Discovery of novel biphenyl compounds bearing hydroxamic acid moiety as the first PD-L1/class I HDACs dual inhibitors by Dandan Yuan, Yali Gao, Lin Xia, Han Liu, Xingye Wu, Xueyan Ding, Yudan Huang, Changchun Deng, Jin Li, Wenqi Dai, Jieqing Liu, Junjie Ma

“…Importantly, 14 could upregulate the expression of PD-L1 and CXCL10 in a PD-L1 low-expression cancer cell line (MCF-7), highlighting the potential to enhance efficacy by recruiting T-cell infiltration into TME and improving the response of PD-1/PD-L1 inhibitor associated with PD-L1 low-expression. …”
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Effect of Selenate on Viability and Selenomethionine Accumulation of Chlorella sorokiniana Grown in Batch Culture by Živan Gojkovic, Carlos Vílchez, Rafael Torronteras, Javier Vigara, Veronica Gómez-Jacinto, Nora Janzer, José-Luis Gómez-Ariza, Ivana Márová, Ines Garbayo

“…The aim of this work was to study the effect of Se(+VI) on viability, cell morphology, and selenomethionine accumulation of the green alga Chlorella sorokiniana grown in batch cultures. …”
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Protective Effects of Tormentic Acid on Unilateral Ureteral Obstruction-Induced Renal Injury, Inflammation, and Fibrosis: A Comprehensive Approach to Reducing Oxidative Stress, Apo... by Ah Young Yang, Jung-Yeon Kim, Mi-Gyeong Gwon, Hyun Hee Kwon, Jaechan Leem, Eon-Ju Jeon

“…Additionally, it inhibited apoptosis and ferroptosis by reducing oxidative stress and modulating key cell death markers. Collectively, these findings indicate that TA provides comprehensive renoprotection in the UUO model by effectively targeting inflammation, fibrosis, oxidative stress, and tubular cell death in CKD progression.…”
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Actin-Binding Proteins as Potential Biomarkers for Chronic Inflammation-Induced Cancer Diagnosis and Therapy by Yu-Gui Zhang, Jiang-Tao Niu, Hong-Wei Wu, Xin-Lei Si, Shu-Juan Zhang, Dong-Hui Li, Tian-Tian Bian, Yue-Feng Li, Xing-Ke Yan

“…Actin-binding proteins (ABPs), by interacting with actin, regulate the polymerization, depolymerization, bundling, and cross-linking of actin filaments, directly or indirectly, thereby mediating the maintenance of cell morphology, cell movement, and many other biological functions. …”
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Automated and virus variant-programmable surrogate test qualitatively compares to the gold standard SARS-CoV-2 neutralization assay by Danielle W. Ali, Maggie L. Bartlett, Christopher D. Heger, Francisco Ramirez, Linwood Johnson, Kevin L. Schully, Eric D. Laing, Wei Wang, Carol D. Weiss, Emilie Goguet, Christopher C. Broder, Stephanie A. Richard, Nusrat J. Epsi, Brian Agan, David Tribble, Mark P. Simons, Timothy H. Burgess, Edward Mitre, Simon Pollett, Darci R. Smith

“…However, assays for neutralizing antibodies, which are a good measure of viral protection, usually require cell culture and either infectious SARS-CoV-2 or pseudotyped viral particles. …”
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An updated review summarizing the anticancer potential of flavonoids via targeting NF-kB pathway by Pratibha Pandey, Sorabh Lakhanpal, Danish Mahmood, Han Na Kang, Byunggyu Kim, Sojin Kang, Jinwon Choi, Min Choi, Shivam Pandey, Mahakshit Bhat, Shilpa Sharma, Fahad Khan, Moon Nyeo Park, Bonglee Kim, Bonglee Kim

“…Nuclear factor-κB (NF-κB) cell signaling pathway is essential for the progression and development of numerous human disorders, including cancer. …”
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A New Pyrrolidone Alkaloid and Other Constituents from Rourea oligophlebia Stems by Thuc Ngoc Dinh, Mai Vu Thi Ha, Luong Ngo Xuan, Huan Trinh Thi, Huong Nguyen Thi, Mai Nguyen Thi Ngoc, Giap Tran Huu, Oanh Vu Thi Kim, Thanh Le Nguyen

