Tumor Necrosis Factor Alpha Mediates GABAA Receptor Trafficking to the Plasma Membrane of Spinal Cord Neurons In Vivo by Ellen D. Stück, Randolph N. Christensen, J. Russell Huie, C. Amy Tovar, Brandon A. Miller, Yvette S. Nout, Jacqueline C. Bresnahan, Michael S. Beattie, Adam R. Ferguson

“…The proinflammatory cytokine TNFα contributes to cell death in central nervous system (CNS) disorders by altering synaptic neurotransmission. …”
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Effective in vivo binding energy landscape illustrates kinetic stability of RBPJ-DNA binding by Duyen Huynh, Philipp Hoffmeister, Tobias Friedrich, Kefan Zhang, Marek Bartkuhn, Francesca Ferrante, Benedetto Daniele Giaimo, Rhett A. Kovall, Tilman Borggrefe, Franz Oswald, J. Christof M. Gebhardt

“…We determine the binding kinetics, transcriptional activity, and genome-wide chromatin occupation of RBPJ and mutant variants by live-cell single-molecule tracking, reporter assays, and ChIP-Seq. …”
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Evaluation of immunomodulatory effects of lamotrigine in BALB/c mice by Abu-Rish Eman Y., Elhayek Shada Y., Mohamed Yehia S., Hamad Islam, Bustanji Yasser

“…These included the in vivo effects of lamotrigine on delayed-type hypersensitivity (DTH) response to sheep red blood cell (SRBC) antigens, hemagglutination titer assays and hematological changes. …”
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A review on the chemical ecology of the Fucaceae holobionts: from fundamental knowledge to applications by Rousseau, Coralie, Demoulinger, Gautier, Rousvoal, Sylvie, Champeval, Delphine, Dolly, Maurane, Michel, Gurvan, Thomas, François, Markov, Gabriel V., Potin, Philippe, Dittami, Simon M., Prado, Soizic, Leblanc, Catherine, Le Guillard, Cécile

“…For some compounds, an alternative to wild harvesting could be the production of molecules of interest by organic synthesis or by biotechnological production, e.g., in microbial cell factories incorporating selected members of the algal microbiota. …”
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Embedded-Based Quadratic Boost Converter With Sliding-Mode Controller for the Integration of Solar Photo-Voltaic Source With Microgrid by S. Chitra Selvi, Ramya Govindaraj, Subrata Chowdhury, Saumya Singh, Baseem Khan

“…Microgrids use renewable energy sources like the wind and solar photo-voltaic energy source, and the fuel cell-based energy conversion systems. DC to DC converters is inevitable in a microgrid. …”
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Nonlinearity of the post-spinel transition and its expression in slabs and plumes worldwide by Junjie Dong, Rebecca A. Fischer, Lars P. Stixrude, Matthew C. Brennan, Kierstin Daviau, Terry-Ann Suer, Katlyn M. Turner, Yue Meng, Vitali B. Prakapenka

“…Here we present laser-heated diamond anvil cell experiments with synchrotron X-ray diffraction to better constrain this boundary, especially at higher temperatures. …”
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P2X7 Receptor Function in Bone-Related Cancer by Elena Adinolfi, Francesca Amoroso, Anna Lisa Giuliani

“…Among these molecules extracellular ATP is emerging as a good candidate in promoting cell growth, neovascularization, tumor-host interactions, and metastatization. …”
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The Pivotal Role of TBK1 in Inflammatory Responses Mediated by Macrophages by Tao Yu, Young-Su Yi, Yanyan Yang, Jueun Oh, Deok Jeong, Jae Youl Cho

“…Inflammation is a complex biological response of tissues to harmful stimuli such as pathogens, cell damage, or irritants. Inflammation is considered to be a major cause of most chronic diseases, especially in more than 100 types of inflammatory diseases which include Alzheimer's disease, rheumatoid arthritis, asthma, atherosclerosis, Crohn's disease, colitis, dermatitis, hepatitis, and Parkinson's disease. …”
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Transport and inhibition of the sphingosine-1-phosphate exporter SPNS2 by Huanyu Z. Li, Ashley C. W. Pike, Yung-Ning Chang, Dheeraj Prakaash, Zuzana Gelova, Josefina Stanka, Christophe Moreau, Hannah C. Scott, Frank Wunder, Gernot Wolf, Andreea Scacioc, Gavin McKinley, Helena Batoulis, Shubhashish Mukhopadhyay, Andrea Garofoli, Adán Pinto-Fernández, Benedikt M. Kessler, Nicola A. Burgess-Brown, Saša Štefanić, Tabea Wiedmer, Katharina L. Dürr, Vera Puetter, Alexander Ehrmann, Syma Khalid, Alvaro Ingles-Prieto, Giulio Superti-Furga, David B. Sauer

“…Accordingly, mutations in the S1P transporter SPNS2 are associated with reduced white cell count and hearing defects. SPNS2 also exports the S1P-mimicking FTY720-P (Fingolimod) and thereby is central to the pharmacokinetics of this drug when treating multiple sclerosis. …”
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An Evaluation of Deep Learning Methods for Small Object Detection by Nhat-Duy Nguyen, Tien Do, Thanh Duc Ngo, Duy-Dinh Le

