The Diagnostic Journey of Dysautonomia Patients: Insights from a Patient-Reported Outcome Study by John A. O’Dell MSN, MBA, Ash Walker DHSc, Andrew J. Latham PhD, Daniel J. Parisian PhD, Lindsay E. Branch BS, Dreena D. Vanderburg, Ava A. Cox, Shelley Chavis, Silvia E. Smith PhD

“…Common comorbid conditions are Ehlers-Danlos syndrome, mast cell disorders, vitamin deficiency, fibromyalgia, and myalgic encephalomyelitis, all of which can contribute to the symptoms burden and can potentially confound the diagnostic process. …”
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Nanobody-thioesterase chimeras to specifically target protein palmitoylation by Chien-Wen Kuo, Caglar Gök, Hannah Fulton, Eleanor Dickson-Murray, Samuel Adu, Emily K. Gallen, Sheon Mary, Alan D. Robertson, Fiona Jordan, Emma Dunning, William Mullen, Godfrey L. Smith, William Fuller

“…Using a thioesterase fused to a nanobody directed against the Ca(v)1.2 beta subunit we reduce palmitoylation of the Ca(v)1.2 alpha subunit, modifying the channel’s voltage dependence and arrhythmia susceptibility in stem cell derived cardiac myocytes. We conclude that nanobody enzyme chimeras represent an approach to specifically manipulate PTMs, with applications in both the laboratory and the clinic.…”
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The Role of Insulin Receptor Isoforms in Diabetes and Its Metabolic and Vascular Complications by O. Escribano, N. Beneit, C. Rubio-Longás, A. R. López-Pastor, A. Gómez-Hernández

“…In some of them, there is a significant increase of IRA/IRB ratio conferring a proliferative and migratory advantage to different cell types and favouring IGF-II actions with a sustained detriment in the metabolic effects of insulin. …”
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Chitosan nanoparticle loaded by epidermal growth factor as a potential protein carrier for wound healing: In vitro and in vivo studies by Samaneh Montazeri, Ali Rastegari, Zohreh Mohammadi, Mahboobeh Nazari, Maryam Yousefi, Fatemeh Yazdi Samadi, Somayeh Najafzadeh, Mehdi Aghsami

“…Obtained results showed nanoparticles with 2:1 ratio of chitosan/EGF were able to release 80% of encapsulated protein after 12 h. Cell proliferation study demonstrated that prepared nanoparticles could protect EGF functionality in physiological pH. …”
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Cdk6’s functions are critically regulated by its unique C-terminus by Alessia Schirripa, Helge Schöppe, Sofie Nebenfuehr, Markus Zojer, Thorsten Klampfl, Valentina Kugler, Belinda S. Maw, Huriye Ceylan, Iris Z. Uras, Lisa Scheiblecker, Elisabeth Gamper, Ulrich Stelzl, Eduard Stefan, Teresa Kaserer, Veronika Sexl, Karoline Kollmann

“…Summary: The vital cell cycle machinery is tightly regulated and alterations of its central signaling hubs are a hallmark of cancer. …”
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Finite element models of intervertebral disc: recent advances and prospects by Tianze Sun, Junlin Wang, Xin Liu, Huagui Huang, Jinzuo Wang, Moran Suo, Jing Zhang, Zhonghai Li

“…In addition, microstructure, cell behavior and complex load should be considered in the process of model construction to build a more realistic model.…”
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Effect of PVA-co-MMA Copolymer on the Physical, Mechanical, and Thermal Properties of Tropical Wood Materials by Md. Saiful Islam, Sinin Hamdan, Mansor B. Ahmad, Mahbub Hasan, Azman Hassan, M. K. Mohamad Haafiz, M. Jawaid

“…The SEM observation showed that polymer converted from monomers filled up wood cell cavities and tightly interacted with wood matrix. …”
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Impact of HIV on HPV-related cancers in men who have sex with men: a review by Zixuan Zhang, Zixuan Zhang, Yuying Xing, Yuying Xing, Tingdan Gong, Wanlin Li, Siwei Zhang, Lanlan Wei

“…In this review, we reviewed the influence of HIV on specific HPV-related cancers in MSM, including oropharyngeal squamous cell carcinoma, penile cancer, and anal cancer. We integrated epidemiological data from the past five years and discussed diagnosis and treatment strategies. …”
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Modulation of CXC Chemokine Receptor Expression and Function in Human Neutrophils during Aging In Vitro Suggests a Role in Their Clearance from Circulation by Katja C. Weisel, Frank Bautz, Gabriele Seitz, Sedat Yildirim, Lothar Kanz, Robert Möhle