“…Compound 11 exhibited good antimicrobial activity on Gram (+) strains and moderate cytotoxicity against KB, Hep-G2, and LU cancer cell lines. Compounds 6 and 8–10 showed selective activity on HepG-2 and MCF-7 over KB and LU cancer cell lines, while compound 7 exhibited similar effects on KB, HepG-2, and MCF-7 cell lines with IC50 values of 36.46 ± 0.81, 32.00 ± 0.58, and 32.03 ± 0.61 µg/mL, respectively.…”
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Toxic Effects of Ethyl Cinnamate on the Photosynthesis and Physiological Characteristics of Chlorella vulgaris Based on Chlorophyll Fluorescence and Flow Cytometry Analysis by Yang Jiao, Hui-Ling Ouyang, Yu-Jiao Jiang, Xiang-Zhen Kong, Wei He, Wen-Xiu Liu, Bin Yang, Fu-Liu Xu

“…After 72 h of exposure to 4 mg/L ethyl cinnamate, the Fv/Fm of C. vulgaris dropped to zero. (3) Ethyl cinnamate also affected the cellular physiology of C. vulgaris, but these effects resulted in the inhibition of cell yield rather than cell death. Exposure to ethyl cinnamate resulted in decreased esterase activities in C. vulgaris, increased average cell size, and altered intensities of chlorophyll a fluorescence. …”
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Inhibitory Effect of Cinobufagin on L-Type Ca2+ Currents, Contractility, and Ca2+ Homeostasis of Isolated Adult Rat Ventricular Myocytes by Pinya Li, Qiongtao Song, Tao Liu, Zhonglin Wu, Xi Chu, Xuan Zhang, Ying Zhang, Yonggang Gao, Jianping Zhang, Li Chu

“…The aim of the present study was to characterize the effect of CBG on intracellular Ca2+ ([Ca2+]i) handling and cell contractility in rat ventricular myocytes. CBG was investigated by determining its influence on ICa-L, Ca2+ transient, and contractility in rat ventricular myocytes using the whole-cell patch-clamp technique and video-based edge-detection and dual-excitation fluorescence photomultiplier systems. …”
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Mitigation of doxorubicin-induced liver toxicity in mice breast cancer model by green tea and Moringa oleifera combination: Targeting apoptosis, inflammation, and oxidative stress by Abdulrahman H. Laftah, Nawfal Alhelfi, Sadeq K. Al Salait, Ammar B. Altemimi, Mohammad Reza Tabandeh, Efstathia Tsakali, Jan F.M. Van Impe, Ahmed A. Abd El-Maksoud, Tarek Gamal Abedelmaksoud

“…This study evaluated the effect of green tea and Moringa oleifera extracts (at 1 % and 2 % concentration) on DOX-treated breast cancer mice. 36 Balb/C female mice with breast cancer were split into healthy mice, 4 T1 cell cancer-induced, and Doxorubicin-induced malignancies. …”
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Parameters Estimation of a Microscopic Traffic Flow Sub-Model Within a Multiscale Approach Using Experimental Data by Facundo Storani, Roberta Di Pace, Shi-Teng Zheng, Rui Jiang, Stefano de Luca

“…The major finding of the paper is that the calibrated parameters obtained using the Simulated Leader approach display greater regularity across different cell lengths.…”
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Modeling of a Non-Aqueous Redox Flow Battery for Performance and Capacity Fade Analysis by Mirko D’Adamo, Nicolas Daub, Lluis Trilla, Jose A. Saez-Zamora, Juan Manuel Paz-Garcia

