Actinorhodopsin: an efficient and robust light-driven proton pump for bionanotechnological applications by Nooraldeen Ayoub, Nadia Djabeur, Daniel Harder, Jean-Marc Jeckelmann, Zöhre Ucurum, Stephan Hirschi, Dimitrios Fotiadis

“…Efficient establishment of a proton gradient across lipid membranes upon light illumination was demonstrated using RlActR-overexpressing E. coli cells and reconstituted RlActR proteoliposomes. In summary, these features make RlActR an attractive energizing building block for the bottom-up assembly of molecular systems for bionanotechnological applications.…”
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Specific detection of tartaric acid chiral isomers based on centrosymmetric terahertz metamaterial sensors by Xujun Xu, Zhen Sun, Guocui Liu, Jianjun Liu, Yong Du

“…In addition, theoretical simulations of the crystalline cells of TACIs were also calculated using the density functional theory. …”
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Antibiofilm Activity of Curcumin and Piperine and Their Synergistic Effects with Antifungals against Candida albicans Clinical Isolates by Ulrich Joël Tsopmene, Christian Ramsès Tokam Kuaté, Prudence Ngalula Kayoka-Kabongo, Borel Ndezo Bisso, Anisel Metopa, Clautilde Teugwa Mofor, Jean Paul Dzoyem

“…C. albicans was susceptible to curcumin and piperine both on planktonic cells and biofilm. The combination of curcumin and piperine with antifungals has shown synergistic effects against multiresistant clinical isolates of Candida albicans representing an alternative drug research for the treatment of clinical candidiasis.…”
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Rad3 decorates critical chromosomal domains with gammaH2A to protect genome integrity during S-Phase in fission yeast. by Sophie Rozenzhak, Eva Mejía-Ramírez, Jessica S Williams, Lana Schaffer, Jennifer A Hammond, Steven R Head, Paul Russell

“…Schizosaccharomyces pombe Rad3 checkpoint kinase and its human ortholog ATR are essential for maintaining genome integrity in cells treated with genotoxins that damage DNA or arrest replication forks. …”
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Design and Construction of a Solar Installation System for a Reading Room at St. Johns Secondary School Ikumba. by Turyashemererwa, Norbet

“…It is radiant heat from the sun that's a natural source of energy using a range of ever-changing and developing technologies such as solar thermal energy, solar architecture, solar heating, molten salt power plants, and artificial photosynthesis. PV cells convert sunlight to direct current (DC) electricity. …”
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Effects of B-Blockers on the Sympathetic and Cytokines Storms in Covid-19. by Al-kuraishy, Hayder M., Al-Gareeb, Ali Ismail, Mostafa-Hedeab, Gomaa, Keneth Iceland, Kasozi, Zirintunda, Gerald, Aslam, Akhmed, Allahyani, Mamdouh, Welburn, Susan Christina, Batiha, Gaber El-Saber

“…The potential mechanisms of SS in Covid-19 are through different pathways such as hypoxia, which activate the central sympathetic center through carotid bodies chemosensory input and induced proinflammatory cytokines, which cross the blood-brain barrier and activation of the sympathetic center. b2-receptors signaling pathway play a crucial role in the production of pro-inflammatory cytokines, macrophage activation, and B-cells for the production of antibodies with inflammation exacerbation. b-blockers have anti-inflammatory effects through reduction release of pro-inflammatory cytokines with inhibition of NF-kB. …”
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Hybrid versus vaccine immunity of mRNA-1273 among people living with HIV in East and Southern Africa: a prospective cohort analysis from the multicentre CoVPN 3008 (Ubuntu) studyRe... by Nigel Garrett, Asa Tapley, Aaron Hudson, Sufia Dadabhai, Bo Zhang, Nyaradzo M. Mgodi, Jessica Andriesen, Azwidihwi Takalani, Leigh H. Fisher, Jia Jin Kee, Craig A. Magaret, Manuel Villaran, John Hural, Erica Andersen-Nissen, Guido Ferarri, Maurine D. Miner, Bert Le Roux, Eduan Wilkinson, Richard Lessells, Tulio de Oliveira, Jackline Odhiambo, Parth Shah, Laura Polakowski, Margaret Yacovone, Taraz Samandari, Zvavahera Chirenje, Peter James Elyanu, Joseph Makhema, Ethel Kamuti, Harriet Nuwagaba-Biribonwoha, Sharlaa Badal-Faesen, William Brumskine, Soritha Coetzer, Rodney Dawson, Sinead Delany-Moretlwe, Andreas Henri Diacon, Samantha Fry, Katherine Margaret Gill, Zaheer Ahmed Ebrahim Hoosain, Mina C. Hosseinipour, Mubiana Inambao, Craig Innes, Steve Innes, Dishiki Kalonji, Margaret Kasaro, Priya Kassim, Noel Kayange, William Kilembe, Fatima Laher, Moelo Malahleha, Vongane Louisa Maluleke, Grace Mboya, Kirsten McHarry, Essack Mitha, Kathryn Mngadi, Pamela Mda, Tumelo Moloantoa, Cissy Kityo Mutuluuza, Nivashnee Naicker, Vimla Naicker, Anusha Nana, Annet Nanvubya, Maphoshane Nchabeleng, Walter Otieno, Elsje Louise Potgieter, Disebo Potloane, Zelda Punt, Jamil Said, Yashna Singh, Mohammed Siddique Tayob, Yacoob Vahed, Deo Ogema Wabwire, M. Juliana McElrath, James G. Kublin, Linda-Gail Bekker, Peter B. Gilbert, Lawrence Corey, Glenda E. Gray, Yunda Huang, Philip Kotze, Sharlaa Badal-Faesen, Kagisho Baepanye, Veronique Bailey, Katekani Baloyi-Oseh, Mumtaz Booley, Johannes Louis Botha, Yolande Brown, Valerie Brown, Lisa Bunts, Soritha Coetzer, Myron Cohen, Shirley Collie, Rodney Dawson, Pallabi Deb, Hana El Sahly, Jill El-Khorazaty, Andries Engelbrecht, Marianne Gildea, Dhevium Govender, Jen Hanke, Jayla Harris, Simone Hendricks, Nick Hopkinson, Haley Howell, Nzeera Ketter, Kentse Khuto, Faatima Laher Omar, Leolin Katsidzira, Kim Linton, James Ludwig, Bongile Mabilane, Matshidiso Malefo, Ndiitwani Mamushiana, Daciana Margineantu, Jeanine May, Fatima Mayat, Cindy Molitor, Yeshnee Naidoo, Michelle Nebergall, Alan Nguyen, Sarah Nikles, Bianca Noronha, Melissa Peda, Tamara Phiri, Shanthie Pillay, Sureshnee Pillay, Lori Proulx-Burns, Laurie Rinn, Lisa Sanders, Carrie Sopher, Smitha Sripathy, Michael Stirewalt, Houriiyah Tegally, Sara Thiebaud, Alicia Toledano, Stephanie Van Wyk, Shamaya Whitby, Stephany Wilcox, Eduan Wilkinson, Haven Wilvich, Charles Wiysonge, Nelisiwe Xaba, Ntokozo Xulu

