Accelerated and precise skin cancer detection through an enhanced machine learning pipeline for improved diagnostic accuracy by SM Masfequier Rahman Swapno, S.M. Nuruzzaman Nobel, P.K. Meena, V.P. Meena, Jitendra Bahadur, Abhishek Appaji

“…Unrepaired DNA damage in skin cells causes mutations leading to skin cancer, a highly aggressive malignancy. …”
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Factors Associated With Missing Biological Samples in the Dog Aging Project by Sydney N. Holland, Amanda K. Tinkle, Jena N. Prescott, Brianna L. Blattman, Robyn L. McClelland, Yunbi Nam, Dog Aging Project Consortium, Kate E. Creevy, Virginia R. Fajt

“…Results EDTA samples for flow cytometry, peripheral blood mononuclear cells (PBMCs), DNA and biobanking were missing at rates of 18.9%, 13.3%, 6.7% and 5.6%, respectively. …”
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Aortic Stiffness Is Related to the Ischemic Brain Injury Biomarker N-Methyl-D-aspartate Receptor Antibody Levels in Aortic Valve Replacement by Emaddin Kidher, Vanash M. Patel, Petros Nihoyannopoulos, Jon R. Anderson, Andrew Chukwuemeka, Darrel P. Francis, Hutan Ashrafian, Thanos Athanasiou

“…Aortic stiffness changes the flow pattern of circulating blood causing microvascular damage to different end-organ tissues, such as brain cells. The relationship between aortic stiffness measured by pulse wave velocity (PWV) and serum ischemic brain injury biomarker N-methyl-D-aspartate receptor antibody (NR2Ab) levels in aortic valve replacement has not been assessed. …”
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Size effect-based improved antioxidant activity of selenium nanoparticles regulating Anti-PI3K-mTOR and Ras-MEK pathways for treating spinal cord injury to avoid hormone shock-indu... by Peixin Liu, Xiaodong Liu, Zihao Wu, Kui Shen, Zhaofeng Li, Xiaowei Li, Qifeng Wu, Leung Chan, Zhong Zhang, Yutong Wu, Liwen Liu, Tianfeng Chen, Yi Qin

“…These compounds effectively protected PC-12 cells from oxidative stress-induced cytotoxicity, alleviated mitochondrial dysfunction, reduced apoptosis. …”
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Exploration of the diagnostic and prognostic roles of decreased autoantibodies in lung cancer by Ying Ye, Ying Ye, Yi Huang, Yi Huang, Jianbo Pan, Jianbo Pan

“…IntroductionTumor-associated antigens (TAA) are proteins expressed during the growth and development of tumor cells, and TAA autoantibodies (TAAbs) can be detected in the serum of lung cancer patients, which can be utilized in the early screening of lung cancer. …”
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Pivotal role of Helicobacter pylori virulence genes in pathogenicity and vaccine development by Ayman Elbehiry, Eman Marzouk, Adil Abalkhail, Wael Sindi, Yasir Alzahrani, Salem Alhifani, Turki Alshehri, Nuha Abdulaziz Anajirih, Turki ALMutairi, Ahmad Alsaedi, Feras Alzaben, Abdullah Alqrni, Abdelmaged Draz, Abdulaziz M. Almuzaini, Sahar N. Aljarallah, Abdulrahman Almujaidel, Akram Abu-Okail

“…Different types of vaccines, including vector-based vaccines, inactivated whole cells, genetically modified protein-based subunits, and multiepitope nucleic acid (DNA) vaccines, have been explored. …”
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Radioprotective effects of polysaccharides from Poria cocos peels against 60Co-γ induced oxidative damage in vitro and in vivo by Keke Suo, Chaoqiang Zheng, Zhipeng Li, Limin Hao, Jiaqing Zhu, Changcheng Zhao, Yanling Shi, Juanjuan Yi, Jike Lu

