Novel thiazolyl-pyrimidine derivatives as potential anticancer agents: Synthesis, biological evaluation, and molecular docking studies by Tariq Z. Abolibda, Abdel-Aziz A.A. El-Sayed, Basant Farag, Magdi E.A. Zaki, Abdulwahed Alrehaily, Hossein M. Elbadawy, Ahmad A. Al-Shahri, Saleh R. Alsenani, Sobhi M. Gomha

“…The growth-inhibitory potential of these compounds against HepG2 liver cancer cells was assessed using the MTT assay. Five compounds, namely 8a, 10, 12a, 12b, and 14, exhibited promising anticancer activity with IC50 values of 5.02 ± 1.83, 4.04 ± 1.37, 3.81 ± 1.96, 2.39 ± 0.75, and 3.27 ± 1.13 μM, respectively, all of which were more effective than doxorubicin (IC50 = 6.18 ± 0.29 μM). …”
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2-O-β-D-Glucopyranosyl-L-ascorbic acid, an ascorbic acid derivative isolated from the fruits of Lycium barbarum L., ameliorates high fructose-induced neuroinflammation in mice: inv... by Wei Dong, Yujia Peng, Guijie Chen, Zhiyong Xie, Weiqi Xu, Wangting Zhou, Jia Mi, Lu Lu, Yi Sun, Xiaoxiong Zeng, Youlong Cao, Yamei Yan

“…AA-2βG also predominantly enhanced the gut barrier integrity, decreased lipopolysaccharide entry into the circulation, which subsequently countered the activation of glial cells and neuroinflammatory response. These beneficial effects were transmissible by horizontal fecal microbiome transplantation, transferring from AA-2βG fed mice to HFrD fed mice. …”
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MicroRNA-33 regulates the synaptic plasticity-related gene ARC in temporal lobe epilepsy by Yuchen Xu, Lily Zhang, Yan Yan, Wenbiao Xiao, Wei Zou, Zhaohui Luo, Bo Xiao, Hongyu Long

“…Following the transfection of HEK cells with a miR-33 mimic, there was a decrease in both ARC mRNA and protein levels, whereas the group treated with a miR-33 inhibitor displayed the opposite effect. …”
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Probiotic biofilm modified scaffolds for facilitating osteomyelitis treatment through sustained release of bacteriophage and regulated macrophage polarization by Junwei Su, Yifan Wu, Zheng Wang, Dong Zhang, Xianquan Yang, Yong Zhao, Aixi Yu

“…More importantly, the inactivated LR biofilm stimulates macrophages RAW264.7 to polarize towards an anti-inflammatory M2 phenotype, creating an immune microenvironment favorable for inducing osteogenic differentiation of rat mesenchymal stem cells in vitro. In a rat model of infectious cranial defects, the scaffold not only effectively eliminated S. aureus and alleviated associated inflammation but also mediated macrophage-mediated immunoregulation, thus resulting in effective osteogenesis. …”
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Hydrogen‐Generating Magnesium Alloy Seed Strand Sensitizes Solid Tumors to Iodine‐125 Brachytherapy by Pan Hu, Letao Lin, Guanyu Chen, Dengyao Liu, Huanqing Guo, Meigui Xiao, Zhihui Zhong, Guang Yang, Bingchen Xu, Dongcun Huang, Sheng Peng, Yong Li, Yanling Zhang, Tao Huang, Fujun Zhang

“…Abstract Radioactive iodine‐125 (125I) seed implantation, a brachytherapy technique, effectively kills tumor cells via X‐rays and gamma rays, serving as an alternative therapeutic option following the failure of frontline treatments for various solid tumors. …”
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Age-related cerebral ventriculomegaly occurs in patients with primary ciliary dyskinesia by Franziska Eisenhuth, Joy E. Agbonze, Adam M. R. Groh, Jesse M. Klostranec, David A. Rudko, Jo Anne Stratton, Adam J. Shapiro

