Prolonged exposure to heat enhances mosquito tolerance to viral infection by Hugo D. Perdomo, Ayda Khorramnejad, Nfamara M. Cham, Alida Kropf, Davide Sogliani, Mariangela Bonizzoni

“…We worked at the intersection between thermal biology and vector immunology and studied shifts in tolerance and resistance to the cell fusing agent virus (CFAV), a prominent component of the mosquito virome known to contribute to shaping mosquito vector competence, in warm-acclimated and warm-evolved Aedes albopictus mosquitoes. …”
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Multicomponent Nanocomposites for Complex Anticancer Therapy: Effect of Aggregation Processes on Their Efficacy by Nataliya Kutsevol, Yuliia Kuziv, Tetiana Bezugla, Vasyl Chumachenko, Vasyl Chekhun

“…Nanocomposites were tested for their photodynamic cytotoxicity for the cell line of breast cancer MCF-7/S. Three-component nanocomposites demonstrated higher efficacy than the four-component ones. …”
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Mathematical modeling and treating tumors in a fuzzy environment by Aadil Sheergojri, Pervaiz Iqbal

“…Even though most documented investigations have not yet reached the competency needed for curing cancer, research has contributed to understanding the statistical principles governing cancer cell development, invasion, and proliferation. This article begins with an overview of mathematical models for tumor development and treatment, which consider stochastic perturbations a therapeutic remedy. …”
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Correlation Between Blood Glucose Fluctuations and Osteoporosis in Type 2 Diabetes Mellitus by Fuhua Chen, Ping Wang, Fang Dai, Qiu Zhang, Ruixue Ying, Liya Ai, Yiqing Chen

“…Mechanistic studies, both in vitro and in vivo, reveal that these effects are largely mediated by oxidative stress, advanced glycation end products, inflammatory mediators, and multiple pathways inducing cell apoptosis or autophagy. Thus, maintaining the long-term stability of blood glucose levels emerges as a target to be pursued in clinical practice in order to safely reduce mean blood glucose and for its direct effects on osteoporosis and fractures in T2DM.…”
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Differential Impairment of Interferon-γ Responses in Two Cases of Pulmonary Nontuberculous Mycobacterial Disease by William Rae, Yifang Gao, Efrem Eren, Rainer Döffinger, Ben Marshall, Anthony P. Williams

“…These cases show that cellular IFN-γ responses may be defective in a proportion of patient suffering PNTM disease and that when assessing responses, the stimulant used in the testing is important to delineate defective cell populations. Impaired IFN-γ responses to IL-12 + BCG seem to be a poor prognostic indicator in PNTM disease and in these cases were not improved by adjuvant IFN-γ.…”
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Investigation of the inhibitory effects of HA-1077 and Y-32885 on the translocation of PKCβI, PKCβII and PKCζ in human neutrophils by Xavier Siomboing, Bernard Gressier, Thierry Dine, Claude Brunet, Michel Luyckx, Michelene Cazin, Jean-Claude Cazin

“…To transmit the information inside the cell, one possibility is the action of an enzyme called kinase that phosphorylates other proteins. …”
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Failure of Recombinant Activated Factor VII in Treatment of Diffuse Alveolar Hemorrhage due to Cryoglobulinemic Vasculitis by Dania Khoulani, Bharat Rao, Ammar Khanshour, Philip Kuriakose, Lenar Yessayan

“…We here report the failure of rFVIIa to control DAH in a patient with CD5+ B-cell non-Hodgkin’s lymphoma and cryoglobulinemic vasculitis.…”
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PPARs in Alveolar Macrophage Biology by Monica R. Smith, Theodore J. Standiford, Raju C. Reddy

“…We then review the role of PPAR-γ and its ligands in deactivating alveolar macrophages—thus limiting the inflammatory response that, if unchecked, could threaten the essential respiratory function of the alveolus—while upregulating the cell's phagocytotic activity. Finally, we examine the role that inadequate or inappropriate PPAR-γ responses play in specific lung diseases.…”
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The role of potential oxidative biomarkers in the prognosis of intracerebral hemorrhage and the exploration antioxidants as possible preventive and treatment options by Jiayong Yao, Xiaohong Dai, Xueping Yv, Lei Zheng, Jia Zheng, Binglin Kuang, Wei Teng, Weiwei Yu, Mingyue Li, Hongtao Cao, Wei Zou, Wei Zou

