The Role of Fusion Technique of Computed Tomography and Non-echo-planar Diffusion-weighted Imaging in the Evaluation of Surgical Cholesteatoma Localization by Ayse Ozlem BALIK, Lutfu SENELDIR, Aysegul VERIM, Sema ZER TOROS

“…Detecting the lesion of localization on the fused images compared to surgical found an almost perfect agreement in the mastoid antrum (k=0.948), strong agreement in the hypotympanum and mastoid cells (k=0.894), moderate agreement in the epitympanum (k=0.653), and weak agreement in those in the mesotympanum (k=0.540). …”
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Clinical Features and Predictors of Lethal Outcome in Tick-Borne Encephalitis: A Retrospective Study from Lithuania by G. Rynkevič, E. Žilinskas, D. Streckytė, D. Radzišauskienė, R. Mameniškienė

“…The latter patients were significantly older (71 vs. 53 years, p=0.003), had higher protein concentration and cytosis in the CSF (1.04 vs. 0.70 g/L, p=0.006 and 422 vs. 84 cells per milliliter, p=0.003, respectively), whereas the percentage of lymphocytes in the CSF was lower (62% vs. 81%, p<0.001). …”
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Case Report: Targeted treatment by fluoxetine/norfluoxetine of a KCNC2 variant causing developmental and epileptic encephalopathy by Ping Li, Alice Butler, Yu Zhou, Karl L. Magleby, Christina A. Gurnett, Lawrence Salkoff

“…The KCNC2 V437A variant showed GOF activity as demonstrated by HEK293 cells expressing variant subunits activating at more hyperpolarized potentials than WT channels. …”
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Human phospholipases A2: a functional and evolutionary analysis by I. I. Turnaev, M. E. Bocharnikova, D. A. Afonnikov

“…The PLA2 superfamily enzymes are widespread and present in most mammalian cells and tissues, regulating metabolism, remodeling the membrane and maintaining its homeostasis, producing lipid mediators and activating inflammatory reactions, so disruption of PLA2-regulated lipid metabolism often leads to various diseases. …”
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The clinical characteristics and implications of acute kidney injury during induction therapy for acute promyelocytic leukemia by Kai Shen, Chenlu Yang, Jie Huang, Xiao Shuai, Ting Niu, Hongbing Ma

“…It is considered to result from a severe systemic inflammatory response mediated by increased expression of cytokines, chemokines, and adhesion molecules on differentiating blast cells. The kidney, as a vital organ rich in the capillary endothelium, could be targeted by differentiating blasts in DS. …”
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Unexpected placenta accreta spectrum in an unscarred uterus causing catastrophic post-partum hemorrhage: a case report and review of the literature by Priyanka Garg, Shweta Semwal, Romi Bansal

“…Simultaneously, she was given four units of packed red cells and fresh frozen plasma in a ratio of 1:1, along with vasopressors and fluid replacement therapy to attain hemodynamic stability. …”
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Golgi scaffold protein PAQR11 in pan-cancer landscape: A comprehensive bioinformatics exploration of expression patterns, prognostic significance, and potential immunological funct... by Zhu Liu, Zhi-Qiang Ling

“…PAQR11 influences lipid metabolism and susceptibility to ferroptosis in cancer cells. This study aims to investigate the prognostic significance of PAQR11, its relevance to immune responses, and its association with drug sensitivity across various cancer types. …”
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Effect of anti-sclerostin antibody on orthodontic tooth movement in ovariectomized rats by Hyunna Ahn, Wonse Park, Sung-Hwan Choi, Namki Hong, Jisun Huh, Seoyeon Jung

“…., Tb.Th. increased, while Tb.Sp. decreased in the ROMO group. More TRAP-positive cells were observed in the compression side of the OVX group, the ROMO group exhibited a marked decrease in the positive expression of the RANKL, OPG, and sclerostin. …”
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Functional analysis of heterozygous variants in the SALL1 gene in 2 children with Townes-Brocks syndrome with FSGS by Rong Liang, Bixia Zheng, Chunli Wang, Sanlong Zhao, Wei Zhou, Ying Chen, Ruochen Che

