Associations of serum and tissue TIMP1 with host response and survival in colorectal cancer by Akseli Kehusmaa, Anne Tuomisto, Päivi Sirniö, Henna Karjalainen, Meeri Kastinen, Vilja V. Tapiainen, Ville K. Äijälä, Taina Tervahartiala, Timo Sorsa, Jukka Rintala, Sanna Meriläinen, Juha Saarnio, Tero Rautio, Markus J. Mäkinen, Juha P. Väyrynen

“…TIMP1 immunohistochemistry and TIMP1 serum concentrations were analyzed in a cohort of 776 colorectal cancer patients. TIMP1 histoscore by cell type (tumor cell, other) was quantified using digital image analysis. …”
Get full text

BMP6, a potential biomarker of inflammatory fibrosis and promising protective factor for dilated cardiomyopathy by Feng Jiang, Jiayang Tang, Xiaoqi Wei, Hai Pan, Xinyi Fan, Peng Zhang, Shuzhen Guo

“…Results We found that DCM hearts exhibit pronounced inflammatory cell infiltration and fibrosis. Both bulk RNA-seq and single-cell RNA-seq analyses revealed aberrant BMP6 expression specifically in fibroblasts. …”
Get full text

Development of a colloidal gold immunochromatographic assay utilizing dual-antibody sandwich method for detecting Orientia tsutsugamushi by Qingyu Lu, Shiyin Yu, Sibo Wang, Min Cao, Liuxin Li, Miao Xin, Weilong Tan, Yong Qi, Yichen Lu, Xiaohui Xiong

“…Furthermore, a detection limit of 1 × 106 copies/μL DNA of O. tsutsugamushi was determined for both PT and SJ infected cell strains by constructing a relationship between cell number and copy number of the pathogen using a quantitative PCR-based standard curve. …”
Get full text

Alternative Expression Pattern of MALT1-A20-NF-κB in Patients with Rheumatoid Arthritis by Xu Wang, Lihua Zhu, Ziwei Liao, Fan Zhang, Ling Xu, Yan Xu, Shaohua Chen, Lijian Yang, Yi Zhou, Yangqiu Li

“…Rheumatoid arthritis (RA) is an inflammatory autoimmune disorder; abnormal T cell immunity plays a critical role in the development of RA. …”
Get full text

Perfluorooctane sulfonate (PFOS) induced bone loss by inhibiting FoxO1-mediated defense against oxidative stress in osteoblast by Liming Xue, Jiale Xu, Ping Xiao, Yiping Jiang, Yuanjie Lin, Chao Feng, Yu’e Jin, Zhijun Zhou, Guoquan Wang, Dasheng Lu

“…Our research is aimed at examining the effects of PFOS on osteoblastic activity and investigating the toxicological mechanisms of PFOS-induced bone loss. Cell proliferation, ALP activity, bone nodule formation, ROS levels, and cell apoptosis were assessed after treating osteoblasts with different concentrations of PFOS. …”
Get full text

Comparative Transcriptome Analysis Reveals Molecular Defensive Mechanism of Arachis hypogaea in Response to Salt Stress by Hao Zhang, Xiaobo Zhao, Quanxi Sun, Caixia Yan, Juan Wang, Cuiling Yuan, Chunjuan Li, Shihua Shan, Fengzhen Liu

“…Further, GO categories of the DEGs highly related to regulation of cell growth, cell periphery, sustained external encapsulating structure, cell wall organization or biogenesis, antioxidant activity, and peroxidase activity were significantly enriched for upregulated DEGs. …”
Get full text

Novel Synthesis of Polyimide Foams with Aromatic and 1,6-Diaminohexane Imide Bonding by Dong-Sen Chen, Chun-Hua Chen, Wha-Tzong Whang, Chun-Wei Su

“…The obtained PIFs containing various HMDA contents (0 to 20 mol%) exhibited different morphologies such as lowered density and larger cell diameter (with higher HMDA content), and open cell ratio was increased as well. …”
Get full text

Application of the Support Vector Machine to Predict Subclinical Mastitis in Dairy Cattle by Nazira Mammadova, İsmail Keskin

“…The output variable was somatic cell counts obtained from milk samples collected monthly throughout the 15 months of the control period. …”
Get full text

An Approach to Modeling the Impact of Traffic Incident on Urban Expressway by Yaping Li, Jian Lu, HongWu Li, Huihui Xiao, Qingchao Liu

“…Regarding the location of traffic incident, the method of cell restructuring settings was discussed. We then proceed to introduce a new concept of the effected length in a given time period as the evaluation indicator to directly depict the influence of traffic incident. …”
Get full text

Immunomodulatory role of phagocyte-derived chloramines involving lymphocyte glutathione by Véronique Witko-Sarsat, Anh Thu Nguyen, Béatrice Descamps-Latscha

“…This study shows that human lymphocytes markedly decrease chloramines (long-lived oxidants) generated by polymorphonuclear neutrophils (PMN) after stimulation by phorbol-myristate-acetate or opsonized zymosan. In a cell-free model, reduced glutathione (GSH) scavenged chloramines, giving rise to oxidized glutathione (GSSG). …”
Get full text

