Effect of 5-Aminolevulinic Acid on the Quality and Volatile Metabolites of Korla Fragrant Pear Fruit by SUN Tianyu, WEN Bo, WANG Chunfeng, TIAN Jia, HAO Zhichao, LIN Yan, WEN Yue, ZHANG Feng

“…Specifically, compared with the control group, the hardness, stone cell content and titratable acid content of the fruit without calyx decreased by 13.45%, 31.03% and 42.31%, respectively, and the soluble solids content and solid/acid ratio increased by 9.95% and 90.57%, respectively; the hardness, titratable acid content and stone cell content of the fruit with calyx decreased significantly by 12.89%, 48.48% and 30.16%, and the soluble solids content, soluble sugar content and solid/acid ratio increased by 19.33%, 23.51% and 131.63%, respectively. …”
Get full text

Functional Analysis and Experimental Validation of the Prognostic and Immune Effects of the Oncogenic Protein CDC45 in Breast Cancer by Zhang JN, Li LW, Cao MQ, Liu X, Yi ZL, Liu SS, Liu H

“…The function of CDC45 was further verified through cell and animal experiments.Results: CDC45 is highly expressed in most tumors, including BC. …”
Get full text

Metabolic phenotype of adult mice offspring obtained from different variants of embryo transfer by M. V. Anisimova, Ya. Gong, N. S. Yudin, Yu. M. Moshkin, L. A. Gerlinskaya

“…Animals were separated in 4 groups according to the variant of embryo transplantation: group (control) – natural mating; group (2cl-bl) – incubation of 2-cell up to blastocysts; group (2cl-2cl) – removal and transplantation of the 2-cell embryo without incubation; group (Bl-bl) removal and transplantation of the blastocysts without incubation. …”
Get full text

Differences in immune-related toxicity between PD-1 and PD-L1 inhibitors: a retrospective cohort study in patients with advanced cancer by Cecilia Olsson Ladjevardi, Marcus Skribek, Anthoula Koliadi, Viktoria Rydén, Ali Inan El-Naggar, Evangelos Digkas, Antonios Valachis, Gustav J. Ullenhag

“…Patients (n = 605) treated for advanced cancer with a PD-L1 or PD-1 inhibitor in monotherapy between June 2016 and August 2022 were included. Non-small cell lung cancer (NSCLC) was the most common malignant disease (n = 251; 41.5%), followed by malignant melanoma (n = 173; 28.6%), renal cell carcinoma (n = 71; 11.7%) and urothelial carcinoma (n = 35; 5.8%). …”
Get full text

Genetic association analysis of lipid-lowering drug target genes in chronic kidney disease by Yi Zhang, Yi Zhang, Guangyang Ou, Lei Peng, Jian Pan, Shaohua Zhang, Jianguo Shi

“…Additionally, mediation analysis was performed utilizing 731 immune cell phenotypes to identify potential mediators.ResultsThe meta-analysis revealed a significant association between ANGPTL3 inhibitors and a reduced risk of CKD (OR [95% CI] = 0.85 [0.75-0.96]). …”
Get full text

The antibiofilm effect and mechanism of silver nanowire-modified glass ionomer cement against multi-species oral biofilm by Tiantian Guo, Dai Wang, Sherry Shiqian Gao

“…Colour stability and fluoride release of GIC specimens were assessed by VITA Easyshade® V and ion chromatography. Cell counting kit-8 (CCK-8) was used to study cytotoxicity. …”
Get full text

Screening for monoclonal B-lymphocyte expansion in a hospital-based Chinese population with lymphocytosis: an observational cohort study by Yue Wang, Jing Li, Peng Liu, Jiadai Xu, Zheng Wei

“…Objectives Screening of monoclonal B-cell lymphocytosis (MBL) has improved the early detection of B-cell lymphoproliferative disorders (B-LPDs). …”
Get full text

Composite submental flaps in facial reconstructive surgery involving the zygoma and orbit by Usman Khan, Sebastian Haupt, Matthew Rigby, S. Mark Taylor, Martin Corsten, Jonathan Trites

“…The second case was an 88-year-old female with several squamous cell carcinomas (SCC), including a dominant 7.1 cm SCC on the right temple with orbital invasion. …”
Get full text

Genetic parameters for milk production traits of Simmental cows with random regression test-day model by A. Otwinowska-Mindur, E. Ptak, W. Jagusiak, A. Zarnecki

“…The mean heritability for daily milk yields and milk composition ranged from 0.12 (somatic cell score) to 0.41 (protein content in milk). The majority of the analysed traits were most heritable at the end of 305-d lactation. …”
Get full text

Effect of total replacement of inorganic with organic sources of key trace minerals on performance and health of high producing dairy cows by P.H. Pomport, H.E. Warren, J. Taylor-Pickard

“…Mastitis rates were lowest for the ORG group (two cows affected), vs four cows for the INORG group and six cows for the CON group. Somatic cell counts were consistently lower in the ORG cows (P<0.05), being less than 300,000 cell counts, compared to peaks of 380,000 counts in the INORG and 550,000 counts in the CON groups. …”
Get full text