“…These innovations proposed comprise region proposals, divided grid cell, multiscale feature maps, and new loss function. …”
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Reconfigurable anomalous reflectors with stretchable elastic substrates at 140 GHz band by Kato Yuto, Yonemura Kazuma, Seki Kento, Kambara Retsuku, Sanada Atsushi

“…The proposed reflector dynamically controls the reflection direction by mechanically stretching the substrate to induce a physical change of the unit cell period. Owing to the simple and scalable tuning mechanism, the proposed approach is applicable in the millimeter-wave and terahertz bands for a wide reflection steering. …”
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Modulating gene expression as a strategy to investigate thyroid cancer biology by Diego Claro de Mello, Joice Moraes Menezes, Antonio Tarelo Freitas de Oliveira, Marcella Maringolo Cristovão, Edna Teruko Kimura, Cesar Seigi Fuziwara

“…Allied with that, the existence of various human cell line models for cancer covering different histotypes and biological behaviors, especially for thyroid cancer, has helped improve the understanding of cancer biology. …”
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NLRP3 Deficiency Attenuates Renal Fibrosis and Ameliorates Mitochondrial Dysfunction in a Mouse Unilateral Ureteral Obstruction Model of Chronic Kidney Disease by Honglei Guo, Xiao Bi, Ping Zhou, Shijian Zhu, Wei Ding

“…The severe glomerular injury and tubulointerstitial fibrosis induced in WT mice by UUO was markedly attenuated in NLRP3−/− mice as evidenced by blockade of extracellular matrix deposition, decreased cell apoptosis, and phenotypic alterations. Moreover, NLRP3 deletion reversed UUO-induced impairment of mitochondrial morphology and function. …”
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A Rare Case of Paraneoplastic Syndrome Presented with Severe Gastroparesis due to Ganglional Loss by Konstantinos N. Argyriou, Martin Peters, Javaid Ishtiaq, Santosh Enaganti

“…In our report, so as to increase the clinical awareness of this rare clinical entity, we present the case of a 70-year-old Caucasian female who presented in our hospital with severe gastroparesis that was later proven to be associated with an overt small cell lung cancer (SCLC) and we discuss the existing knowledge of the pathophysiology, diagnosis, and management of this disorder.…”
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Internal Tremor in Long COVID May Be a Symptom of Dysautonomia and Small Fiber Neuropathy by Svetlana Blitshteyn, Ilene S. Ruhoy, Lauren R. Natbony, David S. Saperstein

“…<b>Conclusions:</b> Based on this case, our clinical experience, and the limited literature available to date, we believe IT is a manifestation of POTS and SFN, which may be driven by hypovolemia, cerebral hypoperfusion, sympathetic overactivity, neuropathic pain, and mast cell hyperactivation. Subjective description, objective findings, and diagnostic and therapeutic considerations in patients with IT and Long COVID are discussed.…”
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Application of Light-Responsive Nanomaterials in Bone Tissue Engineering by Aiguo Liu, Chenxu Wang, Shuang Deng, Sitong Zhang, Ziwen Zhao, Han Xiao, Ting Ying, Chengqing Yi, Dejian Li

“…These materials can regulate cellular biological reactions and promote bone cell adhesion, proliferation, and differentiation by absorbing specific wavelengths of light and converting them into physical and chemical signals. …”
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Synthesis and Crystal Structure of the Bioinorganic Complex [Sb(Hedta)]·2H2O by Di Li, Guo-Qing Zhong

“…The crystal structure of the antimony(III) complex belongs to orthorhombic system, space group Pna2(1), with cell parameters of a=18.4823(18) Å, b=10.9408(12) Å, c=7.3671(5) Å, V=1489.7(2) Å3, Z=4, and Dc=1.993 g cm−3. …”
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Long term survival of advanced hepatoid adenocarcinoma of lung secondary to idiopathic pulmonary fibrosis: a case report by Xiaoli Wang, Xiaoli Wang, Nan Wei, Nan Wei, Huizhen Yang, Huizhen Yang, Xiaoyan Wang, Xiaoju Zhang, Xiaoju Zhang, Qianqian Zhang, Qianqian Zhang

“…Systemic treatment according to guidelines for advanced non-small cell lung cancer resulted in a long-term survival.ConclusionsThis case report documents the first occurrence and prognosis of AFP-producing HAL in a patient with IPF. …”
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Punicalagin attenuated allergic airway inflammation via regulating IL4/IL-4Rα/STAT6 and Notch- GATA3 pathways by Yu Li, Li Jianying

“…Dexamethasone (DEX) was administered to a separate group of mice, as the standard drug control. Inflammatory cell infiltration into the broncho-alveolar lavage fluid (BALF) was substantially decreased in punicalagin-treated mice. …”
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Small-Molecule Hormones: Molecular Mechanisms of Action by Monika Puzianowska-Kuznicka, Eliza Pawlik-Pachucka, Magdalena Owczarz, Monika Budzińska, Jacek Polosak

“…In addition, small-molecule hormones modify the function of the cell by a number of nongenomic mechanisms, involving interaction with proteins localized in the plasma membrane, in the cytoplasm, as well as with proteins localized in other cellular membranes and in nonnuclear cellular compartments. …”
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