“…It usually leads to brain cell damage. According to a large number of experimental research, oxidative stress is an important pathophysiological processes of cerebral hemorrhage. …”
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Study of polymer-stabilized cholesteric liquid crystals for reflective displays in active matrix driving by Kuan-Wu Lin, Jhih-Yi Lu, Heng-Yi Tseng, Chien-Yi Lin, Liang Ying Huang, Yi-Ling Lin, Huan-Hsuan Chang, Tsung-Hsien Lin

“…Key parameters such as cell gap, monomer concentration, polymerization temperature, and different monomer types and liquid crystal hosts are systematically investigated to optimize the electro-optical properties of the liquid crystals for active matrix driving. …”
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The Bacterial Type III Secretion System as a Broadly Applied Protein Delivery Tool in Biological Sciences by Liyu Jia, Lihua Zhu

“…We explore the molecular underpinnings of the T3SS apparatus, which spans bacterial and host cell membranes, and discuss the intricate transport mechanisms of effector proteins. …”
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A CaMoO4 Crystal Low Temperature Detector for the AMoRE Neutrinoless Double Beta Decay Search by G. B. Kim, S. Choi, F. A. Danevich, A. Fleischmann, C. S. Kang, H. J. Kim, S. R. Kim, Y. D. Kim, Y. H. Kim, V. A. Kornoukhov, H. J. Lee, J. H. Lee, M. K. Lee, S. J. Lee, J. H. So, W. S. Yoon

“…The prototype detector cell was composed of a 216 g CaMoO4 crystal and a metallic magnetic calorimeter. …”
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Leguminous Lectins as Tools for Studying the Role of Sugar Residues in Leukocyte Recruitment by N. M. N. Alencar, E. H. Teixeira, A. M. S. Assreuy, B. S. Cavada, C. A. Flores, R. A. Ribeiro

“…The natural physiological ligands for selectins are oligosaccharides found in glycoprotein or glycolipid molecules in cell membranes. In order to study the role of sugar residues in the in vivo lectin anti-inflammatory effect, we tested three leguminous lectins with different carbohydrate binding affinities in the peritonitis and paw oedema models induced by carrageenin in rats. …”
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Biparatopic antibodies: therapeutic applications and prospects by David L. Niquille, Kyle M. Fitzgerald, Nimish Gera

“…These are not only attractive properties for therapeutic antibodies but are increasingly being explored for other modalities such as antibody-drug conjugates, T-cell engagers and chimeric antigen receptors. Recent advances in bpAb engineering have enabled the construction of ever more sophisticated formats that are starting to show promise in the clinic.…”
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Spontaneous Retroperitoneal Bleeding as a Complication of Unusual Renal Paraganglioma by Tawfeeq I. Sangey, Hamim Abdul Rusheke, Ansaar I. Sangey, Nimishkumar Chaya, Advera Ngaiza

“…We report a rare case of spontaneous retroperitoneal bleeding as a complication of an unusual nonfunctional renal paraganglioma, which was initially misdiagnosed as renal cell carcinoma but later confirmed by postoperative histopathology.…”
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Systemic Role for Vitamin D in the Treatment of Psoriasis and Metabolic Syndrome by Lisa Wenyang Fu, Ronald Vender

“…The novel discovery of the systemic role of vitamin D in the modulation of the immune system especially the Type 1 helper T cell (Th1) pathway reveals its potential for treating Th1 inflammatory diseases. …”
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Exploring the electronic and magnetic properties of half-heusler alloy CoMnSb: implications for spintronics by Binay Limbu, Prem Sagar Dahal

“…The total spin magnetic moments have been computed 3µB per unit cell which is in good agreement with the slater pauling rule Mt = Zt − 18 for Half Heusler alloy. …”
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Revisiting substance P in migraine: a methodological approach inspired by anti-CGRP and anti-PACAP success by Lanfranco Pellesi, Lars Edvinsson

“…This approach aims to establish proof of concept for substance P’s role in migraine, laying the groundwork for investigations with animal and cell-based models and advancing the development of innovative treatments for patients refractory to current therapies.…”
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Research progress on the role of extracellular vesicles in the pathogenesis of diabetic kidney disease by Jiangyuan Jin, Mianzhi Zhang

“…Extracellular vesicles (EVs) contain cell-derived membrane proteins, nucleic acids (such as DNA and RNA) and other important cellular components and are involved in intercellular information and substance transmission. …”
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AMPK-Dependent Metabolic Regulation by PPAR Agonists by Woo Hyung Lee, Sang Geon Kim

“…Comprehensive studies support the notion that the peroxisome proliferator-activated receptors, (PPARs), PPARα, PPARβ/δ, and PPARγ, regulate cell growth, morphogenesis, differentiation, and homeostasis. …”
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