Gliadin encapsulated PCOs nanoformulation: An effective therapeutic option for metastatic breast cancer by Sant Lal, Monika Kataria, Neeraj Dilbaghi

“…These findings highlight the potent anticancer activity of PCOs–NF against key cell lines involved in breast cancer metastasis to the lungs and brain. …”
Get full text

Chronic Inflammation as a Link between Periodontitis and Carcinogenesis by Anilei Hoare, Cristopher Soto, Victoria Rojas-Celis, Denisse Bravo

“…In addition, it has been shown that several periodontitis-associated species induce the expression of genes related to cell proliferation, cell cycle, apoptosis, transport, and immune and inflammatory responses. …”
Get full text

CSE-8, a filamentous fungus-specific Shr3-like chaperone, facilitates endoplasmic reticulum exit of chitin synthase CHS-3 (class I) in Neurospora crassa by Samantha Verónica González-Téllez, Meritxell Riquelme

“…Chitin is a crucial structural polysaccharide in fungal cell walls, essential for maintaining cellular plasticity and integrity. …”
Get full text

Bone Response to Surface-Modified Titanium Implants: Studies on the Early Tissue Response to Implants with Different Surface Characteristics by C. Larsson Wexell, P. Thomsen, B.-O. Aronsson, P. Tengvall, M. Rodahl, J. Lausmaa, B. Kasemo, L. E. Ericson

Get full text

GC-MS Profiling and Therapeutic Potentials of Prosopis juliflora (Sw.) DC: Cytotoxic and Antimicrobial Insights by Asaad Khalid, Eltuhami A. Abdalgadir, Iman K. Abdel Gadir, Ashraf N. Abdalla, Husham E. Homeida, Shahnaz Sultana, Zia ur Rehman, Rym Hassani, Ahmed Shaher Alqahtani, Hassan A. Alhazmi

“…The plant extract exhibited the highest level of activity (5.75 μg/mL) against the A2780 cell line, with the MCF-7 cell line showing a somewhat lower level of activity (18.49 μg/mL). …”
Get full text

A study on processes of some haematological parameters in growing male and female japanese quails (coturnix coturnix japonica) by Ercan Keskin, Zafer Durgun, Mehmet Kocabatmaz

“…The RBC was significantly higher in males (3 65x 10⁶) than females (3 28x 10⁶) at 8 week of age (P<0,05), The white blood cell (WBC) and thrombocyte counts did not show evidently changes, whereas WBC in females (24-28x 10³) were found slightly higher than males (21-26 x 10³) at all weeks, in the percentage of leucocyte types were not determined any differences between sexes during eight weeks and the lymphocyte percentages (57-70%) were drastically higher than heterophils (24-36%) in both groups There was no differences between sexes in respect to the blood cell sizes where as RBC sizes were bigger in females than males at either 1 st and 8 th weeks. …”
Get full text

Coupling of alternative splicing and alternative polyadenylation by Zhang Xueying, Liu Feiyan, Zhou Yu

Get full text

Pre-probiotic effects of different bacterial species in aquaculture: behavioral, hematological and oxidative stress responses by Alak Gonca, Kotan Recep, Uçar Arzu, Parlak Veysel, Atamanalp Muhammed

“…Physiological changes in blood tissue [hematological indices: erythrocyte count (RBC), leukocyte count (WBC), hemoglobin (Hb), hematocrit (Hct), platelet count (PLT), mean cell hemoglobin concentration (MCHC), mean cell hemoglobin (MCH), and mean cell volume (MCV)], oxidative stress responses in liver and gill tissues [malondialdehyde (MDA) level, antioxidant enzyme activities: superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), glutathione reductase (GR), glutathione-S-transferase (GST), glucose-6-phosphate dehydrogenase (G6PD)] and acetylcholinesterase (AChE) activity in brain tissue (as neurotoxic biomarker) were investigated. …”
Get full text

Gene Expression Profiling in Dermatitis Herpetiformis Skin Lesions by M. Dolcino, E. Cozzani, S. Riva, A. Parodi, E. Tinazzi, C. Lunardi, A. Puccetti

“…Consistently with the autoimmune origin of DH, functional classification of the differentially expressed genes (DEGs) indicates a B- and T-cell immune response (LAG3, TRAF5, DPP4, and NT5E). …”
Get full text

Mitigating Mercury Chloride-Induced Spleen Toxicity in Wistar Rats: The Efficacy of Newbouldia laevis Ethanol Extract by Calmday-Ombo D, Innih SO

“…Histologically, mercury chloride induced splenic necrosis and follicular hypertrophy, whereas the extract showed no effect on the follicle but caused red cell sequestration. Conclusion: Combined treatments displayed varying effects, with a low extract dose and mercury chloride showing a normal follicle but increased red cell sequestration. …”
Get full text

