Effectiveness and safety of PD-1/L1 inhibitors as first-line therapy for patients with advanced or metastatic urothelial carcinoma who are ineligible for platinum-based chemotherap... by Weiming Liang, Weiming Liang, Zhijing Wang, Zhilong Huang, Yanping Huang, Chunyan Li, Yiwen Liang, Miaoyan Huang, Duo Zhang, Chenchen Li

“…ObjectiveTo evaluate the efficacy and safety of programmed cell death protein 1 or its ligand (PD-1/L1) inhibitors as first-line therapy in advanced or metastatic urothelial carcinoma (mUC) who are ineligible for platinum-based chemotherapy.MethodA systematic search was conducted in four databases (Pubmed, Embase, Web of Science, and the Cochrane Library) to find articles that evaluate the effectiveness of first-line PD-1/L1 inhibitors for mUC, from the establishment of the databases to 22 November 2023. …”
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Development of an in vitro model to study muscle maladaptation to overtraining by Giuseppe Sirago, Clément Lanfranchi, Justin Carrard, Vincent Gremeaux, Nadège Zanou, Nicolas Place

“…., 2021), we electrically stimulated C2C12 myotubes (a mouse skeletal muscle cell line) to simulate endurance exercise (Zanou et al., 2021). …”
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The Effect of Wheat Residues and Vermicompost on the Quality Characteristics of Corn (Zea mays L.) Forage and Soil Fertility by Hasanali Pooresmaeil, Mehdi Dahmradeh, Ahmad Ghanbari

“…Acid detergent fiber (ADF) cell wall contribution includes cellulose and lignin, and dry matter digestibility (DMD) were measured in corn plants. …”
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Psychometric properties and meaningful change thresholds for the QOL-E instrument in patients with myelodysplastic neoplasms by Esther Natalie Oliva, Shien Guo, Jennifer Lord-Bessen, Aylin Yucel, Roberto Latagliata, Massimo Breccia, Giuseppe A. Palumbo, Grazia Sanpaolo, Marta Riva, Valeria Santini, Uwe Platzbecker, Guillermo Garcia-Manero, Pierre Fenaux, Christopher G. Pelligra

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Development and validation of a hyperlipidemia risk prediction model for middle-aged and older adult Chinese using 2015 CHARLS data by Li-xiang Zhang, Shan-Bing Hou, Fang-fang Zhao, Ting-ting Wang, Ying Jiang, Xiao-juan Zhou, Jiao-yu Cao

“…The LASSO regression and multivariate Logistic regression analysis all revealed that Body Mass Index (BMI), fasting blood glucose, serum uric acid, C-reactive protein, and white blood cell count were independent risk factors for hyperlipidemia in this demographic (with Odds Ratios (OR) greater than 1 and p-values less than 0.05). …”
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Risk Factors for Gastrointestinal Bleeding in Patients With Acute Myocardial Infarction: Multicenter Retrospective Cohort Study by Yanqi Kou, Shicai Ye, Yuan Tian, Ke Yang, Ling Qin, Zhe Huang, Botao Luo, Yanping Ha, Liping Zhan, Ruyin Ye, Yujie Huang, Qing Zhang, Kun He, Mouji Liang, Jieming Zheng, Haoyuan Huang, Chunyi Wu, Lei Ge, Yuping Yang

“…Key predictors included red blood cell count, hemoglobin, maximal myoglobin, hematocrit, CHD, and other variables, all of which were strongly associated with GIB risk. …”
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Hubungan Kadar FT4 dan TSH Serum dengan Profil Lipid Darah pada Pasien Hipertiroid yang Dirawat Inap di RSUP Dr. M. Djamil Padang Tahun 2009 - 2013 by Aga Pratama, Eti Yerizel, Rudy Afriant

