Adipocytes from New Zealand Obese Mice Exhibit Aberrant Proinflammatory Reactivity to the Stress Signal Heat Shock Protein 60 by Tina Märker, Jennifer Kriebel, Ulrike Wohlrab, Volker Burkart, Christiane Habich

“…Compared to NOD and C57BL/6J mouse derived cells, Hsp60-induced formation of IL-6, KC, and MCP-1 from NZO mouse-derived (pre-)adipocytes strongly depended on NFκB-activation. …”
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Mitochondrial genome structural variants and candidate cytoplasmic male sterility-related gene in sugarcane by Yihan Li, Shuangyu Li, Xiuting Hua, Yi Xu, Shuqi Chen, Zehuai Yu, Gui Zhuang, Yuhong Lan, Wei Yao, Baoshan Chen, Muqing Zhang, Jisen Zhang

“…Heterologous expression of the mitochondrial chimeric gene ORF113, which is highly expressed in male-sterile S. officinarum flowers, significantly inhibits growth and ATP synthesis in yeast cells, making it a key candidate CMS-related gene in sugarcane. …”
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The Role of Autophagy and Related MicroRNAs in Inflammatory Bowel Disease by Shiyuan Wang, Yan Huang, Cili Zhou, Huangan Wu, Jimeng Zhao, Luyi Wu, Min Zhao, Fang Zhang, Huirong Liu

“…Regarding autophagy-related pathways, miR-146b, miR-221-5p, miR-132, miR-223, miR-155, and miR-21 regulate NF-κB or mTOR signaling to induce or inhibit autophagy in intestinal cells by releasing anti- or proinflammatory factors, respectively.…”
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Intraindividual variation in histone acetylation and its impact on autoimmune thyroid diseases by Emi Haga, Naoya Inoue, Yoshinori Iwatani, Yuya Arakawa, Emi Morita, Hidemi Hashimoto, Yusuke Noguchi, Yoh Hidaka, Mikio Watanabe

“…In this study, we analyzed histone H3 acetylation levels in peripheral blood mononuclear cells (PBMCs) using a histone H3 total acetylation detection fast kit. …”
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Data-driven prediction of critical diameter for deterministic lateral displacement devices: an integrated DPD-ML approach by Shuai Liu, Peng Zhang, Anbin Wang, Keke Tang, Shuo Chen, Chensen Lin

“…Deterministic Lateral Displacement (DLD) has been widely utilized for the high-throughput and efficient separation of microspheres, cells, exosomes, and proteins, playing a crucial role in size-based particle separation. …”
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Abnormal Expression of DICER1 Leads to Dysregulation of Inflammatory Effectors in Human Synoviocytes by Congshan Jiang, Jing Xu, Wenhua Zhu, Yongsong Cai, Si Wang, Yuanxu Guo, Ke Xu, Manman Geng, Nazim Hussain, Yan Han, Fujun Zhang, Qilan Ning, Liesu Meng, Shemin Lu

“…Secondly, the increase of IL-8 and decrease of TGF-β1 and TIMP1 were determined in the supernatant derived from DICER1 siRNA-treated cells, while DICER1 overexpression was found capable to reverse this effect. …”
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Multi-trace elements-enriched functional drink accelerates gastric ulcer repair via the HGF/c-Met/STAT3 pathway by Yongnan Piao, Nuoya Wang, Mingji Jin, Jianyu Piao, Mingfeng Han, Zifei Wang, Chunhua Quan, Jishan Yin, Zhonggao Gao, Wenxiang Cui, Shuangqing Wang, Xiuquan Quan

“…Finally, FD reduced the severity of gastric mucosal injury caused by invasive factors, improved the morphological structure of gastric mucosal cells, enhanced the ability of oxidative stress, and inhibited excessive inflammatory response. …”
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Ex vivo delivery of recombinant IL-10 to human donor lungs by Jonathan C. Yeung, Terumoto Koike, Dirk Wagnetz, Tiago N. Machuca, Riccardo Bonato, Mingyao Liu, Stephen Juvet, Marcelo Cypel, Shaf Keshavjee

