Multidose Streptozotocin Induction of Diabetes in BALB/c Mice Induces a Dominant Oxidative Macrophage and a Conversion of TH1 to TH2 Phenotypes During Disease Progression by Naxin Sun, Guiwen Yang, Heng Zhao, Huub F. J. Savelkoul, Liguo An

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Exploring target selectivity in designing and identifying PI3Kα inhibitors for triple negative breast cancer with fragment-based and bioisosteric replacement approach by Debojyoti Halder, Shreya Mukherjee, R. S. Jeyaprakash

“…PIK3CA gene mutation is one of the important causes of TNBC, which causes dysregulation of the cell cycle and cell proliferation. PI3Kα selective inhibition can decrease the TNBC by a significant level with minimal off-target effects. …”
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Identification of Two Flavonoids as New and Safe Inhibitors of Kynurenine Aminotransferase II via Computational and In Vitro Study by Redouane Rebai, Luc Jasmin, Abdennacer Boudah

“…Their half-maximal inhibitory concentrations (IC50) are 5.98 ± 0.18 µM and 8.76 ± 0.76 µM, respectively. The MTT assay for cell toxicity indicated that the two compounds do not affect HepG2 cell viability at the necessary concentration for KAT-II inhibition. …”
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Five Years Pathological Evaluation of Corneal Regrafts: A Study from Southern Iran by Masoomeh Eghtedari, Mahmood Kamalzadeh, Masoud Yasemi, Hossein Movahedan, Mohammad Javad Ashraf

“…Conclusion. Endothelial cell loss was the major cause of failure in our study. …”
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Potential Health Implications of the Consumption of Thermally-Oxidized Cooking Oils – a Review by Falade Ayodeji Osmund, Oboh Ganiyu, Okoh Anthony Ifeanyi

“…Furthermore, several in vivo studies had suggested that consumption of thermally-oxidized cooking oils might not be healthy as it might negatively influence the lipid profile (increased low density lipoprotein (LDL), decreased high density lipoprotein (HDL) and elevated cholesterol level), haematological system (alteration in concentration of heamoglobin (Hb), packed cell volume (PCV), white blood cell (WBC) count, neutrophil and lymphocyte counts), kidney function, and induce lipid peroxidation and oxidative stress which have been associated with the pathogenesis of various degenerative diseases. …”
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Immunoinformatic strategy for developing multi-epitope subunit vaccine against Helicobacter pylori. by Md Nahian, Md Rasel Khan, Fabiha Rahman, Hossain Mohammed Reza, Imren Bayil, Tanjum Ahmed Nodee, Tabassum Basher, Mostafizur Rahaman Sany, Rabeya Najnin Munmun, S M Ariful Habib, Lincon Mazumder, Mrityunjoy Acharjee

“…Additionally, immune simulations showed elevated levels of cell-mediated immunity, while repeated exposure simulations indicated rapid antigen clearance. …”
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High protein diet increases the risk of allergic sensitization but not asthma in mice through modulation of the cytokine milieu toward Th2 bias by Waleed Al-Herz, MD, Fawaz Azizieh, PhD, Raj Raghupathy, PhD

“…Airway inflammation was tested by measuring total and differential cell counts in bronchoalveolar lavage fluid and by measuring bronchial mucus production, goblet cell hyperplasia and perivascular and peribronchial inflammation severity scores by histologic examination. …”
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β-ecdysone/PLGA composite scaffolds promote skull defect healing in diabetic rat by Yicai Luo, Ziwei Wu, Yingjuan Zhang, Yang Qiao, Yinge Wei, Xuan Yan, Xiangyu Ma, Xianxian Huang, Xiaoxia Zhong, Zhimao Ye, Xinping Lu, Hongbing Liao

“…The CCK8 cytotoxicity assay and live/dead cell staining demonstrated that BMSCs survived and proliferated on the composite scaffold under both low-glucose and high-glucose conditions. …”
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Hypoxia and lipid metabolism related genes drive proliferation migration and immune infiltration mechanisms in colorectal cancer subtyping by Shansong Huang, Huiying Wang, Jiaqing Cao, Qiang Pang

“…Finally, the key genes ITLN1 and SFRP2 were functionally validated in CRC cell lines. HLPG was closely linked to CRC prognosis. …”
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Streptomyces learnhanii sp. nov., unveiling a Mangrove-Derived Novel “Modern Actinobacteria” in Malaysia by Jodi Woan-Fei Law, Vengadesh Letchumanan, Kar-Wai Hong, Sunny Hei Wong, Nurul Syakima Ab Mutalib, Ya-Wen He, Kok-Gan Chan, Loh Teng-Hern Tan

