SpecPCM: A Low-Power PCM-Based In-Memory Computing Accelerator for Full-Stack Mass Spectrometry Analysis by Keming Fan, Ashkan Moradifirouzabadi, Xiangjin Wu, Zheyu Li, Flavio Ponzina, Anton Persson, Eric Pop, Tajana Rosing, Mingu Kang

“…SpecPCM, with up to three bits per cell, achieves speedups of up to <inline-formula> <tex-math notation="LaTeX">$82\times $ </tex-math></inline-formula> and <inline-formula> <tex-math notation="LaTeX">$143\times $ </tex-math></inline-formula> for MS clustering and DB search tasks, respectively, along with a four-orders-of-magnitude improvement in energy efficiency compared with state-of-the-art (SoA) CPU/GPU tools.…”
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Evidence of Divergent Amino Acid Usage in Comparative Analyses of R5- and X4-Associated HIV-1 Vpr Sequences by Gregory C. Antell, Will Dampier, Benjamas Aiamkitsumrit, Michael R. Nonnemacher, Vanessa Pirrone, Wen Zhong, Katherine Kercher, Shendra Passic, Jean Williams, Yucheng Liu, Tony James, Jeffrey M. Jacobson, Zsofia Szep, Brian Wigdahl, Fred C. Krebs

“…Vpr is an HIV-1 accessory protein that plays numerous roles during viral replication, and some of which are cell type dependent. To test the hypothesis that HIV-1 tropism extends beyond the envelope into the vpr gene, studies were performed to identify the associations between coreceptor usage and Vpr variation in HIV-1-infected patients. …”
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A Threshold Technique Study to Understand Patient Preference for Smooth Versus Textured Breast Implants by Dallas Wood, PhD, Peyton N. Williams, MPH, Jessica E. Thompson, PhD, Susana Peinado, PhD, Avery A. Tilley, MS, David Gebben, PhD, Jacqueline M. Major, PhD, Jessica P. Weinberg, MPP, Sung W. Yoon, MD, Michelle E. Tarver, MD, PhD

“…Compared with smooth implants, textured surface implants have a higher risk of breast implant–associated anaplastic large cell lymphoma (BIA-ALCL) but may have a lower risk of capsular contracture (CC). …”
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Chronic GIPR agonism results in pancreatic islet GIPR functional desensitisation by Iona Davies, Alice E. Adriaenssens, William R. Scott, David Carling, Kevin G. Murphy, James S. Minnion, Stephen R. Bloom, Ben Jones, Tricia M-M. Tan

“…Methods: A long-acting GIPR agonist, GIP108, was used to probe the effect of sustained agonist exposure on cAMP responses in dispersed pancreatic islets using live cell imaging, with rechallenge cAMP responses after prior agonist treatment used to quantify functional desensitisation. …”
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Sorafenib-Loaded Silica-Containing Redox Nanoparticle Decreases Tumorigenic Potential of Lewis Lung Carcinoma by Babita Shashni, Hao Thi Tran, Long Binh Vong, Ren-Jei Chung, Yukio Nagasaki

“…<b>Background:</b> Orally administered sorafenib has shown limited improvement in overall survival for non-small-cell lung cancer patients, likely due to poor pharmacokinetics and adverse effects, including gastrointestinal toxicity. …”
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Effects of different vaccination regimes on the immunodiagnosis of tuberculosis in goats and evaluation of defined antigens by Patricia Cuenca-Lara, Patricia Cuenca-Lara, Miriam Blay-Benach, Miriam Blay-Benach, Zoraida Cervera, Zoraida Cervera, Cristian Melgarejo, Cristian Melgarejo, Julia Moraleda, Julia Moraleda, Iker A. Sevilla, Joseba M. Garrido, Mahavir Singh, Gareth J. Jones, Bernat Pérez de Val, Bernat Pérez de Val

“…The two prime-boosted and the single-dose intranasal BCG groups displayed greater cell-mediated immune responses to PPDs than the two single-dose intranasal HIMB vaccines. …”
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A novel TGFBR2 mutation causes Loeys-Dietz syndrome in a Chinese infant: A case report by Xin Liu, Kaiqing Liu, Lifu Hu, Zixiao Liu, Xinhua Liu, Jiantao Wang