“…Conclusions: Gene therapy remains superior as it allows for continued production of IL-10 within the alveoli where it has the potential to continuously act on alveolar macrophages and epithelial cells in a paracrine fashion.…”
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Serum Neuropeptide Y Levels Are Associated with TNF-α Levels and Disease Activity in Rheumatoid Arthritis by Melissa Ramirez-Villafaña, Ana M. Saldaña-Cruz, Javier A. Aceves-Aceves, Edsaul E. Perez-Guerrero, Nicté S. Fajardo-Robledo, Edy D. Rubio-Arellano, Cesar A. Nava-Valdivia, Maria O. Carrillo-Escalante, Sylvia E. Totsuka-Sutto, David Cardona-Müller, Betsabe Contreras-Haro, Mario Salazar-Paramo, Ernesto G. Cardona-Muñoz, M. Huerta, Jorge I. Gamez-Nava, Norma A. Rodriguez-Jimenez, Laura Gonzalez-Lopez

“…Neuropeptide Y (NPY) is a sympathetic neurotransmitter with effects on the regulation of inflammatory cells. The role of NPY on autoimmune inflammatory diseases such as rheumatoid arthritis (RA) is not completely understood. …”
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Therapeutic Effects of BCG Vaccination on Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials by Yu-Chen Chang, Chien-Ju Lin, Yu-Hsuan Hsiao, Yu-Han Chang, Shu-Jung Liu, Hsin-Yin Hsu

“…Type 1 diabetes mellitus (T1DM) causes the irreversible destruction of pancreatic beta cells. The Bacillus Calmette–Guerin (BCG) vaccine can modulate the immune response and decelerate disease progression. …”
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Anti-Interleukin-22-Neutralizing Antibody Attenuates Angiotensin II-Induced Cardiac Hypertrophy in Mice by Jing Ye, Ling Liu, Qingwei Ji, Ying Huang, Ying Shi, Lei Shi, Jianfang Liu, Menglong Wang, Yao Xu, Huimin Jiang, Zhen Wang, Yingzhong Lin, Jun Wan

“…In addition, IL-22 nAb attenuated angiotensin II-induced hypertrophy in H9C2 cells. Conclusion. Our data demonstrated that neutralization of IL-22 alleviated angiotensin II-induced cardiac hypertrophy. …”
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pACP-HybDeep: predicting anticancer peptides using binary tree growth based transformer and structural feature encoding with deep-hybrid learning by Shahid, Maqsood Hayat, Wajdi Alghamdi, Shahid Akbar, Ali Raza, Rabiah Abdul Kadir, Mahidur R. Sarker

“…Despite numerous traditional therapies and wet-laboratory methods for treating cancer-affected cells, these approaches often face limitations, including high costs and substantial side effects. …”
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Sterol‐Targeted Laboratory Evolution Allows the Isolation of Thermotolerant and Respiratory‐Competent Clones of the Industrial Yeast Saccharomyces cerevisiae by Isabel‐Elena Sánchez‐Adriá, Jose A. Prieto, Gemma Sanmartín, Miguel Morard, Estéfani García‐Ríos, Francisco Estruch, Francisca Randez‐Gil

“…ABSTRACT Sterol composition plays a crucial role in determining the ability of yeast cells to withstand high temperatures, an essential trait in biotechnology. …”
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Effector proteins of Funneliformis mosseae BR221: unravelling plant-fungal interactions through reference-based transcriptome analysis, in vitro validation, and protein‒protein doc... by Pratima Vasistha, Pushplata Prasad Singh, Divya Srivastava, Leena Johny, Sadhana Shukla

