HIV-Related Immune Activation and Inflammation: Current Understanding and Strategies by Tingxia Lv, Wei Cao, Taisheng Li

“…This aberrant immune activation and inflammation are considered an accelerator of non-AIDS-related events and one of the driving forces of CD4+ T cell depletion. Unfortunately, HIV-associated immune activation is driven by various factors, while the mechanism of excessive inflammation has not been formally clarified. …”
Get full text

Bioinformatics Analysis of the Human Surfaceome Reveals New Targets for a Variety of Tumor Types by André L. Fonseca, Vandeclécio L. da Silva, Marbella M. da Fonsêca, Isabella T. J. Meira, Thayná E. da Silva, José E. Kroll, André M. Ribeiro-dos-Santos, Cléber R. Freitas, Raimundo Furtado, Jorge E. de Souza, Beatriz Stransky, Sandro J. de Souza

“…It is estimated that 10 to 20% of all genes in the human genome encode cell surface proteins and due to their subcellular localization these proteins represent excellent targets for cancer diagnosis and therapeutics. …”
Get full text

Malignant Fibrous Histiocytoma of the Breast in Young Male Patient: A Case Report and a Review of the Literature by Esengul Kocak Uzel, Metin Figen, Tuba Tulin Bek, Kubilay Inanc, Senem Onder, Hazim orhan Kizilkaya

“…Here, we present a 37-years-old male patient who is diagnosed to have malignant fibrous histiocytoma in a variant of pleomorphic fusiform cell localized in the left breast. Following the wide local excision, the patient was given an adjuvant 50 Gy of external radiotherapy. …”
Get full text

Maxillary Sinus Lift Using Autologous Periosteal Micrografts: A New Regenerative Approach and a Case Report of a 3-Year Follow-Up by Saturnino Marco Lupi, Arianna Rodriguez y Baena, Claudia Todaro, Gabriele Ceccarelli, Ruggero Rodriguez y Baena

“…This report demonstrates the possibility to obtain a sufficient quality and quantity of bone with a progenitor cell-based micrograft and in turn make the site appropriate for an implant-supported rehabilitation procedure, with stable results over a period of two years.…”
Get full text

A Central Symmetrical and Low-Profile Omnidirectional Circularly Polarized Antenna by Zhe Wu, Lin Yang, Jiaji Wu, Zhensen Wu, Xi Li, Yu Yun

“…Based on the combination of two parallel complementary current sources, each unit cell can be realized by a scalloped cavity and a couple of curved strip lines. …”
Get full text

Far beyond Phagocytosis: Phagocyte-Derived Extracellular Traps Act Efficiently against Protozoan Parasites In Vitro and In Vivo by Liliana M. R. Silva, Tamara Muñoz-Caro, Rafael A. Burgos, Maria A. Hidalgo, Anja Taubert, Carlos Hermosilla

“…ETs are released in response to intact protozoan parasites or to parasite-specific antigens in a controlled cell death process. Released ETs consist of nuclear DNA as backbone adorned with histones, antimicrobial peptides, and phagocyte-specific granular enzymes thereby producing a sticky extracellular matrix capable of entrapping and killing pathogens. …”
Get full text

Biocompatible Peritoneal Dialysis Fluids: Clinical Outcomes by Yeoungjee Cho, Sunil V. Badve, Carmel M. Hawley, Kathryn Wiggins, David W. Johnson

“…Several preclinical studies have demonstrated their benefit in terms of improvement in host cell defence, peritoneal membrane integrity, and cytokine profile. …”
Get full text

Two Sides of the Same Coin: TFIIH Complexes in Transcription and DNA Repair by Alexander Zhovmer, Valentyn Oksenych, Frédéric Coin

“…These data highlight the dynamic composition of a fundamental cellular factor that adapts its subunit composition to the cell needs.…”
Get full text

Improving Baking Quality of Weak Gluten Semolina Using Ovine Whey Powder by Nicola Secchi, Costantino Fadda, Ivo Pinna, Alessandra Del Caro, Paola Conte, Antonio Piga, Simonetta Fois, Pasquale Catzeddu

“…Among the different pan bread types, consumers preferred 4T with 5% of substitution, which also showed an improved cell size distribution in the crumb.…”
Get full text

A Perspective on Withania somnifera Modulating Antitumor Immunity in Targeting Prostate Cancer by Seema Dubey, Manohar Singh, Ariel Nelson, Dev Karan

“…The role of WFA is appreciated to polarize tumor-suppressive Th1-type immune response inducing natural killer cell activity and may provide an opportunity to manipulate the tumor microenvironment at an early stage to inhibit tumor progression. …”
Get full text

MicroRNA-19a Targets Fibroblast Growth Factor-Inducible Molecule 14 and Prevents Tubular Damage in Septic AKI by Jun Hong, Bang-Chuan Hu, Liang Xu, Yang Zheng, Zi-Qiang Shao, Run Zhang, Xiang-Hong Yang, Ren-Hua Sun, Shi-Jing Mo