“…We demonstrated highly specific expression levels of known PCD-related genes in human brain multiciliated ependymal cells (p < 0.0001). To assess ventricular size, computed tomography sinus images from patients with PCD (n = 33) and age/sex-matched controls (n = 64) were analysed. …”
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Sorbitol induces flavonoid accumulation as a secondary signal via the nanoencapsulated SPc/lncRNA809-MmNAC17 module against Alternaria alternata in Malus micromalus by Tingting Du, Dong Meng, Hongyan Cao, Yi Lian, Rui Wu, Tengyue Liu, Tianyi Wang, Cai Qin, Zhihua Song, Biying Dong, Yujie Fu, Qing Yang

“…Nanomaterials as an emerging technology tool can efficiently deliver lncRNA to target cells. Here, we found nanoencapsulated lncRNA809 (SPc/lncRNA809) exhibits significant resistance to R1strain. …”
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Antioxidant and anti-diabetic potential of the green synthesized silver nanoparticles using Martynia annua L. root extract by Megha B. Abbigeri, Bothe Thokchom, Sapam Riches Singh, Santosh Mallikarjun Bhavi, B.P. Harini, Ramesh Babu Yarajarla

“…Moreover, the AgNPs enhanced glucose uptake by yeast cells, indicating their promising therapeutic role in managing diabetes mellitus. …”
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Enhancing grape juice with Lacticaseibacillus rhamnosus CWKu-12: Assessing probiotic viability, physicochemical changes, sensory characteristics, and quality kinetics throughout st... by Shaghayegh Echresh, Behrooz Alizadeh Behbahani, Fereshteh Falah, Mohammad Noshad, Salam A. Ibrahim

“…At the end of the storage period, the juice containing 2 % probiotic and stored at 4 °C had the highest viable cells (7.92 log CFU/mL). Moreover, grape juices that had been cold-stored and added probiotics had the highest level of sensory acceptance. …”
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Ideas and perspectives: Microorganisms in the air through the lenses of atmospheric chemistry and microphysics by B. Ervens, P. Amato, P. Amato, K. Aregahegn, K. Aregahegn, M. Joly, A. Khaled, T. Labed-Veydert, F. Mathonat, L. Nuñez López, R. Péguilhan, R. Péguilhan, M. Zhang, M. Zhang

“…We provide ranges of water amounts surrounding bacterial cells both inside and outside clouds and suggest that the small volumes of individual cloud droplets lead to nutrient and oxidant limitations. …”
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Bifidobacterium animalis ssp. lactis BX-245-fermented milk alleviates tumor burden in mice with colorectal cancer by Chengcong Yang, Musu Zha, Lu Li, Jiaqi Qiao, Lai-Yu Kwok, Dandan Wang, Yongfu Chen

“…ABSTRACT: Colorectal cancer (CRC) arises from the accumulation of abnormal mutations in colorectal cells during prolonged inflammation. This study aimed to investigate the potential of probiotic fermented milk containing the probiotic strain, Bifidobacterium animalis ssp. lactis BX-245 (BX-245), in alleviating tumor burden in CRC mice induced by azoxymethane and dextran sodium sulfate. …”
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LEGO-Lipophosphonoxin membrane activity is enhanced by presence of phosphatidylethanolamine but hindered by outer membrane by Hana Brzobohatá, Milica Dugić, Viktor Mojr, Nitjawan Sahatsapan, Ivana Kóšiová, Tomáš Křížek, Tereza Dolejšová, Petra Lišková, Lukasz Cwiklik, Dominik Rejman, Radovan Fišer, Gabriela Mikušová

“…Gram-positive bacteria were more sensitive to LEGO-LPPO action compared to Gram-negatives, which was manifested as a delayed membrane permeabilization, higher minimal inhibitory concentration and lower amount of LEGO-LPPO bound to the cells. Outer membrane permeability measurements and time-kill assay showed that presence of the intact outer membrane brought about reduced susceptibility of Gram-negatives. …”
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Persea americana Glycolic Extract: In Vitro Study of Antimicrobial Activity against Candida albicans Biofilm and Cytotoxicity Evaluation by D. Jesus, J. R. Oliveira, F. E. Oliveira, K. C. Higa, J. C. Junqueira, A. O. C. Jorge, G. N. Back-Brito, L. D. Oliveira

