CSF shunts as conduits for metastasis: is there a discrepancy between retrograde and antegrade spread? by Andrea Cuschieri, Robert Pisani, Shawn Agius

“…Although rare, the dissemination of neoplastic cells along ventriculoperitoneal shunts is well documented, a gap in knowledge exists regarding differences in the direction of neoplastic dissemination along CSF shunts. …”
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Efficacy of Osthole in Management of Hypoperfused Retina by Ran Du, Zhao-yang Meng, Jia-lin Wang, Yan-ling Wang

“…TUNEL staining revealed fewer apoptotic cells in the osthole-IG and osthole-PI groups than in the other groups. …”
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Subhepatic appendicitis in a 27-year-old male: a case report from Odahulle General Hospital of Ethiopia by Abduletif Haji Ababor Abagojam, Abduletif Haji Ababor Abagojam, Remedan Jemal Dekema, Tamirat Godebo Woyimo, Jafer Yasin Mohammed, Kedir Negesso Tukeni

“…Laboratory investigations were unremarkable apart from the stool examinations which revealed many pus and red blood cells and was full of actively motile bacteria. An abdominal ultrasound showed an enlarged subhepatic appendix with an internal fecalith 1 cm in depth, that was partially compressible, with no obvious peri appendiceal free fluid or other pathology. …”
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Trends in blood transfusion and causes of blood wastage: a retrospective analysis in a teaching hospital by Ju-huei Chien, Chao-yuan Yao, Hui-fen Chen, Tsing-Fen Ho

“…Results The hospital released 424,197 units of blood products, with leukocyte-reduced red blood cells accounting for 140,971 units. The highest annual wastage rate was 0.29% in 2011, and the annual average was 0.08%. …”
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Hospitalization outcomes in people living with HIV on Dolutegravir-based regimen in Mwanza, Tanzania: a comparative cohort by Godfrey A. Kisigo, Eric Barongo, Benson Issarow, Cody Cichowitz, Bahati Wajanga, Samuel Kalluvya, Robert N. Peck

“…Male sex, using DTG-based regimen for < 3 months, diagnosis of suspected IRIS, diagnosis of ART side effect, advanced WHO clinical stage, CD4 count < 200 cells/mm3, hemoglobin level 7–11.9 gm/dl and hemoglobin level < 7 gm/dl were all independent risk factors for death. …”
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Crucial Genes in Aortic Dissection Identified by Weighted Gene Coexpression Network Analysis by Hongliang Zhang, Tingting Chen, Yunyan Zhang, Jiangbo Lin, Wenjun Zhao, Yangyang Shi, Huichong Lau, Yang Zhang, Minjun Yang, Cheng Xu, Lijiang Tang, Baohui Xu, Jianjun Jiang, Xiaofeng Chen

“…The gene expression in peripheral mononuclear cells was profiled through next-generation RNA sequencing. …”
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Antiamnesic and Neurotrophic Effects of Parkia biglobosa (Jacq.) R. Br (Fabaceae) Aqueous Extract on In Vivo and In Vitro Models of Excitotoxicity by Antoine Kavaye Kandeda, Liliane Yimta Foutse, Corneille Tongoue, Jean Philippe Djientcheu, Théophile Dimo

“…In addition, the extract (2450 μg/mL) increased (p<0.001) the percentage of viable cells. These results suggest that the extract has effects on amnesia and neurogenesis. …”
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EXamining the feasibility of exerCisE to manage symptoms of Lupus (EXCEL): a protocol for a randomised controlled pilot study by John Reynolds, Katie Hesketh, Matthew Cocks, Megan Quickfall, Alex J Wadley, Scott Green, Jet Veldhuijzen Van Zanten

“…Introduction SLE is a chronic autoimmune disease that results in sustained hyperactivation of innate and adaptive immune cells and widespread inflammatory damage. Regular exercise reduces SLE symptoms including fatigue and joint pain and improves patient quality of life. …”
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A VersaTile Approach to Reprogram the Specificity of the R2-Type Tailocin Towards Different Serotypes of <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> by Dorien Dams, Célia Pas, Agnieszka Latka, Zuzanna Drulis-Kawa, Lars Fieseler, Yves Briers

“…<b>Background:</b> Phage tail-like bacteriocins, or tailocins, provide a competitive advantage to producer cells by killing closely related bacteria. Morphologically similar to headless phages, their narrow target specificity is determined by receptor-binding proteins (RBPs). …”
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The impact of application acellular bovine pericardium supported with autogenous platelet-rich fibrin for cystoplasty in dogs: Histopathological assessments by Sohaib M. Amer, Fouad M. Mohammed

“…The results of the decellularization of the bovine pericardium (BP) patch showed the absence of cells and nuclear components. Clinically, the animals seemed healthy and survived until the completion of the study. …”
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Post-injury treatment with 7,8-dihydroxyflavone attenuates white matter pathology in aged mice following focal traumatic brain injury by Georgios Michalettos, Fredrik Clausen, Elham Rostami, Niklas Marklund

