Novel cycloviruses identified by mining human blood metagenomic data show close relationship to those from animals by Yuanqing Wang, Yuanqing Wang, Xiaojie Jiang, Yuan Xi, Siqi Wei, Songyi Ning, Wen Zhang, Wen Zhang

“…These proteins are crucial for viral replication and host-cell interaction: the Rep protein is involved in initiating viral genome replication, while the Capsid protein plays a key role in the assembly of new virions and the virus's ability to interact with host immune systems. …”
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Biomass production and silage quality of ensiled BRS Capiaçu elephant grass at different regrowth ages and residue heights by Daiana Lopes Lelis, Domingos Sávio Campos Paciullo, Mirton Jose Frota Morenz, Carlos Augusto de Miranda Gomide, João Paulo Santos Roseira, Fernando Cesar Ferraz Lopes, Jackson Silva e Oliveira, Odilon Gomes Pereira, Vanessa Paula da Silva, Fernanda Helena Martins Chizzotti

“…As regrowth age advanced, there were linear increases in the dry matter (DM) concentration, cell wall constituents, and fraction C (acid detergent insoluble nitrogen) of crude protein and reductions in the in vitro digestibility of DM and neutral detergent fiber (IVNDFD) in both the plant and its silage. …”
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The Role of PCNA Posttranslational Modifications in Translesion Synthesis by Montaser Shaheen, Ilanchezhian Shanmugam, Robert Hromas

“…Translesion synthesis is a special pathway that enables the replication fork to bypass blocking lesions. Proliferative Cell Nuclear Antigen (PCNA), which is an essential component of the fork, undergoes posttranslational modifications, particularly ubiquitylation and sumoylation that are critical for lesion bypass and for filling of DNA gaps which result from this bypass. …”
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Anionic liposomes prepared without organic solvents for effective siRNA delivery by Xiu Han, Yan Lu, Zhaoluo Xu, Yanan Chu, Xueping Ma, Haiping Wu, Bingjie Zou, Guohua Zhou

“…And the formation of calcium phosphate could promote the endosomal escape of siRNA effectively. The results from cell viability showed that the anionic liposomes had no obvious cytotoxicity. …”
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IGN: Invariable gene set-based normalization for chromatin accessibility profile data analysis by Shengen Shawn Hu, Hai-Hui Xue, Chongzhi Zang

“…We demonstrate the effectiveness of IGN in analyzing central memory CD8+ T cell activation, a system with anticipated global reprogramming of chromatin and gene expression, and show that IGN outperforms existing methods. …”
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Oxidative Stress and Its Association with COVID-19: A Narrative Review by Hardi Rafat Baqi, Halgord Ali M. Farag, Abdel Hamid H. El Bilbeisi, Rafee Habib Askandar, Amany M. El Afifi

“…Especially the virus’s route to cell entry via angiotensin-converting enzyme 2 (ACE2) receptor is well known that leads to pathogenesis in angiotensin II (AT II) which are critical in NADH/NADPH oxidase inducing ROS generation. …”
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Synthesis of Arginase Inhibitors: An Overview by Maria Cristina Molaro, Chiara Battisegola, Marica Erminia Schiano, Mariacristina Failla, Maria Grazia Rimoli, Loretta Lazzarato, Konstantin Chegaev, Federica Sodano

“…It also mediates different cellular functions and processes such as proliferation, senescence, apoptosis, autophagy, and inflammatory responses in various cell types. In mammals, there are two isoenzymes, ARG-1 and ARG-2; they are functionally similar, but their coding genes, tissue distribution, subcellular localization, and molecular regulation are distinct. …”
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Untargeted metabolomic and proteomic analysis implicates SIRT2 as a novel therapeutic target for diabetic nephropathy by Ruijing Zhang, Runze Chang, Heng Wang, Jinshan Chen, Chuanlong Lu, Keyi Fan, Yuhang Zhang, Lizheng Li, Sheng Yan, Honglin Dong

“…KEGG enrichment analysis showed that HIF-1 signaling pathway and renal cell carcinoma pathway were co-enriched pathways in energy metabolism and inflammatory response. …”
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Effective anti-inflammatory phenolic compounds from dandelion: identification and mechanistic insights using UHPLC-ESI-MS/MS, fluorescence quenching and anisotropy, molecular docki... by Hui Zou, Tingting Ben, Ping Wu, Geoffrey I.N. Waterhouse, Yilun Chen

“…This novel study identifies the effective anti-inflammatory phenolic compounds in dandelion and provides mechanistic insights into their interactions with receptor proteins (toll‐like receptor 4, TLR4; co‐receptor myeloid differentiation protein-2, MD-2) using UHPLC-ESI-MS/MS, lipopolysaccharide (LPS)-stimulated THP-1 cell line, fluorescence quenching and anisotropy, molecular docking (single ligand and multi-ligand docking) and molecular dynamics simulation. …”
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Exposure to Early Life Stress Results in Epigenetic Changes in Neurotrophic Factor Gene Expression in a Parkinsonian Rat Model by Thabisile Mpofana, Willie M. U. Daniels, Musa V. Mabandla

“…Chronic early life stress may alter neurotrophic factor gene expression including those for brain derived neurotrophic factor (BDNF) and glial cell derived neurotrophic factor (GDNF) that are important in neuronal growth, survival, and maintenance. …”
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Fumonisin B1 neurotoxicity: Preclinical evidence, biochemical mechanisms and therapeutic strategies by Blessing A. Obafemi, Isaac A. Adedara, Cássia Pereira Delgado, Olabisi T. Obafemi, Michael Aschner, Joao B.T. Rocha