“…Molecular dynamics simulations and in vitro cell experiments further analyzed the structural changes and functional abnormalities of the variation. …”
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Development of therapeutic supplement using roasted-cashew-nut to protect cerebral vasoconstriction injury triggered by mixture of petroleum hydrocarbons in the hypothalamus and hi... by J.K. Akintunde, V.O. Akomolafe, R.N. Ugbaja, A.M. Olude, A.D. Folayan

“…The regimen period was 28 days. Cell pathological evaluation was done using hematoxylin and eosin staining and visualized under the microscope. …”
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Real‐world efficacy of transfusion with liberal or restrictive strategy in traumatic brain injury by Liang‐Wen Cui, Nian Liu, Chao Yu, Ming Fang, Rui Huang, Cheng Zhang, Min Shao

“…Abstract Objective The short‐term efficacy of red blood cell (RBC) transfusion among general traumatic brain injury (TBI) patients is unclear. …”
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Examining the Formalin Fixation Method for Maintaining High RNA Quality in Surgical Lung Specimens by Takashi Teishikata, Manabu Itoh, Yusuke Okamoto, Naofumi Miyahara, Chiho Nakashima, Koichiro Takahashi, Masafumi Hiratsuka, Keita Kai, Keiji Kamohara

“…ABSTRACT Background Multiplex genetic testing is recommended when treating nonsmall cell lung cancer. A certain percentage of test failures in RNA assays owing to poor surgical specimen quality have been documented, and fixation failure is a possible cause. …”
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Polymorphisms in immunosuppression-related genes are associated with AML by Mingying Li, Mingying Li, Jingjing Ye, Jingjing Ye, Mengyuan Chang, Mengyuan Chang, Lei Feng, Lei Feng, Tingting Liu, Tingting Liu, Di Zhang, Di Zhang, Yuyan Wu, Yuyan Wu, Yuechan Ma, Yuechan Ma, Guangqiang Meng, Guangqiang Meng, Chunyan Ji, Chunyan Ji, Tao Sun, Tao Sun

“…Multi-omics analyses, such as single-cell transcriptomics, have revealed many potential new targets to improve AML prognosis from an immunological perspective.MethodsDNA from 307 AML patients and 316 healthy individuals were extracted. …”
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One Earth-One Health (OE-OH): Antibacterial Effects of Plant Flavonoids in Combination with Clinical Antibiotics with Various Mechanisms by Ganjun Yuan, Fengxian Lian, Yu Yan, Yu Wang, Li Zhang, Jianping Zhu, Aiman Fatima, Yuxing Qian

“…<b>Results</b>: Plant flavonoids in combination with antibiotics present extensive synergistic effects, and 25% of combinations exhibited synergy against <i>S. aureus</i> and 50% against <i>E. coli</i>, particularly with antibiotics affecting cell membranes or ribosomes. <b>Conclusions</b>: The findings align with the drug selection principle of synergistic combinations and suggest that plant flavonoids could extensively enhance antibiotic efficacy. …”
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Identifying neurobiological heterogeneity in clinical high-risk psychosis: a data-driven biotyping approach using resting-state functional connectivity by Xiaochen Tang, Yanyan Wei, Jiaoyan Pang, Lihua Xu, Huiru Cui, Xu Liu, Yegang Hu, Mingliang Ju, Yingying Tang, Bin Long, Wei Liu, Min Su, Tianhong Zhang, Jijun Wang

“…Functional connectivity (FC) features that were correlated with symptom severity were subjected to the single-cell interpretation through multikernel learning (SIMLR) algorithm in order to identify latent homogeneous subgroups. …”
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Direct Effect of Two Naphthalene-Sulfonyl-Indole Compounds on Toxoplasma gondii Tachyzoite by Qasem Asgari, Hossein Keshavarz, Mostafa Rezaeian, Mohammad Hossein Motazedian, Saeedeh Shojaee, Mehdi Mohebali, Ramin Miri

