A Prospective Study Assessing Tumour Response, Survival, and Palliative Care Outcomes in Patients with HIV-Related Kaposi's Sarcoma at Queen Elizabeth Central Hospital, Blantyre, M... by H. Francis, M. J. Bates, L. Kalilani

“…At baseline assessment, the median CD4 T-cell count was 263, and 50% patients had evidence of peripheral neuropathy. …”
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Mechanism of Action of Lacticaseibacillus paracasei HNU502 and Fecal Microbiota Transplantation in Alleviating Antibiotic Side Effects by CHEN Lin, LI Ao, LI Jiahe, ZHANG Zeng, ZHANG Jiachao

“…Both FMT and probiotic supplementation improved gut microbiota composition, but to varying degrees, prevented goblet cell loss, and increased the contents of mucin-2 (MUC-2) and zonula occludens-1 (ZO-1), thus aiding gut mucosal recovery. …”
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Integrated gene expression and alternative splicing analysis in human and mouse models of Rett syndrome by Silvia Gioiosa, Silvia Gasparini, Carlo Presutti, Arianna Rinaldi, Tiziana Castrignanò, Cecilia Mannironi

“…Human and mouse dysregulated genes are involved in two main functional categories: cell-extracellular matrix adhesion regulation and synaptic functions, the first category more significantly enriched in human datasets. …”
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STUDI JUMLAH TROMBOSIT ANTARA PENDONOR LAKI-LAKI DAN PEREMPUAN PADA USIA YANG BERBEDA DI UNIT TRANSFUSI DARAH CABANG KOTA MALANG by Anis Nur Khasanah, Suyadi Suyadi

“…Blood is part of the body which has 6-8 % of total body weight which include of the blood cell and plasma. Thrombocyte is one of component in the blood which has an important function in blood coagulation. …”
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A Novel Hybrid MPPT Controller for PEMFC Fed High Step-Up Single Switch DC-DC Converter by Shaik Rafikiran, C. H. Hussaian Basha, C. Dhanamjayulu

“…At present, there are different types of Renewable Energy Resources (RESs) available in nature which are wind, tidal, fuel cell, and solar. The wind, tidal, and solar power systems give discontinuous power supply which is not suitable for the present automotive systems. …”
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GPX modulation promotes regenerative axonal fusion and functional recovery after injury through PSR-1 condensation by Su-Hyuk Ko, Kyung-Ah Cho, Xin Li, Qitao Ran, Zhijie Liu, Lizhen Chen

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Relationship between Altered Platelet Morphological Parameters and Retinopathy in Patients with Type 2 Diabetes Mellitus by Tolga Yilmaz, Ahu Yilmaz

“…Mean platelet volume (MPV), platelet distribution width (PDW), platelet large cell ratio (PLCR), plateletcrit (PCT) values, and platelet count were measured in the studied groups. …”
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Evolutionary Explanations of the “Actuarial Senescence in the Wild” and of the “State of Senility” by Giacinto Libertini

“…A large set of data suggests that progressive reduction of fitness and senile decay in vertebrates are in correlation with the decline of cell replication capacities. However, the limits in such capacities are hardly explained in evolutionarily terms by current gerontological theories that rule out fitness decline as something genetically determined and regulated, and therefore somehow favored by natural selection.Four theories are tested as possible explanations of the “increasing mortality with increasing chronological age in populations in the wild” (“IMICAW”[1]), alias “actuarial senescence in the wild”[2], and of the observed negative correlation between extrinsic mortality and the ratio between deaths due to intrinsic mortality and deaths due to extrinsic mortality. …”
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Comparison of Mechanical Resistance to Maximal Torsion Stress in Original and Nonoriginal or Compatible Prosthetic Implant Screws: An In Vitro Study by António Sérgio Silva, José Manuel Mendes, Tiago Araújo, Carlos Aroso, Pedro Barreiros

“…The screws were tightened with an MIS® torquemeter until their respective fracture, and the fracture point was measured through the equipment’s load cell, CS-Dental Testing Machine®. The screws were analyzed under an Olympus® SZ61 microscope. …”
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Pleiotropic effects of a recessive Col1a2 mutation occurring in a mouse model of severe osteogenesis imperfecta. by Michelangelo Corcelli, Rachel Sagar, Ellen Petzendorfer, Mohammad Mehedi Hasan, Fleur S van Dijk, Anna L David, Pascale V Guillot

“…The phenotype of differentiated OIM osteoblasts also differs from that of wild type mature osteoblasts, with upregulated oxidative cell stress and autophagy pathways. The extracellular accumulation of defective type I collagen fibres contributes to activation of the TGF-β signalling pathway and activates the inflammatory pathway. …”
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Isolation and Physiomorphological Characterization of Escherichia coli O157:H7-Infecting Bacteriophages Recovered from Beef Cattle Operations by Pushpinder Kaur Litt, Divya Jaroni