“…Among PLWH, the median CD4 count was 635 cells/μl and 18.5% had HIV viraemia. The six-month cumulative incidences in the hybrid immunity and vaccine immunity groups were 2.02% (95% confidence interval [CI] 1.61–2.44) and 3.40% (95% CI 2.30–4.49) for COVID-19, and 0.048% (95% CI 0.00–0.10) and 0.32% (95% CI 0.59–0.63) for severe COVID-19. …”
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Treatment Inertia and Symptom Burden in Anemia of CKD: Insights from the SATISFY Survey in the Middle East, South Africa, and Türkiye by Arici M, Al-Ghamdi SMG, Assounga AG, El-Koraie AF, McMillan A, Camidge LJ, Sumarsono B, Blogg M, Ng DB, Lansang EP

“…Improved awareness of this disagreement may help facilitate physician–patient dialogue to improve patient experience.Plain Language Summary: A survey to understand the experiences of people living with anemia and kidney disease in the Middle East, South Africa, and TürkiyeBackgroundPeople living with kidney disease can have a low number of red blood cells (anemia).This can cause heart problems, make kidney disease worse, and lead to death.Not much is known about the experiences of people living with kidney disease and anemia in the Middle East, South Africa, and Türkiye.For example, what symptoms do they experience, and which treatments do they receive for their anemia?…”
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First-in-Man Evaluation of I-PGN650: A PET Tracer for Detecting Phosphatidylserine as a Biomarker of the Solid Tumor Microenvironment by Richard Laforest PhD, Farrokh Dehdashti MD, Yongjian Liu PhD, Jennifer Frye CMMT, Sarah Frye CMMT, Hannah Luehmann, Deborah Sultan, Joseph S. Shan PhD, Bruce D. Freimark PhD, Barry A. Siegel MD

“…Purpose: PGN650 is a F(ab′) 2 antibody fragment that targets phosphatidylserine (PS), a marker normally absent that becomes exposed on tumor cells and tumor vasculature in response to oxidative stress and increases in response to therapy. …”
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Plant Extracts in the Bone Repair Process: A Systematic Review by Lyvia Lopes Miranda, Vanessa de Paula Guimarães-Lopes, Luciana Schulthais Altoé, Mariáurea Matias Sarandy, Fabiana Cristina Silveira Alves Melo, Rômulo Dias Novaes, Reggiani Vilela Gonçalves

“…Bone tissue repair is coordinated by an inflammatory dynamic process mediated by osteoprogenitor cells of the periosteum and endosteum, responsible for the formation of a new bone matrix. …”
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Mannogalactoglucan from mushrooms protects pancreatic islets via restoring UPR and promotes insulin secretion in T1DM mice by Ting Liu, Si Chen, Yunhe Qu, Lujuan Zheng, Xiaoxuan Yang, Shuhan Men, Yuanning Wang, Hanrui Ma, Yifa Zhou, Yuying Fan

