Suppression of renal crystal formation, inflammation, and fibrosis by blocking oncostatin M receptor β signaling by Ryusuke Deguchi, Tadasuke Komori, Shimpei Yamashita, Tomoko Hisaoka, Mizuki Kajimoto, Yasuo Kohjimoto, Isao Hara, Yoshihiro Morikawa

“…The anti-OSMRβ antibody abrogated OSM-induced phosphorylation of STAT3 and expression of crystal-binding molecules (Opn, Anxa1, Anxa2) and inflammation/fibrosis-associated molecules (Tnfa, Tgfb, Col1a2) in renal tubular epithelial cells and fibroblasts. In glyoxylate-injected mice, a mouse model of renal crystal formation, there was significant suppression of crystal deposits and expression of crystal-binding molecules (Opn, Anxa1, Anxa2), a tubular injury marker (Kim-1), and inflammation/fibrosis-associated molecules (Tnfa, Il1b, Mcp-1, Tgfb, Col1a2) in the kidneys of the anti-OSMRβ antibody-treated mice, compared with those in vehicle- or isotype control antibody-treated mice. …”
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Differentiation of <i>Escherichia coli</i> and <i>Shigella flexneri</i> by Metabolite Profiles Obtained Using Gold Nanoparticles-Based Surface-Assisted Laser Desorption/Ionization... by Adrian Arendowski

“…Metabolite extracts from <i>E. coli</i> and <i>S. flexneri</i> cells were prepared using liquid–liquid extraction in a chloroform–methanol–water system. …”
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Biogenic Synthesis of Gold Nanoparticles from Physalis peruviana and Application in Wound Healing by Stephen Adongo Odongo, Fredrick Oluoch Okumu, Solomon Omwoma Lugasi, Martin Opiyo Onani, Stephen Gaya Agong

“…The inhibition zones for Au NPs at concentration of 100 mM and Physalis peruviana extract vary significantly in all the microbial cells, except for Pseudomonas aeruginosa (one-way ANOVA, F(3,11) = 2.67, P=0.1189). …”
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Maternal Parvovirus B19 Infection Causing First-Trimester Increased Nuchal Translucency and Fetal Hydrops by Olivia Grubman, Farrah Naz Hussain, Zoe Nelson, Lois Brustman

“…Parvovirus B19 is a single-stranded DNA virus that is cytotoxic to erythroid progenitor cells, causing inhibition of erythropoiesis. While maternal disease is usually mild, fetal infection can result in spontaneous abortion, aplastic anemia, nonimmune fetal hydrops, and fetal demise. …”
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Creation of transgenic mice susceptible to coronaviruses: a platform for studying viral pathogenesis and testing vaccines by N. R. Battulin, O. L. Serov

“…It has been established that coronavirus infection (SARS-CoV and SARS-CoV2) occurs through the viral protein S interaction with the lung epithelium – angiotensin-converting enzyme receptor 2 (ACE2) – due to which the virus enters the cells. The most attractive model for studying the development of these diseases is a laboratory mouse, which, however, is resistant to coronavirus infection. …”
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Galectin-1-Dependent Mitochondria Apoptosis Plays an Essential Role in the Potential Protein Targets of DBDCT-Induced Hepatotoxicity as Revealed by Quantitative Proteomic Analyses by Jiayu Song, Yuan Ren, Lihua Liu, Yixin Wang, Chuandao Shi, Xiaoqing Ji, Yunlan Li, Qingshan Li

“…As a result of these modulations, caspase cascades were finally activated, which executed apoptosis in HL7702 liver cells. Correspondingly, NAC (inhibitor of ROS), PDTC (inhibitor of NF-κB), EGF (ERK1/2 activator), and OTX008 (inhibitor of Gal-1) were found to reverse and abolish the DBDCT-associated cytotoxicity partially. …”
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Inflammatory Cytokines, Adipocytokines, and Th17/Treg Balance in Patients with Nonalcoholic Fatty Liver Disease following Administration of Dahuang Zhechong Pills by Xiaohua Duan, Jianlin Lv, Hebei Jiang, Kefei Zheng, Yulin Chen

“…Peripheral TH17 and Treg cells were detected by flow cytometry, and peripheral IL-17, IL-10, hs-CRP, and TNF-α expression levels were determined by enzyme-linked immunosorbent assay (ELISA) methods. …”
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Investigation of the healing effects of Afyon Province hot spring waters on experimentally-induced fatty liver in mice by Bülent Elitok, Ibrahim Kişlalioğlu, Yavuz Ulusoy, Bahadır Kilinç

“…According to different publications mineral water from hot springs has a beneficial effect on liver cells. In this regard, an investigation was performed with the aim to assess the effectiveness of hot spring water from the Süreyya I spring (Afyonkarahisar province) in treatment of fatty liver disease. 50 one-day-old albino mice with an average body weight of 29.6 g were selected for the experiment. …”
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Inhibition of hippocampal interleukin-6 receptor-evoked signalling normalises long-term potentiation in dystrophin-deficient mdx mice by Kimberley A. Stephenson, Aaron Barron, Mark G. Rae, Dervla O'Malley

“…Duchenne muscular dystrophy (DMD), an X-linked neuromuscular disorder, characterised by progressive immobility, chronic inflammation and premature death, is caused by the loss of the mechano-transducing signalling molecule, dystrophin. In non-contracting cells, such as neurons, dystrophin is likely to have a functional role in synaptic plasticity, anchoring post-synaptic receptors. …”
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A Journey into the Complexity of Temporo-Insular Gliomas: Case Report and Literature Review by Manuel De Jesus Encarnacion Ramirez, Gervith Reyes Soto, Carlos Castillo Rangel