“…Post-injury proliferation of Platelet-derived Growth Factor Receptor (PDGFRα)-positive oligodendodrocyte progenitor cells was not altered by 7,8-DHF. Our results suggest that 7,8-DHF can attenuate white matter pathology by mitigating axonal injury and oligodendrocyte death in the aged mouse brain following TBI. …”
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Effect of Essential Microelements on Proteomic Profile of Lamb Muscle Tissue Protein by Tatiana M. Giro, Andrey V. Kulikovsky, Anna V. Giro

“…The tests also revealed superoxide dismutase, which catalyzes the superoxide radical into peroxides and oxygen, thus protecting body cells from free oxygen radicals. The research provided relevant data on the effect of innovative feed additives on the molecular mechanisms that occur in mutton muscle tissue and affect the proteomic profile of meat proteins and electrophoretic activity. …”
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Sustainable pectin extraction from Riang husk using ultrasound-assisted extraction with deep eutectic solvents and its potential in antipollution products by Manee Saelee, Hla Myo, Nuntawat Khat-udomkiri

“…It also attenuated damage caused by PM2.5 in HaCaT cells. The current study highlights UAE combined with DESs as a sustainable and effective method for obtaining high-quality pectin, contributing to the development of antipollution products and supporting sustainability goals.…”
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Utilizing integrated bioinformatics and machine learning approaches to elucidate biomarkers linking sepsis to purine metabolism-associated genes by Fanqi Liang, Man Zheng, Jingjiu Lu, Peng Liu, Xinyu Chen

“…A pivotal element in the pathogenesis and progression of sepsis involves the significant disruption of oncological metabolic networks, where cells within the pathological milieu exhibit metabolic functions that diverge from their healthy counterparts. …”
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An Atypical Presentation of Childhood Paraganglioma with Seizures: A Case Report and Review of the Literature by Elizabeth Eberechi Oyenusi, Uzoamaka Felicia Nwigbo, Oluwadamilola Moromoke Oladipo, Blessing Ebele Kene-Udemezue, Kasarachi Pauline Akowundu, Khadijah Omobusola Oleolo-Ayodeji, Oluwaseun Adunni Afoke, Funmilayo Oluwatoyin Babatunde, Felix Makinde Alakaloko, Gabriel Kolawole Asiyanbi, Ezekiel Olayiwola Ogunleye, Abiola Olufunmilayo Oduwole, Foluso Ebun Afolabi Lesi

“…A paraganglioma (PGL) is a tumour derived from extra-adrenal chromaffin cells of the sympathetic paravertebral ganglia of the thorax, abdomen, and pelvis. …”
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Biological effectiveness of combined exposure to neutrons and gamma radiation applied in two orders of sequence: Relevance for biological dosimetry after nuclear emergencies by Tomas Palmqvist, Milagrosa Lopez-Riego, Martin Bucher, Ursula Oestreicher, Stefan Pojtinger, Ulrich Giesen, Iuliana Toma-Dasu, Andrzej Wojcik

“…Objective: To investigate the potential impact of two different combinations of neutron and gamma radiation on gene expression and dicentric chromosomes in peripheral blood mononuclear cells (PBMC). Methods: Whole blood from 3 human donors was exposed to neutrons with an energy spectrum similar to that of the Hiroshima uranium bomb, to gamma radiation from a 60Co source and to a 50:50 combination of both radiations, given in two orders of sequence. …”
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Light-chain proximal tubulopathy: a retrospective study from a single Chinese nephrology referral center by Xin Wang, Xiao-juan Yu, Su-xia Wang, Fu-de Zhou, Ming-hui Zhao

“…Background Light-chain proximal tubulopathy (LCPT) is a rare disease characterized by the accumulation of monoclonal light chains within proximal tubular cells. This study aimed to investigate the clinical characteristics of LCPT from a single Chinese nephrology referral center.Methods Patients with kidney biopsy-proven isolated LCPT between 2016 and 2022 at Peking University First Hospital were retrospectively included. …”
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Hubungan Antara Volume Prostat dan IPSS Score pada Pasien BPH di Rumah Sakit Siti Khodijah Muhammadiyah Cabang Sepanjang by Shakina Reza Waskita, Muslim Andala Putra, Nur Mujadiddah Mochtar, Budi Himawan

“…<p>Benign Prostatic Hyperplasia (BPH) is the growth of non-malignant cells or hyperplasia of prostate tissue, which causes Lower Urinary Tract Symptoms (LUTS) in men. …”
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Sorption isotherms and kinetics of Crystal Violet dye uptake from aqueous solution by using polyaniline nanocomposite as adsorbent by Piyush Gupta, Amrita Kaushik, Garima Nagpal, Markus Diantoro, Firdaus Mohamad Hamzah, Faisal Islam Chowdhury, Pramod K. Singh

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Extracellular domain of TREM2 possess two distinct ligand recognition sites: Insights from machine-learning guided docking and all-atoms molecular dynamics simulations by Sarbani Mishra, Preety Sthutika Swain, Sanghamitra Pati, Budheswar Dehury

“…The myeloid-specific triggering receptors expressed on myeloid cells 2 (TREM2) is a group of class I receptors expressed in brain microglia plays a decisive role in neurodegenerative diseases such as Alzheimer's disease (AD) and Nasu Hakola disease (NHD). …”
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