“…Type 1 diabetes mellitus (T1DM) lacks insulin secretion due to autoimmune deficiency of pancreatic β-cells. Protecting pancreatic islets and enhancing insulin secretion has been therapeutic approaches. …”
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Eugenol targeting CrtM inhibits the biosynthesis of staphyloxanthin in Staphylococcus aureus by Jiang Chang, Bo Chen, Zeqian Du, Bowen Zhao, Jiahui Li, Ziyi Li, Kannappan Arunachalam, Ting Shi, Dongqing Wei, Chunlei Shi

“…Blocking staphyloxanthin production could help the host immune system counteract the invading S. aureus cells. In this study, we first screened for staphyloxanthin inhibitors using a virtual screening method. …”
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Massa mediastinal em lactente - relato de caso by Thiago Rezende Silveira, Daniel Pinheiro Ferreira, Elina Tosta Oliveira, Danielle Paula de Oliveira Gonçalves, Eliene Machado de Freitas Félix, Adriana Cartafina Perez Bóscollo

“…INTRODUCTION: Mediastinal Teratoma is a neoplasm originating from germ cells and comprises about 8-16% of tumors in this region. …”
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Anti-Inflammatory Effect of IL-37b in Children with Allergic Rhinitis by Wenlong Liu, Li Deng, Yanqiu Chen, Changzhi Sun, Jie Wang, Lifeng Zhou, Huabin Li, Renzhong Luo

“…Peripheral blood mononuclear cells (PBMCs) were purified for in vitro regulation experiment of IL-37b. …”
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Detection of HIV-1 and Human Proteins in Urinary Extracellular Vesicles from HIV+ Patients by Samuel I. Anyanwu, Akins Doherty, Michael D. Powell, Chamberlain Obialo, Ming B. Huang, Alexander Quarshie, Claudette Mitchell, Khalid Bashir, Gale W. Newman

“…Extracellular vesicles (EVs) are membrane bound, secreted by cells, and detected in bodily fluids, including urine, and contain proteins, RNA, and DNA. …”
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Lung-Derived Mediators Induce Cytokine Production in Downstream Organs via an NF-κB-Dependent Mechanism by E. K. Patterson, L. J. Yao, N. Ramic, J. F. Lewis, G. Cepinskas, L. McCaig, R. A. W. Veldhuizen, C. M. Yamashita

“…Exposure of liver endothelial cells to lung-derived mediators resulted in a significant increase in G-CSF, IL-6, CXCL-1, CXCL-2, and MCP-1 production compared to noncirculated control perfusate media (P<0.05). …”
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Endocan Levels in Peripheral Blood Predict Outcomes of Acute Respiratory Distress Syndrome by Ling Tang, Ying Zhao, Daoxin Wang, Wang Deng, Changyi Li, Qi Li, Shicong Huang, Chang Shu

“…To investigate the prognostic significance of endocan, compared with procalcitonin (PCT), C-reactive protein (CRP),white blood cells (WBC), neutrophils (N), and clinical severity scores in patients with ARDS. …”
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Implantable Multifunctional Micro‐Oxygen Reservoir System for Promoting Vascular‐Osteogenesis via Remodeling Regenerative Microenvironment by Min Rui, Jiannan Mao, Hongshuai Wu, Yujian Hui, Hao Shen, Yilin Yang, Tao Ma, Kewei Ren, Juan Wang, Wenguo Cui, Qin Shi, Huilin Yang

“…The CSP‐GM with extra cellular matrix (ECM)‐mimicking structures reconstructed living niches, promoting the adhesion and proliferation of bone marrow stromal cells (BMSCs). As a multifaceted microenvironment regulator, CSP‐GM remodeled the regenerative microenvironment by synergistically producing oxygen and scavenging ROS, recovering mitochondrial homeostasis and antioxidant defenses of BMSCs, promoting angiogenesis and osteogenesis under hypoxia conditions via precisely modulating the Nrf2/HO‐1 signaling pathway. …”
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SEASONAL VARIATION OF PHYTOPLANKTON FUNCTIONAL GROUPS IN TUYEN LAM RESERVOIR, CENTRAL HIGHLANDS, VIETNAM by Thi Hoang Yen Tran, Thi Trang Le, Doan Dang Phan, Thanh Thai Tran, Van Tu Nguyen, Ngoc Lam Nguyen, Thanh Luu Pham

“…Phytoplankton abundance varied from 0.18×105 to 21.2×105 cells/L during the study period, mainly due to cyanobacteria. …”
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<i>In Vitro</i> and <i>In Vivo</i> Evaluation of the Antischistosomal Activity of Polygodial and 9-Deoxymuzigadial Isolated from <i>Drimys brasiliensis</i> Branches by Eric Umehara, Rayssa A. Cajas, Gabriel B. Conceição, Guilherme M. Antar, Adriano D. Andricopulo, Josué de Moraes, João Henrique G. Lago

“…Cytotoxicity assays against Vero cells revealed no toxicity for either compound (CC₅₀ > 200 μM). …”
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