Sudden Vision Loss Secondary to Optic Nerve Infiltration as a Presenting Symptom of Metastatic Lung Adenocarcinoma by M. M. Shamim, M. Whaley, H. Rana, S. K. Jeffus, S. Bhatti, A. B. Sallam

“…To report a rare case of left-sided metastatic optic nerve infiltration and right-sided choroidal mass with exudative retinal detachment caused by EGFR exon 19 deletion positive non-small-cell lung adenocarcinoma that responded to targeted therapy with osimertinib (EGFR-TKI). …”
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siRNA therapeutics for effective management of rheumatoid arthritis by Vishakha R. Chakole, Tathagata Dutta, Priyankar Sen

“…Several treatments are available for RA, including analgesics, corticosteroids, DMARDs, biological agents, combinational therapy, epigenetic and cell therapies which play a crucial role in preventing joint function deterioration, inflammation, synovial edema, etc. …”
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Artificial Neural Network-Based System for PET Volume Segmentation by Mhd Saeed Sharif, Maysam Abbod, Abbes Amira, Habib Zaidi

“…Experimental and Monte Carlo simulated PET phantom data sets and clinical PET volumes of nonsmall cell lung cancer patients were utilised to validate the proposed algorithm which has demonstrated promising results.…”
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Elucidating the potential of EGFR mutated NSCLC and identifying its multitargeted inhibitors by Anakha D. Rajeeve, Ramasamy Yamuna, P. K. Krishnan Namboori

“…Mutations in the epidermal growth factor receptor (EGFR) gene are frequently found in non-small cell lung cancer (NSCLC). Since curcumin and CB[2]UN support various medicinal applications in drug delivery and design, we investigated the effect of curcumin and CB[2]UN-based drugs in controlling EGFR-mutant NSCLC through a dodecagonal computational approach. …”
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Halo-RPD: searching for RNA-binding protein targets in plants by A. O. Shamustakimova

“…Labeling of the fusion protein with custom-made fluorescent dyes makes it possible to study protein expression and to localize it in the cell or the whole organism. A high-affinity substrate has been created to allow covalent binding by chimeric proteins, minimizing protein loss during protein isolation. …”
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Extracellular Cold-Inducible RNA-Binding Protein and Hemorrhagic Shock: Mechanisms and Therapeutics by Naureen Rashid, Zhijian Hu, Asha Jacob, Ping Wang

“…During hemorrhagic shock, hypoperfusion leads to cell necrosis and the release of CIRP into circulation, triggering both systemic inflammation and local tissue damage. …”
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Clinical and Biochemical Features Used to Classify Type-1 and Type-2 Diabetes: A Scoping Review by Ulagamadesan Venkatesan, Anandakumar Amutha, Ranjit Mohan Anjana, Ranjit Unnikrishnan, Bagavandas Mappillairajan, Viswanathan Mohan

“…While age at diagnosis, autoimmune markers, and beta-cell function are among the crucial clinical parameters, biochemical indicators like C-peptide levels and antibody analyses play a pivotal role. …”
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Comparison of some hematological and serum biochemical variables in kangal akkaraman, texel and Île de france ewes in lactation period within sivas province by Mehmet Ekici, Abdurrahman Takcı, Mehmet Buğra Kıvrak

“…Hematological and biochemical variables analysis were performed using automatic cell counting and autoanalyzer devices.<p> <b>Results: </b>There was no significant difference in WBC, Hb, MCHC, MPV levels between ewe breeds (p>0.05). …”
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SARS-CoV-2: Molecular Structure, Pathogenesis, Potential Therapeutic Targets, and Immune Response of the Infected Subject by R. Wumba, M. Mandina, Y. Nlandu, J. R. Makulo, A. Tshimpi, P. Mbala, A. Mbangama, P. Kabututu, J. M. Kayembe

“…Through a documentary review of literature, the authors describe virological and molecular aspects of SARS-CoV-2, the intimate mechanisms of cell infection, and potential therapeutic targets. …”
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Pooled PPIseq: Screening the SARS-CoV-2 and human interface with a scalable multiplexed protein-protein interaction assay platform. by Darach Miller, Adam Dziulko, Sasha Levy

“…This approach combines the mDHFR split-tag reporter with the iSeq2 interaction-barcoding system to permit massively-multiplexed PPI quantification by simple pooled engineering of barcoded constructs, integration of these constructs into budding yeast, and fitness measurements by pooled cell competitions and barcode-sequencing. We applied this method to screen for PPIs between SARS-CoV-2 proteins and human proteins, screening in triplicate >180,000 ORF-ORF combinations represented by >1,000,000 barcoded lineages. …”
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Factors Related to Visual Outcomes after Lens Surgery in Isolated Microspherophakia by Jialei Zheng, Lina Cheng, Zexu Chen, Tianhui Chen, Yongxiang Jiang