“…Moreover, PCPP exhibited significant antioxidant activity and could significantly reduce the damage of AML-12 cells under IR. Animal experiment results showed that PCPP could effectively reduce IR-induced oxidative damage of spleens and livers in mice, and alleviate the damage to the hematopoietic system. …”
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The phytohormone abscisic acid enhances remyelination in mouse models of multiple sclerosis by Femke Van Gaever, Femke Van Gaever, Fleur Mingneau, Fleur Mingneau, Sam Vanherle, Sam Vanherle, Yasmine Driege, Yasmine Driege, Mira Haegman, Mira Haegman, Elien Van Wonterghem, Elien Van Wonterghem, Junhua Xie, Junhua Xie, Roosmarijn E. Vandenbroucke, Roosmarijn E. Vandenbroucke, Jerome J. A. Hendriks, Jerome J. A. Hendriks, Rudi Beyaert, Rudi Beyaert, Jens Staal, Jens Staal, Jens Staal

“…ABA, which is abundant in fruits such as figs, apricots and bilberries, is known to cross the blood-brain barrier and has demonstrated neuroprotective effects in conditions like depression and Alzheimer's disease.MethodsIn this study, we investigated whether ABA supplementation enhances remyelination in both ex vivo and in vivo mouse models.ResultsOur results indicated that ABA enhanced remyelination and that this enhanced remyelination is associated with increased lipid droplet load, reduced levels of degraded myelin, and a higher abundance of F4/80+ cells in the demyelinated brain of mice treated with ABA. …”
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Benefits of Immobilized Bacteria in Bioremediation of Sites Contaminated with Toxic Organic Compounds by Emanuel Gheorghita Armanu, Simone Bertoldi, Łukasz Chrzanowski, Irina Volf, Hermann J. Heipieper, Christian Eberlein

“…It focuses on the following four key areas: (i) the types of organic pollutants impacting environmental and human health, (ii) the bacterial strains used in bioremediation processes, (iii) the types and benefits of immobilization, and (iv) the immobilization of bacterial cells on various carriers for targeted pollutant degradation.…”
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Anthocyanins as functional food components by R. S. Yudina, E. I. Gordeeva, O. Yu. Shoeva, M. A. Tikhonova, E. K. Khlestkina

“…To date, the structure and functions of anthocyanins in plant cells have been well studied, and the pathway of their biosynthesis is one of the most fully characterized pathways of secondary metabolite biosynthesis at both the biochemical and genetic levels. …”
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Pericardial Involvement in Hereditary Hemorrhagic Telangiectasia by Abir Derbel, Mouna Snoussi, Raida Ben Salah, Faten Frikha, Leila Abid, Imed Frikha, Sameh Marzouk, Zouhir Bahloul

“…For her anemia, she received a transfusion of red blood cells. Then, the patient was treated by iron treatment. …”
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Metabolic conversion of phenol to polyhydroxyalkanoate (PHA) for addressing dual environmental challenges: A review by Izzati Sabri, Mohd Zulkhairi Mohd Yusoff, Nor Azlan Nor Muhammad, Li Sim Ho, Norhayati Ramli

“…Understanding the metabolic conversion of phenol to PHA is crucial to enhance its efficiency, especially considering phenol's toxicity to microbial cells and the substrate-dependent nature of microbial PHA production. …”
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The inhibition of ORMDL3 prevents Alzheimer's disease through ferroptosis by PERK/ATF4/HSPA5 pathway by Yankun Shao, Yilin Xu, Huang Di, Xinxiu Shi, Yingying Wang, Hongyu Liu, Lina Song

“…The murine microglial BV‐2 cells also were induced into the vitro model. In serum samples of AD patients, ORMDL3 mRNA expression levels were upregulated. …”
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Antimicrobial Activity of Aspergillus sp. from the Amazon Biome: Isolation of Kojic Acid by Josy Caldas Rodrigues, Weison Lima da Silva, David Ribeiro da Silva, Carolina Rabelo Maia, Clarice Virginia Santos Goiabeira, Haile Dean Figueiredo Chagas, Gigliola Mayara Ayres D’Elia, Gleica Soyan Barbosa Alves, Viviane Zahner, Cecilia Veronica Nunez, Ormezinda Celeste Cristo Fernandes

