Hepatoprotective Role of 4-Octyl Itaconate in Concanavalin A-Induced Autoimmune Hepatitis by Wenchang Yang, Yaxin Wang, Peng Zhang, Tao Wang, Chengguo Li, Xin Tong, Xiangyu Zeng, Yuping Yin, Kaixiong Tao, Ruidong Li

“…Finally, our study revealed that OI inhibited TNF-α, or supernatants from Con A-treated RAW264.7 cells induced hepatocyte apoptosis. In conclusion, our study indicated that OI alleviated Con A-induced hepatic damage by reducing inflammatory response, oxidative stress, and apoptosis.…”
Get full text

Bromhexine Hydrochloride Prophylaxis of COVID-19 for Medical Personnel: A Randomized Open-Label Study by Evgeny N. Mikhaylov, Tamara A. Lyubimtseva, Aleksandr D. Vakhrushev, Dmitry Stepanov, Dmitry S. Lebedev, Elena Yu. Vasilieva, Alexandra O. Konradi, Evgeny V. Shlyakhto

“…Bromhexine hydrochloride has been suggested as a TMPRSS2 protease blocker that precludes the penetration of SARS-CoV-2 into cells. We aimed to assess the preventive potential of regular bromhexine hydrochloride intake for COVID-19 risk reduction in medical staff actively involved in the evaluation and treatment of patients with confirmed or suspected SARS-CoV-2 infection. …”
Get full text

Pulsed Light Accelerated Crosslinking versus Continuous Light Accelerated Crosslinking: One-Year Results by Cosimo Mazzotta, Claudio Traversi, Anna Lucia Paradiso, Maria Eugenia Latronico, Miguel Rechichi

“…Patients underwent clinical examination of uncorrected distance visual acuity and corrected distance visual acuity (UDVA and CDVA), corneal topography and aberrometry (CSO EyeTop, Florence, Italy), corneal OCT optical pachymetry (Cirrus OCT, Zeiss Meditec, Jena, Germany), endothelial cells count (I-Conan Non Co Robot), and in vivo scanning laser confocal microscopy (Heidelberg, Germany) at 1, 3, 6, and 12 months of follow-up. …”
Get full text

Mechanistic insights into gut microbe derived siderophores and PHD2 interactions with implications for HIF-1α stabilization by Jainabbi Irshad Ahmed Patel, Jagadeesha Poyya, Apeksha Padakannaya, Namrata Manjunath Kurdekar, Ajay Sathayanarayan Khandagale, Chandrashekhar Gajanan Joshi, Santosh R. Kanade, Kapaettu Satyamoorthy

“…Abstract In oxygen-deprived conditions, cells respond by activating adaptive mechanisms to bolster their survival and protect tissue integrity. …”
Get full text

Curcumin Targeting NF-κB/Ubiquitin-Proteasome-System Axis Ameliorates Muscle Atrophy in Triple-Negative Breast Cancer Cachexia Mice by Jin Zhang, Jin Zheng, Haitao Chen, Xinrong Li, Chenxiao Ye, Fan Zhang, Zewei Zhang, Qinghua Yao, Yong Guo

“…However, the role of it in breast cancer cachexia remains unclear. Methods. The 4T1 cells were subcutaneously injected into BALB/c mice to induce breast cancer cachexia. …”
Get full text

Successful thoracoscopic-assisted resection of a functional paraganglioma in the mediastinum with extracorporeal circulation: a case report by Zhihui Yang, Xiaojie Huang, Danting Zhou, Tao Tang, Hengxing Liang, Wenliang Liu, Fenglei Yu, Chen Chen

“…Abstract Background Paragangliomas are rare neoplasms arising from extra-adrenal chromaffin cells, with mediastinal paragangliomas representing an exceptionally rare subset. …”
Get full text

兔结膜基质诱导人骨髓间质干细胞分化的初步研究 by 黄丹平, 郑健梁, 高前应, 葛坚, 刘金陵

“…【目的】观察人骨髓间充质干细胞（mesenchymal stem cells，MSCs）在保存人羊膜及兔眼表结膜基质上分化的情况。【方法】24只新西兰兔随机分为2组。…”
Get full text

Evaluation of Five Ready-to-Use Bases for the Topical Administration of Propranolol Hydrochloride to Treat Infantile Hemangioma by Chiara Lacassia, Annalisa Cutrignelli, Flavia Maria la Forgia, Sergio Fontana, Antonio Lopalco, Nunzio Denora, Angela Assunta Lopedota

“…In vitro drug-release and permeability experiments were conducted through synthetic membranes and the outer pavilion of a pig’s ear by utilizing Franz-type diffusion cells. <b>Results</b>: The results indicated that the release of the drug was significantly influenced by the internal structure and physicochemical properties of each base. …”
Get full text

Implication of IL-17 in Bone Loss and Structural Damage in Inflammatory Rheumatic Diseases by Benoit Le Goff, Béatrice Bouvard, Thierry Lequerre, Eric Lespessailles, Hubert Marotte, Yves-Marie Pers, Bernard Cortet

“…At the cellular level, IL-17A is proosteoclastogenic whereas its effects on osteoblasts depend on the stage of differentiation of these cells. In vivo, IL-17A is not required for normal bone homeostasis but plays an important role in bone loss notably in an ovariectomized mouse model of osteoporosis. …”
Get full text

Invasive Aspergillus niger Is the Sole Etiological Agent for CSOM : A Clinical Case from Nepal by Ajay Kumar Chaurasiya, Rabindra Bhakta Pradhananga, Niranjan Prasad Sah, Basista Prasad Rijal, Bharat Mani Pokhrel, Santosh Dulal

