Research hotspots and frontiers of endoplasmic reticulum in glomerular podocytes: a bibliometric and visual analysis from 2005 to 2023 by Wang Junli, Hao Zhihong, Wang Lina, Ou Qiaoqun, Qu Jing, Hu Jiaqi, Shengyou Yu, Shengyou Yu, Shengyou Yu

“…The research primarily focuses on endoplasmic reticulum stress, diabetic nephropathy, and apoptosis, with emerging trends in “foot cell apoptosis,” “cell signaling pathways,” and “autophagy.”ConclusionThe findings highlight the expanding scope of podocyte endoplasmic reticulum research, with a particular emphasis on the mechanisms of endoplasmic reticulum stress and podocyte apoptosis. …”
Get full text

Unprecedented mechanical wave energy absorption observed in multifunctional bioinspired architected metamaterials by Zhendong Li, Xinxin Wang, Kexin Zeng, Zichao Guo, Chong Li, Xiang Yu, Seeram Ramakrishna, Zhonggang Wang, Yang Lu

“…Empowered by the cambered design of cell walls, metamaterials shift catastrophic failure toward a progressive deformation mode characterized by stable stress plateaus and ultrahigh specific energy absorption of 50.7 J/g—a 558.4% increase over the straight-wall design. …”
Get full text

Feature selection enhances peptide binding predictions for TCR-specific interactions by Hamid Teimouri, Hamid Teimouri, Zahra S. Ghoreyshi, Zahra S. Ghoreyshi, Anatoly B. Kolomeisky, Anatoly B. Kolomeisky, Anatoly B. Kolomeisky, Jason T. George, Jason T. George, Jason T. George, Jason T. George

“…IntroductionT-cell receptors (TCRs) play a critical role in the immune response by recognizing specific ligand peptides presented by major histocompatibility complex (MHC) molecules. …”
Get full text

Efficient and accurate machine learning models for volume of fluid (VOF) simulation on uniform Cartesian mesh by Mostafa A. Rushdi, Shigeo Yoshida, Changhong Hu, Tarek N. Dief, Abdulrahman E. Salem, Mohamed M. Kamra

“…The proposed method produced two models: a full augmented (9-cell) stencil and a compact (5-cell) stencil. Both were compared against popular finite difference/volume methods commonly used in VOF schemes. …”
Get full text

Artificial intelligence-derived gut microbiome as a predictive biomarker for therapeutic response to immunotherapy in lung cancer: protocol for a multicentre, prospective, observat... by Ryo Toyozawa, Fumihiro Shoji, Takanori Yamashita, Fumihiko Kinoshita, Shinkichi Takamori, Takatoshi Fujishita, Kensaku Ito, Koji Yamazaki, Naoki Nakashima, Tatsuro Okamoto

“…The main inclusion criteria are as follows: (1) pathologically or cytologically confirmed metastatic or postoperative recurrent lung cancer including non-small cell lung cancer and small cell lung cancer; (2) age≥20 years at the time of informed consent; (3) planned treatment with immunotherapy including combination therapy and monotherapy, as the first-line immunotherapy; and (4) ability to provide faecal samples. …”
Get full text

Corneal Mucin‐Targeting Liposome Nanoplatforms Enable Effective Treatment of Dry Eye Diseases by Integrated Regulation of Ferroptosis and Inflammation by Yin Zhang, Tinglian Zhou, Kai Wang, Chenqi Luo, Dan Chen, Zeen Lv, Haijie Han, Ke Yao

“…Ferroptosis, a new form of programmed cell death characterized by lipid peroxidation, has become a pivotal contributor to dry eye oxidative stress‐driven pathology. …”
Get full text

Long-Term Observation of Triplex Surgery for Cataract after Phakic 6H Implantation for Super High Myopia by Xin Liu, Fan Fan, Xiaoying Wang, Yi Lu, Tianyu Zheng, Peng Zhou, Xingtao Zhou, Yi Luo

“…Best corrected visual acuity (BCVA), endothelial cell density (ECD), and associated adverse events were evaluated. …”
Get full text

Oral Phosphatidylcholine Improves Intestinal Barrier Function in Drug-Induced Liver Injury in Rats by Meijuan Chen, Haijun Huang, Pengcheng Zhou, Jiajie Zhang, Yining Dai, Danhong Yang, Xuegong Fan, Hongying Pan

“…Lower inflammatory cell infiltration in the ileum improved intestinal histology, and reduced serum DAO levels were observed in PC-treated cirrhotic rats. …”
Get full text

Prevention of Peritoneal Metastases from Colon Cancer in High-Risk Patients: Preliminary Results of Surgery plus Prophylactic HIPEC by Paolo Sammartino, Simone Sibio, Daniele Biacchi, Maurizio Cardi, Fabio Accarpio, Pietro Mingazzini, Maria Sofia Rosati, Tommaso Cornali, Angelo Di Giorgio

“…The study compared the outcome in patients with advanced colonic cancer at high risk of peritoneal metastases (mucinous or signet-ring cell) without peritoneal or systemic spread, treated with standard colectomy or a more aggressive combined surgical approach. …”
Get full text

Comparative Analysis of Immunoactivation by Nanosecond Pulsed Electric Fields and PD-1 Blockade in Murine Hepatocellular Carcinoma by Maiweilidan Yimingjiang, Talaiti Tuergan, Xinhua Chen, Hao Wen, Yingmei Shao, RuiQing Zhang, Kasimu Aihaiti, Jing Xue, Tuerganaili Aji, Wei Zhang

