SOCS2 inhibits the tumorigenesis of GISTs and increases the sensitivity of GISTs to imatinib by suppression of KIT activation by Liangying Zhang, Kun Xiao, Shaoting Zhang, Sien Zhao, Zimei Liu, Ming Wang, Kaiyue Qin, Yuanyuan Yu, Shujing Li, Lijun Ma, Jianmin Sun

“…Accordingly, SOCS2 inhibited GIST cell survival and proliferation in vitro. In KITV558A/WT mice, knockout of SOCS2 expression increased the tumorigenesis of GISTs and decreased the life span of the mice. …”
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Integrated electrocatalytic synthesis of ammonium nitrate from dilute NO gas on metal organic frameworks-modified gas diffusion electrodes by Donglai Pan, Muthu Austeria P, Shinbi Lee, Ho-sub Bae, Fei He, Geun Ho Gu, Wonyong Choi

“…Among various integrated-cell configurations, a single-chamber setup produces a higher NH4NO3 yield than a double-chamber setup. …”
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Effectiveness of Fibers from “Cabernet Sauvignon” (Vitis vinifera) Pomace as Fining Agents for Red Wines by Mariona Gil, Rubén Del Barrio-Galán, Cristina Úbeda, Álvaro Peña-Neira

“…Recent findings have highlighted the potential of fibers from grape cell wall material to be fining agents for red wines as alternatives to animal-derived proteins. …”
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Biocompatibility and drug release kinetics of TiNbZrSn femtosecond laser-induced superhydrophilic structures by Tahir Nawaz, Vinod Paul, Sidrah Younus, Shahbaz Ahmad, Mehmet Egilmez, Wael Abuzaid, Ganjaboy Boltaev, Noor Akbar, Mustafa Khamis, Ghaleb A. Husseini, Ali S. Alnaser

“…We also present the in vitro cell viability and biocompatibility of the alloy system. …”
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Wolfram Syndrome: A Case Report and Review of Clinical Manifestations, Genetics Pathophysiology, and Potential Therapies by N. B. Toppings, J. M. McMillan, P. Y. B. Au, O. Suchowersky, L. E. Donovan

“…Insight into the pathophysiology of WS may also inform strategies for β-cell preservation for individuals with type 1 and 2 diabetes.…”
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Identification of the Key Genes and Pathways in Esophageal Carcinoma by Peng Su, Shiwang Wen, Yuefeng Zhang, Yong Li, Yanzhao Xu, Yonggang Zhu, Huilai Lv, Fan Zhang, Mingbo Wang, Ziqiang Tian

“…The upregulated genes were significantly enriched in cell cycle and the downregulated genes significantly enriched in Endocytosis. …”
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Codeine 3-O-demethylase catalyzed biotransformation of morphinan alkaloids in Escherichia coli: site directed mutagenesis of terminal residues improves enzyme expression, stability... by Garrick W. K. Spencer, Xu Li, Kenny W. L. Lam, George Mutch, Fiona H. Fry, Sally L. Gras

“…Bioproduction of morphinan alkaloids in recombinant whole-cell systems provides a promising alternate source of these valuable compounds. …”
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Evaluating CNN Architectures and Hyperparameter Tuning for Enhanced Lung Cancer Detection Using Transfer Learning by Mohd Munazzer Ansari, Shailendra Kumar, Umair Tariq, Md Belal Bin Heyat, Faijan Akhtar, Mohd Ammar Bin Hayat, Eram Sayeed, Saba Parveen, Dustin Pomary

“…The dataset consisted of 460 × 460 × 3 pixel images categorized into squamous cell carcinoma (SCC), normal benign, large cell carcinoma (LCC), and adenocarcinoma (ADC). …”
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Exploring the Potential of SGLT-2 Inhibitors in Cancer Treatment: Mechanisms, Preclinical Findings, and Clinical Implications by Aldona Sokołowska, Klaudia Fikas, Kamil Chwaliszewski, Sebastian Samuła, Michał Mazur, Dorota Waz, Jakub Szarłowicz, Zofia Goliszek, Karolina Łucja Sobek, Wiktoria Tabin-Barczak

“…These agents have demonstrated promise in models of breast, prostate, and pancreatic cancers, reducing cell proliferation and enhancing the efficacy of standard cancer treatments. …”
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A Soft Landing Approach for the Centrifugal Microgel Synthesis Process by Badalan, Matei, Adisson, Lucie, Boldron, Arthur, Achard, Jean-Luc, Ghigliotti, Giovanni, Balarac, Guillaume, Bottausci, Frédéric

