Ammonia electrosynthesis from nitrate using a stable amorphous/crystalline dual-phase Cu catalyst by Yi Wang, Shuo Wang, Yunfan Fu, Jiaqi Sang, Pengfei Wei, Rongtan Li, Dunfeng Gao, Guoxiong Wang, Xinhe Bao

“…The ammonia partial current density and formation rate reach 3.33 ± 0.005 A cm−2 and 15.5 ± 0.02 mmol h−1 cm−2 at a low cell voltage of 2.6 ± 0.01 V, respectively. Remarkably, the dual-phase Cu catalyst can maintain stable ammonia production with a Faradaic efficiency of around 90% at a high current density of 1.5 A cm−2 for up to 300 h. …”
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Isolation of PCSK9-specific nanobodies from synthetic libraries using a combined protein selection strategy by Apisitt Thaiprayoon, Yodpong Chantarasorn, Worrapoj Oonanant, Anongnard Kasorn, Phoomintara Longsompurana, Satita Tapaneeyakorn, Pinpunya Riangrungroj, Fabien Loison, Andrew C. Kruse, Matthew P. DeLisa, Dujduan Waraho-Zhmayev

“…We have developed a reliable protein selection strategy that combines magnetic activated cell sorting (MACS)-based screening of yeast surface display (YSD) libraries and functional ligand-binding identification by Tat-based recognition of associating proteins (FLI-TRAP) to isolate antigen-specific Nbs from synthetic libraries. …”
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Exploratory analysis of a Novel RACK1 mutation and its potential role in epileptic seizures via Microglia activation by Sai Zhang, Zhaofei Dong, Jing Guo, Ze Li, Hong Wu, Linming Zhang, Fuli Min, Tao Zeng

“…In this study, we identified the key gene RACK1 and its novel mutation RACK1-p.L206P as being associated with seizures through single-cell transcriptome sequencing (scRNA-seq) and whole exome sequencing (WES) techniques. …”
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Nanoemulsified Butenafine for Enhanced Performance against Experimental Cutaneous Leishmaniasis by Adriana Bezerra-Souza, Jéssica A. Jesus, Márcia D. Laurenti, Aikaterini Lalatsa, Dolores R. Serrano, Luiz Felipe D. Passero

“…Increased steady-state flux was reported for nanoenabled butenafine formulations with reduced lag time in Franz cell diffusion assays across Strat-M membranes. No toxic or inflammatory reactions were detected in animals treated with BUT-SNEDDS, BUT-SNEDDS gel, or butenafine. …”
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Flat-band based high-temperature ferromagnetic semiconducting state in the graphitic C4N3 monolayer by Chaoyu He, Yujie Liao, Tao Ouyang, Huimin Zhang, Hongjun Xiang, Jianxin Zhong

“…Herein, the 2 × 2 super-cell of the honeycomb lattice with a single-hole defect is proposed as a new lattice model (HL-D-1/8) to realize nontrivial isolated flat-bands. …”
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Necrostatin-1 Alleviates Diffuse Pulmonary Haemorrhage by Preventing the Release of NETs via Inhibiting NE/GSDMD Activation in Murine Lupus by Xinai Han, Xiaoming Zhang, Rui Song, Shiqi Li, Shujing Zou, Quanguang Tan, Tianyang Liu, Shugeng Luo, Zhe Wu, Hongyu Jie, Jinhong Wang

“…In vitro experiments revealed that Nec-1 inhibited alveolar epithelial cell damage by preventing the release of NETs. Furthermore, vivo studies showed that Nec-1 alleviated lupus pulmonary haemorrhage in mice by reducing lung pathology severity, body weight, and serum inflammatory cytokine levels. …”
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A Comparative Study of the In Vitro Intestinal Permeability of Pinnatoxins and Portimine by Rachelle Lanceleur, Vincent Hort, Marion Peyrat, Denis Habauzit, Andrew I. Selwood, Valérie Fessard

