Effects of using different levels of dietary chitosan on some immune indices and antioxidant defense system in Vannamei shrimp, Litopenaeus vannamei by Saeed Dayani, Valiallah Jafari, Roghayeh Safari, Seyed Hossein Hoseinifar

“…For this purpose, diets supplemented with feed additives have won the interest of researchers who are concerned with the aquaculture field, the most important of which is chitosan, a cationic biopolymer, derived from the alkaline deacetylation of chitin; a natural polymer found in the exoskeletons of insects, crustaceans and fungal cell walls. Therefore, the purpose of this study was to examine the effects of using dietary chitosan in some immune indices and antioxidant defence system in Vannamei shrimp, Litopenaeus vannamei. …”
Get full text

Genetic diversity of VIR Raphanus sativus L. collections on aluminum tolerance by A. B. Kurina, I. A. Kosareva, A. M. Artemyeva

“…The accumulation of aluminum in root tissues disrupts the processes of cell division, initiation and growth of the lateral roots, the supply of plants with minerals and water. …”
Get full text

Preserved Expression of Skin Neurotrophic Factors in Advanced Diabetic Neuropathy Does Not Lead to Neural Regeneration despite Pancreas and Kidney Transplantation by František Saudek, Monika Cahová, Terezie Havrdová, Klára Zacharovová, Helena Daňková, Luděk Voska, Věra Lánská, Nurcan Üçeyler, Claudia Sommer

“…Compared to DM and HC groups, we found a significantly higher (p < 0.05–0.001) expression of NGF (nerve growth factor), NGFR (NGF receptor), NTRK1 (neurotrophic receptor tyrosine kinase 1), GDNF (glial cell-derived neurotrophic factor), GFRA1 (GDNF family receptor alpha 1), and GFAP (glial fibrillary acidic protein) in both transplant groups (Tx1 and Tx2). …”
Get full text

Molecular Docking Appraisal of Phytochemicals as Potential Inhibitors of PI3K/Akt Pathway for Breast Cancer Treatment by Magdalene Eno Effiong, Mercy Bella-Omunagbe, Israel Sunmola Afolabi, Shalom Nwodo Chinedu

“…Phosphoinositide 3-kinase, phosphatase and tensin homolog (PTEN), mTOR, Akt, 3-phosphoinositide-dependent kinase 1 (PDK1), FoxO1, glycogen synthase kinase 3 (GSK-3), mouse double minute 2 (MDM2), H-Ras, and proapoptotic B-cell lymphoma 2 (BCL-2) family protein (BAD) proteins are key drivers of this pathway and potential therapeutic targets. …”
Get full text

Health-Related Quality of Life, Treatment Satisfaction, Adherence and Persistence in β-Thalassemia and Myelodysplastic Syndrome Patients with Iron Overload Receiving Deferasirox: R... by John Porter, Donald K. Bowden, Marina Economou, Jacques Troncy, Arnold Ganser, Dany Habr, Nicolas Martin, Adam Gater, Diana Rofail, Linda Abetz-Webb, Helen Lau, Maria Domenica Cappellini

Get full text

A Nanoparticle Comprising the Receptor-Binding Domains of Norovirus and <i>Plasmodium</i> as a Combination Vaccine Candidate by Ming Xia, Pengwei Huang, Frank S. Vago, Wen Jiang, Xi Jiang, Ming Tan

“…The protruding (P) domain of norovirus VP1 and the αTSR domain of the circumsporozoite protein (CSP) of <i>Plasmodium</i> sporozoite are the glycan receptor-binding domains of the two pathogens for host cell attachment, making them excellent targets for vaccine development. …”
Get full text

Relationship of monocyte to high-density lipoprotein ratio (MHR) and other inflammatory biomarkers with sarcopenia: a population-based study by Zhiwei Xue, Jian Cao, Jianhui Mou, Rui Wang, Peng Liu

“…Abstract Objectives In previous studies, several inflammatory biomarkers derived from complete blood cell counts (CBC), such as systemic immune inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), and non‑high‑density lipoprotein cholesterol to high‑density lipoprotein cholesterol ratio (NHHR) have been identified as predictors of sarcopenia. …”
Get full text

