Combining a WT1 Vaccine (Galinpepimut-S) With Checkpoint Inhibition (Nivolumab) in Patients With WT1–Expressing Diffuse Pleural Mesothelioma: A Phase 1 Study by Prashasti Agrawal, MD, Michael Offin, MD, Victoria Lai, MD, Michelle S. Ginsberg, MD, Prasad S. Adusumilli, MD, FACS, Valerie W. Rusch, MD, Jennifer L. Sauter, MD, Teresa Ho, BS, Phillip Wong, PhD, Marjorie G. Zauderer, MD

“…Three of the 10 patients (30%) reported vaccine-specific T-cell responses. There were no partial responses; three patients had prolonged stable disease with up to 17% decrease in tumor volume. …”
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Comparison of Two Synthesis Methods for 3D PLA-Ibuprofen Nanofibrillar Scaffolds by Esteban Mena-Porras, Annaby Contreras-Aleman, María Francinie Guevara-Hidalgo, Esteban Avendaño Soto, Diego Batista Menezes, Marco Antonio Alvarez-Perez, Daniel Chavarría-Bolaños

“…The drug release profile was assessed by ultraviolet-visible spectrophotometry (UV-Vis), and cell adhesion and viability were evaluated using fibroblast culture assays. …”
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Case report: Chest radiotherapy-induced vertebral fractures in lung cancer patients: a case series and literature review by Oscar Arrieta, Francisco Lozano-Ruiz, Alberto Guijosa, Pamela Soberanis-Pina, Monika Blake-Cerda, Ana Pamela Gómez-García, Federico Maldonado-Magos, Emilio Conde-Flores, Andrés F. Cardona, Sandra Ileana Pérez Álvarez, Luis Antonio Cabrera-Miranda

“…However, radiotherapy-induced vertebral fractures in lung cancer patients remain an exceedingly rare and underrecognized condition that could be mistaken for bone metastasis.Case presentationWe identified three LC patients (all long-term survivors), aged 67 to 81, who developed thoracic vertebral fractures post-chest radiotherapy, within irradiated fields; two had advanced non-small cell lung cancer (NSCLC) and one had extensive small cell lung cancer (SCLC). …”
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Downregulation of TNF-α/TNF-R1 Signals by AT-Lipoxin A4 May Be a Significant Mechanism of Attenuation in SAP-Associated Lung Injury by Suhui Yu, Jianming Xie, Yukai Xiang, Shengjie Dai, Dinglai Yu, Hongwei Sun, Bicheng Chen, Mengtao Zhou

“…In vitro, we found that AT-Lipoxin A4 markedly suppressed protein expression in TNF-α signals in human pulmonary microvascular endothelial cell, such as tumor necrosis factor receptor-associated factor 2 (TRAF2), TNF-R1-associated death domain (TRADD), receptor-interacting protein (RIP), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin. …”
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Adaptive Autophagy Offers Cardiorenal Protection in Rats with Acute Myocardial Infarction by Zhendong Feng, Han Xue Jiang, Huiyang Chen, Yu Ning Liu, Yahui Wang, Rui Bing Yang, Xueting Han, Chen Hui Xia, Ze Bing Zhu, Hongcai Shang, Aiming Wu, Wei Jing Liu

“…In vitro, HK-2 and AC16 cell injuries and the autophagy pathway were assayed after autophagy was inhibited by 3-methyladenine (3-MA) in a hypoxia incubator. …”
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Novel (±)-trans-β-lactam ureas: Synthesis, in silico and in vitro biological profiling by Jurin Mladenka, Stepanić Višnja, Bojanić Krunoslav, Vadlja Denis, Kontrec Darko, Dražić Tonko, Roje Marin

“…The b-lactam urea 4o showed the most potent antiproliferative activity against the ovarian carcinoma (A2780) cell line. Compounds 4o and 4p exhibited strong cytotoxic effects against human non-tumor cell line HFF1. …”
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Allium cepa L. as a natural antioxidant: Its efficacy in combating heat stress-induced physiological alterations by Ayobami O. Sobanke, Afusat Aiyeola, Frances I. Okwuonu, Wuraola S. Nnaemeka, Jeremiah C. Ndubuisi, Franklin I. Udeoji, Jane N. Adiele