“…We identify Fn14 as a bona fide target of miR-19a, which directly binds to 3′ UTR of Fn14 for repression independent of cylindromatosis (CYLD), the deubiquitinase (DUB) downstream of miR-19a, and thereby antagonizes the LPS-induced tubular cell apoptosis. Genetic ablation of Fn14, but not of CYLD, abolishes the ability of miR-19a to antagonize the tubular apoptosis by lipopolysaccharide (LPS). …”
Get full text

Cellular Energy Absorbing TRIP-Steel/Mg-PSZ Composite: Honeycomb Structures Fabricated by a New Extrusion Powder Technology by Ulrich Martin, David Ehinger, Lutz Krüger, Stefan Martin, Thomas Mottitschka, Christian Weigelt, Christos G. Aneziris, Mathias Herrmann

“…Magnetic balance measurements and electron backscatter diffraction (EBSD) were used to identify the deformation-induced martensite evolution in the cell wall material. The honeycomb composite samples exhibit an increased strain hardening up to a certain engineering compressive strain and an extraordinary high specific energy absorption per unit mass and unit volume, respectively. …”
Get full text

Dopamine Neurons in the Ventral Tegmental Area: An Autopsy Case of Disorganized Type of Schizophrenia by Keiko Ikemoto, Tatsuro Oda, Akiyoshi Nishimura, Katsuji Nishi

“…A free floating method using 50-μm cryostat sections and three-dimensional imaging analyzer AxioVision were applied to observe the wide range structures of TH-immunoreactive (-ir) neurons. TH-ir neuronal cell bodies in the VTA of the present case had irregular shape and various size, and TH-ir neuronal processes had irregular thickness and straightened shape or curved shape having many corners, when compared to a control autopsy case with no detectable neurological and psychiatric diseases (64-year-old male). …”
Get full text

Complex Variant of Philadelphia Translocation Involving Chromosomes 9, 12, and 22 in a Case with Chronic Myeloid Leukaemia by F. Malvestiti, C. Agrati, S. Chinetti, A. Di Meco, S. Cirrincione, M. Oggionni, B. Grimi, F. Maggi, G. Simoni, F. R. Grati

“…Chronic myeloid leukemia (CML) is a hematopoietic stem cell disorder included in the broader diagnostic category of myeloproliferative neoplasms, associated with fusion by BCR gene at chromosome 22q11 to ABL1 gene at chromosome 9q34 with the formation of the Philadelphia (Ph) chromosome. …”
Get full text

Kaji Eksperimental Sifat Mekanik Honeycomb Sandwich Komposit Serat Karbon dengan Uji Bending by Marsono Marsono, Nuha Desi Anggraeni, Fajar Ahmad Faisal

“…These honeycomb sandwich panels are made with varying thickness of core cell wall, which are made by 1 layer and 2 layers of fiber-carbon sheet. …”
Get full text

Radiation Degradation of β-Glucan Extracted from Brewer’s Yeast for Enhancing Growth Promotion and Immunostimulant Activities on Broilers by Nguyen Thanh Long, Tran Le Truc Ha, Hoang Nghia Son, Le Quang Luan

“…Water-soluble low molecular weight β-glucan (WSLMG) was successfully prepared via γ-irradiation of insoluble β-glucan extracted from brewer’s yeast cell walls. The WSLMG content in an irradiated sample increased as the irradiation dose increased. …”
Get full text

Dietary Supplementation with Omega-3-PUFA-Rich Fish Oil Reduces Signs of Food Allergy in Ovalbumin-Sensitized Mice by Olívia Gonçalves de Matos, Sylvia Stella Amaral, Pedro Elias Marques Pereira da Silva, Denise Alves Perez, Débora Moreira Alvarenga, Adaliene Versiani Matos Ferreira, Jacqueline Alvarez-Leite, Gustavo Batista Menezes, Denise Carmona Cara

“…Allergic group mice had increased serum levels of antiovalbumin IgE and IgG1 and changes in small intestine, characterized by an increased edema, number of rolling leukocytes in microcirculation, eosinophil infiltration, mucus production, and Paneth cell degranulation, in comparison to non-allergic group. …”
Get full text

Genetic Risk Factors of Systemic Lupus Erythematosus in the Malaysian Population: A Minireview by Hwa Chia Chai, Maude Elvira Phipps, Kek Heng Chua

“…These candidate genes include MHC genes and genes encoding complement components, TNF, FcγR, T-cell receptors, and interleukins. However, most of the polymorphisms investigated in these genes did not show significant associations with susceptibility to SLE in the Malaysian scenario, except for those occurring in MHC genes and genes coding for TNF-α, IL-1β, IL-1RN, and IL-6.…”
Get full text

Blocking Type I Interferon Production: A New Therapeutic Option to Reduce the HIV-1-Induced Immune Activation by Moritz Ries, Kathrin Pritschet, Barbara Schmidt

“…The promises of immune reconstitution and normal life expectancy, however, fall short for a number of patients, either through inadequate recovery of CD4+ T-cell counts or the occurrence of non-AIDS defining malignancies. …”
Get full text

Pro-Inflammatory Cytokine-Mediated Anemia: Regarding Molecular Mechanisms of Erythropoiesis by F. Morceau, M. Dicato, M. Diederich

“…Some recent publications have demonstrated the direct effect of pro-inflammatory cytokines on cell differentiation towards erythroid pathway, without erythropoietin defect. …”
Get full text