Transcriptome-Based Modeling Reveals that Oxidative Stress Induces Modulation of the AtfA-Dependent Signaling Networks in Aspergillus nidulans by Erzsébet Orosz, Károly Antal, Zoltán Gazdag, Zsuzsa Szabó, Kap-Hoon Han, Jae-Hyuk Yu, István Pócsi, Tamás Emri

“…Many of them, including the downregulation of the mitotic cell cycle, as the MSB stress-specific upregulation of FeS cluster assembly and the MSB stress-specific downregulation of nitrate reduction, tricarboxylic acid cycle, and ER to Golgi vesicle-mediated transport, showed AtfA dependence. …”
Get full text

The involvement of CgCaspase-3 in regulating the expressions of proinflammatory cytokines through NF-κB/Rel signaling pathway in oysters by Zihan Wang, Xiaopeng Li, Jiejie Sun, Shuyi Mu, Wei Wu, Renle Chang, Lingling Wang, Linsheng Song

“…Cysteinyl aspartate specific proteinase-3 (Caspase-3) is a prominent mediator of apoptosis and participates in the cell death signaling cascade. In our previous study, CgCaspase-3 identified from Crassostrea gigas was involved in CgGSDME-dependent pyroptosis. …”
Get full text

Age and Gender: Affecting the Positive Rates of Serum PAB and ANCA in Patients with Inflammatory Bowel Disease by Qingquan Chen, Shirong Huang, Yue Wu, Shuyu Zhang, Qicai Liu, Min Chen

“…The present study is aimed at investigating the effect of age and gender on the positive rates of anti-Saccharomyces cerevisiae antibodies (ASCA), anti-neutrophil cytoplasmic antibodies (ANCA), anti-intestinal goblet cell antibodies (GAB), and antibodies to exocrine pancreas (PAB) in IBD patients. …”
Get full text

All-natural charge gradient interface for sustainable seawater zinc batteries by Wenjie Fan, Chunliu Zhu, Xingjie Wang, Huanlei Wang, Yue Zhu, Jingwei Chen, Weiqian Tian, Jingyi Wu, Guihua Yu

“…The seawater-based Zn | |NaV3O8·7H2O cell delivers an initial areal discharge capacity of 5 mAh cm-2 and operates over 500 cycles at 500 mA g-1.…”
Get full text

Protein Identification Improvement in Complex Samples Using Higher Frequency MS Acquisition and PEAKS Software by Arman Kulyyassov, Saya Makhsatova, Aruzhan Kurmanbay

“…Our findings indicate that increasing acquisition frequency generally improves protein identification, although the extent of improvement depends on the sample type. For CHO cell lysates, protein identifications increased by over 10%, while <i>E. coli</i> and albumin-depleted plasma samples demonstrated gains of 3.6% and 2.6%, respectively. …”
Get full text

Evaluation of 3D seed structure and cellular traits in-situ using X-ray microscopy by Marcus Griffiths, Barsanti Gautam, Clara Lebow, Keith Duncan, Xinxin Ding, Pubudu Handakumbura, John C. Sedbrook, Christopher N. Topp

“…Cellular analysis showed that cotyledon cell size was a driving factor for larger seeds. …”
Get full text

The inflammatory profiling in a cohort of older patients suffering from cognitive decline and dementia by Beatrice Arosio, Paolo Dionigi Rossi, Evelyn Ferri, Ernesto Consorti, Simona Ciccone, Tiziano Angelo Lucchi, Nicola Montano

“…Background: During aging, there is a progressive impairment of immune cell function that triggers the production of pro-inflammatory cytokines causing the so-called “inflammaging”. …”
Get full text

Characterization of the ZDSD Rat: A Translational Model for the Study of Metabolic Syndrome and Type 2 Diabetes by Richard G. Peterson, Charles V. Jackson, Karen Zimmerman, Willem de Winter, Norman Huebert, Michael K. Hansen

“…A lean ZDF rat with the propensity for beta-cell failure was crossed with a polygenetically obese Crl:CD (SD) rat. …”
Get full text

<i>Epigynum auritum</i>-Derived Near-Infrared Carbon Dots for Bioimaging and Antimicrobial Applications by Wenfeng Shi, Jiahui Li, Junmei Pu, Guiguang Cheng, Yaping Liu, Shanshan Xiao, Jianxin Cao

“…The antimicrobial effect is likely attributed to the NIR-CDs disrupting the cell membrane integrity, leading to the leakage of the intracellular contents. …”
Get full text

Simultaneous Determination of Three Active Forms of Vitamin B12 In Situ Produced During Fermentation by LC-MS/MS by Zhihao Fan, Yajie Li, Xia Fan, Pei Wang, Runqiang Yang, Chong Xie

“…At last, the developed method was applied for the determination of VB12 in fermented rice bran and the cell mass of <i>Propionibacterium freudenreichii</i>. …”
Get full text