“…Some ocular biometric parameters, such as corneal curvature, corneal pachymetry, endothelial cell count (ECC), anterior chamber depth (ACD), and axial length, were evaluated. …”
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First-Principles Calculation of Conductivity of Ce-C Codoped SnO2 Contacts by Can Ding, Zhenjiang Gao, Xing Hu, Zhao Yuan

“…The results show that Ce, C single doping, and Ce-C codoping all increase the cell volume and lattice constant. When the elements are codoped, the enthalpy change is the largest, and the thermal stability is the best. …”
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Safety and Efficacy of Two Trabecular Micro-Bypass Stents as the Sole Procedure in Japanese Patients with Medically Uncontrolled Primary Open-Angle Glaucoma: A Pilot Case Series by Daisuke Shiba, Shingo Hosoda, Saori Yaguchi, Naoki Ozeki, Kenya Yuki, Kazuo Tsubota

“…Intraocular pressure (IOP) and endothelial cell density (ECD) were determined at baseline and at 1, 3, and 6 months postoperatively. …”
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Mouse Model of Lipopolysaccharide (LPS)-Induced Pulpitis by Lanting Shao, Baian Chen, Ying Zheng

“…Additionally, we noted many more neutrophils and a small amount of chronic inflammatory cell infiltrates at the junction between inflamed and normal tissue. …”
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Development and Validation of Analytical Procedure for Elemental Impurities in Rosuvastatin Calcium Tablets by ICP-MS and Microwave Digestion by Yajie Hao, Guang Yin, Xuemei Wang, Juan Fu, Qihui Cao, Qinyong Sun, Guimin Zhang, Zhong Feng

“…The measurement mode was collision cell mode with kinetic energy discrimination (KED). 209Bi+, 115In+, and 89Y+ were chosen as internal standard elements. …”
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Effects of Undernutrition and Predictors on the Survival Status of HIV-Positive Children after Started Antiretroviral Therapy (ART) in Northwest Ethiopia by Mulugeta Molla, Fassikaw Kebede, Tsehay Kebede, Assefa Haile

“…The overall mortality rate in this study was determined as 5.4 per 100 child-years (95% CI: 3.6, 5.8). Children with CD4 cell counts below the threshold [AHR=1.6; 95% CI (1.19, 7.85)], advanced WHO clinical stages (III and IV) HIV [AHR=4.5; 95% CI (2.80, 8.40)], and being severe stunting at the beginning [AHR=2.9; 95% CI (1.80, 6.40)] were significantly associated with mortality of HIV-positive children. …”
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Significantly Delayed Development of Polyarthritis with Active Tenosynovitis after Possible Temporary Neutropenic Immune-Related Adverse Events Caused by Atezolizumab Treatment: A... by Yoshitaka Saito, Yoh Takekuma, Hajime Asahina, Ryo Hisada, Mitsuru Sugawara

“…Here, we report a case of significantly delayed rheumatic irAEs (Rh-irAEs) with prior possible temporary neutropenic irAEs in a patient with atezolizumab-treated non-small-cell lung cancer and its management. A man in his sixties received atezolizumab monotherapy as the sixth-line treatment. …”
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Posterior Reversible Encephalopathy Syndrome as Presenting Form of Very Early Systemic Sclerosis by María Isabel Pedraza, Julia Barbado, Marina Ruiz, Ángel Luis Guerrero

“…In SSc anti-endothelial cell antibodies impair vascular endothelium and liberation of vasoconstrictors leads to BP increasing and disruption of blood-brain barrier autoregulation mechanisms. …”
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Are Ancient Durum Wheats Less Toxic to Celiac Patients? A Study of α-Gliadin from Graziella Ra and Kamut by M. Stella Colomba, Armando Gregorini

“…Although some DQ2-Glia-α1 and DQ2-Glia-α2 variants evidenced herein were previously reported to have a diminished or abolished T cell stimulatory capacity, present results cannot confirm that ancient durum wheats would be less CD-toxic. …”
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Prevalence and Risk Factors of Trypanosomosis in Dromedary Camels in the Pastoral Areas of the Guji Zone in Ethiopia by Gossa Alemu, Rahmeto Abebe

“…Statistically, the mean packed cell volume was significantly lower (P<0.05) in parasitemic camels (26.5%±7) as compared with aparasitemic camels (33.9%±9.1). …”
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