“…This represents a significant limitation of this technology, since capsule shape regularity is an important requirement for various biomedical applications (e.g. cell therapy implants, drug delivery). In this article we propose and validate experimentally an adaptation of the centrifugal microencapsulation, based on the concept of “soft landing” [1]. …”
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Combined Inositol Hexakisphosphate and Inositol Supplement Consumption Improves Serum Alpha-Amylase Activity and Hematological Parameters in Streptozotocin-Induced Type 2 Diabetic... by Shadae R. Foster, Lowell L. Dilworth, Jean Sparks, Ruby L. Alexander-Lindo, Felix O. Omoruyi

“…Combined IP6 and inositol supplement consumption may protect people with diabetes from increased risk of cardiovascular diseases due to the supplement's ability to maintain red cell distribution width percentage towards the normal control group.…”
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Fluorinated molecular diamond improved polymer electrolytes enable stable cycling with high capacity of all-solid-state lithium-metal batteries by Mengbing Zhuang, Yuan Liao, Junshuai Liang, Yixiao Deng, Jin-Cheng Zheng, Hao Yan, Tinglu Song, Yang Dai

“…Importantly, the 1-Fluoroadamantane mediates the generation of LiF in the interfaces, which fosters the interfacial stability, contributing to the long-term cycling. Hence, the symmetric cell (Li/Li) exhibits a long-term lithium plating/stripping for over 2,400 h. …”
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Hemorheological Alterations in Patients with Heart Failure with Reduced Ejection Fraction Treated by Resveratrol by Roland Gal, Dora Praksch, Peter Kenyeres, Miklos Rabai, Kalman Toth, Robert Halmosi, Tamas Habon

“…However, significant improvement of red blood cell aggregation was observed in the resveratrol group compared to baseline after 3 months. …”
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March1 E3 Ubiquitin Ligase Modulates Features of Allergic Asthma in an Ovalbumin-Induced Mouse Model of Lung Inflammation by Osama A. Kishta, Antoine Sabourin, Leora Simon, Toby McGovern, Maxime Raymond, Tristan Galbas, Abdelilah Majdoubi, Satoshi Ishido, James G. Martin, Jacques Thibodeau

“…Membrane-associated RING-CH-1 (March1) is a member of the March family of E3 ubiquitin ligases. March1 downregulates cell surface expression of MHC II and CD86 by targeting them to lysosomal degradation. …”
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Transcriptomic analysis reinforces the implication of spatacsin in neuroinflammation and neurodevelopment by Liriopé Toupenet Marchesi, Daniel Stockholm, Typhaine Esteves, Marion Leblanc, Nicolas Auger, Julien Branchu, Khalid Hamid El Hachimi, Giovanni Stevanin

“…Notably, we also observed early deregulation in cellular pathways related to cell proliferation. Our results represent a significant step towards a better understanding of the functions of spatacsin in the cell and the underlying cellular mechanisms disrupted by its absence.…”
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The Fractal Dimension of Nuclear Chromatin as a Prognostic Factor in Acute Precursor B Lymphoblastic Leukemia by Randall L. Adam, Rosana C. Silva, Fernanda G. Pereira, Neucimar J. Leite, Irene Lorand-Metze, Konradin Metze

“…The fractal nature of the DNA arrangement has been postulated to be a common feature of all cell nuclei. We investigated the prognostic importance of the fractal dimension (FD) of chromatin in blasts of patients with acute precursor B lymphoblastic leukemia (B-ALL). …”
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Microwave Synthesis, Spectral, Thermal and Antimicrobial Studies of Some Co(II), Ni(II) and Cu(II) Complexes Containing 2-Aminothiazole Moiety by A. P. Mishra, H. Purwar, Rajendra K. Jain, S. K. Gupta

“…The crystal system, lattice parameter, unit cell volume and number of molecules in unit cell in the lattice of complexes have been determined by XRD analysis. …”
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Alloreactivity-Based Medical Conditions by Stanislav Vukmanovic, Margaret G. Petroff, Anne M. Stevens, Daniel Rukavina

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Editorial: Metaflammation in obesity and diabetes by Suprabhat Mukherjee, Rakesh Kundu, Melita Vidaković

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Disclosing the Complexities of Childhood Neurodevelopmental Disorders by Luigi Tarani, Marco Fiore

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