“…The results of the cytotoxicity test showed that MRC5 cells presented viability at concentrations from 500 to 7.81 μg/mL. …”
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Repurposing of phosphodiesterase-5 inhibitor sildenafil as a therapeutic agent to prevent gastric cancer growth through suppressing c-MYC stability for IL-6 transcription by Zhenzhan Zhang, Wuqing Huang, Donghua Huang, Zhou Xu, Qingfeng Xie, Xin Tan, Wenjun He, Weihao Yang, Guoxin Li, Jianguang Ji, Hao Liu

“…The anti-tumor effect and mechanism of the PDE5 inhibitor sildenafil were evaluated via using tumor cells, patient-derived tumor organoids and xenograft animal models in GC. …”
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Hemorrhagic syndrome at liver cirrhosis by I. A. Kurkina, O. S. Volkova, M. V. Mayevskaya, V. T. Ivashkin

“…Physiology of hemostatic system is intimately related to liver function because parenchymatous cells produce the majority of coagulating and fibrinolytic systems factors. …”
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JAK2, STAT3 Gene Polymorphisms in Turkish Patients with Behçet’s Disease by Darya Farhoomand Aksoy, Rahime Aksoy, Sevim Gönen, Ümit Ölmez

“…Objective: Behçet’s disease (BD) is a chronic, multisystemic inflammatory disorder with an unknown etiology. T cells are crucial in the pathogenesis of BD. Janus kinase-2 (JAK2) and signal transducer and activator of transcription 3 (STAT3) are intracellular signal transduction molecules that increase the risk of developing some autoimmune diseases. …”
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Organic iron at ultralow doses catalyzes hydrogen peroxide to eliminate cyanobacterial blooms: a study on algicidal effects and mechanisms under natural conditions by Yongdong Lin, Ziru Niu, Juan Li, Sijin Li, Hai Li, Lei Li

“…Under neutral conditions, Fe3+ ions precipitate as large-sized goethite, which adheres to the extracellular polymeric substances (EPS) of cyanobacterial cells, thereby hindering H2O2 catalysis and hydroxyl radical (·OH) formation in natural waters. …”
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From gut to liver: Exploring the crosstalk between gut-liver axis and oxidative stress in metabolic dysfunction-associated steatotic liver disease by Mi Zhou, Jianyu Lv, Xinli Chen, Yujie Shi, Guanqun Chao, Shuo Zhang

“…Our analysis reveals several key findings: (1) Bile acid dysregulation can trigger oxidative stress through enhanced ROS production in hepatocytes and Kupffer cells, leading to mitochondrial dysfunction and lipid peroxidation; (2) Gut microbiota dysbiosis disrupts intestinal barrier function, allowing increased translocation of endotoxins like LPS, which activate inflammatory pathways through TLR4 signaling and promote oxidative stress via NADPH oxidase activation; (3) The redox-sensitive transcription factors NF-κB and Nrf2 serve as crucial mediators in the gut-liver axis, with NF-κB regulating inflammatory responses and Nrf2 orchestrating antioxidant defenses; (4) Oxidative stress-induced damage to intestinal barrier function creates a destructive feedback loop, further exacerbating liver inflammation and disease progression. …”
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Inflammation mediates the adverse effects of urinary phthalate exposure on metabolic disease risk: Results from NHANES 2005–2016 by Chenyang Gu, Teng Yao, Chenxian Dong, Zuhai Chen, Wanting Wei, Xiaoju Li, Qiang Niu, Yizhong Yan, Yunhua Hu

“…Mediated analysis was used to explore the mediating role of immune cells in the relationship between phthalate exposure and obesity and its complications. …”
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