“…Both nsPEF ablation and anti-PD-1 treatment induced immune cell infiltration in local tumors and modulated cytokine levels in the peripheral blood, with distinct changes in the two treatment groups. …”
Get full text

D-loop mutations in mitochondrial DNA are a risk factor for chemotherapy resistance in esophageal cancer by Takashi Harino, Koji Tanaka, Daisuke Motooka, Yasunori Masuike, Tsuyoshi Takahashi, Kotaro Yamashita, Takuro Saito, Kazuyoshi Yamamoto, Tomoki Makino, Yukinori Kurokawa, Kiyokazu Nakajima, Hidetoshi Eguchi, Yuichiro Doki

“…We investigated mtDNA mutations in Human esophageal squamous cell carcinoma (ESCC) cancer cell lines (TE8 and TE11) and patient samples (27 pre- and post-chemotherapy, and 96 post-chemotherapy) using next-generation sequencing. …”
Get full text

Influenza A virus hemagglutinin: from classical fusion inhibitors to proteolysis targeting chimera-based strategies in antiviral drug discovery by Francisco Javier Hermoso-Pinilla, Aitor Valdivia, María-José Camarasa, Tiziana Ginex, Francisco Javier Luque

“…The influenza virus glycoprotein hemagglutinin (HA) participates in critical steps of the attachment of viral particles to the host cell membrane receptor and membrane fusion. Due to its crucial involvement in the initial phases of influenza A infections, HA emerges as a promising target in the search of novel drug-like candidates. …”
Get full text

Progress of CCL20-CCR6 in the airways: a promising new therapeutic target by Ya -Jing Li, Wan-Li Geng, Chen-Chen Li, Jia-Hao Wu, Fei Gao, Yong Wang

“…Abstract The chemokine CCL20, a small cytokine that belongs to the C–C chemokine family, interacts with its homologous receptor CCR6, which is expressed on wide range of cell types. According to current research, the CCL20-CCR6 has been established as acritical player in a diverse range of inflammatory, oncogenic, and autoimmune diseases. …”
Get full text

Mice with NOP2/sun RNA methyltransferase 5 deficiency die before reaching puberty due to fatal kidney damage by Hongya Zhang, Xiaohui Li, Jing Bai, Cong Zhang

“…Furthermore, we found that the kidneys of Nsun5-/- mice showed increased expression of the apoptotic signal Caspase-3 and accumulated stronger DNA damage at PD 21.Conclusions In our study, we found that mice lacking NSUN5 died before puberty due to kidney fatal damage caused by DNA damage and cell apoptosis. These results suggest that NSUN5 plays a vital role in preventing the accumulation of DNA damage and cell apoptosis in the kidney.…”
Get full text

The Survivin −31 Snp in Human Colorectal Cancer Correlates with Survivin Splice Variant Expression and Improved Overall Survival by Anna G. Antonacopoulou, Konstantina Floratou, Vasiliki Bravou, Anastasia Kottorou, Fotinos-Ioannis Dimitrakopoulos, Stella Marousi, Michalis Stavropoulos, Agelos K. Koutras, Chrisoula D. Scopa, Haralabos P. Kalofonos

“…Background: Survivin is involved in the regulation of cell division and survival, two key processes in cancer. …”
Get full text

Facts about Phosphorus by Nancy J. Gal, Wendy J. Dahl

“… Phosphorus is a mineral found in every cell of the body, usually in the form of phosphate. …”
Get full text

Nonbacterial Osteitis of the Clavicle: Longitudinal Imaging Series from Initial Diagnosis to Clinical Improvement by E. Roos, M. Maas, S. J. M. Breugem, G. R. Schaap, J. A. M. Bramer

“…The differential diagnoses were sarcoma, osteitis, and Langerhans cell histiocytosis. After biopsy the diagnosis nonbacterial osteitis (NBO) was established. …”
Get full text

Gastrointestinal Stromal Tumours: Etiology, Pathology and Clinical Management by Martin E Blackstein, Pierre Dubé, Jonathan A Fletcher, Oliver R Keller, Margaret Knowling, Richard Létourneau, Donald Morris, Robert Riddell, Stewart Rorke, Carol J Swallow, Canadian Advisory Committee on GIST

“…Investigation of the regulation of cell growth, differentiation and death by signalling pathways has led to a greater understanding of how alterations in these pathways play a critical role in the development of some cancers, and has opened new opportunities for their treatment. …”
Get full text

Intercostal Nerve Block in Patient with Chronic Obstructive Pulmonary Disease: Lessons Learned by Rhythm Mathur, Bharat Paliwal, Manoj Kamal, Pradeep Kumar Bhatia

“…An elderly male with chronic obstructive pulmonary disease and undergoing chemotherapy for mediastinal metastasis of small-cell liver carcinoma developed severe postherpetic neuralgia resistant to pharmacological therapy. …”
Get full text

Investigation of Pre-Pulse Effects on Ultrashort-Pulse Laser Interaction with Structured Targets by Artem Kim, Indranuj Dey, Alexander Bespaly, Pavel Komm, Assaf Shaham, Jenya Papeer, Mordechai Botton, Arie Zigler

“…Plasma emission spectrum and Particle-in-Cell simulations provide a possible explanation of the obtained experiment results.…”
Get full text