“…Leveraging the redox pair 10-[2-(2-methoxy ethoxy)ethyl]-10H-phenothiazine and 2-ethylterephthalonitrile, the system delivers a discharge cell voltage ranging from approximately 2.25 V to 1.9 V. …”
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Single-nucleus transcriptomes reveal the underlying mechanisms of dynamic whitening in thermogenic adipose tissue in goats by Manman Li, Nange Ma, Shujie Luo, Yuyi Lu, Xixi Yan, Yang Li, Xinmei Li, Zhuohui Li, Zhipei Wu, Zhenyu Wei, Wei Wang, Huimei Fan, Yu Jiang, Yan Xiong, Yu Wang

“…In this study, we employed single-nucleus RNA-seq to construct a cell atlas during whitening progression and identified the characteristics of thermogenic adipocytes. …”
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Hydrogen gas inhalation ameliorates glomerular enlargement after hypoxic-ischemic insult in asphyxiated piglet model by Takuma Iwaki, Shinji Nakamura, Takayuki Wakabayashi, Yasuhiro Nakao, Yinmon Htun, Toui Tsuchiya, Tsutomu Mitsuie, Kosuke Koyano, Aya Morimoto, Noriko Fuke, Takayuki Yokota, Sonoko Kondo, Yukihiko Konishi, Takanori Miki, Masaki Ueno, Takashi Iwase, Takashi Kusaka

“…H2 gas effectively suppressed this glomerular cell increase and tubular lumen narrowing.…”
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Transcriptional Profiling Reveals Kidney Neutrophil Heterogeneity in Both Healthy People and ccRCC Patients by Yiliang Meng, Kai Cai, Jingjie Zhao, Keyu Huang, Xiumei Ma, Jian Song, Yunguang Liu

“…Neutrophil is known to critically impact the development of renal diseases (e.g., the clear cell renal cell carcinoma (ccRCC)), whereas the heterogeneity of neutrophils in ccRCC remains unclear. …”
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Integrative analysis of ferroptosis in the hypoxic microenvironment of gastric cancer unveils the immune landscape and personalized therapeutic strategies by Xiao Xu, Liangling Fa, Xiaoxiao Sun, Fangfang Yang, Yongrui Liu, Jifu Song, Yongli Zhao, Jigang Dong, Jigang Dong

“…BackgroundFerroptosis is a cell death mode caused by excessive accumulation of lipid peroxides caused by disturbance of intracellular metabolic pathway, which is closely related to iron and cholesterol metabolism homeostasis. …”
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Sparse Gene Coexpression Network Analysis Reveals EIF3J-AS1 as a Prognostic Marker for Breast Cancer by Xin Chen, Zuyuan Yang, Chao Yang, Kan Xie, Weijun Sun, Shengli Xie

“…The differentially expressed genes were significantly overlapped with gene modules regulating cell cycle and cell adhesion. The cell cycle-related lncRNAs were consistently downregulated in breast cancer. …”
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Ferroptosis-Related Genes in IgA Nephropathy: Screening for Potential Targets of the Mechanism by Wenhui Zhu, Yao Chen, Jing Xiao, Chuchu Cheng, Guijie Ma, Yang Wang, Yonggang Zhang, Ming Chen

“…Conclusions: Our results show that JUN and ATF3 are possibly critical genes in the process of IgAN ferroptosis and may be related with immune cell infiltration.…”
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Advancing the Indian cattle pangenome: characterizing non-reference sequences in Bos indicus by Sarwar Azam, Abhisek Sahu, Naveen Kumar Pandey, Mahesh Neupane, Curtis P Van Tassell, Benjamin D Rosen, Ravi Kumar Gandham, Subha Narayan Rath, Subeer S Majumdar

“…These protein-coding genes were enriched for functions such as chemical synaptic transmission, cell junction organization, cell-cell adhesion, and cell morphogenesis. …”
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A hammerhead ribozyme selects mechanically stable conformations for catalysis against viral RNA by Man Lu, Zhiqiang Cao, Luoan Xiong, Hongying Deng, Kangkang Ma, Ning Liu, Yanding Qin, Shen-Bo Chen, Jun-Hu Chen, Yao Li, Yijin Liu, Zhongbo Yu

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