LIMFOMA NON-HODGKIN SEL B PADA MAMMAE by Ninda Septia Yuspar, Irza Wahid

“…Pada pemeriksaan Imunohistokimia dengan hasil diffuse large B cell lymphoma, CD20 positif, Non GCB. Pasien didiagnosis Limfoma non hodgkin pada mammae relaps. …”
Get full text

Synthesis of chitosan/PVA/copper oxide nanocomposite using Anacardium occidentale extract and evaluating its antioxidant, antibacterial, anti-inflammatory and cytotoxic activities by Manickam Rajkumar, S. I. Davis Presley, Prabha Govindaraj, Dharmalingam Kirubakaran, Farha Farahim, Talat Ali, Mohd Shkir, Sellapillai Latha

“…CS/PVA/CuONCs was shown to have strong cytotoxicity against MCF-7 cell lines. It also had the highest cell viability inhibition, at 13.66 ± 0.58%. …”
Get full text

Molecular characterization of a rare TP63 variant associated with split-hand/split-foot malformation 4 and incomplete penetrance: disruption of the p63-Dlx signaling pathway by Jianlong Zhuang, Yanqing Li, Yu’e Chen, Hegan Zhang, Shufen Liu, Manman Hu, Chunnuan Chen

“…RNA sequencing results demonstrated an increased expression level of TP63 and its downstream genes (PERP, CDH3, and DLX5) compared with the controls, indicating an enrichment of cell adhesion molecules the differentially expressed genes in the patient. …”
Get full text

N6-methyladenosine regulates metabolic remodeling in kidney aging through transcriptional regulator GLIS1 by Li Xu, Shuo Chen, Qiuling Fan, Yonghong Zhu, Hang Mei, Jiao Wang, Hongyuan Yu, Ying Chen, Fan Liu

“…Abstract Background Age-related kidney impairment, characterized by tubular epithelial cell senescence and renal fibrosis, poses a significant global public health threat. …”
Get full text

Uncovering the role of microRNAs in esophageal cancer: from pathogenesis to clinical applications by Zhenglin He, Yishuo Ji, Yutong Yuan, Tianfang Liang, Chenglin Liu, Yiping Jiao, Yimeng Chen, Yiming Yang, Liang Han, Liang Han, Yue Hu, Yue Hu, Xianling Cong, Xianling Cong, Xianling Cong

“…We elucidate how miRNAs modulate oncogenic pathways and tumor suppressor genes, influencing EC cell behavior and treatment outcomes. By integrating insights from genetic sequencing and molecular biology, we identify key miRNAs that promote or inhibit EC progression and treatment resistance. …”
Get full text

Antibiotic Resistance of Enteric Bacteria in HIV-Infected Patients at the Banka Ad-Lucem Hospital, West Region of Cameroon by Ornella J. T. Ngalani, Armelle T. Mbaveng, Wiliane J. T. Marbou, Roland Y. Ngai, Victor Kuete

“…This study was conducted to define the bacterial aetiologies of enteric disorders and their association with CD4+ T-lymphocyte cell count and serum hs-CRP in HIV-seropositive patients coming for consultation at the AD-Lucem Banka Hospital. …”
Get full text

Proton pump inhibitors versus histamine-2 receptor antagonists for stress ulcer prophylaxis during extracorporeal membrane oxygenation: a propensity score-matched analysis by Hiroki Matsui, Hideo Yasunaga, Hiroshi Tanaka, Yutaka Kondo, Hiroyuki Ohbe, Kiyohide Fushimi

“…The secondary outcomes were red blood cell transfusion, hospital-acquired pneumonia and Clostridium difficile infection during hospitalisation.Results Of 11 328 eligible patients, 9738 received PPIs and 1590 received H2RAs. …”
Get full text

Être étranger dans 'La Nouvelle Héloïse' by Nathalie Ferrand

“…Mais il est bien des manières d’être étranger dans La Nouvelle Héloïse, et cette question dépasse celle des nationalités. Une pluralité de figures de l’étranger peuplent ce grand roman qui correspondent remarquablement à celles qu’a rencontrées l’historienne Simona Cerutti au fil de l’enquête qu’elle a conduite dans Étrangers: étude d’une condition d’incertitude dans une société d’Ancien Régime. …”
Get full text

KIF5A regulates axonal repair and time-dependent axonal transport of SFPQ granules and mitochondria in human motor neurons by Irune Guerra San Juan, Jessie W. Brunner, Kevin Eggan, Ruud F. Toonen, Matthijs Verhage

Get full text

The potential role of differentially expressed tRNA-derived fragments in high glucose-induced podocytes by Zhenxing Zhang, Yunyang Qiao, Jialing Ji, Chan Huang, Huimin Shi, Weihua Gan, Aiqing Zhang

“…KEGG pathway analysis revealed that tRFs may be involved in signaling pathways related to growth hormones, phospholipase D, the regulation of stem cell pluripotency, and T-/B-cell receptors. Overexpression of tRF-1:24, one of the most differentially expressed tRFs, attenuated podocyte injury induced by HG. …”
Get full text