Chemical Synthesis, Efficacy, and Safety of Antimalarial Hybrid Drug Comprising of Sarcosine and Aniline Pharmacophores as Scaffolds by Jean Baptiste Niyibizi, Peter G. Kirira, Francis T. Kimani, Fiona Oyatsi, Joseph K. Ng’ang’a

“…Cytotoxicity results revealed that sarcosine-aniline hybrid was safe to vero cells with a CC50 of 50.18 ± 3.53 μg/ml. Sarcosine-aniline hybrid was significantly less toxic compared with artesunate, chloroquine, and doxorubicin. …”
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Lack of activity of HIV-1 integrase strand-transfer inhibitors on recombinase activating gene (RAG) activity at clinically relevant concentrations by Sally Demirdjian, Vincent N. Duong, Jennifer N. Byrum, Arabinda Nayak, Cooper B. McKinney, Jason K. Perry, Christian Callebaut, Karla K. Rodgers, Brie Falkard, Joy Y. Feng

“…Additionally, we optimized an extrachromosomal V(D)J recombination cellular assay using murine mCherry-core RAG1, full-length murine mCherry-RAG2, and a plasmid substrate green fluorescent protein (GFP) reporter system, transfecting them into cells in the absence or presence of inhibitors. This setup enabled high-throughput analysis of V(D)J recombination for multiple compounds in a dose–response manner via flow cytometry. …”
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Increased expression of plasma mir-9-3p and let-7b-3p in methamphetamine use disorder and its clinical significance by Wei Wang, Chen Li, Guangsheng Sun, Cunxi Qiu, Junyi Fan, Yuhan Jin, Kunpeng Liu, Peng Sun

“…Furthermore, qRT-PCR and Western blot analyses demonstrated that transfection with miR-9-3p mimic led to overexpression of miR-9-3p, while transfection with let-7-3p mimic promoted overexpression of let-7-3p, concurrently inhibiting the protein levels of BDNF and GSK3B in cells (P < 0.05); ROC curve analysis indicated that the AUC for miR-9-3p was 0.782 (95% CI 0.716–0.848) and for let-7b-3p was 0.720 (95% CI 0.650–0.789). …”
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The Role of Intravenous Selexipag in Managing PAH and Bridging Gaps in Oral Treatment: A Narrative Review by Goren S, Kidwai N, Aronow WS, Lanier GM

“…Oral selexipag, approved by the Food and Drug Administration (FDA) in 2015 for the treatment of PAH, targets prostacyclin receptors on pulmonary arterial vascular smooth muscle and endothelial cells to improve blood flow through the lungs and reduce pulmonary vascular resistance. …”
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A Model H5N2 Vaccine Strain for Dual Protection Against H5N1 and H9N2 Avian Influenza Viruses by Jin-Ha Song, Seung-Eun Son, Ho-Won Kim, Se-Hee An, Chung-Young Lee, Hyuk-Joon Kwon, Kang-Seuk Choi

“…<b>Results:</b> The rvH5N2-aM2e-vPB2 strain demonstrated high productivity in ECEs and exhibited complete inhibition of replication in mammalian cells. Furthermore, compared with using F/A inactivation, inactivation using BEI significantly enhanced the immune response, particularly against NA. …”
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Nano-Zinc Oxide Can Enhance the Tolerance of Apple Rootstock M9-T337 Seedlings to Saline Alkali Stress by Initiating a Variety of Physiological and Biochemical Pathways by Jietao Zhai, Xulin Xian, Zhongxing Zhang, Yanxiu Wang

“…In summary, 150 mg/L ZnO NPs(T3) can effectively maintain the hormone balance, osmotic balance and ion balance of plant cells by promoting the photosynthetic capacity of M9-T337 seedlings, and enhance the antioxidant defense mechanism, thereby improving the saline alkaline tolerance of M9-T337 seedlings.…”
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Synergistic impact of Salmonella typhimurium and Eimeria spp. coinfection on turkey poults: Growth performance, salmonella colonization, and ceca microbiota insights by Hamid Reza Rafieian-Naeini, Hanseo Ko, Doyun Goo, Venkata Sesha Reddy Choppa, Seshidhar Reddy Gudidoddi, Hemanth Reddy Katha, Woo Kyun Kim