“…Effector secreted by AM fungi influence symbiotic relationship by modifying host cells, suppressing host defense and promoting infection to derive nutrients from the host. …”
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Forskolin Inhibits Lipopolysaccharide-Induced Modulation of MCP-1 and GPR120 in 3T3-L1 Adipocytes through an Inhibition of NFκB by Jeanne Durendale Chiadak, Tatjana Arsenijevic, Kevin Verstrepen, Françoise Gregoire, Nargis Bolaky, Valérie Delforge, Véronique Flamand, Jason Perret, Christine Delporte

“…The aim of this study was to determine the signaling pathway by which Forskolin (FK), a cyclic adenosine monophosphate- (cAMP-) promoting agent causing positive changes in body composition in overweight and obese adult men, affects MCP-1 and GPR120 expression during an inflammatory response induced by lipopolysaccharide (LPS) in adipocytes, such as in an obese state. 3T3-L1 cells differentiated into adipocytes (DC) were stimulated with LPS in the absence or presence of FK and inhibitors of TLR-4 and inhibitor of kappa B (IκBα). …”
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Intensive critical care and management of asthmatic and smoker patients in COVID-19 infection by Lu Dongming, Yaqoob Obaid, Kumar Manish, Kushwah Ajay Singh, Sharma Rahul Kumar, Kumar Devinder, Mavai Yogendra, Khan Rukaiya

“…The intensity of COVID-19 symptoms is lessened in patients with asthma who have superior levels of T-cells. Several antibiotics, antivirals, antipyretics, and anti-inflammatory drugs have been suggested to suppress COVID-19 symptoms in asthmatic persons. …”
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Argonaute2 modulates megakaryocyte development and sex-specific control of platelet protein expression and reactivity by Sophia Lazar, Jeremy G.T. Wurtzel, Shayan Askari, Matthew Cooper, Xuefei Zhao, Peisong Ma, Lawrence E. Goldfinger

“…Female Ago2-deleted platelets selectively showed downregulation of a protein cohort established in breast cancer cells to be transcriptionally regulated by estrogen receptor-beta coupled to Ago2, whereas male Ago2-deleted platelets did not. …”
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Surface Planarization‐Epitaxial Growth Enables Uniform 2D/3D Heterojunctions for Efficient and Stable Perovskite Solar Modules by Dongxu Lin, Jun Fang, Sibo Li, Zhenye Zhan, Huan Li, Xin Wang, Guanshui Xie, Daozeng Wang, Nuanshan Huang, Haichen Peng, Weiguang Xie, Luis K. Ono, Yabing Qi, Longbin Qiu

“…Abstract Two‐dimensional/three‐dimensional (2D/3D) halide perovskite heterojunctions are widely used to improve the efficiency and stability of perovskite solar cells. However, interfacial defects between the 2D and 3D perovskites and the poor coverage of the 2D capping layer still hinder long‐term stability and homogeneous charge extraction. …”
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Reduced Presence of SARS-CoV-2 microRNA-like Small RNA in the Serum of Patients with Post-Acute Sequelae SARS-CoV-2 Infection by Maria Alfreda Stincarelli, Isabella Abbate, Giulia Matusali, Michele Tanturli, Marta Camici, Rosaria Arvia, Elisabetta Lazzari, Eleonora Cimini, Alessandra Vergori, Fabrizio Maggi, Simone Giannecchini

“…Initially, it was demonstrated that three previously identified SARS-CoV-2 miRNA-like small RNAs, specifically svRNA 1 and 2 and miR-07a, were significantly expressed in infected cells in vitro and released into the supernatant following infection by different SARS-CoV-2 variants. …”
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The Effects of Krill Oil on mTOR Signaling and Resistance Exercise: A Pilot Study by John Georges, Matthew H. Sharp, Ryan P. Lowery, Jacob M. Wilson, Martin Purpura, Troy A. Hornberger, Flint Harding, James H. Johnson, David M. Peele, Ralf Jäger

“…Methods. C2C12 myoblasts cells were stimulated with krill oil or soy-derived phosphatidylcholine (S-PC), and then, the ratio of P-p70-389 to total p70 was used as readout for mTOR signaling. …”
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