“…Hematological parameters, inflammatory markers, and lipid profiles were analyzed using blood samples obtained through heart puncture.The findings demonstrated that HS significantly lowered levels of hemoglobin (HB), red blood cell (RBC) counts, and antioxidant enzyme activity. …”
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Machine learning based on blood test biomarkers predicts fast progression in advanced NSCLC patients treated with immunotherapy by Jie Yang, Jian-Guo Zhou, Benjamin Frey, Hu Ma, Haitao Wang, Markus Hecht, Rainer Fietkau, Udo Gaipl, Xiaofei Chen, Ada Hang-Heng Wong, Fangya Tan, Si-Si He, Gang Shen, Yun-Jia Wang, Wenzhao Zhong

“…Objective Fast progression (FP) represents a desperate situation for advanced non-small cell lung cancer (NSCLC) patients undergoing immune checkpoint inhibitor therapy. …”
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Extracellular vesicles-derived miR-21 as a biomarker for early diagnosis and tumor activity in breast cancer subtypes by Claudia Omarini, Virginia Catani, Ilenia Mastrolia, Angela Toss, Federico Banchelli, Chrystel Isca, Daniele Medici, Ornella Ponzoni, Marco Brucale, Francesco Valle, Maria Cristina Baschieri, Roberto D’Amico, Valentina Masciale, Chiara Chiavelli, Federica Caggia, Carlo Augusto Bortolotti, Federico Piacentini, Massimo Dominici

“…Abstract Emerging evidence highlights the key role of microRNA (miR)-21 in cell-to-cell communication and tumorigenesis. However, limited knowledge exists on the levels and clinical meaning of miR-21 in extracellular vesicles (EVs) of patients with breast cancer (BC). …”
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A lipidated peptide derived from the C-terminal tail of the vasopressin 2 receptor shows promise as a new β-arrestin inhibitor by Rebecca L. Brouillette, Christine E. Mona, Michael Desgagné, Malihe Hassanzedeh, Émile Breault, Frédérique Lussier, Karine Belleville, Jean-Michel Longpré, Michel Grandbois, Pierre-Luc Boudreault, Élie Besserer-Offroy, Philippe Sarret

“…In addition, we showed that ARIP was unable to recruit β-arrestins to the cell membrane by itself, and that it did not interfere with G protein signalling. …”
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Diagnostic Potential of Multidetector Computed Tomography for Characterizing Small Renal Masses by Maria Elisabetta Mancini, Annamaria Albergo, Marco Moschetta, Mariacristina Angelelli, Arnaldo Scardapane, Giuseppe Angelelli

“…The intralesional density on enhanced scans, peak enhancement, and washout do not seem significant for differentiating clear cell, chromophobe carcinomas, angiomyolipomas, and oncocytomas.…”
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Amyloidogenic immunoglobulin light chains disturb contractile function and calcium transients in a human cardiac spheroid model of light chain (AL) amyloidosis by Mélanie Bézard, Jean-Sébastien Vartanian-Grimaldi, Julien Henri, Denisa Calin, Amira Zaroui, Mounira Kharoubi, Thibaud Damy, Onnik Agbulut, Ekaterini Kordeli

“…An important cytotoxic impact of amyloidogenic prefibrillar LC oligomers on cardiomyocytes is by now established in isolated rodent cardiomyocytes, simple animal models, or cardiomyocyte-like cell lines. However, the response of human cardiomyocytes to this pathogenic condition is currently unknown. …”
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Establishment and internal validation of a model to predict the efficacy of Adalimumab in Crohn’s disease by Fang Wang, He Zhou, Yujie Zhang, Yu Da, Tiantian Zhang, Yanting Shi, Tong Wu, Jie Liang

