The Emerging Role of Rab5 in Membrane Receptor Trafficking and Signaling Pathways by Wanqiong Yuan, Chunli Song

“…In this review, we summarize the role of small Rab GTPases Rab5 in membrane receptor trafficking and the activation of signaling pathways, such as Ras/MAPK and PI3K/Akt, which ultimately affect cell growth, apoptosis, tumorigenesis, and tumor development. …”
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Clinical Significance and Pathogenic Mechanisms of Long Non-Coding RNA TRPM2-AS in Cancers by Shichen Huang MS, Bowen Li MS, Huanyu Chen MD, Cheng Rong, Zheng Yang MD, Xianqin Zhang PhD

“…Moreover, TRPM2-AS is involved in regulating the cell proliferation, migration, invasion, apoptosis, drug or radio resistance by serving as a competing endogenous RNA, directly bounding to proteins and regulating multiple signaling pathways. …”
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Histoplasmosis Presenting as Granulomatous Hepatitis: Case Report and Review of the Literature by Nancy A. Rihana, Manasa Kandula, Ana Velez, Kumud Dahal, Edward B. O’Neill

“…Emphasizing histoplasmosis as a major cause of acute granulomatous hepatitis and fever of unknown origin in cell mediated immunodeficient population, this case highlights the need for high index of suspicion and the importance of prompt diagnosis since any delay of treatment can be life threatening in this population.…”
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Synthesis, characterization and gene expression of novel bis-Schiff base compounds and study their anti-bacterial activity using different genes by Mohammed Adnan Abid, Mustafa A-Jabbar Al-Jumaili, Ali Adnan Abed

“…These genes are control for example biosynthesis of cell walls. Targeting these two genes plays a role to inhibiting the bacterial growth of E. coli.…”
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Photoelectrocatalytic Performance of Benzoic Acid on TiO2 Nanotube Array Electrodes by Hongchong Chen, Jinhua Li, Quanpeng Chen, Di Li, Baoxue Zhou

“…The photoelectrocatalytic performance of benzoic acid on TiO2 nanotube array electrodes was investigated. A thin-cell was used to discuss the effect of the bias voltage, illumination intensity, and electrolyte concentration on the photoelectrocatalytic degradation efficiency of benzoic acid. …”
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Engineering soft-hard tissue interfaces in dental and craniofacial system by spatially controlled bioactivities by Hun Jin Jeong, Lan Anh P. Hoang, Neeve Chen, Elen Zhu, Albert Wang, Bozhi Chen, Emma Y. Wang, Christopher L. Ricupero, Chang H. Lee

“…The interface between soft and hard tissues is constituted by a gradient change of cell types and matrix compositions that are optimally designed for proper load transmission and injury protection. …”
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Species- and strain-specific microbial modulation of interferon, innate immunity, and epithelial barrier in 2D air–liquid interface respiratory epithelial cultures by Mian Horvath, Ruoyu Yang, Diana Cadena Castaneda, Megan Callender, Elizabeth S. Aiken, Anita Y. Voigt, Ryan Caldwell, José Fachi, Blanda Di Luccia, Zoe Scholar, Peter Yu, Andrew Salner, Marco Colonna, Karolina Palucka, Julia Oh

“…To explore how the microbiome’s biodiversity affects microbe-epithelial interactions, we screened 58 phylogenetically diverse microbes for their transcriptomic effect on human primary bronchial air–liquid interface (ALI) cell cultures. Results We found distinct species- and strain-level differences in host innate immunity and epithelial barrier response. …”
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Unraveling the Effect of Immunogenicity on the PK/PD, Efficacy, and Safety of Therapeutic Proteins by Alison Smith, Hugh Manoli, Stacey Jaw, Kimberley Frutoz, Alan L. Epstein, Leslie A. Khawli, Frank-Peter Theil

“…Biologics have emerged as a powerful and diverse class of molecular and cell-based therapies that are capable of replacing enzymes, editing genomes, targeting tumors, and more. …”
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Synthesis, Characterization, and Anticancer Activity of New Metal Complexes Derived from 2-Hydroxy-3-(hydroxyimino)-4-oxopentan-2-ylidene)benzohydrazide by Abdou Saad El-Tabl, Moshira Mohamed Abd El-Waheed, Mohammed Ahmed Wahba, Nahla Abd El-Halim Abou El-Fadl

“…The cytotoxic activity of the ligand and its metal complexes showed potent cytotoxicity effect against growth of human liver cancer HepG2 cell lines compared to the clinically used Sorafenib (Nexavar).…”
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Transmembrane voltage-gated nanopores controlled by electrically tunable in-pore chemistry by Makusu Tsutsui, Wei-Lun Hsu, Chien Hsu, Denis Garoli, Shukun Weng, Hirofumi Daiguji, Tomoji Kawai