Cardiogenic Shock due to Kounis Syndrome following Cobra Bite by W. D. D. Priyankara, E. M. Manoj, A. Gunapala, A. G. R. M. A. Ranaweera, K. S. Vithanage, M. Sivasubramanium, E. Snajeeva

“…Kounis syndrome is associated with mast cell activation resulting in acute coronary syndrome secondary to an allergic insult. …”
Get full text

Per1/Per2 double knockout transcriptome analysis reveals circadian regulation of hepatic lipid metabolism by Yiran Bu, Si Chen, Mengcheng Ruan, Libang Wu, Hualin Wang, Na Li, Xiuju Zhao, Xiaoli Yu, Zhiguo Liu

“…Hepatic transcriptome sequencing analysis showed that DKO mice exhibited multiple dysfunctions in diurnal rhythm, drug metabolism, cell cycle, cancer pathways, and lipid metabolism. …”
Get full text

Machine Learning Model for Gas–Liquid Interface Reconstruction in CFD Numerical Simulations by Tamon Nakano, Michele Alessandro Bucci, Jean-Marc Gratien, Thibault Faney

“…The relative volume fraction in each cell is used to recover the interface properties (i.e., normal, location, and curvature). …”
Get full text

Metabolic rate and insulin-independent glucose uptake increase in a TDP-43Q331K mouse model of amyotrophic lateral sclerosis by Tanya S. McDonald, Cedric S. Cui, Titaya Lerskiatiphanich, Jianina Marallag, John D. Lee

“…We also examined plasma hormone levels and quantified α- and β-cell areas in pancreatic islets. Throughout disease progression, TDP-43Q331K mice exhibited elevated metabolic rates, with a transient increase in food intake at the early stages. …”
Get full text

Manganese Inhalation as a Parkinson Disease Model by José Luis Ordoñez-Librado, Verónica Anaya-Martínez, Ana Luisa Gutierrez-Valdez, Laura Colín-Barenque, Enrique Montiel-Flores, Maria Rosa Avila-Costa

“…The present study examines the effects of divalent and trivalent Manganese (Mn2+/Mn3+) mixture inhalation on mice to obtain a novel animal model of Parkinson disease (PD) inducing bilateral and progressive dopaminergic cell death, correlate those alterations with motor disturbances, and determine whether L-DOPA treatment improves the behavior, to ensure that the alterations are of dopaminergic origin. …”
Get full text

PRKD2 as a novel target for targeting the diabetes–osteoporosis nexus by Rongjin Chen, Chenhui Yang, Hefang Xiao, Ao Yang, Changshun Chen, Fei Yang, Bo Peng, Bin Geng, Yayi Xia

“…These findings were further validated using external datasets, and a series of functional enrichment analyses, gene set enrichment analyses, and immune cell infiltration studies were conducted. Our analyses revealed a distinct progression pattern from a normal state through DM to DMOP, characterized by dynamic gene expression changes. …”
Get full text

Study of the effect of the introduction of mitochondrial import determinants into the gRNA structure on the activity of the gRNA/SpCas9 complex in vitro by E. G. Zakirova, Y. V. Vyatkin, N. A. Verechshagina, V. V. Muzyka, I. O. Mazunin, K. E. Orishchenko

“…The clinical symptoms of mitochondrial diseases and the degree of their manifestation directly depend on the number of mutant mtDNA molecules in the cell. The possible way to reduce adverse effects of the mutation is by shifting the level of heteroplasmy towards the wild-type mtDNA molecules. …”
Get full text

L-Lactic Acid Production by Lactobacillus rhamnosus ATCC 10863 by Ana Lívia Chemeli Senedese, Rubens Maciel Filho, Maria Regina Wolf Maciel

“…Considering that lactic acid was produced due to the low concentration of the well consumed sugars, the final amount was considerable. The cell growth was checked and no substrate inhibition was observed. …”
Get full text

Effects of Microbes on Insect Host Physiology and Behavior Mediated by the Host Immune System by Shan Zhang, Zhengyan Wang, Qiong Luo, Lizhen Zhou, Xin Du, Yonglin Ren

“…Therefore, this paper first briefly reviews the main innate immune signaling and insulin signaling of insects, then summarizes the relationship between immune signaling activated by microbes and insect growth and development, reproduction, pesticide resistance, chemical communication, cell turnover, lifespan, sleep, energy generation pathways and their possible underlying mechanisms. …”
Get full text

Unlocking precision medicine: clinical applications of integrating health records, genetics, and immunology through artificial intelligence by Yi-Ming Chen, Tzu-Hung Hsiao, Ching-Heng Lin, Yang C. Fann

“…AI-enabled immunology data analysis, including dimensionality reduction, cell population identification, and sample classification, provides unprecedented insights into complex immune responses. …”
Get full text