Risk factors and machine learning prediction models for intrahepatic cholestasis of pregnancy by Yingchun Ren, Xiaoying Shan, Gengchao Ding, Ling Ai, Weiying Zhu, Ying Ding, Fuzhou Yu, Yun Chen, Beijiao Wu

“…Through univariable and lasso regression analysis, total bile acid, gamma-glutamyl transferase, multiple pregnancy, lymphocyte percentage, hematocrit, neutrophil percentage, prothrombin time, Aspartate aminotransferase, red blood cell count, lymphocyte count and platelet count were identified as risk factors of ICP. …”
Get full text

Comprehensive computational analysis of differentially expressed miRNAs and their influence on transcriptomic signatures in prostate cancer by Fahad M. Aldakheel, Hadeel Alnajran, Ayesha Mateen, Shatha A. Alduraywish, Mohammed S. Alqahtani, Rabbani Syed

“…This analysis uncovered their substantial impact on critical biological processes and molecular functions, such as cyclin-dependent protein kinase activity, mitotic DNA damage checkpoint signalling, stress-activated MAPK cascade, regulation of extrinsic apoptotic signalling pathway, and positive regulation of cell adhesion. Our analysis of miRNAs and DEGs genes revealed an intriguing mix of established and potentially novel regulators in prostate cancer development. …”
Get full text

Management of Bone Defects and Complications After Bone Tumor Resection Using Ilizarov Method by Kai Zheng, Xiu‐Chun Yu, Jinfang Cai, Ming Xu, Haocheng Cui, Qian Chen, Jing‐Yu Zhang

“…Nine patients were diagnosed with osteosarcoma, while one presented with Ewing's sarcoma and another with a giant cell tumor of bone. Three young children were successfully treated with epiphyseal stretching; however, one patient experienced treatment failure. …”
Get full text

Effects and Mechanisms of Cutting Upper Thoracic Sympathetic Trunk on Ventricular Rate in Ambulatory Canines with Persistent Atrial Fibrillation by Jie Cai, Min Tang, Hao Liu, Shiao Ding, Rongxin Lu, Wei Wang, Nan Ma, Ju Mei, Zhaolei Jiang

“…Compared with the control group, both left stellate ganglion (LSG) and right stellate ganglion (RSG) of the experimental group caused neural remodeling characterized by decreased ganglionic cell density and reduced TH staining. TH-positive component was significantly decreased in the left atrium of the experimental group compared with the control group. …”
Get full text

Optimizing Energy and Spectral Efficiency in Mobile Networks: A Comprehensive Energy Sustainability Framework for Network Operators by Luis Mata, Marco Sousa, Pedro Vieira, Maria Paula Queluz, Antonio Rodrigues

“…The framework can be flexibly applied at the location (site), BS (cell), or equipment type (hardware) levels. Notably, the implemented ML and XAI model achieved an F1-Score of 0.78 for 5G scenarios and 0.83 for 4G scenarios in predicting the Energy Sustainability Class, relying on a reduced set of indicators encompassing the most influential factors. …”
Get full text

Physical Inactivation of Monodon Baculovirus (Mbv), a Pathogenic Virus of Tiger Prawn (Penaeus Monodon Fab.) by M. Alifuddin

“…Presence of infection indicated by histological observation of hipertropied hepatopancreas cell containing inclusion bodies of virus.  Inactivation of MBV was done by heating at 40, 45, 50 and 55 'C for 30 minute and uv radiation for 5, 10, 15 and 20 minute with the distance 30 cm from the uv lamp 15 watt as radiation sources.  …”
Get full text

Renal impairment and in-hospital adverse renal events in critically ill patients assessed by age-adapted estimated glomerular filtration rate criteria by Chong Zhang, Weiru Liang, Meng Ning, Bin Su, Tingting Guo, Kun Hu, Wei Su, Yi Chen, Wenjin Peng, Yingwu Liu