“…It has spesific effects on cell metabolism, including lipid metabolism.L ipid metabolism disorder in hyperthyroid will inflict clinical manifestation; such as mood disorders, depression, and increased aggressive behavior. …”
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The interaction of tPA with NMDAR1 drives neuroinflammation and neurodegeneration in α-synuclein-mediated neurotoxicity by Daniel Torrente, Enming J. Su, Alí Francisco Citalán-Madrid, Gerald P. Schielke, Daniel Magaoay, Mark Warnock, Tamara Stevenson, Kris Mann, Flavie Lesept, Nathalie Delétage, Manuel Blanc, Erin H. Norris, Denis Vivien, Daniel A. Lawrence

“…Importantly, tPA deficiency protects DA-neurons from degeneration, prevents behavioral deficits, and reduces microglia activation and T-cell infiltration induced by α-synuclein overexpression. …”
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Association of ambient air pollutants with blood physiological and biochemical indicators and systemic immune inflammation index in people living around Beijing: an analysis of air... by Bingqian DU, Zhiqiang REN, Peian CHEN, Zhenjun LI

“…ResultsSpearman correlation analysis showed that the concentrations of particulate matter with an aerodynamic diameter of less than 2.5 μm (PM2.5) and carbon monoxide (CO) were positively correlated with monocyte count (MO#), eosinophil count (EOS#), and red blood cell distribution width standard deviation (RDW-SD), and negatively correlated with mean corpuscular hemoglobin concentration (MCHC) and platelet crit (PCT) (all P < 0.05). …”
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Ecologie alimentaire des bonobos en mosaïque forêt-savane : aliments de base et aliments de réserve by Victor Narat, Flora Pennec, Jean Christophe Bokika Ngawolo, Sabrina Krief

“…En comparant notre liste alimentaire avec celles publiées dans les autres sites d’études, il apparaît que Manzano est le site avec la plus grande diversité de familles botaniques consommées par les bonobos. …”
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Inhalation d'aérosols liquides ou solides chez les Primates Non Humains by Jérôme Montharu, Chrystophe Aubert, Georges Roseau, Laurent Vecellio, Antoine Guillon, Michèle de Monte

“…La procédure est très proche de celle mise en œuvre lors d'une séance d'aérosolthérapie humaine ; elle est donc tout à fait pertinente pour réaliser des études de dépôt afin de prédire la distribution pulmonaire d'un médicament nébulisé dans un modèle pédiatrique. …”
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Comment prendre en compte les mobilités saisonnières du bétail dans l’estimation de la charge animale d’un territoire sud-sahélien ? by Yanoussa Yakoubou Alzouma, Pierre Hiernaux, Mahamane Larwanou, Maguette Kaire, Issa Garba, Amadou Adamou Kalilou, Sambo Bode, Mahaman Maaouia Abdou Moussa, Harouna Abdou Bawa

“…Conclusions : les estimations des besoins fourragers saisonniers seront confrontées à celles d’ingestion fourragère faites à partir de l’analyse des échantillons de fèces prélevés selon les saisons. …”
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Effect of different photoperiods on growth indices of female sterlet sturgeon, Acipenser ruthenus by Bahman Meknatkhah, Masoud Sattari, Bahram Falahatkar, Samaneh Poursaeid

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Detection of fusion events by RNA sequencing in FFPE versus freshly frozen colorectal cancer tissue samples by Maxim Sorokin, Maxim Sorokin, Maxim Sorokin, Maxim Sorokin, Vladimir Lyadov, Vladimir Lyadov, Vladimir Lyadov, Maria Suntsova, Marat Garipov, Anna Semenova, Natalia Popova, Egor Guguchkin, Rustam Heydarov, Marianna Zolotovskaia, Xiaowen Zhao, Qing Yan, Ye Wang, Evgeny Karpulevich, Anton Buzdin, Anton Buzdin, Anton Buzdin, Anton Buzdin