“…On the other side, coccidiosis is induced by Eimeria (E.) species. involves the destruction of host intestinal epithelial cells and subsequent invasion of pathogens, resulting in performance reduction and enhanced pathogen infection in poultry and economic losses for the poultry industry. …”
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Hubungan antara Kadar Troponin T dengan Luas Infark Miokard yang Diukur dengan Menggunakan Metode Skoring QRS Selvester pada Pasien Infark Miokard Akut by Muhammad Lingga Primananda, Masrul Syafri, Malinda Meinapuri3

“…Troponin T is one of cardiac enzyme that will increase if  there is a myocardial cells damage. The objective of this study was to determine the correlation between troponin T level and myocardial infarction size that measured by using Selvester QRS scoring method. …”
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Effect of Bee Resin on Blood Profiles of Infected Carassius auratus by Aeromonas hydrophila by Sri Nuryati, Y. Kuswardani, Y. Hadiroseyani

“… Bee resin is an organic matter that can be used as immunostimulant to induce cells and tissues regeneration for fast injury recovery. …”
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Experimental evidence-based construction of electroacupuncture for ischemic stroke: a meta-analysis and systematic review by Yaoguang Guo, Sihan Hu, Sihan Hu, Shiman Luo, Lang Tu, Yao Tang, Fang Zeng, Fang Zeng, Fang Zeng

“…Meta-analysis revealed that EA significantly reduced cerebral infarction volumes [MD = −15.78, 95%CI (−21.40, −10.16), p &lt; 0.05] and TUNEL-positive cells [MD = −26.46, 95%CI (−40.40, −12.51), p &lt; 0.05], indicating reduced apoptosis. …”
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Analysis of the effect of initial hemostasis resuscitation with recombinant human coagulation factor VII a on the treatment of postoperative hemorrhage in cardiac surgery by Yan Yu, Maomao Liu, Xuran Lu, Li Yu, Nan Liu

“…Result In this study, patients in the initial hemostasis resuscitation group received a lower dose of recombinant activated factor VII (rFVIIa) [29.41 (26.23, 34.63) µg/kg vs. 36.04 (28.57, 59.27) µg/kg, P = 0.002], had lower blood product requirements [41 (40.2%) vs. 31 (62%), P = 0.011], received fewer units of packed red blood cells within 24 h postoperatively [0 (0, 2) U vs. 2 (0, 6) U, P = 0.018], had a lower volume of plasma transfusion [0 (0, 0) ml vs. 0 (0, 400) ml, P = 0.021], exhibited a lower peak value of D-dimer after surgery [756 (415.5, 2140.5) ng/ml vs. 1742.5 (675.25, 3392) ng/ml, P = 0.003], experienced fewer postoperative neurological complications [4 (3.92%) vs. 12 (24%), P < 0.001], had a lower mortality rate [8 (7.84%) vs. 14 (28%), P = 0.001], and had a shorter duration of mechanical ventilation [17 (12, 60.13) hours vs. 39.5 (15.75, 115.13) hours, P = 0.022]. …”
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Ecologie alimentaire des bonobos en mosaïque forêt-savane : aliments de base et aliments de réserve by Victor Narat, Flora Pennec, Jean Christophe Bokika Ngawolo, Sabrina Krief

“…En comparant notre liste alimentaire avec celles publiées dans les autres sites d’études, il apparaît que Manzano est le site avec la plus grande diversité de familles botaniques consommées par les bonobos. …”
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Inhalation d'aérosols liquides ou solides chez les Primates Non Humains by Jérôme Montharu, Chrystophe Aubert, Georges Roseau, Laurent Vecellio, Antoine Guillon, Michèle de Monte

“…La procédure est très proche de celle mise en œuvre lors d'une séance d'aérosolthérapie humaine ; elle est donc tout à fait pertinente pour réaliser des études de dépôt afin de prédire la distribution pulmonaire d'un médicament nébulisé dans un modèle pédiatrique. …”
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Comment prendre en compte les mobilités saisonnières du bétail dans l’estimation de la charge animale d’un territoire sud-sahélien ? by Yanoussa Yakoubou Alzouma, Pierre Hiernaux, Mahamane Larwanou, Maguette Kaire, Issa Garba, Amadou Adamou Kalilou, Sambo Bode, Mahaman Maaouia Abdou Moussa, Harouna Abdou Bawa

