Unlocking the potential of antimicrobial peptides: Beta-defensins and the future of cancer diagnostics by Saranya Velmurugan, Gowtham Kumar Subbaraj

“…Studies have shown dysregulation of beta-defensins, particularly hBD-3, may contribute to oral squamous cell carcinoma progression via modulation of inflammation and immune responses. …”
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Recent advances in the structure and immunomodulatory activity of food-derived glycoprotein complex by Yu Zhong, Jiangxiong Zhu, Bifen Zhu, Hao Yin, Danfeng Wang, Yun Deng, Minyan Zhang, Chunrong Zhang

“…Glycoprotein complex can affect the expression of immune-related proteins and factors by activating cell surface receptors, regulating intracellular immune signal transduction, and ultimately play an immunomodulatory role in the body. …”
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Neurotrophic Receptor Tyrosine Kinase 2 (NTRK2) Alterations in Low-Grade Gliomas: Report of a Novel Gene Fusion Partner in a Pilocytic Astrocytoma and Review of the Literature by Siobhan S. Pattwell, Eric Q. Konnick, Yajuan J. Liu, Rebecca A. Yoda, Laligam N. Sekhar, Patrick J. Cimino

“…NTRK2 encodes for the protein tropomyosin receptor kinase B (TrkB), which is a neurotrophin receptor with high affinity for Brain-Derived Neurotrophic Factor (BDNF), and plays a role in several physiological functions of neurons, including cell survival and differentiation. In this report, we describe a novel PML-NTRK2 gene fusion occurring in an adult sporadic pilocytic astrocytoma and review the biology and implications of specific NTRK2 mutations occurring in CNS neoplasms.…”
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Spectroscopy in heterogenous media and applications for bioprocess and environmental monitoring by Frank Schael, Oliver Reich, Sonja Engelhard

“…Applications of reflectance measurements for monitoring of cell growth during fermentation processes and for in-situ investigations of soils are presented.…”
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Electrospun short fibers: a new platform for cancer nanomedicine applications by Yifan Huang, Mengsi Zhan, Mingwu Shen, Lili Zhang, Xiangyang Shi

“…Herein, this paper provides an overview of the recent advances in the design of electrospun short fibers that retain the advantages of nanofibers with good dispersibility for different nanomedicine applications, including cancer cell capture, cancer treatments, and cancer theranostics. …”
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Dihydromyricetin Acts as a Potential Redox Balance Mediator in Cancer Chemoprevention by Liang Chen, Meng Shi, Chenghao Lv, Ying Song, Yuanjie Wu, Suifei Liu, Zhibing Zheng, Xiangyang Lu, Si Qin

“…DHM is considered a potential redox regulator for chronic disease prevention, and its biological activities are abundantly evaluated by using diverse cell and animal models. However, clinical investigations are still scanty. …”
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Lipid Chaperones and Metabolic Inflammation by Masato Furuhashi, Shutaro Ishimura, Hideki Ota, Tetsuji Miura

“…On the other hand, inside the cell, fatty acid-binding proteins (FABPs), a family of lipid chaperones, as well as endoplasmic reticulum (ER) stress, and reactive oxygen species derived from mitochondria play significant roles in promotion of metabolically triggered inflammation. …”
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e-Cadherin in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Parkinson Disease by Samuela Cataldi, Michela Codini, Stéphane Hunot, François-Pierre Légeron, Ivana Ferri, Paola Siccu, Angelo Sidoni, Francesco Saverio Ambesi-Impiombato, Tommaso Beccari, Francesco Curcio, Elisabetta Albi

“…The results showed a strong expression of e-cadherin, variation of length and thickness of the heavy neurofilaments, increase of interleukin-6, and reduction of tyrosine hydroxylase known to be expression of dopamine cell loss, reduction of phosphatase and tensin homolog described to impair responses to dopamine, and reduction of caveolin-1 known to be expression of epithelial-mesenchymal transition and fibrosis. …”
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Engineering of SauriCas9 with enhanced specificity by Xiaoqi Zhang, Chen Tao, Miaomiao Li, Sufang Zhang, Puping Liang, Yan Huang, Huihui Liu, Yongming Wang

“…To validate its efficacy, we employed SauriCas9-R253A to disrupt three genes (B2M, TRAC, and PDCD1), a strategy integral to the development of allogeneic chimeric antigen receptor T cell (CAR-T) therapies. Our results demonstrated that the most efficient single-guide RNAs for SauriCas9-R253A exhibited comparable activity to SpCas9 and showed no detectable off-target effects in the disruption of these genes, highlighting its therapeutic potential.…”
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Culture dependent and independent approaches reveal the role of specific bacteria in human skin aging by Jing‐jing Xia, Qian Zhong, Zhi‐ming Li, Qing‐zhen Wei, Liu‐yi‐qi Jiang, Cheng Duan, Hui‐jue Jia, Yi‐mei Tan, Lian‐yi Han, Jean Krutmann, Jiucun Wang, Xiao Liu