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Bi-allelic variants in WDR47 cause a complex neurodevelopmental syndrome by Efil Bayam, Peggy Tilly, Stephan C Collins, José Rivera Alvarez, Meghna Kannan, Lucile Tonneau, Elena Brivio, Bruno Rinaldi, Romain Lecat, Noémie Schwaller, Ludovica Cotellessa, Sateesh Maddirevula, Fabiola Monteiro, Carlos M Guardia, João Paulo Kitajima, Fernando Kok, Mitsuhiro Kato, Ahlam A A Hamed, Mustafa A Salih, Saeed Al Tala, Mais O Hashem, Hiroko Tada, Hirotomo Saitsu, Mariano Stabile, Paolo Giacobini, Sylvie Friant, Zafer Yüksel, Mitsuko Nakashima, Fowzan S Alkuraya, Binnaz Yalcin, Juliette D Godin

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Disponibilité spatiale et temporelle des espèces alimentaires des chimpanzés et variations de densité inter-communautés dans le Parc national de Kibale (Ouganda) by Sarah Bortolamiol, Marianne Cohen, Protase Rwaburindore, John Kasenene, Andrew Seguya, Flora Pennec, Quentin Vignaud, Sabrina Krief

“…Bien que les variations temporelles de la fructification des espèces alimentaires de la communauté de chimpanzés de Sebitoli diffèrent des deux autres sites d’étude (rôle des activités anthropiques passées et présentes), elles sont sensiblement plus similaires de celles de Kanyawara que de Ngogo. Les interactions spatiales entre les éléments anthropiques et les animaux sauvages, le maintien d’espaces de surface suffisante pour assurer les migrations entre les communautés ainsi que d’autres variables environnementales sont des facteurs non mis en évidence ici qui ont rôle dans la conservation et la distribution des chimpanzés.…”
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Phase I clinical trial testing the dose escalation and expansion of Pressurized IntraThoracic Hyperthermic Aerosol Cisplatin administration (PITHAC) for the management of pleural c... by Louis-Emmanuel Chriqui, Etienne Abdelnour-Berchtold, Edoardo Zanfrini, Severine Devesa-Perez, Michel Gonzalez, Thorsten Krueger, Kim Ellefsen, Alice Destaillats, David Bonnet, Martin Hübner, Hasna Bouchaab, Michal Bassani-Sternberg, Solange Peters, Sabrina Cavin, Jean Y Perentes

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Reconnaissance des indices attentionnels humains par le babouin olive (Papio anubis) by Marie Bourjade, Adrien Meguerditchian, Florence Gaunet

“…Toutefois, la reconnaissance des indices posturaux d’attention intra- ou interspécifiques, celle-là même qui détermine cette flexibilité communicationnelle, peut provenir d’apprentissages sociaux dont les mécanismes restent méconnus. …”
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Harnessing new mHealth technologies to Strengthen the Management of Multidrug-Resistant Tuberculosis in Vietnam (V-SMART trial): a protocol for a randomised controlled trial by Ben J Marais, Joel Negin, James Johnston, Virginia Wiseman, Greg J Fox, Thu Anh Nguyen, Binh Hoa Nguyen, Viet Nhung Nguyen, Justin Beardsley, Guy Barrington Marks, Kavindhran Velen, Tho Dang, Hoang Anh Nguyen, Dinh Hoa Vu, Thu Thuong Do, Cuong Pham Duc, Huu Lan Nguyen, Huu Thuong Pham, Warwick Britton

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Phase I study of pembrolizumab in combination with ibrutinib for the treatment of unresectable or metastatic melanoma by Yuan Yao, Yiyi Yan, Vera J. Suman, Allan B. Dietz, Courtney L. Erskine, Anastasios Dimou, Svetomir N. Markovic, Svetomir N. Markovic, Robert R. McWilliams, Heather N. Montane, Matthew S. Block, Matthew S. Block

“…The small molecule ibrutinib is a dual-target agent that inhibits Bruton’s Tyrosine Kinase (BTK) and Interleukin-2-inducible T-cell Kinase (ITK), a key regulator of Th2 immunity. …”
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