“…Findings of laboratory analysis indicated that Gram staining of aural discharge displayed pus cells with fungal spores but did not exhibit bacteria. …”
Get full text

Evaluation of Pentraxin-3 and Interleukin-6 Levels in Serum and Gingival Crevicular Fluid in Patients with Generalized Periodontitis and Periodontal Health Controls before and afte... by Siamak Yaghobee, Sadegh Hasannia, Fatemeh Hamidzadeh, Saman Valadan Tahbaz, Rojin Shahmohammadi, Farzaneh Poursafar

“… Objectives: Pentraxin-3 (PTX3) and interleukin-6 (IL-6) are two of the most important inflammatory cytokines produced by cells in periodontal tissues. The present study aims to evaluate the levels of PTX3 and IL-6 in serum and gingival crevicular fluid (GCF) in patients with generalized periodontitis stages II and III, grades A and B, and periodontal health individuals before and after scaling and root planing (SRP). …”
Get full text

The impact of the Hsp67Bc gene product on Drosophila melanogaster longevity, fecundity, and acute heat stress tolerance by D. Malkeyeva, S. A. Fedorova, E. Kiseleva

“…Overexpression of the Hsp67Bc gene has been shown to enhance macroautophagy in Drosophila S2 cells, and the deletion of this gene leads to the formation of a slightly increased number of autophagic vacuoles in the fruit f ly brain neurons. …”
Get full text

The prognostic and immunomodulatory role of the MMR system in patients with stomach adenocarcinoma by Zhihui Tian, Lili Yang, Rong Yang, Wenhui Yang

“…The immune infiltration levels of most immune cells were upregulated in the high-risk group with elevated expression of PDCD1 and low TMB score. …”
Get full text

Druggability and molecular docking of essential secondary metabolites from Azadirachta indica leaf against angiotensin converting enzyme-2: Covid-19 in focus by Paul Chijioke Ozioko, Ukamaka Owohetete, Daniel Danladi Gaiya

“…The SARS-CoV-2 utilizes peptidase, angiotensin-converting enzyme 2 (ACE2) for entrance and invasion into host cells. Thus, this study explored the in-silico druggability and molecular docking of essential secondary metabolites (ESMs) from Azadirachta indica leaf as potential inhibitors of ACE-2, a main receptor for the SARS-CoV-2 virus causing the COVID-19 pandemic. …”
Get full text

The effect of replacing red algae on histomorphology and enzymes of digestive tract of Nile tilapia, Oreochromis niloticus by Sanaz Kord, Rahim Abdi, Isaac Zamani, Rhima Peyghan

“…Results: Histological examination in the mid-esophagus, anterior, middle, and posterior parts of the intestine showed that the highest number of mucous cells, the highest thickness of the epithelium and muscle layer, as well as the highest height and thickness of the esophageal villi were observed in the group receiving the diet containing 9% red algae. …”
Get full text

Modern classification and molecular-genetic aspects of osteogenesis imperfecta by A. R. Zaripova, R. I. Khusainova

“…In the last decade, it has become  known that autosomal recessive, autosomal dominant and X-linked mutations in a wide range of genes, encoding  proteins that are involved in the synthesis of type I collagen, its processing, secretion and post-translational modification, as well as in proteins that regulate the differentiation and activity of bone-forming cells, cause imperfect  osteogenesis. A large number of causative genes complicated the classical classification of the disease and, due to new advances in the molecular basis of the disease, the classification of the disease is constantly being improved.  …”
Get full text

P-glycoprotein and/or Histone Deacetylase 2 Regulates Steroid Responsiveness in Childhood Nephrotic Syndrome by Harshit Singh, Narayan Prasad, Durga Prasanna Misra, Akhilesh Kumar Jaiswal, Vikas Agarwal

“…Background: P-glycoprotein (P-gp) overexpression in peripheral blood mononuclear cells (PBMCs) has been reported in patients with steroid-resistant nephrotic syndrome (SRNS). …”
Get full text

Research and Discussion on the Relationships between Noise-Induced Hearing Loss and ATP2B2 Gene Polymorphism by Suhao Zhang, Enmin Ding, Haoyang Yin, Hengdong Zhang, Baoli Zhu

“…The ATP2B2 gene polymorphism can destroy cochlear hair cells and increase the risk of NIHL. A case-control study of 760 Chinese textile workers was conducted to investigate the relationship between ATP2B2 polymorphisms and NIHL susceptibility. …”
Get full text

Effectiveness of Sambiloto (Andrographis paniculata) Supplementation on Antibody Titers of Newcastle Disease, Avian Influenza and Infectious Bursal Disease in Broilers by Madi Hartono, Muhammad Mirandy Pratama Sirat, Purnama Edy Santosa, Ratna Ermawati

“…The content of andrographolide and flavonoids are thought to act as immunostimulants for specific and non-specific immune functions through the production of NK cells, macrophages, cytokine induction, IL-2 production, and lymphocyte proliferation. …”
Get full text

Effect of niacin on blood metabolities, rumen protozoa, insulin levels and fatty liver in experimentally induced ketosis in ewes by Veysi Aslan, Reşat Aştı, Ali Muhtar Tiftik, Mürsayettin Eksen

“…These parameters have been changed at the end of phlorizin injection (on the 12 day) as 105.72 U/ L, 4.52 mIU\ ml, 32.3 mg) dl, 6.6 gr\ dl, 315.8 mEqjL, 17 mEq/L, 5.24 % mg, 28 %, 13.9 X 103 respectively and total rumen protozoa count decreased to 20.200 + 4852 / ml and diffuse lipit infiltrastion was seen in epithelial cells of liver. On the 12 the day of the experiment, niacin was given orally to the animals for five days. …”
Get full text