“…Introduction: Temporo-insular gliomas, rare brain tumors originating from glial cells, comprise about 30% of brain tumors and vary in aggressiveness from grade I to IV. …”
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Hematological parameters in pediatric pulmonary and extrapulmonary tuberculosis in Vietnam: a prospective observational study by Chau Duc Nguyen-Huu, Thi Hanh Chan Tran, Thi Hong Nhung La, Van-Tuy Nguyen

“…Pulmonary tuberculosis had significantly higher levels of inflammatory markers such as white blood cells, neutrophils, ESR, and CRP compared to extrapulmonary tuberculosis. …”
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Multiple Morphological Constraints-Based Complex Gland Segmentation in Colorectal Cancer Pathology Image Analysis by Kun Zhang, JunHong Fu, Liang Hua, Peijian Zhang, Yeqin Shao, Sheng Xu, Huiyu Zhou, Li Chen, Jing Wang

“…Another innovation is that we propose the combination of the internal lumen contour of adenoma and the outer contour of epithelial cells to obtain a precise gland contour. We compare the performance of the proposed algorithm against that of several state-of-the-art technologies on publicly available datasets. …”
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A novel hybrid cooling system for a Lithium-ion battery pack based on forced air and fins integrated with phase change material by Mohanad F. Hassan, Abdul Hadi N. Khalifa, Ahmed J. Hamad

“…The first model (Air model) is a forced air cooled battery pack of 9 cells tested under different air velocities: 1, 2, and 3 m/s. …”
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Fever, uveitis, and myocarditis as the initial presentation of Behcet's Disease: A case report and review of the literature by Vishal Mangal, Yogendra Mishra, Amar Tej Atal, Divya Kochhar, Durga Madhab Tripathy, Manish Manrai

“…On evaluation, she was diagnosed to have bilateral intermediate uveitis based on the clinical finding of conjunctival congestion, and 1+ cells in the anterior chamber of both eyes, dispersion of iris pigments on the anterior surface of lens bilaterally, and Grade 1 vitreous haze on slit-lamp examination. …”
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Influence of Inflammatory Cytokines IL-1β and IFNγ on Sarcoplasmic Aggregation of p62 and TDP-43 in Myotubes by Bryony McCord, Richard M. Day

“…None of the cytokine treatments affected TDP-43 protein expression, size, or frequency of TDP-43 aggregates or localization, suggesting IL-1β and IFNγ may influence TDP-43 processing in human skeletal muscle cells. TDP-43 was localized to the sarcoplasm under control conditions, suggesting this may not be a pathological feature. …”
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Brown Bowel Syndrome Is a Rare and Commonly Missed Disease: A Case Report and Literature Review by Joaquin Ponce-Zepeda, Wenchang Guo, Giorgioni Carmen, Daniel Moon Kim, Gregory C. Albers, Vishal Suresh Chandan, Xiaodong Li

“…Microscopic examination revealed unremarkable mucosa, but dense granular brown pigments were identified in the cytoplasm of the smooth muscle cells in the muscularis propria. These deposits resulted to be lipofuscin, and BBS was diagnosed. …”
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IL-33/ST2 Activation Is involved in Ro60-Regulated Photosensitivity in Cutaneous Lupus Erythematosus by Yitian Song, Fangzhi Wei, Ying Liu, Feng Han, Lihui Ma, Yanping Zhuang, Chengdan Pan, Zhandong Jia, Aimin Gong

“…Herein, we proposed to disclose the impacts on IL-33/ST2 activation and Ro60 on CLE and their potential implications in the photosensitization of CLE cells. IL-33, ST2, and Ro60 in CLE patients’ skin lesions were detected. …”
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Myocarditis Concurrent with Sweet Syndrome: A Presentation of Acute Myeloid Leukemia by Christopher G. Burkeen, David Pottinger, Chaitanya Iragavarapu, Reshma Ramlal, Gerhard Hildebrandt

“…The patient had persistent leukemia cells on day 14 postinduction bone marrow biopsy and was treated with high-dose cytarabine reinduction treatment. …”
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Determination of Urinary Neutrophil Gelatinase-Associated Lipocalin (uNGAL) Reference Intervals in Healthy Adult and Pediatric Individuals Using a Particle-Enhanced Turbidimetric I... by Tabari M. Baker, Christopher A. Bird, Dennis L. Broyles, Ursula Klause

“…Neutrophil gelatinase-associated lipocalin (NGAL) is a 25-kDa protein produced and secreted by injured kidney tubule epithelial cells, and can serve as an early urinary biomarker for AKI. …”
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Mechanistic insights into endosomal escape by sodium oleate-modified liposomes by Ebrahim Sadaqa, Satrialdi, Fransiska Kurniawan, Diky Mudhakir

“…This study investigates sodium oleate-modified liposomes (SO-Lipo) as an innovative strategy to enhance endosomal escape and improve cytosolic delivery in 4T1 triple-negative breast cancer cells. We aimed to elucidate the mechanistic role of sodium oleate in promoting endosomal escape and compared the performance of SO-Lipo with unmodified liposomes (Unmodified-Lipo) and Aurein 1.2-modified liposomes (AUR-Lipo). …”
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