“…After treatment, biofilm cells were scraped off and dilutions were plated on Sabouraud dextrose agar. …”
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Selenium-enriched oolong tea (Camellia sinensis) extract exerts anti-inflammatory potential via targeting NF-κB and MAPK pathways in macrophages by Qi Wang, Juqing Huang, Yafeng Zheng, Xuefang Guan, Chenchun Lai, Huiying Gao, Chi-Tang Ho, Bin Lin

“…The aim of this study is to investigate the anti-inflammatory effects of Se-enriched oolong tea extract (Se-TE) and underlying mechanism in lipopolysaccharide (LPS)-induced RAW264.7 cells. Se-TE treatments (50 and 150 μg/mL) significantly suppressed the over-production of nitric oxide (NO) and prostaglandin E2 (PGE2) in LPS-stimulated macrophages via downregulating the expression of nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). …”
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Effects of Maternal Hypoxia during Pregnancy on Bone Development in Offspring: A Guinea Pig Model by Alice M. C. Lee, Janna L. Morrison, Kimberley J. Botting, Tetyana Shandala, Cory J. Xian

“…MH during late gestation did not change the pool of osteogenic cells before birth or growth plate heights before and after birth. …”
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Evaluation of blood parameters changes of mice exposed to long-term Wi-Fi waves as a major environmental pollutant by Hamed Akbari, Lobat Taghavi, Seyed Kamal Eshagh Hossaini, Mohammad Gholami-Fesharaki, Seyed Alireza Hajiseyed Mirzahosseini

“…This study shows that blood cells are affected by long-term exposure to Wi-Fi waves by decrease in number and volume. …”
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Nontraditional Use of Biomass at Certified Forest Management Units: Forest Biomass for Energy Production and Carbon Emissions Reduction in Indonesia by Asep S. Suntana, Kristiina A. Vogt, Eric C. Turnblom, Daniel J. Vogt, Ravindra S. Upadhye

“…The net carbon emissions avoided could vary from 323 to 8,503 Mg when biomethanol was substituted for the natural gas methanol in fuel cells and from 294 to 7,730 Mg when it was used as a gasoline substitute.…”
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Targeting S100A9 attenuates social dysfunction by modulating neuroinflammation and myelination in a mouse model of autism by Hong Gong, Yao Lu, Shi-Long Deng, Ke-Yi Lv, Jing Luo, Yi Luo, Zhu-Lin Du, Ling-Feng Wu, Tian-Yao Liu, Xia-Qing Wang, Jing-Hui Zhao, Lian Wang, Mei-Ling Xia, Dong-Mei Zhu, Li-Wei Wang, Xiao-Tang Fan

“…Notably, S100A9 inhibition decreased c-Fos+ cells and promoted myelination in the cornu ammonis 3 of BTBR mice. …”
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Microscale insight into the proton concentration during electrolytic reaction via an optical microfiber: potential for microcurrent monitoring by a dielectric probe by Yunyun Huang, Jiaxuan Liang, Haotian Wu, Pengwei Chen, Aoxiang Xiao, Bai-Ou Guan

“…Examples include photocurrent attenuation in photogenerated carrier materials during illumination, electrical activation in nerve cells, and fluctuations in the efficiency of electrical energy generation during battery discharge. …”
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Unravelling the Digestibility and Structure–Function Relationship of Lentil Protein Through Germination and Molecular Weight Fractionation by Armin Mirzapour-Kouhdasht, Samaneh Shaghaghian, Marjan Majdinasab, Jen-Yi Huang, Marco Garcia-Vaquero

“…Cytotoxicity tests on L929 cells revealed the slight adverse effects of low-MW fractions during germination. …”
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