“…Phages had a rise period between 19 and 40 min, a short latent period between 12 and 30 min, and a large burst size (89–631 virions per infected cell), indicating high lytic activity. Phages remained stable for 24 h at a wide pH (1–11) and temperature range (40–60°C) and for 90 d in cold storage. …”
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The study of the regulatory region of the Drosophila melanogaster Notch gene by new methods of directed genome editing by O. V. Andreyenkov, E. I. Volkova, N. G. Andreyenkova, S. A. Demakov

“…In eukaryotic organisms, the Notch pathway is involved in cell fate determination. The Notch gene was first discovered in Drosophila melanogaster. …”
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The role of ESRP1 in solid tumor development through the regulation of CD44 splicing and EMT processes by Lili Wang, Min Zhang, Lei Ke Zhao, Xiaohan Yuan, Houyu Zhao, Yanting Liu, Yinghua Ji, Ping Lu

“…ESRP1 is a key intracellular molecule that plays a crucial role in cell growth and differentiation. As an emerging biomarker, ESRP1 has a decisive impact on the formation and development of solid tumors by regulating the alternative splicing of CD44 and the epithelial-mesenchymal transition (EMT) process. …”
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Trigonelline exerts its neuroprotective effects in experimental spinal cord injury through modulation of inflammation, apoptosis, and neurotrophic factors by Zhi-Lan Ye, Yuan Cao

“…Histological examination of spinal cord tissue indicated that trigonelline significantly (P<0.05) ameliorated the histological damage caused by SCI, thereby improving neuronal degeneration, inflammatory cell infiltration, and necrosis. Conclusions: Trigonelline shows neuroprotective properties in SCI rats by reducing allodynia, hyperalgesia, and inflammation, stabilizing mitochondrial enzyme complexes, and modulating apoptotic and neurotrophic factors. …”
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Antitrypanosomal and Anthelminthic Properties of Ethanol Extracts of Carica papaya Linn. and Ceiba pentandra (L) Gaertn. by Ahmed Wahab Obeng, Yaw Duah Boakye, Theresa Appiah Agana, Vivian Etsiapa Boamah, James Oppong-Kyekyeku, Abena Amponsaa Brobbey, Francis Adu, Stephen Yao Gbedema, Christian Agyare

“…All the extracts showed weak selective indices (SI) when tested on Jurkat cell lines, which is indicative of a potential toxic effect. …”
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Carbon nanodots from used green tea biochar: antibacterial applications and antibiofilm carbon coatings by E. Elsa Sharon, Jae-Wook Oh, Judy Gopal

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Early Therapy Evaluation of Combined Cetuximab and Irinotecan in Orthotopic Pancreatic Tumor Xenografts by Dynamic Contrast-Enhanced Magnetic Resonance Imaging by Hyunki Kim, Karri D. Folks, Lingling Guo, Jeffery C. Sellers, Naomi S. Fineberg, Cecil R. Stockard, William E. Grizzle, Donald J. Buchsbaum, Desiree E. Morgan, James F. George, Kurt R. Zinn

“…The K trans changes in the peripheral tumor region after 3 days of therapy were linearly correlated with 21-day decreases in tumor volume ( p < .001), bioluminescent signal ( p = .050), microvessel densities ( p = .002), and proliferating cell densities ( p = .001). This study supports the clinical use of DCE-MRI for pancreatic cancer patients for early assessment of an anti–epidermal growth factor receptor therapy combined with chemotherapy.…”
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Cryptosporidiosis in a Zoonotic Gastrointestinal Disorder Perspective by Thivya Balendran, Devika Iddawela, Sajanee Lenadora

“…The immunity of the host and the decrease in CD4+ T-cell count were found to the main factors which decide the susceptibility and the severity of infection. …”
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The Different Characteristics of Cirrus Optical Coherence Tomography between Superior Segmental Optic Hypoplasia and Normal Tension Glaucoma with Superior Retinal Nerve Fiber Defec... by Jong Chul Han, Da Ye Choi, Changwon Kee

“…The peripapillary RNFL (pRNFL) and ganglion cell inner plexiform layer (GCIPL) of the two groups were compared to age-matched normal controls using cirrus OCT. …”
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Meta-Analysis of Pulmonary Transcriptomes from Differently Primed Mice Identifies Molecular Signatures to Differentiate Immune Responses following Bordetella pertussis Challenge by René H. M. Raeven, Jeroen L. A. Pennings, Elly van Riet, Gideon F. A. Kersten, Bernard Metz

“…Complement-mediated responses were more prominent in mice immunized with an outer membrane vesicle pertussis vaccine than in mice that received a whole-cell pertussis vaccine. Additionally, 46 genes encoding for secreted proteins may serve as markers in blood for the degree of protection (Cxcl9, Gp2, and Pla2g2d), intensity of infection (Retnla, Saa3, Il6, and Il1b), or adaptive recall responses (Ighg, C1qb). …”
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