“…Studies have also shown that neurotoxicity due to FB1 involves dysregulation of several biochemical events in the brain, such as induction of oxidative stress and inflammation, mitochondrial dysfunction and associated programmed cell death, inhibition of acetylcholinesterase and alteration of neurotransmitter levels, decreased activity of Na+K+ ATPase, as well as disruption of blood-brain barrier. …”
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Mutations in the ARAP3 Gene in Three Families with Primary Lymphedema Negative for Mutations in Known Lymphedema-Associated Genes by Maurizio Ricci, Rita Compagna, Bruno Amato, Sercan Kenanoglu, Dominika Veselenyiova, Danjela Kurti, Mirko Baglivo, Syed Hussain Basha, Roberta Serrani, Giacinto Abele Donato Miggiano, Barbara Aquilanti, Giuseppina Matera, Giuseppe Marceddu, Valeria Velluti, Lucilla Gagliardi, Munis Dundar, Juraj Krajcovic, Matteo Bertelli

“…ARAP3 is a small GTPase-activating protein regulator, which has important functions in lymphatic vessel organogenesis and modulation of cell adhesion and migration. Mutations in the ARAP3 gene are associated with impaired lymphatic vessel formation. …”
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Iron Deficiency and Iron Deficiency Anemia Are Common Epidemiological Conditions in Saudi Arabia: Report of the National Epidemiological Survey by Tarek Owaidah, Nouf Al-Numair, Ayman Al-Suliman, Mohammed Zolaly, Rana Hasanato, Faisal Al Zahrani, Mohameed Albalawi, Layla Bashawri, Khawar Siddiqui, Faisal Alalaf, Abdulkareem Almomen, Muhammad Raihan Sajid

“…Thalassemia trait and sickle cell trait were detected in 1.3% and 7% of participants, respectively. …”
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Clinical Features and Genetic Analysis of 20 Chinese Patients with X-Linked Hyper-IgM Syndrome by Lin-Lin Wang, Wei Zhou, Wei Zhao, Zhi-Qing Tian, Wei-Fan Wang, Xiao-Fang Wang, Tong-Xin Chen

“…Six patients received hematopoietic stem cell transplantations and four of them had immune reconstructions and clinical remissions. …”
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Lower FOXP3 mRNA Expression in First-Trimester Decidual Tissue from Uncomplicated Term Pregnancies with a Male Fetus by Tom E. C. Kieffer, Anne Laskewitz, Marijke M. Faas, Sicco A. Scherjon, Jan Jaap H. M. Erwich, Sanne J. Gordijn, Jelmer R. Prins

“…Early-pregnancy decidual mRNA expression of the regulatory T-cell marker, FOXP3, was sixfold lower (p<0.01) in pregnancies with a male fetus compared to pregnancies with a female fetus. …”
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Self-propelled ferroptosis nanoinducer for enhanced cancer therapy by Wenxin Xu, Hao Tian, Yanzhen Song, Hanfeng Qin, Junbin Gao, Yichi Chen, Weichang Huang, Lin Lin, Haixin Tan, Yicheng Ye, Xiaoting Zhang, Daniela A Wilson, Guang Yang, Fei Peng, Yingfeng Tu

“…Ferroptosis is a newly proposed type of programmed cell death, which has been associated with a variety of diseases including tumors. …”
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PTLD Burkitt Lymphoma in a Patient with Remote Lymphomatoid Granulomatosis by A. Stravodimou, A. Cairoli, T. Rausch, R. Du Pasquier, P. Michel

“…The majority of PTLD is of B-cell origin, and 90% are associated with the Epstein-Barr virus (EBV). …”
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Polyurethane-Keratin Membranes: Structural Changes by Isocyanate and pH, and the Repercussion on Cr(VI) Removal by María D. Manrique-Juárez, Ana L. Martínez-Hernández, Oscar F. Olea-Mejía, Jaime Flores-Estrada, José L. Rivera-Armenta, Carlos Velasco-Santos

“…When pH in keratin solution is low (2.5), the protein separates from water, and a more closed cell in the membrane is obtained affecting its mechanical properties. …”
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Primary Neuroendocrine Carcinoma of Ocular Adnexa by Daisuke Yamanouchi, Toshiyuki Oshitari, Yosuke Nakamura, Jiro Yotsukura, Kaoru Asanagi, Takayuki Baba, Tomohiro Nizawa, Takashi Kishimoto, Yoko Yonemori, Satoshi Ota, Shuichi Yamamoto

“…We present our findings in a case of primary neuroendocrine carcinoma (NEC) of the lacrimal gland and a case of primary Merkel cell carcinoma (MCC) of the eyelid. An 86-year-old man noticed a swelling of the left upper eyelid three months earlier. …”
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Cloning and Characterization of Immunological Properties of Haemophilus influenzae Enolase by Yesenia Osorio-Aguilar, Maria Cristina Gonzalez-Vazquez, Patricia Lozano-Zarain, Ygnacio Martinez-Laguna, Alejandro Carabarin-Lima, Rosa del Carmen Rocha-Gracia

“…In this study, 10 linear B cell epitopes and 13 CTL epitopes and a putative plasminogen-binding motif (252FYNKENGMY260) and the presence of enolase on the surface of different strains of H. influenzae were identified in the enolase sequence of H. influenzae. …”
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