“…The genetic function was investigated through cultured cells transfected with variants. The Sall1 protein expression level was detected by western blotting. …”
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RECK as a Potential Crucial Molecule for the Targeted Treatment of Sepsis by Qin Y, Liao S, Sun J, Ye H, Li J, Pan J, He J, Xia Z, Shao Y

“…Yuting Qin,1,&ast; Shuanglin Liao,1,&ast; Jianbo Sun,2 Huiyun Ye,1 Jiafu Li,1 Jiahui Pan,1 Junbing He,3 Zhengyuan Xia,4,5 Yiming Shao1,6 1Dongguan Key Laboratory of Sepsis Translational Medicine, The Intensive Care Unit, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, Guangdong, People’s Republic of China; 2Dongguan Key Laboratory of Chronic Inflammatory Diseases, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, Guangdong, People’s Republic of China; 3The Key Laboratory of Organ Dysfunction and Protection Translational Medicine, Jieyang Medical Research Center, Jieyang People’s Hospital, Jieyang, Guangdong, People’s Republic of China; 4Department of Anesthesiology and Perioperative Medicine, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, People’s Republic of China; 5State Key Laboratory of Pharmaceutical Biotechnology, Department of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, People’s Republic of China; 6The Key Laboratory of Sepsis Translational Medicine, Guangdong Medical University, Zhanjiang, Guangdong, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Yiming Shao, Dongguan Key Laboratory of Sepsis Translational Medicine, the Intensive Care Unit,The First Dongguan Affiliated Hospital, Guangdong Medical University, Jiaoping Road 42, Tangxia Town, Dongguan, Guangdong Province, 523710, People’s Republic of China, Tel +86 18826690188, Email sym@gdmu.edu.cn Zhengyuan Xia, Department of Anesthesiology and Perioperative Medicine, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, People’s Republic of China, Tel +852-68798794, Email zyxia@hku.hkAbstract: Reversion inducing cysteine rich protein with kazal motifs (RECK), a Kazal motif-containing protein, regulates pro-inflammatory cytokines production, migration of inflammatory cells, vascular endothelial growth factor (VEGF) and Wnt pathways and plays critical roles in septic inflammatory storms and vascular endothelial dysfunction. …”
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The relationship of the carriership of allelic variations in rs2228145 (A > C) of the<i>IL6R</i> gene with the levels of <i>VCAM1</i> and <i>ICAM1</i> gene transcripts in patients... by L. V. Topchieva, V. A. Korneva, I. V. Kurbatova

“…The levels of plasma interleukin 6 and its soluble receptors were found to be elevated in subjects with cardiovascular diseases, which points to amplification of the IL-6-mediated trans-signaling pathway in cells and the development of chronic inflammation. …”
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The Prognostic Value of Peripheral Blood Inflammatory Markers in Hepatocellular Carcinoma Treated with Lenvatinib Combined with PD-1 Inhibitors by Xin Y, Liu N, Peng G, Huang X, Cao X, Zhou X

“…Yujing Xin,1 Ning Liu,2 Gang Peng,3 Xiaoyu Huang,3 Xiaojing Cao,3 Xiang Zhou3 1Department of Oncology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, People’s Republic of China; 2School of Software, Shandong University, Jinan, Shandong, 250101, People’s Republic of China; 3National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, People’s Republic of ChinaCorrespondence: Xiang Zhou, Email zhou.xiang@yeah.netPurpose: To investigate the prognostic value of inflammatory indexes based on peripheral blood cells in unresectable hepatocellular carcinoma (HCC) patients treated with Lenvatinib combined with PD-1 inhibitors.Methods: This study retrospectively collected baseline inflammatory indexes from HCC patients received Lenvatinib and PD-1 inhibitor-based combination therapy at the Cancer Hospital of the Chinese Academy of Medical Sciences between October 2018 and October 2021. …”
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Case report: Chemotherapy plus sintilimab for the treatment of gastroesophageal junction hepatoid adenocarcinoma with liver metastasis: a case study with literature review by Genlin Lu, Jiarui Tu, Jinming Tu, Renya Jiang