Get full text

Differential HLA Association of GAD65 and IA2 Autoantibodies in North Indian Type 1 Diabetes Patients by Neihenuo Chuzho, Neeraj Kumar, Neetu Mishra, Nikhil Tandon, Uma Kanga, Gurvinder Kaur, Paras Singh, Gunja Mishra, Shreya Sharma, Narinder K. Mehra

“…The human leucocyte antigen (HLA) association with type 1 diabetes (T1D) is well known but there are limited studies investigating the association between β-cell autoantibodies and HLA genes. We evaluated the prevalence of GAD65 and IA-2 autoantibodies (GADA and IA2A) in 252 T1D patients from North India and investigated the genetic association of GADA and IA2A with HLA class I and class II genes/haplotypes. …”
Get full text

Transcriptome analysis of ovarian cancer uncovers association between tumor-related inflammation/immunity and patient outcome by Jingfang Wang, Wenrui Zhu, Xia Li, Yuanyuan Wu, Wenhui Ma, Yangzhou Wang, Weihong Zhao, Fang Wei, Wenhao Wang

“…With the rapid development of PD-1/PD-L1, CTLA-4, oncolytic viruses, cancer vaccines, adoptive cell therapy, etc., tumor immunotherapy has provided new opportunities for the treatment of ovarian cancer.MethodsThis study used comprehensive transcriptome analysis across multiple databases to gather gene transcripts and clinical features of normal ovarian samples and tissue samples from ovarian cancer. …”
Get full text

Qinggan Yipi capsule ameliorates hepatic fibrosis in rats by down-regulating the TGF-β1/Smad2/3 signaling pathway and improving gut microbiota imbalance by Wenjing Xue, Haiqing Liu, Ziheng Su, Siqi Wang, Junping Cheng, Yunzhi Pan, Lurong Zhang

“…This study aims to clarify the anti-liver fibrosis effect of QgYp and its mechanism of action.MethodsThis study uses a carbon tetrachloride (CCl4) induced HF rat model and TGF-β1 stimulated HSC-T6 cell line (rat HSCs) as experimental models. The therapeutic effects were evaluated through pathology, biochemical tests, and ELISA. …”
Get full text

A Bibliometric and Visualised Analysis of Proliferative Verrucous Leucoplakia From 2003 to 2023 by Long Zhu, Lijia Ou, Yang Yang, Danwei Zhao, Binjie Liu, Rui Liu, Ousheng Liu, Hui Feng

“…The top 3 keywords include “Proliferative Verrucous Leucoplakia,” “Squamous-Cell Carcinoma,” “Oral Leucoplakia,” and “Potentially Malignant Disorders.” …”
Get full text

Mapping neutron biological effectiveness for DNA damage induction as a function of incident energy and depth in a human sized phantom by Alice Mentana, Virgilio Quaresima, Pavel Kundrát, Isabella Guardamagna, Leonardo Lonati, Ombretta Iaria, Andrea Previtali, Giorgia Santi Amantini, Luca Lunati, Virginia Boretti, Livio Narici, Luca Di Fino, Luca Bocchini, Claudio Cipriani, Giorgio Baiocco

“…In particular, two classes of DNA damage were considered: sites and clusters of double-strand breaks (DSBs), which are known to be correlated with cell fate following radiation exposure. Within a coherent modelling framework, this approach tackles the variation of neutron RBE in a wide energy range, from thermal neutrons to neutrons of hundreds of GeV, and reproduces effects related to depth in the human-sized receptor, as well as to the receptor size itself. …”
Get full text

Advancements in noninvasive techniques for transplant rejection: from biomarker detection to molecular imaging by Yuan Song, Yihui Wang, Wenyuan Wang, Yuji Xie, Junmin Zhang, Jing Liu, Qiaofeng Jin, Wenqian Wu, He Li, Jing Wang, Li Zhang, Yali Yang, Tang Gao, Mingxing Xie

“…For example, donor-derived cell-free DNA (dd-cfDNA) is highly sensitive in detecting early graft injury, whereas gene expression profiling effectively excludes moderate-to-severe acute rejection (AR). …”
Get full text