“…Conclusions : les estimations des besoins fourragers saisonniers seront confrontées à celles d’ingestion fourragère faites à partir de l’analyse des échantillons de fèces prélevés selon les saisons. …”
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Serum ALT activity and its isoenzymes as potential biomarkers for diagnosis of Sarcopenia in older adults: a retrospective, cross-sectional study by Jiangping Zeng, Nannan Li, Jiaying Ge, Huihui Ma, Siqi Sun, Yujie Jing, Chunhua Qian, Ran Cui, Shen Qu, Hui Sheng

“…Abstract Background Alanine aminotransferase (ALT) is an enzyme crucial for energy and protein metabolism in muscle cells. Despite this, its association with sarcopenia remains inadequately explored. …”
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Thiol-Disulfide Homeostasis in Noise-Induced Hearing Loss in Rats by Enes Aydın, Serpil Mungan Durankaya, Osman Yilmaz, Günay Kirkim, Safiye Aktaş, Salim Neşelioğlu, Özcan Erel, Yüksel Olgun, Abdullah Dalgıç

“…After sacrificing the rats, the right and left temporal bones of each rat were removed and stained with hematoxylin eosin for histological studies to explore any pyknotic changes in spiral ganglion cells. Results: Intergroup comparisons by frequency on day 5 of noise exposure showed statistically significantly lower responses in ABR measurements at 8 kHz, 12 kHz, and 16 kHz in group 2 compared to group 3 (P = .003, P=.006, and P=.002). …”
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EGFR inhibition augments the therapeutic efficacy of the NAT10 inhibitor Remodelin in Colorectal cancer by Yongbin Zheng, Dan Song, Ming Guo, Chenhong Wang, Mingzhen Ma, Gongcai Tao, Licui Liu, Xiaobo He, Fengyu Cao, Dan Luo, Qingchuan Zhao, Zhongyuan Xia, Yanxin An

“…However, treatment with the NAT10 inhibitor Remodelin induced only a limited and reversible growth arrest in CRC cells. Further epigenetic and transcriptomic analysis revealed that NAT10 enhances the stability of ERRFI1 mRNA by binding to its coding sequence region in an ac4C-dependent manner. …”
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Disponibilité spatiale et temporelle des espèces alimentaires des chimpanzés et variations de densité inter-communautés dans le Parc national de Kibale (Ouganda) by Sarah Bortolamiol, Marianne Cohen, Protase Rwaburindore, John Kasenene, Andrew Seguya, Flora Pennec, Quentin Vignaud, Sabrina Krief

“…Bien que les variations temporelles de la fructification des espèces alimentaires de la communauté de chimpanzés de Sebitoli diffèrent des deux autres sites d’étude (rôle des activités anthropiques passées et présentes), elles sont sensiblement plus similaires de celles de Kanyawara que de Ngogo. Les interactions spatiales entre les éléments anthropiques et les animaux sauvages, le maintien d’espaces de surface suffisante pour assurer les migrations entre les communautés ainsi que d’autres variables environnementales sont des facteurs non mis en évidence ici qui ont rôle dans la conservation et la distribution des chimpanzés.…”
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Reconnaissance des indices attentionnels humains par le babouin olive (Papio anubis) by Marie Bourjade, Adrien Meguerditchian, Florence Gaunet

“…Toutefois, la reconnaissance des indices posturaux d’attention intra- ou interspécifiques, celle-là même qui détermine cette flexibilité communicationnelle, peut provenir d’apprentissages sociaux dont les mécanismes restent méconnus. …”
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A review of literature of a functional, congenital intrathoracic kidney by Sahil Sabharwal, Brandyn Young, Sarat Sabharwal, Kristen Brandon, Sarah Assem

“…However, in our patient, the kidney metanephric cells migrated past the diaphragm prior to diaphragmatic closure, which resulted in a functional kidney located in the thorax without any associated diaphragmatic defect. …”
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