Sarcopenia and cachexia: molecular mechanisms and therapeutic interventions by Tiantian Wang, Dong Zhou, Zhen Hong

“…This review discusses the muscle microenvironment's changes contributing to these conditions, recent therapeutic approaches like lifestyle modifications, small molecules, and nutritional interventions, and emerging strategies such as gene editing, stem cell therapy, and gut microbiome modulation. We also address the challenges and opportunities of multimodal interventions, aiming to provide insights into the pathogenesis and molecular mechanisms of sarcopenia and cachexia, ultimately aiding in innovative strategy development and improved treatments.…”
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Coprecipitation Method of Synthesis, Characterization, and Cytotoxicity of Pr3+:LaF3 (CPr = 3, 7, 12, 20, 30%) Nanoparticles by Maksim S. Pudovkin, Pavel V. Zelenikhin, Victoria Shtyreva, Oleg A. Morozov, Darya A. Koryakovtseva, Vitaly V. Pavlov, Yury N. Osin, Vladimir G. Evtugyn, Albert A. Akhmadeev, Alexey S. Nizamutdinov, Vadim V. Semashko

“…The Pr3+:LaF3 (CPr = 7%) nanoparticles were nontoxic at micromolar concentrations toward COLO-320 cell line. The lifetime curves were fitted biexponentially, and for the Pr3+:LaF3 (CPr = 7%) NPs, the luminescence lifetimes of Pr3+ ions were 480 ± 2 and 53 ± 5 nanosec.…”
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Chemical Synthesis, Characterization, and Biocompatibility Study of Hydroxyapatite/Chitosan Phosphate Nanocomposite for Bone Tissue Engineering Applications by Nabakumar Pramanik, Debasish Mishra, Indranil Banerjee, Tapas Kumar Maiti, Parag Bhargava, Panchanan Pramanik

“…Primary murine osteoblast cell culture study proves that the nanocomposite is osteocompatible and highly in vitro osteogenic. …”
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Phytogenic Synthesis and Characterization of NiO-ZnO Nanocomposite for the Photodegradation of Brilliant Green and 4-Nitrophenol by Sirajul Haq, Aqsa Waheed Raja, Sadiq Ur Rehman, Amine Mezni, Manel Ben Ali, Amor Hedfi, Muhammad Imran Shahzad, Wajid Rehman, Nadia Shahzad, Muhammad Waseem, Pervaiz Ahmad

“…X-ray diffraction (XRD) was used for examined crystallinity, cell dimensions, and crystallite size (7.6 nm). To determine the purity of sample and weight percentage, energy dispersive X-ray (EDX) is used. …”
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Monoclonal antibody development and antigenic epitope identification of chicken pro-IL-1β by Mengmeng Xu, Mengmeng Huang, Guodong WANG, Jingzhe HAN, Xinxin NIU, Jinze HAN, Hangbo YU, Yulong ZHANG, Runhang LIU, Ziwen WU, Hongyu Cui, Yanping Zhang, Suyan Wang, Yongzhen Liu, Yuntong Chen, Yulu Duan, Liuan Li, Yulong Gao, Xiaole Qi

“…This study cloned and expressed chicken pro-IL-1β, and developed a hybridoma cell line 1E12 capable of stably secreting chicken pro-IL-1β monoclonal antibody (mAb). …”
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Decoding the molecular, cellular, and functional heterogeneity of zebrafish intracardiac nervous system by Andrea Pedroni, Elanur Yilmaz, Lisa Del Vecchio, Prabesh Bhattarai, Inés Talaya Vidal, Yu-Wen E. Dai, Konstantinos Koutsogiannis, Caghan Kizil, Konstantinos Ampatzis

“…Here, we present a comprehensive taxonomy of the IcNS, utilizing single-cell RNA sequencing, anatomical studies, and electrophysiological techniques. …”
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Evaluation of WHO Criteria for Viral Failure in Patients on Antiretroviral Treatment in Resource-Limited Settings by Barbara Castelnuovo, Joseph Sempa, Kiragga N. Agnes, Moses R. Kamya, Yukari C. Manabe

“…Patients with sustained suppression had better CD4+ T cell count increases over time compared to viremic patients (𝑃<.001). …”
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Molecular Monitoring in Adult Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia with the Variant e13a3 BCR-ABL1 Fusion by Mireille Crampe, Laura Kearney, David O’Brien, C. Larry Bacon, Derville O’Shea, Stephen E. Langabeer

“…Molecular monitoring reflected the disease response from diagnosis through allogeneic stem cell transplantation which resulted in undetectable e13a3 BCR-ABL1 transcripts. …”
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Identification of therapeutic targets for Alzheimer’s Disease Treatment using bioinformatics and machine learning by ZhanQiang Xie, YongLi Situ, Li Deng, Meng Liang, Hang Ding, Zhen Guo, QinYing Xu, Zhu Liang, Zheng Shao

“…By integrating differential gene expression analysis, weighted gene co-expression network analysis, Mfuzz clustering, single-cell RNA sequencing, and machine learning algorithms including LASSO regression, SVM-RFE, and random forest, five hub genes related to AD, including PLCB1, NDUFAB1, KRAS, ATP2A2, and CALM3 were identified. …”
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Effect of <i>Satureja montana</i> Essential Oil on Model Lipid Membranes by Simona Sennato, Silvia Trabalzini, Maria Gioia Fabiano, Domenico Truzzolillo, Edouard Chauveau, Cecilia Bombelli, Federica Rinaldi, Maria Carafa