“…In our study, we provide evidence that also in human neutrophils, expression (cell surface and mRNA), chemotactic and signaling functions of the homing-related chemokine receptor CXCR4 are upregulated during aging in vitro, independent of addition of stimulatory cytokines (TNF, IL-1, IL-8, G-CSF). …”
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Hybrid Carcinoma of the Larynx: A Case Report (Adenoid Cystic and Adenocarcinoma) and Review of the Literature by Ilias Karasmanis, John K. Goudakos, Iosif Vital, Thomas Zarampoukas, Victor Vital, Konstantinos Markou

“…The nonsquamous carcinomas of the larynx are considered rare with the majority of malignant tumors in this area, reaching the rate of 95%, to be squamous cell neoplasms. Case Report. The case refers to a 53-year-old man that presented with symptomatology of motor nerve disease. …”
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Finite volume modeling of neural communication: Exploring electrical signaling in biological systems by Muzammal Saleem, Muhammad Saqib, Badar Saad Alshammari, Shahid Hasnain, Amjad Ayesha

“…These ion channels regulate ion movement across cell membranes, which is essential for neuronal activity. …”
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A Comparative Cytotoxic Evaluation of Acrylamide and Diacetone Acrylamide to Investigate Their Suitability for Holographic Photopolymer Formulations by Dervil Cody, Alan Casey, Izabela Naydenova, Emilia Mihaylova

“…The comparative cytotoxic evaluation of two monomers, diacetone acrylamide (DA) and acrylamide (AA) used in holographic photopolymer formulations, is reported. Two normal cell lines were used: BEAS-2B and HaCaT. Cellular viability was assessed using the MTT assay for three different exposure times. …”
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The Effect of Mycobacterium avium Complex Infections on Routine Mycobacterium bovis Diagnostic Tests by Claire Barry, David Corbett, Douwe Bakker, Peter Andersen, Jim McNair, Sam Strain

“…This study describes the cell-mediated immune responses of cattle exposed to Mycobacterium avium subspecies paratuberculosis (Map) and Mycobacterium avium subspecies avium with particular reference to routine antefmortem Mycobacterium bovis diagnostic tests. …”
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CRMP2 and CRMP4 Are Differentially Required for Axon Guidance and Growth in Zebrafish Retinal Neurons by Zhi-Zhi Liu, Jian Zhu, Chang-Ling Wang, Xin Wang, Ying-Ying Han, Ling-Yan Liu, Hong A. Xu

“…In zebrafish embryos, we find that CRMP2 and CRMP4 are expressed in the retinal ganglion cell layer when retinal axons are crossing the midline. …”
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Changes in microbiome composition during ontogeny and dispersal of the coral boring sponge Thoosa mismalolli by Eric Bautista-Guerrero, José Luis Carballo, Fabián Alejandro Rodríguez Zaragoza, Bruno Goméz-Gil, Alejandra García-Gasca, Alma P. Rodríguez-Troncoso, Adrián González-Castillo

“…TEM confirmed a substantial change in cell structure and microbial composition, attributed to symbionts’ massive phagocytosis. …”
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Characterization of Zebrafish von Willebrand Factor Reveals Conservation of Domain Structure, Multimerization, and Intracellular Storage by Arunima Ghosh, Andy Vo, Beverly K. Twiss, Colin A. Kretz, Mary A. Jozwiak, Robert R. Montgomery, Jordan A. Shavit

“…Recombinant zebrafish Vwf forms large multimers and pseudo-Weibel-Palade bodies (WPBs) in cell culture. Larval expression is in the pharyngeal arches, yolk sac, and intestinal epithelium. …”
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Seroprevalence of Antibodies against Human Herpesvirus 6 in the Quebec City Area by Louise Deschênes, Jean R Joly, Michel Couillard, Gilles Richer

“…Human herpesvirus 6 was grown in the HSB-2 cell line, and antibody litres were measured by indirect immunofluorescence. …”
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Exploring Host Genetic Polymorphisms Involved in SARS-CoV Infection Outcomes: Implications for Personalized Medicine in COVID-19 by Omar Ramos-Lopez, Lidia Daimiel, Ana Ramírez de Molina, Diego Martínez-Urbistondo, Juan A. Vargas, J. Alfredo Martínez

“…Thus, genes implicated in key pathophysiological processes such as the mechanisms related to the entry of the virus into the cell and the antiviral immune/inflammatory responses were identified. …”
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Convolutional Recurrent Neural Network for Fault Diagnosis of High-Speed Train Bogie by Kaiwei Liang, Na Qin, Deqing Huang, Yuanzhe Fu

“…Then, four recurrent layers with simple recurrent cell are used to model the context information in the extracted features. …”
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Anesthetic conduction in giant ovarian tumor by José Luis Muñoz Gallardo, Arletys Curbelo Hernández, José Luis Muñoz Fernández

“…Introduction: Teratoma is a germ cell tumor that frequently occurs in childbearing age, and is mostly benign. …”
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