“…Therefore, we investigated the impact of PnTX analogs (PnTX-A, -E, -F, -G, and -H) and portimine (8, 16, and 32 ng/mL) on intestinal barrier integrity and their oral bioavailability using human Caco-2 cell monolayers treated for 2, 6, and 24 h. Our results demonstrated that all of the toxins could impair barrier integrity after 24 h, with differences observed for PnTX-A, -E, and -F, as well as portimine, the most potent of all. …”
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Exploring northeast India’s culturable soil Actinomycetia for potent antibacterial agents against gram-positive bacterial pathogens of clinical importance by Aditya Narayan Konwar, Surajit Basak, Shalini Gurumayum, Jagat Chandra Borah, Debajit Thakur

“…Toxicity studies against animal liver cell lines indicated that the ethyl acetate extract was non-toxic at concentrations below 125 µg/mL, compared to Vancomycin, which was found to be hepatotoxic at similar concentrations. …”
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Follistatin-Like 1: A Potential Mediator of Inflammation in Obesity by Nengguang Fan, Haiyan Sun, Yufan Wang, Yifei Wang, Lijuan Zhang, Zhenhua Xia, Liang Peng, Yanqiang Hou, Weiqin Shen, Rui Liu, Jiajing Yin, Yongde Peng

“…The expression of proinflammatory mediators including IL-6, TNF-α, and MCP-1 was upregulated by recombinant FSTL1 in a dose-dependent manner, paralleled with activation of the IKKβ-NFκB and JNK signaling pathways in the two cell lines. Moreover, FSTL1 impaired insulin signaling in 3T3-L1 adipocytes, as revealed by attenuated phosphorylation of both Akt and IRS-1 in response to insulin stimulation. …”
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Expression‐based machine learning models for predicting plant tissue identity by Sourabh Palande, Jeremy Arsenault, Patricia Basurto‐Lozada, Andrew Bleich, Brianna N. I. Brown, Sophia F. Buysse, Noelle A. Connors, Sikta Das Adhikari, Kara C. Dobson, Francisco Xavier Guerra‐Castillo, Maria F. Guerrero‐Carrillo, Sophia Harlow, Héctor Herrera‐Orozco, Asia T. Hightower, Paulo Izquierdo, MacKenzie Jacobs, Nicholas A. Johnson, Wendy Leuenberger, Alessandro Lopez‐Hernandez, Alicia Luckie‐Duque, Camila Martínez‐Avila, Eddy J. Mendoza‐Galindo, David Cruz Plancarte, Jenny M. Schuster, Harry Shomer, Sidney C. Sitar, Anne K. Steensma, Joanne Elise Thomson, Damián Villaseñor‐Amador, Robin Waterman, Brandon M. Webster, Madison Whyte, Sofía Zorilla‐Azcué, Beronda L. Montgomery, Aman Y. Husbands, Arjun Krishnan, Sarah Percival, Elizabeth Munch, Robert VanBuren, Daniel H. Chitwood, Alejandra Rougon‐Cardoso

“…Results The identity of belowground tissue can be predicted more accurately than other tissue types, and the ability to predict tissue identity is not correlated with phylogenetic distance from Arabidopsis. k‐nearest neighbors is the most successful algorithm, suggesting that gene expression signatures, rather than marker genes, are more valuable to create models for tissue and cell type prediction in plants. Discussion Our data‐driven results highlight that the assertion that knowledge from Arabidopsis is translatable to other plants is not always true. …”
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Liquid biopsy approaches to capture tumor evolution and clinical outcomes during cancer immunotherapy by Susan Scott, Mark Sausen, Valsamo Anagnostou, Jennifer Jackson, Vincent Lam, Joseph C Murray, Lavanya Sivapalan, Jenna Vanliere Canzoniero, Blair Landon, Benjamin P. Levy

“…Circulating cell-free tumor DNA (ctDNA) can serve as a real-time biomarker of tumor burden and provide unique insights into the evolving molecular landscape of cancers under the selective pressure of immunotherapy. …”
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Histopathological Study of Skin Adnexal Tumours—Institutional Study in South India by Ankit Sharma, Deepak G. Paricharak, Jitendra Singh Nigam, Shivani Rewri, Priyanka Bhatia Soni, Anita Omhare, Preethi Sekar