“…Moraxella osloensis isolated from healthy skin regulates collagen metabolism and extracellular matrix assembly, and promotes cell senescence in human keratinocytes and fibroblasts, making it potentially applicable in the development of antiaging interventions.…”
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Catalytic asymmetric C–N cross-coupling towards boron-stereogenic 3-amino-BODIPYs by Baoquan Zhan, Li-Qing Ren, Jiayi Zhao, Hua Zhang, Chuan He

“…Abstract 3-Amino boron dipyrromethenes (BODIPYs) are a versatile class of fluorophores widely utilized in live cell imaging, photodynamic therapy, and fluorescent materials science. …”
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Effects of X-ray and electron beam irradiation on wine quality: Emphasizing phenolic compounds and aroma profiles by Weikang Ding, Qian Tu, Xuexue Xi, Xiaojie Wu, Junqing Bai, Shuang Liu, Junjun Li, Chunlong Yuan

“…The content of flavor compounds in wine is limited by factors such as climate warming and the resistance of cell walls to maceration. This study used X-rays (ionizing radiation) and electron beams (particle radiation) at 0.5, 2, and 7 kGy for grape pre-treatment before winemaking. …”
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A Rare Case of Primary Bilateral Adrenal Lymphoma by Veeraraghavan Meyyur Aravamudan, Phang Kee Fong, Yang Shiyao Sam, Pavel Singh, Siok-Bian Ng, Gollamudi Satya Pavan Kumar

“…Histology of adrenal gland biopsy showed features consistent with diffuse large B-cell lymphoma. She was started on R-CHOP chemotherapy and had a good clinical response and remained in complete remission for five months after chemotherapy.…”
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Suggestive Diagnostic Process in a Case of Multiple Myeloma with Gastrointestinal Immunoglobulin Light-Chain Amyloidosis Accompanied by Protein-Losing Enteropathy by Katsuya Endo, Takehito Ito, Jun Nomura, Keigo Murakami, Shiho Kondo, Tomonori Satoh, Daisuke Fukushi, Yuki Yoshino, Yoshiteru Sasaki, Atsuko Takasu, Takayuki Kogure, Morihisa Hirota, Takayoshi Meguro, Kazuhiro Murakami, Junichi Kameoka, Kennichi Satoh

“…Multiple myeloma is a type of plasma cell neoplasm that produces monoclonal immunoglobulin. …”
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A guide to selecting high-performing antibodies for STING1 (Uniprot ID: Q86WV6) for use in western blot, immunoprecipitation, and immunofluorescence [version 2; peer review: 2 appr... by Vera Ruíz Moleón, Carl Laflamme, Kathleen Southern, Riham Ayoubi, Charles Alende, Maryam Fotouhi

“…This study aims to improve reliability of STING1 research as we have characterized sixteen STING1 commercial antibodies for western blot, immunoprecipitation, and immunofluorescence using a standardized experimental protocol based on comparing read-outs in knockout cell lines and isogenic parental controls. These studies are part of a larger, collaborative initiative seeking to address antibody reproducibility issues by characterizing commercially available antibodies for human proteins and publishing the results openly as a resource for the scientific community. …”
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Spindle Bursts in Neonatal Rat Cerebral Cortex by Jenq-Wei Yang, Vicente Reyes-Puerta, Werner Kilb, Heiko J. Luhmann

“…Disturbances in spindle burst activity during corticogenesis may contribute to disorders in cortical architecture and in the activity-dependent control of programmed cell death. In this review we discuss (i) the functional properties of spindle bursts, (ii) the mechanisms underlying their generation, (iii) the synchronous patterns and cortical networks associated with spindle bursts, and (iv) the physiological and pathophysiological role of spindle bursts during early cortical development.…”
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Canadian Clinical Practice Guidelines for Invasive Candidiasis in Adults by Eric J Bow, Gerald Evans, Jeff Fuller, Michel Laverdière, Coleman Rotstein, Robert Rennie, Stephen D Shafran, Don Sheppard, Sylvie Carle, Peter Phillips, Donald C Vinh

“…Over the past few years, a new and broader understanding of the epidemiology and pathogenesis of C/IC has emerged and has been coupled with the availability of new antifungal agents and defined strategies for targeting groups at risk including, but not limited to, acute leukemia patients, hematopoietic stem cell transplants and solid organ transplants, and critical care unit patients. …”
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Unusual syphilis manifestation: From breast implant rupture to systemic erythroderma by Vivien Moris, Eliott Laine, Sahal Khan, Leslie Ann See

“…Pathological findings showed chronic inflammation, with concerns about a cutaneous T-cell lymphoproliferative disorder, but no signs of malignancy were observed. …”
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Phototreatment of Water by Organic Photosensitizers and Comparison with Inorganic Semiconductors by Merlyn Thandu, Clara Comuzzi, Daniele Goi

“…These photosensitizers cause cell death by generating reactive oxygen species (ROS) especially singlet oxygen in the presence of light. …”
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Designing Novel Interfaces via Surface Functionalization of Short-Chain-Length Polyhydroxyalkanoates by S. Vigneswari, J. M. Chai, K. Shantini, K. Bhubalan, A. A. Amirul

“…However, some studies revealed that PHA is hydrophobic and has no recognition site for cell attachment and this is often a limitation in tissue engineering aspects. …”
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