Synthesis and Biological Evaluation of New (−)-Gossypol-Derived Schiff Bases and Hydrazones by Vu Van Vu, Trinh Thi Nhung, Nguyen Thi Thanh, Luu Van Chinh, Vu Dinh Tien, Vu Thu Thuy, Do Thi Thao, Nguyen Hai Nam, Angela Koeckritz, Tran Khac Vu

“…Bioassays showed that several compounds exhibited cytotoxic effects against three human cancer cell lines. Compound 8a showed the greatest cytotoxic effect against hepatocellular carcinoma (HepG2), lung carcinoma (LU-1), and breast cancer (MCF-7) cell lines with IC50 values of 20.93, 13.58, and 9.40 μM, respectively. …”
Get full text

Implementation of an Innovative Method to Design Reflectarray Antennas by Abdelhamid Tayebi, Josefa Gómez, Iván González, Felipe Cátedra

“…The developed approach automatically generates the geometrical model of reflectarray antennas taking into account some input parameters, such as, the unit cell type and dimensions, frequency, focal length, periodicity, dielectric materials, and desired main beam radiating direction. …”
Get full text

Purpuric pityriasis rosea in patients with anorexia nervosa by Giulia Ciccarese, Antonio Guadagno, Astrid Herzum, Valentina Amicarelli, Francesco Drago

“…So far, no cases of PR in AN patients have been reported in the literature. In AN, impaired cell-mediated immunity may favor the endogenous systemic reactivation of HHV- 6 and/or HHV-7, causing PR. …”
Get full text

Chemical Composition and Mechanism of Vibriocidal Action of Essential Oil from Resin of Protium heptaphyllum by Josiane Lima Mendes, Thiago Ferreira de Araújo, Mário Geraldo de Carvalho, Francisco Eduardo Aragão Catunda Júnior, Renata Albuquerque Costa

“…Biofilm biomass inhibition and biomass reduction of the preformed biofilm were detected at 4 mg/mL EOPH concentration. The assays of cell constituent release and membrane permeability indicated that EOPH may disrupt the cell membrane, leading to leakage of intracellular constituent as reducing sugars and materials with an absorbance of 260 nm.…”
Get full text

The Impact of Zinc Oxide Nanoparticles on Cytotoxicity, Genotoxicity, and miRNA Expression in Barley (Hordeum vulgare L.) Seedlings by Ilona Plaksenkova, Inese Kokina, Anastasija Petrova, Marija Jermaļonoka, Vjačeslavs Gerbreders, Marina Krasovska

“…The objective of this study was to examine the impact of different concentrations of zinc oxide nanoparticles on barley Hordeum vulgare L. seed germination, seedling morphology, root cell viability, stress level, genotoxicity, and expression of miRNAs. …”
Get full text

Gelatin Nanoemulsion-Based Co-Delivery of Terbinafine and Essential Oils for Treatment of <i>Candida albicans</i> Biofilms by Muhammad Aamir Hassan, Sadaf Noor, Jungmi Park, Ahmed Nabawy, Maitri Dedhiya, Robin Patel, Vincent M. Rotello

“…Eugenol and methyl eugenol/terbinafine T-GNEs had an additive efficacy, while carvacrol (CT-GNE) worked synergistically with terbinafine, providing effective antifungal treatment with minimal mammalian cell toxicity. Confocal microscopy demonstrated that CT-GNE penetrated the dense <i>C. albicans</i> biofilm and disrupted the fungal cell membrane. …”
Get full text

Crystal Structures of Tcl1 Family Oncoproteins and Their Conserved Surface Features by John M. Petock, Ivan Y. Torshin, Yuan-Fang Wang, Garrett C. Du Bois, Carlo M. Croce, Robert W. Harrison, Irene T. Weber

“…Members of the TCL1 family of oncogenes are abnormally expressed in mature T-cell leukemias and B-cell lymphomas. The proteins are involved in the coactivation of protein kinase B (Akt/PKB), a key intracellular kinase. …”
Get full text

RNA diagnostics and therapeutics: a comprehensive review by Adeela Fathima Saju, Aditi Mukundan, Divyashree MS, Raghu Chandrashekhar, Archana Mahadev Rao

“…RNA-based techniques also have close to no risk of genotoxicity and can efficiently target undruggable regions of the cell. RNA treatments have effectively shown the future of the medical industry in the past couple of decades, and they will only be seen to improve. …”
Get full text

Characteristics of Suppressor Macrophages Induced by Mycobacterial and Protozoal Infections in relation to Alternatively Activated M2 Macrophages by Haruaki Tomioka, Yutaka Tatano, Win Win Maw, Chiaki Sano, Yuichi Kanehiro, Toshiaki Shimizu

“…In the advanced stages of mycobacterial infections, host immune systems tend to change from a Th1-type to Th2-type immune response, resulting in the abrogation of Th1 cell- and macrophage-mediated antimicrobial host protective immunity. …”
Get full text

DNA methylation: a cause and consequence of type 2 diabetes by Mirang Kim

“…DNA methylation is a relatively stable epigenetic modification that can regulate and stabilize gene expression patterns and hence establish cell identity. Because metabolic intermediates are key factors of DNA methylation and demethylation, perturbations in metabolic homeostasis can trigger alterations in cell-specific patterns of DNA methylation and contribute to disease development, including type 2 diabetes (T2D). …”
Get full text