“…The commonest age group was 51–60 years and the commonest affected body part was head and neck region (64.28%, 36/56) followed by trunk (14.28%, 8/56). Clear cell hidradenoma and pilomatricoma were commonest benign tumors and sebaceous carcinoma was the only malignant tumor seen. …”
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Dissecting the Molecular Mechanism of Wang-Bi Capsule in the Treatment of Experimental Rheumatoid Arthritis Based on Synovial Tissue Proteomic Analysis by Haiyang Shu, Yingjie Shi, Li Li, Ning Zhao, Cheng Lu, Aiping Lu, Xiaojuan He

“…Furthermore, the proteomic analysis of synovial tissue showed that WB could regulate several signaling pathways associated with inflammation or cell migration, such as “IL-1 signaling,” “IL-8 signaling,” and “CXCR4 signaling.” …”
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Chinese Medicine Huzhen Tongfeng Formula Effectively Attenuates Gouty Arthritis by Inhibiting Arachidonic Acid Metabolism and Inflammatory Mediators by Jianping Deng, Zicong Wu, Chen Chen, Zhenling Zhao, Yifei Li, Zhengquan Su, Yiguang Lin, Yifei Wang, Zhiping Wang

“…Validation experiments showed that HZTF significantly inhibited the inflammatory cell infiltration into gouty joints, improved the swelling of affected joints, and increased the pain threshold. …”
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Mechanism of Cordyceps Cicadae in Treating Diabetic Nephropathy Based on Network Pharmacology and Molecular Docking Analysis by Yi Qian, Xin Sun, Xin Wang, Xin Yang, Mengyao Fan, Jiao Zhong, Zejun Pei, Junping Guo

“…GO and KEGG pathway analysis showed that these targets were mostly involved in R-HSA-450341, 157.14-3-3 cell cycle, and PDGF pathways. Docking studies suggested that myriocin can fit in the binding pocket of two target proteins (AKT1 and MAPK8). …”
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Clinical and Renal Biopsy Findings Predicting Outcome in Renal Thrombotic Microangiopathy: A Large Cohort Study from a Single Institute in China by Xiao-Juan YU, Feng YU, Di Song, Su-Xia Wang, Yan Song, Gang Liu, Ming-Hui Zhao

“…Other associated disorders included 17 patients with connective tissue disorders, 2 patients with hematopoietic stem cell transplantation, 4 patients with Castleman’s disease, 1 patient with cryoglobulinemia, and 2 patients with glomerulopathy. …”
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Global research landscape and hotspots for ferroptosis in glioma: A comprehensive bibliometric and visual analysis by Xinyue Zheng, Mengyao Diao, Shan Tong, Shuo Yang, Jing Lin, Shenghua Zhuo, Ting Wang, Jian Dai, Shenbo Chen, Kai Wang

“…Visual keyword analysis highlighted ''tumor biology'' ''cell death mechanisms'' and ''gene expression and metabolic processes'' as central themes in the research network. …”
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Microbiome analysis in individuals with human papillomavirus oral infection by David Israel Escobar Marcillo, Grete Francesca Privitera, Francesca Rollo, Alessandra Latini, Eugenia Giuliani, Maria Benevolo, Massimo Giuliani, Barbara Pichi, Raul Pellini, Maria Gabriella Donà

“…High-risk (hr)HPV infection causes oropharyngeal squamous cell carcinoma but only in a fraction of hrHPV+ individuals, suggesting that other factors play a role in cancer development. …”
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An exploratory study to evaluate efficacy and safety of frequent Transcutaneous Electrical Stimulation for Leber Hereditary Optic Neuropathy by Fumio Takano, Kaori Ueda, Takuji Kurimoto, Mina Arai, Takayuki Nagai, Yuko Yamada-Nakanishi, Makoto Nakamura

“…Safety endpoints included the corneal endothelial cell density and complications during ES. Fourteen patients participated in the study; four dropped out. …”
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The Identification of Key Genes and Pathways in Glioma by Bioinformatics Analysis by Mingfa Liu, Zhennan Xu, Zepeng Du, Bingli Wu, Tao Jin, Ke Xu, Liyan Xu, Enmin Li, Haixiong Xu

“…GO analysis demonstrated that the DEGs were enriched in cellular protein modification, regulation of cell communication, and regulation of signaling. …”
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