“…In this framework, we investigated the interaction of SEO with lipid monolayers, which represent simplified models of cell membranes, using the Langmuir monolayer technique, complemented by fluorescence anisotropy and differential scanning calorimetry on lipid bilayers. …”
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Case report: A case report and literature review on the efficacy of high-dose aumolertinib combined intrathecal pemetrexed by Ommaya reservoir for EGFR-mutated NSCLC with leptomeni... by Maoxi Zhong, Maoxi Zhong, Maoxi Zhong, Li Zhou, Li Zhou, Li Zhou, Jing Guo, Jing Guo, Jing Guo, Chuan Chen, Chuan Chen, Chuan Chen, Wei Wang, Wei Wang, Wei Wang, Xiaoping Huang, Xiaoping Huang, Xiaoping Huang, Yi Liu, Yi Liu, Yi Liu

“…Leptomeningeal metastasis (LM) is a significant complication of advanced non-small cell lung cancer (NSCLC), occurring in only 3-5% of patients and exceedingly rare in newly diagnosed NSCLC patients. …”
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Synaptic Wnt/GSK3β Signaling Hub in Autism by Mario O. Caracci, Miguel E. Ávila, Giancarlo V. De Ferrari

“…The convergence of these variants in networks of genes associated with synaptic function warrants the study of cell signaling pathways involved in the regulation of the synapse. …”
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Development of an experimental setup for propeller performance measurements by Pugna Andreea, Hrab Călin, Hînsa Liviu-Nicolae, Hopârtean Andrei, Giurgea Corina-Maria, Marcu Lucian

“…The setup integrates off-the-shelf components, including a brushless motor controlled by an electronic speed controller (ESC), a load cell for precise thrust measurement, and a custom-built current sensor for power consumption analysis. …”
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Barcoded screening identifies nanocarriers for protein delivery to kidney by Luyao Wang, Wen Zhou, Hang Chen, Xiangqian Jia, Peiyuan Zheng, Haolin Jiang, Mengling Wu, Yaning Zhang, Yanchao Ding, Yexi Peng, Rui Zhu, Tiantian Li, Boxue Tian, Bujie Du, Juanjuan Du

“…In vitro and in vivo screening, using female mice, identify nanocapsules with high cell association and different biodistribution. Our investigation into kidney-enriched nanocapsules highlights the crucial role of polymer composition in biodistribution, demonstrating the potential of surface engineering for precise control over nanoparticle distribution. …”
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Predicting the Onset of Cavitation in Automotive Torque Converters—Part II: A Generalized Model by D. L. Robinette, J. M. Schweitzer, D. G. Maddock, C. L. Anderson, J. R. Blough, M. A. Johnson

“…Stator torque thresholds at the onset of cavitation for the stall operating condition were experimentally determined with a dynamometer test cell using nearfield acoustical measurements. Cavitation torques, design parameters, and operating conditions were resolved into a set of dimensionless quantities for use in the development of dimensionless empirical models. …”
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Annotation-free deep learning for predicting gene mutations from whole slide images of acute myeloid leukemia by Bo-Han Wei, Xavier Cheng-Hong Tsai, Kuo-Jui Sun, Min-Yen Lo, Sheng-Yu Hung, Wen-Chien Chou, Hwei-Fang Tien, Hsin-An Hou, Chien-Yu Chen

“…Our model predicts NPM1 mutations and FLT3-ITD without requiring patch-level or cell-level annotations. Using a dataset of 572 WSIs, the largest database with both WSI and genetic mutation information, our model achieved an AUC of 0.90 ± 0.08 for NPM1 and 0.80 ± 0.10 for FLT3-ITD in the testing cohort. …”
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HSCT-GAVE as a Manifestation of Chronic Graft versus Host Disease: A Case Report and Review of the Existing Literature by Michael J. Grant, Mitchell E. Horwitz

“…Over 30 cases of hematopoietic stem cell transplant-related GAVE (HSCT-GAVE) have been reported in the literature to date and there are likely many more that go undiagnosed or are attributed to another cause of upper gastrointestinal bleeding. …”
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Rare skin adverse reactions induced by osimertinib: a case report and literature review by Ye Zhang, Mingzhu Ling, Min Wang, Ye Chen, Liting Zhang

“…Osimertinib is a third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) used in the treatment of EGFR mutation-positive advanced non-small cell lung cancer. Osimertinib-induced cutaneous vasculitis is a rare skin adverse reaction. …”
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Novel thiophene derivatives with sulfonamide, isoxazole, benzothiazole, quinoline and anthracene moieties as potential anticancer agents by Ghorab Mostafa M., Bashandy Mahmoud S., Alsaid Mansour S.

“…All newly synthesized compounds were evaluated for their in vitro anticancer activity against human breast cancer cell line (MCF7). Most of the screened compounds showed cytotoxic activities compared to doxorubicin as a positive control. …”
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Correction of Iron Deficiency in the Cardiorenal Syndrome by Donald S. Silverberg, Dov Wexler, Adrian Iaina, Doron Schwartz

“…Iron deficiency has been shown to reduce energy production in the cell in animals and humans. Iron deficiency is common in both Chronic Kidney Disease (CKD) and in CHF. …”
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