Defective homologous recombination and genomic instability predict increased responsiveness to carbon ion radiotherapy in pancreatic cancer by Brock J. Sishc, Janapriya Saha, Elizabeth M. Alves, Lianghao Ding, Huiming Lu, Shih-Ya Wang, Katy L. Swancutt, James H. Nicholson, Angelica Facoetti, Arnold Pompos, Mario Ciocca, Todd A. Aguilera, Michael D. Story, Anthony J. Davis

“…We utilized a panel of human PDAC cell lines with diverse genetic profiles to determine their sensitivity to CIRT compared to γ-rays, assessing relative biological effectiveness (RBE) at 10% survival, which ranged from 1.96 to 3.04. …”
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Dynamic Beamforming for Three-Dimensional MIMO Technique in LTE-Advanced Networks by Yan Li, Xiaodong Ji, Dong Liang, Yuan Li

“…Compared with the conventional 2D beamforming algorithm, throughput of cell edge UEs and cell center UEs can be improved by the proposed algorithm. …”
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Integrating Prior Knowledge Using Transformer for Gene Regulatory Network Inference by Guangzheng Weng, Patrick Martin, Hyobin Kim, Kyoung Jae Won

“…However, existing methods often struggle to generalize across diverse cell types and account for unseen regulators. Here, this work presents GRNPT, a novel Transformer‐based framework that integrates large language model (LLM) embeddings from publicly accessible biological data and a temporal convolutional network (TCN) autoencoder to capture regulatory patterns from single‐cell RNA sequencing (scRNA‐seq) trajectories. …”
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The Strange Case: The Unsymmetric Cisplatin-Based Pt(IV) Prodrug [Pt(CH3COO)Cl2(NH3)2(OH)] Exhibits Higher Cytotoxic Activity with respect to Its Symmetric Congeners due to Carrier... by Elisabetta Gabano, Ilaria Zanellato, Giulia Pinton, Laura Moro, Mauro Ravera, Domenico Osella

“…The complexes were tested on a panel of human tumor cell lines. Complex 2 showed an anomalous higher cytotoxicity (similar to that of cisplatin) with respect to their analogues 1 and 3. …”
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DLK-dependent axonal mitochondrial fission drives degeneration after axotomy by Jorge Gómez-Deza, Matthew Nebiyou, Mor R. Alkaslasi, Francisco M. Nadal-Nicolás, Preethi Somasundaram, Anastasia L. Slavutsky, Wei Li, Michael E. Ward, Trent A. Watkins, Claire E. Le Pichon

“…Abstract Currently there are no effective treatments for an array of neurodegenerative disorders to a large part because cell-based models fail to recapitulate disease. Here we develop a reproducible human iPSC-based model where laser axotomy causes retrograde axon degeneration leading to neuronal cell death. …”
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MftG is crucial for ethanol metabolism of mycobacteria by linking mycofactocin oxidation to respiration by Ana Patrícia Graça, Vadim Nikitushkin, Mark Ellerhorst, Cláudia Vilhena, Tilman E Klassert, Andreas Starick, Malte Siemers, Walid K Al-Jammal, Ivan Vilotijevic, Hortense Slevogt, Kai Papenfort, Gerald Lackner

“…Cell-free enzyme assays and respirometry using isolated cell membranes indicated that MftG acts as a mycofactocin dehydrogenase shuttling electrons toward the respiratory chain. …”
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High-density multielectrode arrays bring cellular resolution to neuronal activity and network analyses of corticospinal motor neurons by Christopher A. Quintanilla, Zachary Fitzgerald, Omar Kashow, Mihailo S. Radojicic, Emel Ulupinar, Dila Bitlis, Baris Genc, Pavle Andjus, Wim van Drongelen, P. Hande Ozdinler

“…Here, we combine optical imaging with high-density microelectrode array (HD-MEA) system enabling single cell resolution and utilize UCHL1-eGFP mice to bring cell-type specificity to our understanding of the electrophysiological features of healthy CSMN, as they mature and form network connections with other cortical neurons, in vitro. …”
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Feline Papillomatosis by Herman Egberink, Katrin Hartmann, Ralf Mueller, Maria Grazia Pennisi, Sándor Belák, Séverine Tasker, Karin Möstl, Diane D. Addie, Corine Boucraut-Baralon, Tadeusz Frymus, Regina Hofmann-Lehmann, Fulvio Marsilio, Etienne Thiry, Uwe Truyen, Margaret J. Hosie

