain the balance between high levels of heterologous gene expression and cell viability. Decisive understanding of gene regulation mechanisms is essential for reaching this goal. …”
Get full text

Integrating melt electrospinning writing and microfluidics to engineer a human cardiac microenvironment for high-fidelity drug screening by Yu-hong Wang, Ting-ting Liu, Yan-ping Guo, Shuo-ji Zhu, Zi-ming Liao, Jia-mei Song, Xi-ming Zhu, Jia-liang Liang, Moussa Ide Nasser, Nan-bo Liu, De-hua Chang, Ping Zhu, Bin Yao

“…Although human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) and the engineered heart organoid have been used for drug screening and mimicking disease models, they are always limited by the immaturity and lack of functionality of the cardiomyocytes. …”
Get full text

Targeting RNA splicing modulation: new perspectives for anticancer strategy? by Xuemei Lv, Xiaoyu Sun, Yang Gao, Xinyue Song, Xiaoyun Hu, Lang Gong, Li Han, Miao He, Minjie Wei

“…In this review, we summarize the splice-altered signatures of cancer cell transcriptomes and the contributions of splicing aberrations to tumorigenesis and progression. …”
Get full text

Partial intestinal obstruction caused by duodenal obstruction by the superior mesenteric artery and abdominal aorta in a middle-aged woman: A case report by Xu Zhang, Wenyu Sun, Ming Yao, Qiu Xia, Qing Zhang, Shuai Guo, Lixia Ma, Ze Li

“…A 55-year-old woman with non-small cell lung carcinoma complained of epigastric pain, bloating, anorexia and postprandial nausea and vomiting over a five-year period. …”
Get full text

Label free, capillary-scale blood flow mapping in vivo reveals that low-intensity focused ultrasound evokes persistent dilation in cortical microvasculature by YuBing Y. Shen, Jyoti V. Jethe, Ashlan P. Reid, Jacob Hehir, Marcello Magri Amaral, Chao Ren, Senyue Hao, Chao Zhou, Jonathan A. N. Fisher

“…The brain’s ability to provide blood flow to electrically active regions involves a multitude of non-neuronal cell types and signaling pathways in the cerebral vasculature; an open question is whether persistent effects can be attributed, at least partly, to vascular mechanisms. …”
Get full text

Fecal Calprotectin Use in Inflammatory Bowel Disease and Beyond: A Mini-Review by Bashaar Alibrahim, Mohammed I Aljasser, Baljinder Salh

“…One recently described test that may fulfill several of these attributes is based on leakage of a mononuclear cell cytoplasmic protein, calprotectin, along the intestinal tract, which can then be quantified in feces. …”
Get full text

Endothelial Dysfunction and Diabetes: Effects on Angiogenesis, Vascular Remodeling, and Wound Healing by Gopi Krishna Kolluru, Shyamal C. Bir, Christopher G. Kevil

“…It is well known that type 2 DM causes amplification of the atherosclerotic process, endothelial cell dysfunction, glycosylation of extracellular matrix proteins, and vascular denervation. …”
Get full text

Mechanism and Treatment Strategy of Osteoporosis after Transplantation by Lei Song, Xu-Biao Xie, Long-Kai Peng, Shao-Jie Yu, Ya-Ting Peng

“…Using the signaling pathway or implantation bone marrow stem cell provides a novel direction for the treatment of OP, especially OP after transplantation. …”
Get full text

Hodgkin's Disease in Patients with HIV Infection by Michele Spina, Antonino Carbone, Annunziata Gloghini, Diego Serraino, Massimiliano Berretta, Umberto Tirelli

“…Moreover, in the last years the feasibility of high dose chemotherapy and peripheral stem cell rescue has allowed to save those patients who failed the upfront treatment. …”
Get full text