“…Past studies have stated that the parasitostatic effect of IFN-γ is most likely due to the starvation of Toxoplasma gondii for tryptophan in the host cell. The aim of this study was to evaluate the direct effect of two new Naphthalene-Sulfonyl-Indole compounds as competitive molecules for tryptophan on viability and infectivity of Toxoplasma tachyzoites. …”
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Lipidic folding pathway of α-Synuclein via a toxic oligomer by Vrinda Sant, Dirk Matthes, Hisham Mazal, Leif Antonschmidt, Franz Wieser, Kumar T. Movellan, Kai Xue, Evgeny Nimerovsky, Marianna Stampolaki, Magdeline Nathan, Dietmar Riedel, Stefan Becker, Vahid Sandoghdar, Bert L. de Groot, Christian Griesinger, Loren B. Andreas

“…Consistent with reports of anti-parallel β-strands being a defining feature of toxic αS pre-fibrillar intermediates, I1 impacts viability of neuroblasts and disrupts cell membranes, resulting in an increased calcium influx. …”
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A Rewired NADPH-Dependent Redox Shuttle for Testing Peroxisomal Compartmentalization of Synthetic Metabolic Pathways in <i>Komagataella phaffii</i> by Albert Fina, Sílvia Àvila-Cabré, Enrique Vázquez-Pereira, Joan Albiol, Pau Ferrer

“…The introduction of heterologous pathways into microbial cell compartments offers several potential advantages, including increasing enzyme concentrations and reducing competition with native pathways, making this approach attractive for producing complex metabolites like fatty acids and fatty alcohols. …”
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Species classification of Tabanus (Diptera: Tabanidae) in Western Thailand: Integrating DNA barcoding and modern morphometrics by Tanasak Changbunjong, Thekhawet Weluwanarak, Sedthapong Laojun, Tanawat Chaiphongpachara

“…Our GM analyses employed the landmark-based method for the entire wing and the outline-based method for the first submarginal cell. While shape-based GM analyses demonstrated high reliability, with adjusted total accuracy scores of 97% and 96%, size-based GM analyses yielded significantly lower accuracy, with scores of only 27% and 23%, respectively. …”
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Actinidia deliciosa as a complemental therapy against nephropathy and oxidative stress in diabetic rats by Ali Y. Naoom, Wenyi Kang, Nora F. Ghanem, Mohamed M. Abdel-Daim, Fatma M. El-Demerdash

“…Moreover, STZ produced upregulation of inflammatory associated genes (tumor necrosis factor-alpha; TNF-α and transforming growth factor β1; TGF-β1) and triggered apoptosis by upregulating apoptotic related gene [Bcl2-associated X protein (Bax)] and downregulating anti-apoptotic related gene B-cell lymphoma-2 (Bcl-2) based on real-time PCR data. …”
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5‐Hydroxymethylcytosine Profiles of cfDNA in Urine as Diagnostic, Differential Diagnosis and Prognostic Markers for Multiple Myeloma by Weiwei Xie, Xuehui Li, Hangyu Chen, Jinlin Chu, Lei Zhang, Bo Tang, Wenrong Huang, Linlin Li, Jian Lin, Yujun Dong

“…ABSTRACT Background An effective urine‐based method for the diagnosis, differential diagnosis and prognosis of multiple myeloma (MM) has not yet been developed. Urine cell‐free DNA (cfDNA) carrying cancer‐specific genetic and epigenetic aberrations may enable a noninvasive “liquid biopsy” for diagnosis and monitoring of cancer. …”
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Identification of Staphylococcus aureus, Enterococcus faecium, Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter baumannii from Raman spectra by Artificial Intelligen... by Yu-Tzu Lin, Hsiu-Hsien Lin, Chih-Hao Chen, Kun-Hao Tseng, Pang-Chien Hsu, Ya-Lun Wu, Wei-Cheng Chang, Nai-Shun Liao, Yi-Fan Chou, Chun-Yi Hsu, Yu-Hui Liao, Mao-Wang Ho, Shih-Sheng Chang, Po-Ren Hsueh, Der-Yang Cho

“…Spectral differences between Gram-positive and Gram-negative bacteria were linked to structural variations in their cell walls, such as peptidoglycan and lipopolysaccharides. …”
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