DNA methylation of leptin before and after weight loss intervention program among sample of Egyptian obese females: Epigenetic approach in obesity by Nayera E. Hassan, Sahar A. El-Masry, Waheba A. Zarouk, Nayra S. Mehanna, Rehab M. Mosaad, Maha M Kobesiy, Mohamed S. Kishta, Mohamed Selim, Mahmoud A.S. Afify, Khadija Alian, Aya Khalil, Heba T. Aboud

“…DNA methylation constitutes the most relevant epigenetic mechanism that regulates gene expression in human cells. Leptin (LEP) has a promoter region that presents CpG (CG dinucleotide repeats) islands which may undergo a methylation process. …”
Get full text

Quality of Life Philosophy VI. The Concepts by Soren Ventegodt, Niels Jørgen Andersen, Joav Merrick

“…The same power that ties together all the cells in our body, seems to tie us together in relationships and new wholeness. …”
Get full text

Phenols from Vaccinium dunalianum Wight: Secondary Mass Spectrometry Fragmentation and Neuroprotective Effect by ZHOU Tang, WANG Ji, QIAO Wenhao, LIN Zhiqi, ZHU Hongbo, CHANG Yue, HU Weiyan, ZHANG Rongping, CHEN Xinglong

“…Compounds 1–4, 6, 10 and 16 had protective effects on SH-SY5Y cells damaged by H2O2. The neuroprotective effect of compound 3 (Icariside F2) increased with increasing its concentration at 5, 10, and 20 μmol/L, and the survival rate exceeded 80% at all three concentrations. …”
Get full text

An Unusual Presentation of Glandular Fever by Dominic Worku, Li Hui Chang, Ian Blyth

“…Histopathology of the core biopsy revealed Sternberg-reed cells and a mixed immunoblastic reaction in keeping with resolving IM. …”
Get full text

Overcoming barriers for investigating nickel-pincer nucleotide cofactor-related enzymes by Jorge L. Nevarez, Aiko Turmo, Santhosh Gatreddi, Swati Gupta, Jian Hu, Robert P. Hausinger

“…Here, we show that when the Lactiplantibacillus plantarum lar genes are cloned into the Duet expression system and cultured in Escherichia coli, they confer lactate racemase activity to the cells. By replacing L. plantarum larA with related genes from other microorganisms, this system allows for the generation of active LarA homologs. …”
Get full text

Inhibition of Aberrant IGF-I Signaling in Diabetic Male Rat Retina Prevents and Reverses Changes of Diabetic Retinopathy by Gang Xi, Christine Wai, David Clemmons

“…The anti-IAP antibody inhibited IGF-I-stimulated SHPS-1, p52Shc, MAP kinase phosphorylation, and proliferation in endothelial cells. To determine if it could reverse established pathophysiologic changes in vivo, this antibody or normal rat IgG F(ab)2 was injected intraperitoneally for 6 weeks into rats that had diabetes for 4 weeks. …”
Get full text

A Novel Adjuvant “Sublancin” Enhances Immune Response in Specific Pathogen-Free Broiler Chickens Inoculated with Newcastle Disease Vaccine by Yangke Liu, Jiang Zhang, Shuai Wang, Yong Guo, Tao He, Rui Zhou

“…On 7 and 21 dpv, pinocytosis of peritoneal macrophages, B lymphocyte proliferation assay, measurement of CD4+ and CD8+ T cells, and serum cytokine quantitation were carried out. …”
Get full text

NLRP3 is a BMI-independent mediator of stable COPD by Yonca Gungor, Selin Ercan, Saliha Selin Özuygur Ermiş, Yiğit Kozalı, Gizem Kursunluoglu, Ceyda Sahan, Aylin Ozgen Alpaydin, Hulya Ayar Kayali

“…Peripheral blood mononuclear cells were isolated, and total RNA was extracted for real-time quantitative polymerase chain reaction (qPCR) analysis to measure the expression levels of inflammasome molecules. …”
Get full text

Peut-il y avoir une vie sobre sans travail sobre ? by Valérie Deruelle, Jean-Luc Metzger

“…Parmi les facteurs permettant d’identifier les vulnérabilités et leur inégale distribution, le travail joue un rôle clé.Nous poserons qu’un travail peut être dit sobre s’il respecte les conditions suivantes : 1) les travailleurs participent aux décisions concernant leur production et l’organisation de leur activité ; 2) celles-ci répondent à l’intérêt général ; 3) ils prennent en compte l’impératif de limiter les empreintes de leurs activités ; 4) les évolutions du droit du travail rendent pérenne cette configuration.Pour tester la pertinence de ce cadre d’analyse, nous mobilisons les résultats d’une étude empirique portant sur des travailleurs « engagés » du numérique : a) les premiers ont mis en oeuvre des projets/organisations de plateformes coopératives numériques ; b) les seconds, salariés d’une multinationale, essayent, dans leurs pratiques quotidiennes, de mener des activités sobres. …”
Get full text

Integrating multiomics analysis and machine learning to refine the molecular subtyping and prognostic analysis of stomach adenocarcinoma by Miaodong Wang, Qin He, Zeshan Chen, Yijue Qin

“…Patients in the low-CMLS group had better survival, more enriched immune cells, and higher tumor mutation load scores, suggesting better immunotherapy responsiveness and a possible “hot tumor” phenotype. …”
Get full text