“…Three variables were selected through the least absolute shrinkage and selection operator regression method, including Adalimumab-positive cell count, disease duration, and neutrophil count of Crohn’s disease patients. …”
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Reducing the uncertainty in the distribution of cm-scale rock properties in the near well-bore region by Seyed Ahmad Mortazavi, Seyed Ahmad Mortazavi, Achyut Mishra, Achyut Mishra, Julie Dickinson, Julie Dickinson, Ralf R. Haese, Ralf R. Haese

“…The analysis suggests that smaller grid cell size (1 m × 1 m × 0.3 m) compared to the typical industry standard (10 m × 10 m × 2 m) significantly improves the representation of cm-scale rock properties. …”
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Iodine/Chlorine Multi‐Electron Conversion Realizes High Energy Density Zinc‐Iodine Batteries by Jiajin Zhao, Yan Chen, Mengyan Zhang, Ziqi An, Binbin Nian, Wenfeng Wang, Hao Wu, Shumin Han, Yuan Li, Lu Zhang

“…Moreover, the pouch cell exhibits 3.72 mAh cm−2 capacity with an energy density of 4.52 mWh cm−2, exhibiting robust cycling stability. …”
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Production of a new variant of soluble trimer Env of HIV-1 CRF63_02A6 SOSIP.664 by Nadezhda B. Rudometova, Andrey P. Rudometov, Anastasia A. Fando, Danil I. Vahitov, Alexander A. Ilyichev, Alexander P. Agafonov, Larisa I. Karpenko

“…A stable producer of trimer Env was obtained by transfection of the CHO-K1 cell line using the developed plasmid vector. Purification of the protein complex was performed using affinity chromatography and gel filtration. …”
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Sleep Disorders and Reproductive Health: Mechanisms, Consequences, and Potential Interventions by Magdalena Rosa-Bończak Rosa, Patrycja Marta, Filip Maciej Huzarski, Klaudia Anna Pawełek, Gabriela Monika Ferfecka, Agata Ossolińska, Natalia Morawiecka, Lucyna Stolarska, Oliver Carlton, Weronika Kłosowicz

“…Reduced fertility, resulting from the deterioration of reproductive cell quality due to hormonal imbalances, may be a consequence of sleep deprivation. …”
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A synthetic cyclic peptide for promoting antigen presentation and immune activation by Jiahui Zhang, Harrison Y. R. Madge, Asmaa Mahmoud, Lantian Lu, Wanyi Wang, Wenbin Huang, Prashamsa Koirala, Jazmina L. Gonzalez Cruz, Wei Yang Kong, Sahra Bashiri, Ahmed O. Shalash, Waleed M. Hussein, Zeinab G. Khalil, James W. Wells, Istvan Toth, Rachel J. Stephenson

“…We identified a cyclic deca-peptide incorporating lipoamino acids for delivering T helper and B cell epitopes against group A Streptococcus (GAS), eliciting robust humoral immune responses. …”
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Decoding the mannose receptor-mAb interaction: the importance of high-mannose N-glycans and glycan-pairing by Julia Baumeister, Maximilian Meudt, Sybille Ebert, Frank Rosenau, Boris Mizaikoff, Michaela Blech, Kristina M. J. Aertker, Fabian Higel

“…The high-mannose N-glycan content of mAbs can be influenced during the cell culture process by factors such as cell lines, process conditions, and media. …”
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The Relevance of the Virchow Node and Virchow Triad in Renal Cancer Diagnosis by Luiza-Roxana Dorobantu-Lungu, Viviana Dinca, Andrei Gegiu, Dan Spataru, Andreea Toma, Luminita Welt, Mihaela Florentina Badea, Constantin Caruntu, Cristian Scheau, Ilinca Savulescu-Fiedler

“…<b>Background:</b> The purpose of this article is to overview the clinical significance of left supraclavicular adenopathy and review the etiology of inferior vena cava (IVC) thrombosis, starting from a presentation of a rare case of renal cell carcinoma (RCCs) with Xp11.2 translocation involving TFE3 gene fusion. …”
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