“…Analysis of whole-cell sugars revealed the presence of glucose, ribose and mannose. …”
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Suppression of In Vivo Neovascularization by the Loss of TRPV1 in Mouse Cornea by Katsuo Tomoyose, Yuka Okada, Takayoshi Sumioka, Masayasu Miyajima, Kathleen C. Flanders, Kumi Shirai, Tomoya Morii, Peter S. Reinach, Osamu Yamanaka, Shizuya Saika

“…Blocking TRPV1 receptor did not affect VEGF-dependent neovascularization in cell culture. Lacking TRPV1 inhibited neovascularization in corneal stroma following cauterization. …”
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Gene Expression of CD70 and CD27 Is Increased in Alopecia Areata Lesions and Associated with Disease Severity and Activity by Radwa El- Sayed Mahmoud Marie, Noha M. Abd El-Fadeel, Yara El-Sayed Marei, Lina M. Atef

“…Alopecia areata (AA) is an acquired hair loss disorder induced by a cell-mediated autoimmune attack against anagen hair follicles. …”
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Enhancers and genome conformation provide complex transcriptional control of a herpesviral gene by David W Morgens, Leah Gulyas, Xiaowen Mao, Alejandro Rivera-Madera, Annabelle S Souza, Britt A Glaunsinger

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KAI2-dependent signaling controls vegetative reproduction in Marchantia polymorpha through activation of LOG-mediated cytokinin synthesis (14) by Aino Komatsu, Mizuki Fujibayashi, Kazato Kumagai, Hidemasa Suzuki, Yuki Hata, Yumiko Takebayashi, Mikiko Kojima, Hitoshi Sakakibara, Junko Kyozuka

“…Activation of MpLOG by KAI2-dependent signaling occurs in a highly cell-type-specific manner, leading to cell-specific induction of GEMMA CUP-ASSOCIATED MYB1 (GCAM1), the master regulator of vegetative reproduction of M. polymorpha. …”
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Emodin promotes the recovery of rheumatoid arthritis by regulating the crosstalk between macrophage subsets and synovial fibroblast subsets by Lianying Cheng, Xiaofeng Rong

“…In vitro experimental methods such as enzyme linked immunosorbent assay (ELISA), Western blotting, Transwell assays, CCK‐8 assays and cell coculture were used to assess cell proliferation, migration and secretion of inflammatory factors. …”
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An improved double chamber triaxial volume change measurement system for unsaturated soils by Tingyu Wu, Tingyu Wu, Chaobo Xia, Hui Chen, Xiaocong Xu, Daoming Pan, Jun Chen

“…Under the net confining pressure (the difference between cell pressure and the initial cell pressure) of 400 kPa, the volume change error of system is only 0.037% of specimen volume, the measurement error is very small. …”
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PPARβ/δ Agonism with GW501516 Increases Myotube PGC-1α Content and Reduces BCAA Media Content Independent of Changes in BCAA Catabolic Enzyme Expression by Caroline N. Rivera, Jason S. Hinkle, Rachel M. Watne, Trent C. Macgowan, Andrew J. Wommack, Roger A. Vaughan

“…These findings suggest heightened BCAA uptake (and possibly metabolism) may occur without substantial changes in the protein levels of related cell machinery.…”
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Optimizing in vitro fertilization in four Caribbean coral species by Valérie F. Chamberland, Matthew-James Bennett, Tania Doblado Speck, Kelly R. W. Latijnhouwers, Margaret W. Miller

“…For each species, we exposed eggs from a single dam to pooled sperm samples from three sires (1) at concentrations ranging from zero to 109 cell mL−1, (2) after letting gametes age for 2 to 6 h, and (3) for a period of 15 to 120 min. …”
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A Novel Necroptosis-Associated lncRNA Signature Can Impact the Immune Status and Predict the Outcome of Breast Cancer by Xin Zhang, Xingda Zhang, Guozheng Li, Yi Hao, Lei Liu, Lei Zhang, Yihai Chen, Jiale Wu, Xinheng Wang, Shuai Yang, Shouping Xu

“…Necroptosis is a type of programmed cell death (PCD) and exhibits regulatory effects on tumor progression, but few studies have focused on the relationships between necroptosis-associated lncRNAs and BRCA. …”
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Digital Gangrene: An Unusual Manifestation of Non-Hodgkin Lymphoma by Muhammad Shoaib Momen Majumder, Shamim Ahmed, Tajkia Haque, Syed Atiqul Haq, Saumitra Chakravarty, Md. Abu Shahin, Din-E-Mujahid Mohammad Faruque Osmany, Johannes J. Rasker

“…We present, to our knowledge, the first report of peripheral T cell lymphoma, NOS presenting with gangrene in all digits complicated by methamphetamine and cannabis abuse. …”
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