“…There was a small intraluminal mass at the GEJ and a metastatic lesion in liver segment VIII, as well as enlarged perigastric and retroperitoneal lymph nodes. Tumor cells in both the GEJ and liver tissue exhibited a glandular shape with a nest-like adenoid structure. …”
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Clinical Efficacy of Platelet-Rich Plasma in the Treatment of Neurotrophic Corneal Ulcer by Dominika Wróbel-Dudzińska, Jorge Alio, Alejandra Rodriguez, Ewa Suchodoła-Ratajewicz, Ewa Kosior-Jarecka, Beata Rymgayłło-Jankowska, Agnieszka Ćwiklińska-Haszcz, Tomasz Żarnowski

“…Platelet-rich plasma (PRP) is an autologous blood product without preservatives and rich in proteins and growth factors which make it possible for cells to differentiate, proliferate, and migrate, thus stimulating healing and regeneration of tissues. …”
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Physical, chemical and biological properties of MTA Angelus and novel AGM MTA: an in vitro analysis by Sara Nashibi, Parisa Amdjadi, SeyedehSana Ahmadi, Sara Hekmatian, Maryam Torshabi

“…Moreover, the cytotoxicity was assessed through the MTT assay on human dental pulp stem cells (hDPSCs) after 24 and 72 h of exposure to the set/fresh status of various dilutions of MTA extracts, following the ISO 10993-12 standard. …”
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Identification of novel PfEMP1 variants containing domain cassettes 11, 15 and 8 that mediate the Plasmodium falciparum virulence-associated rosetting phenotype. by Florence E McLean, Brian R Omondi, Nouhoum Diallo, Stanley Otoboh, Carolyne Kifude, Abdirahman I Abdi, Rivka Lim, Thomas D Otto, Ashfaq Ghumra, J Alexandra Rowe

“…Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a diverse family of variant surface antigens, encoded by var genes, that mediates binding of infected erythrocytes to human cells and plays a key role in parasite immune evasion and malaria pathology. …”
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Preparation and In Vivo Expression of CS-PEI/pCGRP Complex for Promoting Fracture Healing by Chun-Liang Li, Feng Qin, Rong-rong Li, Jia Zhuan, Hai-Yong Zhu, Yu Wang, Kai Wang

“…CS-PEI/pCGRP could obviously increase CGRP expression in rat bone marrow stromal cells. In vivo fracture healing experiments demonstrated that CGRP could be delivered to the body via the CS-PEI and expressed in situ after a 3-week treatment. …”
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麝香组分诱导成年大鼠骨髓间质干细胞体外定向分化为神经元样细胞的能力 by 肖庆忠, 李浩威, 黄少华

“…收稿日期:2002 -08 -18 　　　　摘　要:【目的】探讨麝香组分体外诱导成年大鼠骨髓间质干细胞(adult rat bone marrow mesenchymal stem cells , rBMMSCs) 定向分化为神经元样细胞的能力。【方法】分别采用含麝香多肽或麝香酮的L-DMEM 培养基体外定向诱导第5 代至10 代的rBMMSCs , 并分别应用相差显微镜观察神经元样细胞和免疫细胞组化检测神经元样细胞所表达的神经干细胞特异性标 志(nestin)、神经元特异性标志[ 神经元特异性烯醇化酶(neuron specific enolase , NSE)和神经丝蛋白(neurofilament , NF)] 及星 形胶质细胞特异性标志[ 胶质纤维酸性蛋白(glia fiber acid pro tein , GFAP)] , 并进行神经元样细胞记数分析。…”
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Serum Apelin Levels and Correlation with illness Severity in Nonobese Patients with Bronchial Asthma by Rohan Pattanaik, Pratima Kumari Sahu, Monalisa Mohapatro, Jeetendra Kumar Patra, Nirjharini Dhal

“…Apelin is demonstrated in mature adipocytes and is highly expressed in pulmonary tissue, including bronchial and alveolar epithelial cells and small pulmonary blood vessels. Aim: The aim of this study was to evaluate the level of serum apelin in adult nonobese patients diagnosed with bronchial asthma cases and compare with healthy volunteers. …”
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Characterization of demethylating DNA glycosylase ROS1 from Nicotiana tabacum L. by D. V. Petrova, N. V. Permyakova, I. R. Grin, D. O. Zharkov

“…Expression of the NtROS1 gene in cultured human cells resulted in a global decrease in the level of genomic DNA methylation. …”
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