The Effect of Storage Time of Fresh Human Amniotic Membrane on the Levels of Growth Factors Epidermal Growth Factor, Transforming Growth Factor Beta, and Basic Fibroblast Growth Fa... by Ida Bagus Nyoman Ananta Awatara, Yuanita Safitri Dianti, Sitti Rizaliyana, Vijayendran Swaminathan

“…After cryopreservation, fibroblasts and epithelial cells in the amnion membrane remain viable, but their viability decreases when the membrane is freeze dried. …”
Get full text

Morphological influence of graphene and FeSO4 on polyaniline and application of nanocomposite towards oxygen reduction reactions in acid medium by Francklin Philips Muthukrishnan, Pavithra Bharathi Sundararajan, Akilan Murugesan

“…The aim of non-precious metal catalysts (NPMCs) is to replace expensive Pt-based catalysts for fuel cells. NPMCs require not only high oxygen reduction reaction (ORR) catalytic activity but also cheap ingredients and the facile synthetic method of the catalyst is amendable to mass production. …”
Get full text

Cryptogenic Organizing Pneumonia with a Rare Radiographic Presentation of a Diffuse Micronodular Pattern Mimicking Miliary Lung Infiltration: A Case Report and Review of the Litera... by Jakrin Kewcharoen, Kittika Poonsombudlert, Sakda Sathirareuangchai, Wichit Sae-Ow, Hanh La, Narin Sriratanaviriyakul

“…The pathology result showed organizing pneumonia (OP) pattern with heavy lymphoplasmacytic infiltrates and numerous multinucleated giant cells. His final culture results, microbiological data and serology workup for autoimmune disease were all unremarkable. …”
Get full text

The Use of Low‐Quality Cotton‐Derived Cellulose Films as Templates for In Situ Conductive Polymer Synthesis as Promising Biomaterials in Biomedical Applications by Sahin Demirci, Mehtap Sahiner, Shaida S. Rumi, Selin S. Suner, Noureddine Abidi, Nurettin Sahiner

“…All PPY@CF composites exhibit better biocompatibility than PANI@CF composites on L929 fibroblast cells with more than 70±8% viability at 1 mg of CF‐based conductive polymer composites. …”
Get full text

Fungsi Tiroid Pasca Radioterapi Tumor Ganas Kepala- Leher by Ade Chandra, Sukri Rahman

“…Abnormalities of the thyroid after radiotherapy is associated with damage cells and small blood vessels of the thyroid gland and capsule fibrosis of the thyroid gland which in turn causes the thyroid gland to shrink. …”
Get full text

Molecular Detection of Panton Valentine Leukocidin Toxin in Clinical Isolates of Staphylococcus aureus from Kiambu County, Kenya by Sani Iliya, Jonathan Mwangi, Ronald Maathai, Mary Muriuki, Christopher Wainaina

“…MRSA produces PVL toxins through lukS and lukF proteins causing tissue necrosis by damaging membrane of the defense cells. Presence of PVL toxin was tested from the 54 S. aureus clinical isolates obtained from Thika and Kiambu Level 5 Hospitals, in Kiambu County, Kenya, by Geno Type® MRSA assay (Hain Life Science, Nehren, Germany). …”
Get full text

Correlation between Cellular Autophagy and Color Changes in Qinchuan Cattle Meat during Postmortem Aging by LIANG Yanqun, SI Jianfang, MA Meng, GAO Shuang, LI Yalei, LUO Ruiming

“…Moreover, the key proteins related to cellular autophagy were expressed to different degrees during the postmortem process, and muscle cells exhibited autophagy, the strongest autophagic activity being observed at 96 h. …”
Get full text

Efficacy of DNA vaccine encoding koi herpesvirus glycoprotein GP-25in common carp juvenile by immersion by Soko Nuswantoro, . Alimuddin, Munti Yuhana, Ayi Santika, Sri Nuryati, Zakki Zainun, Mira Mawardi

“…A total of 400 common carp juveniles at 30-day-old were immersed in 1-L water containing 1.3×108CFU/mL of the killed Escherichia coli cells carrying DNA vaccine. Three frequencies and three duration of fish immersion were tested, namely: 1×30 minutes, 1×60 minutes, 1× 90 minutes, 2×90 minutes and 3×90 minutes by interval of 24 hours. …”
Get full text

High-Throughput Oxford Nanopore Sequencing Unveils Complex Viral Population in Kansas Wheat: Implications for Sustainable Virus Management by Nar B. Ranabhat, John P. Fellers, Myron A. Bruce, Jessica L. Shoup Rupp

“…Wheat leaves exhibiting virus-like symptoms were collected, total RNA was extracted, and cDNA libraries were prepared using a PCR-cDNA barcoding kit, then loaded onto ONT MinION flow cells. Sequencing reads aligned with cereal virus references identified eight wheat virus species. …”
Get full text

Heterozygous pathogenic STT3A variation leads to dominant congenital glycosylation disorders and functional validation in zebrafish by Linxue Meng, Zhixu Fang, Li Jiang, Yinglan Zheng, Siqi Hong, Yu Deng, Lingling Xie

“…We constructed wild-type and variant plasmids, transfected them into HEK293T cells and detected the expression levels of the STT3A protein. …”
Get full text