Optical Imaging of Integrin αβ Expression with Near-Infrared Fluorescent RGD Dimer with Tetra(ethylene glycol) Linkers by Zhaofei Liu, Shuanglong Liu, Gang Niu, Fan Wang, Shuang Liu, Xiaoyuan Chen

“…Fluorescent dye–labeled E[PEG 4 -c(RGDfK)] 2 were subjected to in vitro cell staining, in vivo NIRF imaging, ex vivo NIRF imaging, and histologic studies. …”
Get full text

Severe Plasmodium falciparum malaria is associated with circulating ultra-large von Willebrand multimers and ADAMTS13 inhibition. by Deirdre Larkin, Bas de Laat, P Vince Jenkins, James Bunn, Alister G Craig, Virginie Terraube, Roger J S Preston, Cynthia Donkor, George E Grau, Jan A van Mourik, James S O'Donnell

“…Plasmodium falciparum infection results in adhesion of infected erythrocytes to blood vessel endothelium, and acute endothelial cell activation, together with sequestration of platelets and leucocytes. …”
Get full text

Development and Evaluation of Polymethacrylate-Based Ophthalmic Nanofiber Inserts Containing Dual Drug-Loaded Dorzolamide and Timolol: In Vivo Study in Rabbit’s Eye by Ahmad Karami, Shahla Mirzaeei, Leila Rezaei, Ali Nokhodchi

“…Morphological examination demonstrated uniform nanofibers with mean diameters < 465 nm. The cell compatibility test showed a high percentage of cell survival, and none of the formulations irritated the rabbit’s eye. …”
Get full text

Effect of Black Cumin on the Expression of Genes Related to Lipid Metabolism in Adipose Tissue: A Mouse Model Study by Roya Maleki, Ali Ahadi, Hoda Ayat

“…Finally, GraphPad prisim 9.0 was applied to statistically evaluate the cell size difference and gene expression changes. …”
Get full text

Hijacking of the nervous system in cancer: mechanism and therapeutic targets by Yu Zhang, Qili Liao, Xuyang Wen, Jiayan Fan, Tifei Yuan, Xuemei Tong, Renbing Jia, Peiwei Chai, Xianqun Fan

“…Abstract The activity of neurons in the vicinity of tumors is linked to a spectrum of cellular mechanisms, including the facilitation of tumor cell proliferation, synapse formation, angiogenesis, and macrophage polarization. …”
Get full text

Molecular subtype of gastric cancer based on apoptosis-related genes reveals differential immune microenvironment and intratumoral microorganisms distribution by Xuan Yu, Yongfu Shao, Haotian Dong, Jianing Yan, Xinjun Zhang, Guoliang Ye

“…Furthermore, PCR assays validated that these three key genes exhibited significantly low expression levels in both GC cell lines and tissues. Finally, knocking down key genes expression significantly promoted cell proliferation, colony formation and invasion of GC. …”
Get full text

PPIH is a novel diagnostic biomarker associated with immune infiltration in cholangiocarcinoma by Jun Ye, Zhitao Chen, Chuan Zhang, Rui Xie, Haini Chen, Peng Ren

“…Moreover, PPIH may influence tumor progression through its involvement in cell cycle regulation and spliceosome pathways, and is associated with immune cell infiltration levels. …”
Get full text

The Role of Quercetin, a Flavonoid in the Management of Pathogenesis Through Regulation of Oxidative Stress, Inflammation, and Biological Activities by Hajed Obaid A. Alharbi, Mohammad Alshebremi, Ali Yousif Babiker, Arshad Husain Rahmani

“…Additionally, numerous in vitro and in vivo studies have shown that quercetin’s efficacies in cancer management involve inhibiting cell signaling pathways, such as inflammation, cell cycle, and angiogenesis, activating cell signaling pathways including tumor suppressor genes, and inducing apoptosis. …”
Get full text

Suppression of Aldosterone Synthesis and Secretion by Channel Antagonists by Keiichi Ikeda, Tsuyoshi Isaka, Kouki Fujioka, Yoshinobu Manome, Katsuyoshi Tojo

Get full text

Prophage-DB: a comprehensive database to explore diversity, distribution, and ecology of prophages by Etan Dieppa-Colón, Cody Martin, James C. Kosmopoulos, Karthik Anantharaman

“…Temperate phages adopt the lysogenic mode of infection, where the genome integrates into the host cell genome forming a prophage. Prophages enable viral genome replication without host cell lysis, and often contribute novel and beneficial traits to the host genome. …”
Get full text