“…Abstract Gating is a fundamental process in ion channels configured to open and close in response to specific stimuli such as voltage across cell membranes thereby enabling the excitability of neurons. …”
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Synthesis and Crystalline Structure of Zinc Complexes with Antihypertensive Drug Lisinopril by Márcia C. de Souza, Luan F. Diniz, Chris H. J. Franco, Renata Diniz

“…LISZn2 forms a one-dimensional (1D) coordination polymer and presents disorder atoms in its unit cell.…”
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Monoclonal Antibodies for Non-Hodgkin's Lymphoma: State of the Art and Perspectives by Giulia Motta, Michele Cea, Eva Moran, Federico Carbone, Valeria Augusti, Franco Patrone, Alessio Nencioni

“…The use of monoclonal antibodies in B-cell Non-Hodgkin's lymphomas (NHL) represents the greatest example of these advances, as the introduction of the anti-CD20 antibody rituximab has had a dramatic impact on how we treat this group of diseases today. …”
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Lung transplantation for pulmonary chronic graft-versus-host disease: a missed opportunity? by Andrea Zajacova, MD, Hélène Schoemans, MD, PhD, Mark Greer, MD, MRCP, Hildegard Greinix, MD, Peter Jaksch, MD, Osnat Shtraichman, MD, Rayid Abdulqawi, MD, PhD, Are M. Holm, MD, PhD, Robin Vos, MD, PhD, Saskia Bos, MD, PhD

“…Chronic graft-versus-host disease is a common complication after allogeneic hematopoietic stem cell transplantation, with pulmonary chronic graft-versus-host disease (PcGvHD) particularly associated with a dismal prognosis. …”
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The neuroscience in breast cancer: Current insights and clinical opportunities by Jia-feng Wang, Meng-chuan Wang, Lei-lei Jiang, Neng-ming Lin

“…Moreover, we reviewed neural cell factors and their impact on breast cancer progression, alongside the interactions between nerves and immunology, microbiota in breast cancer. …”
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Chimeric Osteocutaneous Free Flap Solution to Variation in Vascular Anatomy by Augustine J. Deering, III, BS, Payden A. Harrah, BS, Brian Wong Won, MD, John Michael Austin, BS, Mustafa T. Khan, DO, Jay K. Ferrell, MD, C. Anton Fries, MD, PhD

“…Summary:. When squamous cell carcinoma necessitates mandibular resection, the resultant defect can be complex. …”
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Swallowing Disorders after Oral Cavity and Pharyngolaryngeal Surgery and Role of Imaging by Caterina Giannitto, Lorenzo Preda, Valeria Zurlo, Luigi Funicelli, Mohssen Ansarin, Salvatore Di Pietro, Massimo Bellomi

“…Head and neck squamous cell carcinoma is the sixth most common cancer diagnosed worldwide and the eighth most common cause of cancer death. …”
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Spontaneous Retroperitoneal Hemorrhage in a Patient with Prolymphocytic Transformation of Chronic Lymphocytic Leukemia by Gwynivere A. Davies, Alejandro Lazo-Langner, Michael Shkrum, Leonard Minuk

“…We present the case of a 76-year-old gentleman with a previous diagnosis of chronic lymphocytic leukemia who presented with fatigue, fever, and a white blood cell count of 500 000 with prolymphocytes on peripheral blood examination. …”
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Recurrent Plasmacytomas after Allografting in a Patient with Multiple Myeloma by Allen N. Stawis, Diane Maennle, Moreno Festuccia, Zia Uddin, Benedetto Bruno

“…Extramedullary recurrence in multiple myeloma patients has been reported after both autologous and allogeneic hematopoietic cell transplantation and, more recently, after treatment with so-called new drugs with potent antimyeloma activity. …”
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Recent advances in the structure and immunomodulatory activity of food-derived glycoprotein complex by Yu Zhong, Jiangxiong Zhu, Bifen Zhu, Hao Yin, Danfeng Wang, Yun Deng, Minyan Zhang, Chunrong Zhang

“…Glycoprotein complex can affect the expression of immune-related proteins and factors by activating cell surface receptors, regulating intracellular immune signal transduction, and ultimately play an immunomodulatory role in the body. …”
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Neurotrophic Receptor Tyrosine Kinase 2 (NTRK2) Alterations in Low-Grade Gliomas: Report of a Novel Gene Fusion Partner in a Pilocytic Astrocytoma and Review of the Literature by Siobhan S. Pattwell, Eric Q. Konnick, Yajuan J. Liu, Rebecca A. Yoda, Laligam N. Sekhar, Patrick J. Cimino

“…NTRK2 encodes for the protein tropomyosin receptor kinase B (TrkB), which is a neurotrophin receptor with high affinity for Brain-Derived Neurotrophic Factor (BDNF), and plays a role in several physiological functions of neurons, including cell survival and differentiation. In this report, we describe a novel PML-NTRK2 gene fusion occurring in an adult sporadic pilocytic astrocytoma and review the biology and implications of specific NTRK2 mutations occurring in CNS neoplasms.…”
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