“…Different types of feline papillomaviruses (PVs) are associated with a variety of skin lesions and neoplasia, such as papillomas and cell carcinomas, but the virus can also be found in healthy skin. …”
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Fenofibrate Exerts Antitumor Effects in Colon Cancer via Regulation of DNMT1 and CDKN2A by Rui Kong, Nan Wang, Wei Han, Wen Bao, Jie Lu

“…In vitro experiments showed that fenofibrate regulated cell cycle distribution, promoted apoptosis, and suppressed cell proliferation and epithelial mesenchymal transition by activating PPARA. …”
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MethylBERT enables read-level DNA methylation pattern identification and tumour deconvolution using a Transformer-based model by Yunhee Jeong, Clarissa Gerhäuser, Guido Sauter, Thorsten Schlomm, Karl Rohr, Pavlo Lutsik

“…Read-level methylomes enable more in-depth analyses, due to their broad genomic coverage and preservation of rare cell-type signals, compared to summarized data such as 450K/EPIC microarrays. …”
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Exploring PANoptosis in head and neck cancer: A novel approach to cancer therapy by Li Wang, Baisheng Lin, Feixiang Wang, Zili Dai, Guofeng Xie, Jian Zhang

“…PANoptosis is a newly discovered complex programmed cell death (PCD) form. In the field of cancer research, PANoptosis is involved in multiple cell death pathways that affect tumor cell survival, proliferation, and response to treatment, serving as an innovative strategy for cancer therapy. …”
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In silico modelling of organ-on-a-chip devices: an overview by Yue Wang, Lucia Marucci, Lucia Marucci, Lucia Marucci, Martin E. Homer

“…We discuss the opportunities for integrating multiphysics with multicellular computational models to better characterize and predict cell culture dynamics. Additionally, we explore how developing more detailed OOAC models would support a more rapid and effective development of microdevices, and the design of robust protocols to grow and control cell cultures.…”
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Subacute parkinsonism induced by immune checkpoint inhibitors by Lénia Silva, Inês Laranjinha, Cláudia Casais, Raquel Samões

“…A woman with treatment-refractory intestinal T-cell lymphoma was initiated pembrolizumab and developed a daily fever and parkinsonian syndrome 2 weeks later. …”
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Drp1 is essential for PINK1/Parkin signaling in H9c2 cardiomyocytes by Xuecong Ren, Ni Zhang, Xiao‐Yi Chen, Hui Huang, Pei Luo

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TRP Channels in Human Prostate by Carl Van Haute, Dirk De Ridder, Bernd Nilius

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Small Bowel Review: Part I by ABR Thomson, J Hasan, M Keelan, G Wild

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Dynamic pilot assignment in massive MIMO system based on user classification by Jinyan ZHANG, Feng JIN, Lixin YIN

“…Aiming at the problem of pilot contamination in massive MIMO system,a dynamic pilot assignment strategy based on user classification was proposed.The target cell user was divided into the central user and the edge user based on the variance of target cell user signal intensity.The central user used the maximum C/I algorithm to assign pilots to maximize the channel capacity of the central user.The edge user used greedy algorithm to assign pilots to improve the signal to interference and noise ratio of each edge user.Simulation results show that the proposed strategy can improve the channel capacity of the system while improving the signal to interference and noise ratio of the edge user.…”
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Recurrent Bilateral Optic Neuritis Associated with Myelin Oligodendrocyte Glycoprotein Antibody: A Case Report from Nepal by Sangam Shah, Rajeev Ojha, Sanjeeta Sitaula, Dosti Regmi, Ragesh Karn, Bikram Prasad Gajurel, Reema Rajbhandari, Niraj Gautam, Sunanda Paudel, Aashish Shrestha

“…Myelin oligodendrocyte glycoprotein (MOG) expressed on the oligodendrocyte cell surface and on the outermost cell surface of the myelin sheath may also be present in patients with NMOSD bilateral optic neuritis. …”
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Atypical carcinoid of the primary kidney with retroperitoneal metastasis 15 years later: A case report and literature review by Qiang Wang, Dong Zhuo, Houbao Huang, Jianping Tao

“…According to pathological manifestations, carcinoid can be divided into four types: typical carcinoid, atypical carcinoid, large cell and small cell neuroendocrine carcinoma. Primary or secondary retroperitoneal carcinoid is even rarer than renal carcinoid. …”
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PI3K/AKT/PTEN Signaling as a Molecular Target in Leukemia Angiogenesis by Naoko Okumura, Hitomi Yoshida, Yasuko Kitagishi, Mutsumi Murakami, Yuri Nishimura, Satoru Matsuda

“…The signaling pathway is activated in leukemia patients as well as leukemia cell lines together with a decrease in the expression of PTEN gene. …”
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